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Tag Content
iUUCD ID IUUC-Afu-008967
Ensembl Protein ID CADAFUAP00001732
UniProt Accession A4D9P4; ATG12_ASPFU
Genbank Protein ID EBA27356.1
Protein Name Ubiquitin-like protein ATG12; Autophagy-related protein 12
Genbank Nucleotide ID AAHF01000006
Gene Name AFUA_6G09165; atg12
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
CADAFUAG00001732 CADAFUAT00001732 CADAFUAP00001732
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
ULD/UBL/ATG12 28.74 2.00e-10 62.80 IUUC-Hsa-046903
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Aspergillus fumigatus
Functional Description
(View)

Functional Description


     Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy. Conjugation with atg5 through a ubiquitin-like conjugating system involving also atg7 as an E1-like activating enzyme and atg10 as an E2-like conjugating enzyme, is essential for its function. The atg12-atg5 conjugate functions as an E3-like enzyme which is required for lipidation of atg8 and atg8 association to the vesicle membranes (By similarity).
 Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy. Conjugation with atg5 through a ubiquitin-like conjugating system involving also atg7 as an E1-like activating enzyme and atg10 as an E2-like conjugating enzyme, is essential for its function. The atg12-atg5 conjugate functions as an E3-like enzyme which is required for lipidation of atg8 and atg8 association to the vesicle membranes (By similarity).
Protein Sequence
(Fasta)
MDSPSPENPS GTESPNPKSP QTTGTRLSHR PASRQKPALD SNTRSAPIPD DEHGADLPIT 60
MSASVVLSSL PRDAHRALAD AEAVDTGKVT VRFQPLPSAP ILKNRVFKIS ASQKFETVVK 120
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Protein Fasta Sequence


>IUUC-Afu-008967|ULD,ATG12|Aspergillus fumigatus
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Nucleotide Sequence
(Fasta)
ATGGACTCTC CATCACCAGA AAACCCCTCA GGGACAGAAT CTCCAAATCC AAAATCCCCA 60
CAAACAACGG GCACCAGACT CAGCCATCGA CCTGCTAGTA GACAAAAACC AGCTTTGGAT 120
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Nucleotide Fasta Sequence


>IUUC-Afu-008967|ULD,ATG12|Aspergillus fumigatus
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Sequence Source Ensembl
Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0833--Ubl conjugation pathway
Interpro

IPR007242--Atg12
IPR029071--Ubiquitin-rel_dom
Pfam

PF04110--APG12
Gene Ontology

GO:0034045--C:pre-autophagosomal structure membrane
GO:0000045--P:autophagosome assembly
GO:0015031--P:protein transport
KEGG afm:AFUA_6G09165
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001177 Aegilops tauschii 42.53 3.00e-15 71.20
IUUC-Aml-002116 Ailuropoda melanoleuca 29.89 2.00e-12 63.20
IUUC-Atr-002615 Amborella trichopoda 41.38 5.00e-14 67.00
IUUC-Apl-003753 Anas platyrhynchos 47.50 1.00e-07 45.40
IUUC-Aca-005231 Anolis carolinensis 29.89 6.00e-09 51.20
IUUC-Aly-006172 Arabidopsis lyrata 43.68 7.00e-15 70.10
IUUC-Ath-006953 Arabidopsis thaliana 43.68 4.00e-16 73.90
IUUC-Ago-007970 Ashbya gossypii 44.83 9.00e-14 68.20
IUUC-Acl-008072 Aspergillus clavatus 99.12 3.00e-64 234.00
IUUC-Afl-008725 Aspergillus flavus 82.61 1.00e-75 273.00
IUUC-Ani-009248 Aspergillus nidulans 85.14 3.00e-71 258.00
IUUC-Ang-009684 Aspergillus niger 75.14 2.00e-75 272.00
IUUC-Aor-009947 Aspergillus oryzae 82.61 1.00e-75 273.00
IUUC-Ame-011656 Astyanax mexicanus 28.26 6.00e-11 57.80
IUUC-Bgr-012174 Blumeria graminis 55.00 7.00e-26 107.00
IUUC-Bta-012483 Bos taurus 28.74 5.00e-12 61.20
IUUC-Bci-013755 Botrytis cinerea 57.38 2.00e-31 125.00
IUUC-Bdi-014156 Brachypodium distachyon 42.86 2.00e-16 75.50
IUUC-Bol-015683 Brassica oleracea 43.68 4.00e-16 73.90
IUUC-Bra-016802 Brassica rapa 42.53 4.00e-15 70.50
IUUC-Cel-018242 Caenorhabditis elegans 35.16 3.00e-12 62.00
IUUC-Cja-019514 Callithrix jacchus 28.74 9.00e-12 61.20
IUUC-Cfa-020748 Canis familiaris 29.89 2.00e-12 63.50
IUUC-Cpo-021965 Cavia porcellus 29.89 4.00e-12 62.40
IUUC-Cre-023009 Chlamydomonas reinhardtii 39.13 3.00e-13 64.30
IUUC-Csa-023494 Chlorocebus sabaeus 28.74 4.00e-12 62.00
IUUC-Cho-024631 Choloepus hoffmanni 28.74 5.00e-12 62.00
IUUC-Cin-025609 Ciona intestinalis 44.83 3.00e-20 87.80
IUUC-Cgl-026722 Colletotrichum gloeosporioides 50.00 8.00e-34 134.00
IUUC-Dre-027479 Danio rerio 29.36 3.00e-12 62.00
IUUC-Dno-029693 Dasypus novemcinctus 45.00 2.00e-06 43.10
IUUC-Dse-031440 Dothistroma septosporum 56.74 5.00e-45 171.00
IUUC-Dme-031892 Drosophila melanogaster 26.67 2.00e-10 55.50
IUUC-Ete-032550 Echinops telfairi 32.00 2.00e-11 59.30
IUUC-Eca-033553 Equus caballus 28.74 3.00e-12 62.40
IUUC-Eeu-034975 Erinaceus europaeus 38.64 6.10e-01 27.70
IUUC-Fca-036524 Felis catus 29.89 7.00e-11 58.20
IUUC-Fal-036942 Ficedula albicollis 31.40 5.00e-12 60.10
IUUC-Fox-037753 Fusarium oxysporum 64.17 9.00e-39 150.00
IUUC-Gmo-039498 Gadus morhua 28.74 1.00e-10 56.60
IUUC-Ggr-039852 Gaeumannomyces graminis 60.33 1.00e-30 124.00
IUUC-Gga-041263 Gallus gallus 29.89 2.00e-12 62.80
IUUC-Gac-042346 Gasterosteus aculeatus 30.95 6.00e-11 57.40
IUUC-Gma-042896 Glycine max 41.38 9.00e-14 66.20
IUUC-Ggo-045601 Gorilla gorilla 28.74 6.00e-12 62.00
IUUC-Hsa-046903 Homo sapiens 28.74 4.00e-12 62.00
IUUC-Hvu-047239 Hordeum vulgare 43.68 2.00e-15 71.20
IUUC-Itr-048445 Ictidomys tridecemlineatus 28.74 4.00e-12 62.00
IUUC-Kpa-049355 Komagataella pastoris 32.54 3.00e-14 68.90
IUUC-Lch-050619 Latimeria chalumnae 32.18 2.00e-13 65.90
IUUC-Loc-052102 Lepisosteus oculatus 27.27 1.00e-03 32.30
IUUC-Lma-053299 Leptosphaeria maculans 58.33 2.00e-32 128.00
IUUC-Laf-054205 Loxodonta africana 28.74 2.00e-12 62.80
IUUC-Meu-056804 Macropus eugenii 29.89 3.00e-12 62.00
IUUC-Mor-057052 Magnaporthe oryzae 58.97 1.00e-30 123.00
IUUC-Mtr-057961 Medicago truncatula 42.53 2.00e-14 68.60
IUUC-Mla-059045 Melampsora laricipopulina 50.00 2.00e-25 105.00
IUUC-Mvi-060360 Microbotryum violaceum 49.00 4.00e-24 101.00
IUUC-Mmr-061654 Microcebus murinus 28.74 3.00e-12 62.00
IUUC-Mdo-062649 Monodelphis domestica 28.74 2.00e-12 62.80
IUUC-Mmu-064105 Mus musculus 28.74 4.00e-12 62.00
IUUC-Mac-065532 Musa acuminata 43.68 2.00e-15 71.60
IUUC-Mpu-066269 Mustela putorius furo 29.89 1.00e-12 63.90
IUUC-Mlu-067631 Myotis lucifugus 28.74 2.00e-12 63.20
IUUC-Nfi-068468 Neosartorya fischeri 100.00 7.00e-65 236.00
IUUC-Ncr-068750 Neurospora crassa 55.73 8.00e-39 150.00
IUUC-Nle-069483 Nomascus leucogenys 28.74 2.00e-12 63.50
IUUC-Opr-070936 Ochotona princeps 28.74 4.00e-12 62.40
IUUC-Obr-076322 Oryza brachyantha 40.22 2.00e-15 71.60
IUUC-Ogl-077226 Oryza glaberrima 39.76 2.00e-13 65.10
IUUC-Oin-079220 Oryza indica 38.81 3.00e-10 54.70
IUUC-Olo-080688 Oryza longistaminata 39.76 2.00e-13 65.10
IUUC-Ome-081265 Oryza meridionalis 39.76 2.00e-13 65.10
IUUC-Oru-084342 Oryza rufipogon 41.38 2.00e-14 70.90
IUUC-Osa-086212 Oryza sativa 39.76 2.00e-13 65.10
IUUC-Ola-087277 Oryzias latipes 28.89 1.00e-11 59.30
IUUC-Olu-087780 Ostreococcus lucimarinus 34.07 8.00e-09 50.10
IUUC-Oga-088175 Otolemur garnettii 28.74 4.00e-12 62.00
IUUC-Oar-089477 Ovis aries 28.74 7.00e-12 61.60
IUUC-Ptr-091129 Pan troglodytes 28.74 6.00e-12 62.00
IUUC-Psi-093351 Pelodiscus sinensis 28.74 8.00e-12 60.80
IUUC-Pno-094948 Phaeosphaeria nodorum 57.94 7.00e-34 134.00
IUUC-Ppa-095788 Physcomitrella patens 41.38 4.00e-15 70.90
IUUC-Pfo-096993 Poecilia formosa 26.60 1.00e-10 56.60
IUUC-Pab-098502 Pongo abelii 28.74 5.00e-12 62.40
IUUC-Pop-098819 Populus trichocarpa 37.93 1.00e-13 65.50
IUUC-Pca-100144 Procavia capensis 16.09 1.30e-02 30.80
IUUC-Ppe-101560 Prunus persica 41.18 4.00e-13 63.90
IUUC-Pva-102810 Pteropus vampyrus 26.87 2.00e-07 46.20
IUUC-Pgr-103531 Puccinia graminis 50.00 1.00e-25 106.00
IUUC-Ptt-103753 Puccinia triticina 50.98 2.00e-25 105.00
IUUC-Pyt-104733 Pyrenophora triticirepentis 52.82 7.00e-41 157.00
IUUC-Rno-106072 Rattus norvegicus 29.89 2.00e-12 63.20
IUUC-Sce-106275 Saccharomyces cerevisiae 45.56 1.00e-19 87.80
IUUC-Sha-107554 Sarcophilus harrisii 29.89 1.00e-12 63.50
IUUC-Sja-107682 Schizosaccharomyces japonicus 39.52 2.00e-25 105.00
IUUC-Spo-108275 Schizosaccharomyces pombe 42.22 3.00e-18 82.00
IUUC-Smo-109151 Selaginella moellendorffii 41.86 8.00e-14 66.20
IUUC-Sit-110270 Setaria italica 42.53 3.00e-15 71.20
IUUC-Sly-111862 Solanum lycopersicum 41.30 2.00e-14 68.60
IUUC-Stu-112663 Solanum tuberosum 40.00 1.00e-04 36.60
IUUC-Sbi-114148 Sorghum bicolor 42.53 3.00e-15 71.20
IUUC-Sre-115216 Sporisorium reilianum 48.48 9.00e-25 103.00
IUUC-Ssc-116051 Sus scrofa 28.74 3.00e-12 62.40
IUUC-Tru-118466 Takifugu rubripes 27.91 2.00e-09 51.60
IUUC-Tsy-119334 Tarsius syrichta 26.44 6.00e-09 52.00
IUUC-Tni-119792 Tetraodon nigroviridis 27.91 3.00e-10 54.30
IUUC-Tca-121861 Theobroma cacao 42.53 6.00e-14 67.40
IUUC-Tvi-122499 Trichoderma virens 59.50 4.00e-35 137.00
IUUC-Tae-123431 Triticum aestivum 42.53 3.00e-15 71.20
IUUC-Tme-126934 Tuber melanosporum 52.43 8.00e-28 114.00
IUUC-Ttr-129001 Tursiops truncatus 26.44 8.00e-08 48.10
IUUC-Uma-129324 Ustilago maydis 47.47 2.00e-24 102.00
IUUC-Vda-129846 Verticillium dahliae 61.67 2.00e-37 145.00
IUUC-Vpa-130202 Vicugna pacos 45.00 5.00e-07 45.80
IUUC-Vvi-131474 Vitis vinifera 44.29 5.00e-10 55.10
IUUC-Xtr-132782 Xenopus tropicalis 31.03 9.00e-13 63.90
IUUC-Xma-134140 Xiphophorus maculatus 26.60 4.00e-10 55.10
IUUC-Yli-134517 Yarrowia lipolytica 46.67 7.00e-19 85.10
IUUC-Zma-134764 Zea mays 42.53 2.00e-15 71.60
Created Date 25-Jun-2017

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