iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Afu-008755

Ensembl Protein ID

CADAFUAP00000689

UniProt Accession

Q4WCT7; Q4WCT7_ASPFU

Genbank Protein ID

EAL85801.1

Protein Name

Ubiquitin C-terminal hydrolase, putative

Genbank Nucleotide ID

AAHF01000012

Gene Name

AFUA_6G02380

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
CADAFUAG00000689	CADAFUAT00000689	CADAFUAP00000689

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.30e-58	197.8	110	564
ULD/UDP/UBQ/UBQ_Other	4.70e-11	41.4	8	75

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenp.............kepkgellkslqklfeelwkskkkavsprellkalkkea 81
           Gl+NlgNtCY+NS+LQ+L ++pel++ ll+ +k +   ++               + + +l++sl++lf+++ +++++ + p ++l+al+++ 
   Q: 110  GLQNLGNTCYLNSTLQTLRSVPELQQELLN-YKPSAGSSAGsrlsdlsslglggLGASMDLVSSLRDLFKQM-SETQEGFPPLMFLNALRSVF 200
           9*****************************.4444433333356666666666667777*************.99999*************** PP
   S: 82   eefs.......gyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikc.....lec.dn 161
           ++f        gy+qqDa+E +++++ ql+++l       + +            + e +   + s++++ + g+++s + c     ++  ++
   Q: 201  PQFAqkdrnghGYAQQDAEEAWSQIVTQLRSKL-------VIK------------EGEGDSATEVSFVDKFLAGRFESVTECddpaaKAAgEE 274
           ***999***************************.......111............2345677889****************955443233134 PP
   S: 162  vssreepfldlslpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkve 254
            +++ + f++l +++ ++++     l+d + +   ee++e+     +++ +++   +k+ ++ +lP++L++h+ Rf +++e++++ ki +kv+
   Q: 275  ATKSSDIFFKLDCHIGKETN----HLHDGILAG-LEEKIEK----RSPTLDRDAVYTKRSRIARLPKYLTVHFVRFFWKRETQKKAKIMRKVT 358
           44777778888888888886....577776433.3567774....7899999999************************************** PP
   S: 255  fpleLdlspfcts..............................................................peekqke........... 274
           fp eLd+ +fct+                                                              +     e           
   Q: 359  FPAELDVVEFCTEelkkqlipirdkvrdirkeevdverarkrqklahqreeelkraaesdagleplqkkkategqK-----Eatksgeqdgdt 446
           *************777777777777777777777777777777777776666666666666666666666555550.....055555555566 PP
   S: 275  ...........................................kkkYeLiavvvHsG.slssGHYvayvkn.......ekgkWllfdDskVte 316
                                                      +  YeL av+ H+G s++sGHY++yvk+       e+gkW+ f+D+kVte
   Q: 447  amtdvfksdaeyeaekyasilaakkelaalidpklasdagtnnSGLYELRAVITHQGaSADSGHYTSYVKKqpngkgvEDGKWWWFNDEKVTE 539
           6666666666666666666666666666666666666666666****************************88888877999*********** PP
   S: 317  vkeeevleetg....staYvlfYkr 337
           v+ e++++  g    ++a +l+Y+ 
   Q: 540  VDGEKIETLAGggesHSALILLYRA 564
           ********8889***********85 PP

ULD/UDP/UBQ/UBQ_Other

   S: 8    ldgseltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiLeddktLadyglkdgstihllekksg 75
            +g++++++++ps++  +LK ++++++g+ pe+q++++kG  L+d  +L+++++k+g+t++++ + sg
   Q: 8    HQGKRHEVELDPSANGETLKYQMYSLTGVEPERQKILVKGGQLKDETPLSALNAKPGQTFMMMGTPSG 75
           47889**********************************************************99876 PP

Organism

Aspergillus fumigatus

Protein Sequence
(Fasta)

MFSVIVKHQG KRHEVELDPS ANGETLKYQM YSLTGVEPER QKILVKGGQL KDETPLSALN 60
AKPGQTFMMM GTPSGGQDAV DLGRPKEPVK FLEDMTEAEA ARAEGAIPAG LQNLGNTCYL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTTCTCAG TTATCGTGAA GCATCAAGGC AAACGTCATG AAGTCGAGCT CGATCCGTCT 60
GCAAATGGCG AAACGCTGAA ATATCAAATG TACTCCTTGA CTGGAGTTGA ACCCGAGAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50053--UBIQUITIN_2
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00240--ubiquitin
PF00443--UCH

SMART

SM00213--UBQ

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005838--C:proteasome regulatory particle
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1901799--P:negative regulation of proteasomal protein catabolic process
GO:0016579--P:protein deubiquitination
GO:0032434--P:regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

afm:AFUA_6G02380

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000893	Aegilops tauschii	27.08	7.00e-28	116.00
IUUC-Aml-002053	Ailuropoda melanoleuca	34.72	3.00e-78	284.00
IUUC-Atr-002725	Amborella trichopoda	36.18	7.00e-75	272.00
IUUC-Apl-004031	Anas platyrhynchos	34.37	4.00e-81	293.00
IUUC-Aca-004361	Anolis carolinensis	35.74	4.00e-88	316.00
IUUC-Aly-006176	Arabidopsis lyrata	37.10	3.00e-84	303.00
IUUC-Ath-007658	Arabidopsis thaliana	36.11	2.00e-85	308.00
IUUC-Ago-007796	Ashbya gossypii	33.16	5.00e-82	296.00
IUUC-Acl-008258	Aspergillus clavatus	89.96	0.00e+00	927.00
IUUC-Afl-008732	Aspergillus flavus	86.07	0.00e+00	948.00
IUUC-Ani-009148	Aspergillus nidulans	80.49	0.00e+00	860.00
IUUC-Ang-009878	Aspergillus niger	84.48	0.00e+00	907.00
IUUC-Aor-010239	Aspergillus oryzae	85.89	0.00e+00	946.00
IUUC-Ate-010243	Aspergillus terreus	83.77	0.00e+00	907.00
IUUC-Ame-011327	Astyanax mexicanus	45.12	2.00e-16	79.00
IUUC-Bgr-012231	Blumeria graminis	63.59	0.00e+00	696.00
IUUC-Bta-012553	Bos taurus	34.43	2.00e-80	291.00
IUUC-Bci-013606	Botrytis cinerea	65.74	0.00e+00	695.00
IUUC-Bdi-014567	Brachypodium distachyon	37.82	9.00e-80	288.00
IUUC-Bol-015565	Brassica oleracea	39.40	3.00e-89	320.00
IUUC-Bra-017297	Brassica rapa	39.05	3.00e-88	317.00
IUUC-Cel-018140	Caenorhabditis elegans	30.69	5.00e-61	226.00
IUUC-Cja-019516	Callithrix jacchus	34.66	2.00e-79	288.00
IUUC-Cfa-020808	Canis familiaris	34.95	1.00e-80	292.00
IUUC-Cpo-021688	Cavia porcellus	34.31	4.00e-78	283.00
IUUC-Cre-022663	Chlamydomonas reinhardtii	30.92	4.00e-51	193.00
IUUC-Csa-023429	Chlorocebus sabaeus	34.31	7.00e-78	282.00
IUUC-Cho-024347	Choloepus hoffmanni	34.78	5.00e-79	286.00
IUUC-Cin-025198	Ciona intestinalis	34.09	1.00e-65	241.00
IUUC-Csv-026007	Ciona savignyi	36.13	1.00e-57	215.00
IUUC-Cgl-026757	Colletotrichum gloeosporioides	59.93	3.00e-170	590.00
IUUC-Cne-026963	Cryptococcus neoformans	36.70	1.00e-80	291.00
IUUC-Cme-027240	Cyanidioschyzon merolae	35.23	4.00e-50	190.00
IUUC-Dre-027647	Danio rerio	35.53	6.00e-85	306.00
IUUC-Dno-029967	Dasypus novemcinctus	34.31	2.00e-77	281.00
IUUC-Dor-030886	Dipodomys ordii	32.70	1.00e-42	165.00
IUUC-Dse-031466	Dothistroma septosporum	55.74	6.00e-156	542.00
IUUC-Dme-032079	Drosophila melanogaster	37.60	9.00e-63	232.00
IUUC-Ete-032351	Echinops telfairi	35.68	7.00e-61	226.00
IUUC-Eca-033461	Equus caballus	37.74	3.00e-72	264.00
IUUC-Eeu-035220	Erinaceus europaeus	32.16	4.00e-38	150.00
IUUC-Fca-036210	Felis catus	34.78	2.00e-80	291.00
IUUC-Fal-037528	Ficedula albicollis	35.46	8.00e-80	289.00
IUUC-Fox-037805	Fusarium oxysporum	61.31	0.00e+00	647.00
IUUC-Fso-038177	Fusarium solani	58.38	0.00e+00	640.00
IUUC-Gmo-038953	Gadus morhua	37.50	2.00e-68	251.00
IUUC-Ggr-039972	Gaeumannomyces graminis	59.79	1.00e-177	614.00
IUUC-Gga-040462	Gallus gallus	34.20	4.00e-80	290.00
IUUC-Gac-041312	Gasterosteus aculeatus	34.49	2.00e-78	284.00
IUUC-Gma-043255	Glycine max	37.35	1.00e-81	295.00
IUUC-Ggo-045458	Gorilla gorilla	31.27	2.00e-57	215.00
IUUC-Hsa-045706	Homo sapiens	34.31	1.00e-77	282.00
IUUC-Hvu-047821	Hordeum vulgare	40.70	2.00e-37	147.00
IUUC-Itr-048654	Ictidomys tridecemlineatus	37.65	5.00e-69	253.00
IUUC-Lch-050464	Latimeria chalumnae	33.57	4.00e-76	276.00
IUUC-Lpe-051419	Leersia perrieri	37.17	4.00e-80	290.00
IUUC-Loc-052732	Lepisosteus oculatus	37.78	6.00e-70	256.00
IUUC-Lma-053177	Leptosphaeria maculans	64.12	0.00e+00	657.00
IUUC-Laf-053822	Loxodonta africana	34.60	7.00e-80	289.00
IUUC-Mcc-055893	Macaca mulatta	34.31	1.00e-77	281.00
IUUC-Meu-056307	Macropus eugenii	37.19	6.00e-62	229.00
IUUC-Mor-057171	Magnaporthe oryzae	56.50	0.00e+00	625.00
IUUC-Mpo-057415	Magnaporthe poae	57.58	7.00e-178	615.00
IUUC-Mtr-057901	Medicago truncatula	37.02	5.00e-82	296.00
IUUC-Mla-058897	Melampsora laricipopulina	38.59	1.00e-95	342.00
IUUC-Mga-060016	Meleagris gallopavo	34.20	1.00e-77	282.00
IUUC-Mvi-060562	Microbotryum violaceum	39.12	2.00e-87	315.00
IUUC-Mmr-060624	Microcebus murinus	35.47	9.00e-85	305.00
IUUC-Mdo-061809	Monodelphis domestica	32.13	2.00e-68	251.00
IUUC-Mmu-063869	Mus musculus	37.16	8.00e-66	242.00
IUUC-Mac-064876	Musa acuminata	36.55	2.00e-73	268.00
IUUC-Mpu-066480	Mustela putorius furo	35.12	3.00e-81	293.00
IUUC-Mlu-067866	Myotis lucifugus	34.95	4.00e-80	290.00
IUUC-Nfi-068393	Neosartorya fischeri	97.20	0.00e+00	1062.00
IUUC-Ncr-068815	Neurospora crassa	60.55	0.00e+00	627.00
IUUC-Nle-070121	Nomascus leucogenys	37.41	2.00e-38	150.00
IUUC-Opr-070712	Ochotona princeps	33.19	3.00e-32	131.00
IUUC-Ont-071544	Oreochromis niloticus	39.20	2.00e-66	244.00
IUUC-Oan-073635	Ornithorhynchus anatinus	33.86	3.00e-65	240.00
IUUC-Ocu-074926	Oryctolagus cuniculus	34.37	4.00e-77	280.00
IUUC-Oba-075633	Oryza barthii	41.94	1.00e-67	248.00
IUUC-Obr-076423	Oryza brachyantha	36.99	1.00e-75	275.00
IUUC-Ogl-077913	Oryza glaberrima	37.52	6.00e-79	286.00
IUUC-Ogu-078435	Oryza glumaepatula	41.94	1.00e-67	248.00
IUUC-Oin-080072	Oryza indica	41.94	1.00e-67	248.00
IUUC-Olo-080535	Oryza longistaminata	32.93	4.00e-67	246.00
IUUC-Ome-081309	Oryza meridionalis	41.94	1.00e-67	248.00
IUUC-Oni-083113	Oryza nivara	41.94	1.00e-67	248.00
IUUC-Opu-083168	Oryza punctata	40.86	2.00e-63	234.00
IUUC-Oru-084253	Oryza rufipogon	41.94	1.00e-67	248.00
IUUC-Osa-085554	Oryza sativa	37.64	8.00e-79	285.00
IUUC-Ola-086998	Oryzias latipes	38.69	4.00e-66	243.00
IUUC-Olu-087818	Ostreococcus lucimarinus	32.75	3.00e-60	224.00
IUUC-Oga-088571	Otolemur garnettii	34.43	6.00e-79	286.00
IUUC-Oar-089526	Ovis aries	34.95	2.00e-81	294.00
IUUC-Ptr-091433	Pan troglodytes	34.31	1.00e-77	281.00
IUUC-Pan-091966	Papio anubis	34.31	7.00e-78	282.00
IUUC-Psi-093458	Pelodiscus sinensis	36.64	1.00e-86	311.00
IUUC-Pma-094343	Petromyzon marinus	34.10	6.00e-41	159.00
IUUC-Pno-095109	Phaeosphaeria nodorum	64.09	0.00e+00	666.00
IUUC-Ppa-095756	Physcomitrella patens	38.31	5.00e-91	326.00
IUUC-Pfo-096514	Poecilia formosa	38.19	3.00e-66	244.00
IUUC-Pab-098477	Pongo abelii	30.87	6.00e-60	223.00
IUUC-Pop-099221	Populus trichocarpa	37.05	2.00e-80	291.00
IUUC-Pca-100791	Procavia capensis	30.06	1.00e-27	115.00
IUUC-Ppe-101812	Prunus persica	36.73	2.00e-82	297.00
IUUC-Pva-102462	Pteropus vampyrus	35.83	4.00e-54	203.00
IUUC-Pgr-103623	Puccinia graminis	43.13	6.00e-75	273.00
IUUC-Ptt-103767	Puccinia triticina	35.79	2.00e-76	278.00
IUUC-Pte-104109	Pyrenophora teres	66.61	0.00e+00	690.00
IUUC-Pyt-104766	Pyrenophora triticirepentis	66.27	0.00e+00	673.00
IUUC-Rno-105351	Rattus norvegicus	36.67	3.00e-64	237.00
IUUC-Sce-106168	Saccharomyces cerevisiae	33.39	5.00e-77	280.00
IUUC-Sha-107491	Sarcophilus harrisii	35.22	2.00e-82	297.00
IUUC-Sja-107769	Schizosaccharomyces japonicus	38.53	6.00e-98	349.00
IUUC-Spo-108174	Schizosaccharomyces pombe	39.86	3.00e-104	370.00
IUUC-Ssl-108659	Sclerotinia sclerotiorum	65.28	0.00e+00	674.00
IUUC-Smo-108805	Selaginella moellendorffii	42.60	6.00e-76	276.00
IUUC-Sit-110361	Setaria italica	36.84	9.00e-76	275.00
IUUC-Sly-110965	Solanum lycopersicum	37.11	5.00e-83	299.00
IUUC-Sar-113355	Sorex araneus	36.23	4.00e-53	200.00
IUUC-Sbi-114778	Sorghum bicolor	44.77	1.00e-74	272.00
IUUC-Sre-115011	Sporisorium reilianum	39.72	5.00e-98	349.00
IUUC-Ssc-116273	Sus scrofa	37.03	8.00e-66	242.00
IUUC-Tgu-117063	Taeniopygia guttata	35.28	7.00e-80	289.00
IUUC-Tru-118381	Takifugu rubripes	33.97	5.00e-75	273.00
IUUC-Tsy-119076	Tarsius syrichta	29.35	7.00e-28	116.00
IUUC-Tni-119941	Tetraodon nigroviridis	38.40	1.00e-67	248.00
IUUC-Tca-121246	Theobroma cacao	37.17	1.00e-82	298.00
IUUC-Tre-121969	Trichoderma reesei	58.76	3.00e-169	586.00
IUUC-Tvi-122543	Trichoderma virens	57.69	5.00e-177	612.00
IUUC-Tae-125744	Triticum aestivum	38.05	1.00e-84	305.00
IUUC-Tur-126128	Triticum urartu	34.62	1.00e-18	86.30
IUUC-Tbe-128030	Tupaia belangeri	33.50	5.00e-56	209.00
IUUC-Ttr-128701	Tursiops truncatus	36.64	5.00e-51	193.00
IUUC-Uma-129657	Ustilago maydis	39.69	6.00e-96	342.00
IUUC-Vda-129723	Verticillium dahliae	58.73	0.00e+00	639.00
IUUC-Vpa-130284	Vicugna pacos	33.17	6.00e-26	110.00
IUUC-Vvi-131037	Vitis vinifera	36.82	8.00e-85	305.00
IUUC-Xtr-132235	Xenopus tropicalis	35.76	5.00e-85	306.00
IUUC-Xma-133840	Xiphophorus maculatus	38.19	2.00e-66	244.00
IUUC-Yli-134453	Yarrowia lipolytica	43.74	5.00e-116	409.00
IUUC-Zma-135791	Zea mays	36.89	1.00e-80	291.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence