iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ago-007948

Ensembl Protein ID

AAS50247

UniProt Accession

Q75F47; ATG18_ASHGO

Genbank Protein ID

AAS50247.1

Protein Name

Autophagy-related protein 18

Genbank Nucleotide ID

AE016814

Gene Name

ATG18; AAL119W

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AGOS_AAL119W	AAS50247	AAS50247

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.30e-07	28.5	258	294

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgt.ikvWDlrtgvl 35
           H++++ +la+  d tll+++s  gt i+v+++ t+++
   Q: 258  HKGEIAALALsKDgTLLATASEKGTiIRVFSVETCTK 294
           999*******9777***********999***998876 PP

Organism

Ashbya gossypii

Functional Description
(View)

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct ATG9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity).

Protein Sequence
(Fasta)

MSRTGMPVIN FINFNQTGTC ISMGTSEGLK IFNCDPFGRF YSDEDGGCGI VEMLFSTSLL 60
AVVGIGDNPS MSPRRLRILN TKRHSVICEV TFPTTILAVK MNRSRLVVLL QEQIYIYDIN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCGAGGA CGGGGATGCC AGTGATCAAC TTTATAAACT TCAACCAGAC GGGAACATGT 60
ATCTCTATGG GGACATCAGA GGGGCTGAAA ATCTTCAACT GCGATCCTTT TGGGAGATTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-0967--Endosome
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0926--Vacuole
KW-0853--WD repeat

Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0005829--C:cytosol
GO:0010008--C:endosome membrane
GO:0000329--C:fungal-type vacuole membrane
GO:0070772--C:PAS complex
GO:0034045--C:pre-autophagosomal structure membrane
GO:0080025--F:phosphatidylinositol-3,5-bisphosphate binding
GO:0032258--P:CVT pathway
GO:0045324--P:late endosome to vacuole transport
GO:0044805--P:late nucleophagy
GO:0016236--P:macroautophagy
GO:0030242--P:pexophagy
GO:0034727--P:piecemeal microautophagy of nucleus
GO:0006624--P:vacuolar protein processing

KEGG

ago:AGOS_AAL119W

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000966	Aegilops tauschii	30.53	2.00e-28	117.00
IUUC-Atr-002710	Amborella trichopoda	43.36	1.00e-32	131.00
IUUC-Aca-004975	Anolis carolinensis	31.85	9.00e-28	115.00
IUUC-Aly-006440	Arabidopsis lyrata	35.14	5.00e-23	99.80
IUUC-Ath-007660	Arabidopsis thaliana	41.26	6.00e-30	122.00
IUUC-Acl-008148	Aspergillus clavatus	38.62	3.00e-72	263.00
IUUC-Afl-008562	Aspergillus flavus	54.73	2.00e-47	180.00
IUUC-Afu-008936	Aspergillus fumigatus	33.95	4.00e-72	263.00
IUUC-Ani-009254	Aspergillus nidulans	39.27	5.00e-78	282.00
IUUC-Ang-009798	Aspergillus niger	39.73	9.00e-76	275.00
IUUC-Aor-010066	Aspergillus oryzae	54.73	2.00e-47	180.00
IUUC-Ate-010266	Aspergillus terreus	55.41	6.00e-48	182.00
IUUC-Ame-010727	Astyanax mexicanus	42.31	1.00e-28	118.00
IUUC-Bta-012655	Bos taurus	31.85	1.00e-27	114.00
IUUC-Bci-013627	Botrytis cinerea	29.81	2.00e-43	167.00
IUUC-Bdi-014739	Brachypodium distachyon	30.66	3.00e-28	117.00
IUUC-Bol-015492	Brassica oleracea	41.26	2.00e-29	120.00
IUUC-Bra-017319	Brassica rapa	28.67	3.00e-23	100.00
IUUC-Cja-018761	Callithrix jacchus	27.12	2.00e-27	114.00
IUUC-Cpo-022235	Cavia porcellus	41.56	2.00e-27	114.00
IUUC-Cre-022613	Chlamydomonas reinhardtii	38.46	1.00e-31	128.00
IUUC-Csa-023963	Chlorocebus sabaeus	41.30	5.00e-24	103.00
IUUC-Cin-025682	Ciona intestinalis	27.83	8.00e-29	118.00
IUUC-Cgl-026425	Colletotrichum gloeosporioides	38.21	5.00e-26	109.00
IUUC-Cne-026947	Cryptococcus neoformans	58.52	4.00e-44	169.00
IUUC-Dre-027490	Danio rerio	42.31	1.00e-28	118.00
IUUC-Dor-030931	Dipodomys ordii	28.25	1.00e-27	114.00
IUUC-Dse-031215	Dothistroma septosporum	28.17	7.00e-45	172.00
IUUC-Dme-031881	Drosophila melanogaster	42.17	2.00e-14	70.90
IUUC-Ete-032276	Echinops telfairi	30.61	6.00e-18	83.20
IUUC-Eeu-034479	Erinaceus europaeus	39.60	3.00e-17	79.70
IUUC-Fox-037797	Fusarium oxysporum	53.42	2.00e-45	174.00
IUUC-Fso-038174	Fusarium solani	54.11	3.00e-45	173.00
IUUC-Ggr-040113	Gaeumannomyces graminis	53.38	5.00e-46	176.00
IUUC-Gga-040690	Gallus gallus	31.85	9.00e-28	115.00
IUUC-Gac-041360	Gasterosteus aculeatus	43.92	2.00e-28	117.00
IUUC-Gma-043876	Glycine max	46.26	2.00e-34	137.00
IUUC-Ggo-045610	Gorilla gorilla	40.35	1.00e-19	88.60
IUUC-Hvu-047851	Hordeum vulgare	30.53	2.00e-28	117.00
IUUC-Kpa-049378	Komagataella pastoris	52.85	8.00e-97	345.00
IUUC-Lch-049800	Latimeria chalumnae	34.48	3.00e-19	86.70
IUUC-Lpe-051205	Leersia perrieri	41.26	1.00e-29	122.00
IUUC-Loc-052379	Lepisosteus oculatus	34.56	9.00e-18	82.00
IUUC-Lma-052948	Leptosphaeria maculans	28.63	3.00e-49	187.00
IUUC-Laf-054007	Loxodonta africana	31.85	1.00e-27	115.00
IUUC-Mcc-055829	Macaca mulatta	30.86	4.00e-22	96.70
IUUC-Meu-056020	Macropus eugenii	39.60	3.00e-17	80.10
IUUC-Mor-057125	Magnaporthe oryzae	53.42	1.00e-44	171.00
IUUC-Mpo-057416	Magnaporthe poae	44.83	9.00e-18	82.40
IUUC-Mtr-058609	Medicago truncatula	37.93	6.00e-19	86.30
IUUC-Mla-058885	Melampsora laricipopulina	37.80	2.00e-13	67.00
IUUC-Mvi-060219	Microbotryum violaceum	65.00	2.00e-46	177.00
IUUC-Mmr-061021	Microcebus murinus	40.35	7.00e-20	89.00
IUUC-Mdo-062881	Monodelphis domestica	31.85	8.00e-28	115.00
IUUC-Mmu-063787	Mus musculus	42.57	1.00e-27	115.00
IUUC-Mac-064838	Musa acuminata	30.58	6.00e-30	122.00
IUUC-Mpu-066019	Mustela putorius furo	39.88	6.00e-25	106.00
IUUC-Nfi-068424	Neosartorya fischeri	38.16	1.00e-73	267.00
IUUC-Ncr-068833	Neurospora crassa	47.17	8.00e-43	165.00
IUUC-Nle-069047	Nomascus leucogenys	34.48	2.00e-19	87.40
IUUC-Opr-070933	Ochotona princeps	48.48	2.00e-18	84.70
IUUC-Ont-072495	Oreochromis niloticus	43.92	2.00e-28	117.00
IUUC-Ocu-074689	Oryctolagus cuniculus	42.95	5.00e-27	113.00
IUUC-Oba-075827	Oryza barthii	41.26	1.00e-29	121.00
IUUC-Obr-076476	Oryza brachyantha	41.26	6.00e-30	122.00
IUUC-Ogl-077630	Oryza glaberrima	41.26	1.00e-29	121.00
IUUC-Ogu-078126	Oryza glumaepatula	41.26	1.00e-29	121.00
IUUC-Oin-080115	Oryza indica	41.26	1.00e-29	121.00
IUUC-Olo-080657	Oryza longistaminata	30.42	3.00e-29	122.00
IUUC-Ome-081702	Oryza meridionalis	30.42	2.00e-29	121.00
IUUC-Oni-083063	Oryza nivara	40.69	1.00e-21	95.10
IUUC-Opu-083460	Oryza punctata	30.42	4.00e-29	121.00
IUUC-Oru-084193	Oryza rufipogon	41.26	1.00e-29	121.00
IUUC-Osa-085948	Oryza sativa	41.26	1.00e-29	121.00
IUUC-Ola-086628	Oryzias latipes	33.79	5.00e-22	96.30
IUUC-Olu-087808	Ostreococcus lucimarinus	28.62	3.00e-27	113.00
IUUC-Oar-090011	Ovis aries	27.75	6.00e-28	115.00
IUUC-Pan-092111	Papio anubis	42.57	3.00e-27	113.00
IUUC-Pma-094403	Petromyzon marinus	45.05	9.00e-20	88.60
IUUC-Pno-095015	Phaeosphaeria nodorum	48.67	2.00e-37	147.00
IUUC-Ppa-095377	Physcomitrella patens	40.82	5.00e-24	103.00
IUUC-Pca-100176	Procavia capensis	39.47	1.00e-19	88.20
IUUC-Ppe-101963	Prunus persica	28.77	1.00e-22	98.20
IUUC-Pva-102156	Pteropus vampyrus	27.32	1.00e-25	108.00
IUUC-Pgr-103496	Puccinia graminis	34.78	2.00e-12	64.70
IUUC-Ptt-103915	Puccinia triticina	33.01	1.00e-12	65.50
IUUC-Pte-104139	Pyrenophora teres	48.99	3.00e-39	153.00
IUUC-Pyt-104488	Pyrenophora triticirepentis	49.32	3.00e-39	153.00
IUUC-Rno-105990	Rattus norvegicus	42.57	1.00e-27	115.00
IUUC-Sce-106327	Saccharomyces cerevisiae	58.46	8.00e-175	604.00
IUUC-Sja-107913	Schizosaccharomyces japonicus	52.86	6.00e-41	159.00
IUUC-Spo-108068	Schizosaccharomyces pombe	54.55	6.00e-39	152.00
IUUC-Ssl-108418	Sclerotinia sclerotiorum	30.26	5.00e-56	209.00
IUUC-Smo-108755	Selaginella moellendorffii	30.28	3.00e-28	117.00
IUUC-Sit-110095	Setaria italica	30.77	5.00e-29	119.00
IUUC-Sly-111030	Solanum lycopersicum	40.41	4.00e-30	123.00
IUUC-Stu-112534	Solanum tuberosum	28.92	6.00e-26	109.00
IUUC-Sar-113276	Sorex araneus	39.60	3.00e-17	79.70
IUUC-Sbi-114020	Sorghum bicolor	30.77	5.00e-29	119.00
IUUC-Sre-115219	Sporisorium reilianum	57.53	8.00e-43	165.00
IUUC-Ssc-116360	Sus scrofa	31.85	2.00e-27	114.00
IUUC-Tsy-119533	Tarsius syrichta	39.47	1.00e-19	87.40
IUUC-Tni-119729	Tetraodon nigroviridis	33.79	8.00e-22	95.50
IUUC-Tca-121732	Theobroma cacao	39.86	1.00e-26	111.00
IUUC-Tre-121895	Trichoderma reesei	54.05	6.00e-46	176.00
IUUC-Tvi-122311	Trichoderma virens	54.05	6.00e-46	176.00
IUUC-Tae-123911	Triticum aestivum	30.88	5.00e-29	119.00
IUUC-Tur-126757	Triticum urartu	30.88	4.00e-29	119.00
IUUC-Ttr-128703	Tursiops truncatus	38.60	5.00e-19	86.30
IUUC-Uma-129438	Ustilago maydis	58.22	9.00e-43	165.00
IUUC-Vda-129782	Verticillium dahliae	38.86	3.00e-27	113.00
IUUC-Vvi-131053	Vitis vinifera	36.36	4.00e-24	103.00
IUUC-Xtr-131806	Xenopus tropicalis	34.48	1.00e-19	88.20
IUUC-Yli-134337	Yarrowia lipolytica	34.22	8.00e-55	205.00
IUUC-Zma-135654	Zea mays	30.07	5.00e-26	109.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence