iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mga-060165

Ensembl Protein ID

ENSMGAP00000019613.1

UniProt Accession

G5E7T5; G5E7T5_MELGA

Protein Name

Uncharacterized protein

Gene Name

BRWD1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000014556.2	ENSMGAT00000019235.1	ENSMGAP00000019613.1
ENSMGAG00000014556.2	ENSMGAT00000016370.2	ENSMGAP00000015414.2
ENSMGAG00000014556.2	ENSMGAT00000019955.1	ENSMGAP00000017234.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.80e-34	116.0	173	208
UBD/Beta-Prp	9.40e-54	182.3	276	532

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgv 34
           gH +sv+c+af  + +++ +GsdD+ +k+W+++ g+
   Q: 173  GHLSSVYCVAFdRTgHRIFTGSDDCLVKIWSTHNGR 208
           8**********955599**************98876 PP

UBD/Beta-Prp

   S: 23   sllatgsrdgtikvwdvttgkl......lrslsgheaevt..avkfspdgkilvtgseDrtikvw..dlstgkcvhtlkghedsvlsls 101
           ++++++++dg +  w+++t ++      ++  ++  ++v+  + +fs  g +l+tgs+D++i+ +    +t++ +  l+ h d+v s++
   Q: 276  RYMVSTGADGNVCFWQWDTDSMkfsnrpVKFTEKPRPGVQmlCSSFSVGGMFLATGSTDHVIRMYyfGSETPERIAELESHADKVDSIQ 364
           69999***********99998877888666667777777722556888888**************99999******************* PP
   S: 102  fspsgdklvsGshdrtirvwdletgqclee...............tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl 175
           fs sgd+++sGs+d t+r+w  e+ ++ +                 ++  +  v+++++++++n++v++ ++  +++W+++tg+ll++l
   Q: 365  FSNSGDRFISGSRDGTARIWRFEEAEWRSIlldmsdrlpgdmcseEDKFMRPKVTMIAWNQNDNYVVTAVNNHLLKVWNSSTGQLLHDL 453
           ***************************9999**********8887777777789*********************************** PP
   S: 176  tgghtdsvysls...fdsngkelvsgsldgtvklwdlqtgec......vrtlnghtdnvksvrfspnderlvsgssDgsiriW 249
            g h d v  l+   fds  + ++s+++dg + +wd+ +g+       + + +gh   v + +fsp++++++++ s+g + i+
   Q: 454  VG-HADEVFVLEthpFDS--RIMLSAGHDGNIFIWDITKGTKtkhyfnMIEGQGH-GAVFDCKFSPDGQHFACTDSHGHLLIF 532
           *9.*********555555..99****************77763344433334444.566678999*********999998886 PP

Organism

Meleagris gallopavo

Protein Sequence
(Fasta)

PLIESELYFL IARFLSTGPC RGTLRVLVQE LEQHQLLPKR LDWEGNEHYR SYEELVLSNK 60
HVAPDHLLQI CKRIGPILDK EIPPSISRVN SLLGAGRQSL LRTAKDCRNT VWKGSAFAAL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCGCTCATTG AGTCAGGTAA CGGCGGCGGG CCGCGGGCCG CTGCTCCCTG CCGCCATCTT 60
CCCGAGGGCG GCGATGGATT ACAGCCGCCC CCGTGGCCCC GCCTCGCTCA CTCCCGTCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0103--Bromodomain
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR001487--Bromodomain
IPR018359--Bromodomain_CS
IPR027295--Quinoprotein_ADH-like_fam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00439--Bromodomain
PF00400--WD40

PRINTS

PR00503--BROMODOMAIN

SMART

SM00297--BROMO
SM00320--WD40

Gene Ontology

GO:0005829--C:cytosol
GO:0005730--C:nucleolus
GO:0007010--P:cytoskeleton organization
GO:0008360--P:regulation of cell shape
GO:0006357--P:regulation of transcription from RNA polymerase II promoter

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001113	Aegilops tauschii	30.74	6.00e-64	239.00
IUUC-Aml-002332	Ailuropoda melanoleuca	72.48	0.00e+00	2280.00
IUUC-Apl-004083	Anas platyrhynchos	83.83	0.00e+00	2710.00
IUUC-Aca-004348	Anolis carolinensis	68.54	0.00e+00	2113.00
IUUC-Aly-006517	Arabidopsis lyrata	30.51	3.00e-72	267.00
IUUC-Ath-006577	Arabidopsis thaliana	29.73	8.00e-71	262.00
IUUC-Ame-010718	Astyanax mexicanus	73.07	0.00e+00	1178.00
IUUC-Bta-013217	Bos taurus	74.48	0.00e+00	2350.00
IUUC-Bdi-014797	Brachypodium distachyon	29.59	5.00e-60	226.00
IUUC-Bol-015737	Brassica oleracea	29.23	5.00e-70	259.00
IUUC-Bra-017829	Brassica rapa	29.91	5.00e-71	263.00
IUUC-Cja-019966	Callithrix jacchus	70.23	0.00e+00	2326.00
IUUC-Cfa-021037	Canis familiaris	73.97	0.00e+00	2332.00
IUUC-Cpo-021934	Cavia porcellus	75.65	0.00e+00	2253.00
IUUC-Cre-023003	Chlamydomonas reinhardtii	33.45	3.00e-33	136.00
IUUC-Csa-023352	Chlorocebus sabaeus	68.67	0.00e+00	2117.00
IUUC-Cho-024690	Choloepus hoffmanni	88.03	0.00e+00	697.00
IUUC-Csv-025813	Ciona savignyi	43.63	0.00e+00	637.00
IUUC-Dre-028205	Danio rerio	71.41	0.00e+00	1162.00
IUUC-Dme-031752	Drosophila melanogaster	51.13	0.00e+00	682.00
IUUC-Eca-034349	Equus caballus	73.74	0.00e+00	2249.00
IUUC-Fal-037307	Ficedula albicollis	87.14	0.00e+00	2966.00
IUUC-Gga-040865	Gallus gallus	96.87	0.00e+00	3306.00
IUUC-Gma-043340	Glycine max	30.51	9.00e-69	255.00
IUUC-Ggo-045500	Gorilla gorilla	69.84	0.00e+00	2331.00
IUUC-Hsa-046350	Homo sapiens	70.27	0.00e+00	2343.00
IUUC-Itr-047962	Ictidomys tridecemlineatus	75.68	0.00e+00	884.00
IUUC-Lpe-051619	Leersia perrieri	30.10	9.00e-71	262.00
IUUC-Laf-053848	Loxodonta africana	77.04	0.00e+00	2229.00
IUUC-Mcc-054638	Macaca mulatta	70.16	0.00e+00	2338.00
IUUC-Meu-056739	Macropus eugenii	74.09	0.00e+00	1061.00
IUUC-Mtr-058094	Medicago truncatula	30.19	1.00e-71	265.00
IUUC-Mmr-061227	Microcebus murinus	70.12	0.00e+00	2347.00
IUUC-Mmu-064075	Mus musculus	68.36	0.00e+00	2341.00
IUUC-Mac-065343	Musa acuminata	30.50	4.00e-74	273.00
IUUC-Mpu-066643	Mustela putorius furo	72.04	0.00e+00	2203.00
IUUC-Mlu-067735	Myotis lucifugus	69.28	0.00e+00	2225.00
IUUC-Nle-069402	Nomascus leucogenys	73.23	0.00e+00	2329.00
IUUC-Ont-072298	Oreochromis niloticus	62.58	0.00e+00	1839.00
IUUC-Ocu-074456	Oryctolagus cuniculus	76.61	0.00e+00	2217.00
IUUC-Oba-075709	Oryza barthii	28.47	3.00e-61	231.00
IUUC-Obr-076619	Oryza brachyantha	29.27	3.00e-69	257.00
IUUC-Opu-083233	Oryza punctata	29.39	1.00e-64	241.00
IUUC-Oru-085195	Oryza rufipogon	28.47	2.00e-61	231.00
IUUC-Olu-087745	Ostreococcus lucimarinus	28.08	5.00e-53	202.00
IUUC-Oga-087938	Otolemur garnettii	63.91	0.00e+00	2049.00
IUUC-Oar-090214	Ovis aries	73.92	0.00e+00	2247.00
IUUC-Ptr-091213	Pan troglodytes	70.05	0.00e+00	2341.00
IUUC-Pan-092444	Papio anubis	69.98	0.00e+00	2328.00
IUUC-Psi-093271	Pelodiscus sinensis	78.94	0.00e+00	2480.00
IUUC-Pma-094427	Petromyzon marinus	66.05	4.00e-130	457.00
IUUC-Ppa-095793	Physcomitrella patens	29.06	3.00e-71	264.00
IUUC-Pfo-097318	Poecilia formosa	59.15	0.00e+00	1786.00
IUUC-Pab-097573	Pongo abelii	76.35	0.00e+00	2200.00
IUUC-Pop-099672	Populus trichocarpa	30.75	7.00e-73	269.00
IUUC-Ppe-101849	Prunus persica	30.13	1.00e-73	272.00
IUUC-Pva-102782	Pteropus vampyrus	76.83	0.00e+00	2187.00
IUUC-Rno-105687	Rattus norvegicus	67.96	0.00e+00	2295.00
IUUC-Sly-111348	Solanum lycopersicum	30.32	1.00e-73	272.00
IUUC-Sar-113519	Sorex araneus	68.92	0.00e+00	1306.00
IUUC-Sbi-114195	Sorghum bicolor	28.36	8.00e-61	228.00
IUUC-Tgu-116513	Taeniopygia guttata	86.57	0.00e+00	2955.00
IUUC-Tsy-118921	Tarsius syrichta	74.80	0.00e+00	1707.00
IUUC-Tni-120656	Tetraodon nigroviridis	58.41	0.00e+00	1615.00
IUUC-Tca-121615	Theobroma cacao	30.30	5.00e-67	249.00
IUUC-Tae-125478	Triticum aestivum	29.84	4.00e-71	263.00
IUUC-Tur-126809	Triticum urartu	29.64	7.00e-69	256.00
IUUC-Ttr-128561	Tursiops truncatus	70.93	0.00e+00	2163.00
IUUC-Vpa-130444	Vicugna pacos	74.86	0.00e+00	1997.00
IUUC-Vvi-131362	Vitis vinifera	29.54	1.00e-72	268.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence