iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ptr-090617

UUCD1 version

UUC-PaT-01032

Ensembl Protein ID

ENSPTRP00000038879.3

UniProt Accession

G2HJ78; G2HJ78_PANTR

Genbank Protein ID

BAK63786.1; JAA03453.1; JAA13193.1; JAA26530.1; JAA43834.1

Protein Name

NEDD8-activating enzyme E1 regulatory subunit

Genbank Nucleotide ID

AACZ03102765; GABC01007885; GABF01008952; GABD01006570; GABE01000905

Gene Name

NAE1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000024077.4	ENSPTRT00000044977.3	ENSPTRP00000038879.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	5.90e-134	447.3	13	525

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvn 89
           YDRQ+rlwG+++qe+l+sa+v+l++a+++G+E+lKnLvl G+gs+t++D+++v+ ++ +++F+++++++gk++A +a+e+l+eln+dv+
   Q: 13   YDRQLRLWGDHGQEALESAHVCLINATATGTEILKNLVLPGIGSFTIIDGNQVSGEDAGNNFFLQRSSIGKNRAAAAMEFLQELNSDVS 101
           ***************************************************************************************** PP
   S: 90   veaheesiteleeeiv.FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dppqktiPfc 174
           ++++ees+++l ++++ Ff++f+vVv+++ +++++++++++++n ++pl++++t+Gl+G++r+iik++++++s++d   +++++++Pf+
   Q: 102  GSFVEESPENLLDNDPsFFCRFTVVVATQLPESTSLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPDnalEDLRLDKPFP 190
           ***************************************************************************************** PP
   S: 175  tlketpn.........aaehtiewavlfnklleeeageeevlekldseekeegkdkvkselks......edeenfeeaieiavkafakt 248
           +l+e+++         +++++++w+v+++k+l+++++e++++ +++++eke+++d++++++ +      edeenfeeai+++++a+++t
   Q: 191  ELREHFQsydldhmekKDHSHTPWIVIIAKYLAQWYSETNGRIPKTYKEKEDFRDLIRQGILKnengapEDEENFEEAIKNVNTALNTT 279
           *****99999999998***********************************************9************************* PP
   S: 249  tins.ikqllksfecdivtkskspfwv.............................................................. 274
           +i+s i++++++++c ++tk++++fw+                                                              
   Q: 280  QIPSsIEDIFNDDRCINITKQTPSFWIlaralkefvakegqgnlpvrgtipdmiadsgkyiklqnvyrekakkdaaavgnhvakllqsi 368
           ***************************************************************************************** PP
   S: 275  .............sfcsnaealqvp...........ekvekdeevvkasap.....lylllralerfekkkgrkpgelsfekddds..a 332
                         +csn++ l+v            ++++kde+++++++p     lyl+lra++rf+k++gr+pg++++++++d+  +
   Q: 369  gqapesisekelkLLCSNSAFLRVVrcrslaeeyglDTINKDEIISSMDNPdneivLYLMLRAVDRFHKQHGRYPGVSNYQVEEDIgkL 457
           *************99********7777777888888**************9***********************************999 PP
   S: 333  vdlvtaaanlraeslgiepkldddlikeiagniipaiattnavvgGlaaqEviKvvsgkfeplknfflfdae 404
            +++t ++    +++g++ +++dd+++e++++++++ +t++a++gG+aaqEviK+++++f+ ++n++++ ++
   Q: 458  KSCLTGFL----QEYGLSVMVKDDYVHEFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQFVIFNNTYIYSGM 525
           ********....********************************************************9776 PP

Organism

Pan troglodytes

Functional Description
(View)

Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M.

Protein Sequence
(Fasta)

MAQLGKLLKE QKYDRQLRLW GDHGQEALES AHVCLINATA TGTEILKNLV LPGIGSFTII 60
DGNQVSGEDA GNNFFLQRSS IGKNRAAAAM EFLQELNSDV SGSFVEESPE NLLDNDPSFF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTGCGCCTG CGCGCTTGTG GAGCTGGTGG CGGCGCTCCG CAGGGGCTCG GCTGTTTTCC 60
GCGCGGCAGG CGCAGCCATG GCGCAGCTGG GGAAGCTGCT CAAGGAGCAG AAGTACGACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0019781--F:NEDD8 activating enzyme activity
GO:0033314--P:mitotic DNA replication checkpoint
GO:0051402--P:neuron apoptotic process
GO:0045116--P:protein neddylation
GO:0043523--P:regulation of neuron apoptotic process

KEGG

ptr:467995

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000764	Aegilops tauschii	42.53	7.00e-126	444.00
IUUC-Aml-002333	Ailuropoda melanoleuca	97.39	0.00e+00	1085.00
IUUC-Atr-002644	Amborella trichopoda	41.27	5.00e-114	404.00
IUUC-Apl-003446	Anas platyrhynchos	84.01	0.00e+00	919.00
IUUC-Aca-004450	Anolis carolinensis	80.30	0.00e+00	917.00
IUUC-Aly-006187	Arabidopsis lyrata	40.46	8.00e-125	440.00
IUUC-Ath-007600	Arabidopsis thaliana	41.03	4.00e-126	444.00
IUUC-Ago-007900	Ashbya gossypii	26.70	9.00e-40	157.00
IUUC-Acl-008333	Aspergillus clavatus	34.69	2.00e-81	296.00
IUUC-Afl-008529	Aspergillus flavus	36.72	1.00e-87	317.00
IUUC-Afu-009071	Aspergillus fumigatus	33.69	1.00e-81	296.00
IUUC-Ani-009443	Aspergillus nidulans	33.87	3.00e-79	289.00
IUUC-Ang-009669	Aspergillus niger	33.51	2.00e-82	300.00
IUUC-Aor-009914	Aspergillus oryzae	36.04	2.00e-84	306.00
IUUC-Ate-010450	Aspergillus terreus	34.70	2.00e-84	306.00
IUUC-Ame-011183	Astyanax mexicanus	72.21	0.00e+00	832.00
IUUC-Bgr-012111	Blumeria graminis	33.15	2.00e-66	246.00
IUUC-Bta-012583	Bos taurus	97.94	0.00e+00	1092.00
IUUC-Bci-013892	Botrytis cinerea	33.15	4.00e-65	242.00
IUUC-Bdi-014592	Brachypodium distachyon	43.32	4.00e-128	451.00
IUUC-Bol-016399	Brassica oleracea	40.08	2.00e-123	436.00
IUUC-Bra-017506	Brassica rapa	39.05	4.00e-119	421.00
IUUC-Cel-018456	Caenorhabditis elegans	35.98	5.00e-94	338.00
IUUC-Cja-020007	Callithrix jacchus	98.14	0.00e+00	1093.00
IUUC-Cfa-020324	Canis familiaris	97.94	0.00e+00	1090.00
IUUC-Cpo-022248	Cavia porcellus	66.36	0.00e+00	642.00
IUUC-Csa-023149	Chlorocebus sabaeus	99.34	0.00e+00	937.00
IUUC-Cho-024537	Choloepus hoffmanni	85.68	0.00e+00	811.00
IUUC-Cin-025763	Ciona intestinalis	49.53	1.00e-156	546.00
IUUC-Csv-026113	Ciona savignyi	46.67	8.00e-147	513.00
IUUC-Cgl-026428	Colletotrichum gloeosporioides	31.64	4.00e-65	242.00
IUUC-Cne-026884	Cryptococcus neoformans	30.07	5.00e-72	265.00
IUUC-Cme-027210	Cyanidioschyzon merolae	27.11	2.00e-19	90.50
IUUC-Dre-028140	Danio rerio	73.53	0.00e+00	852.00
IUUC-Dno-030033	Dasypus novemcinctus	98.10	0.00e+00	967.00
IUUC-Dor-030513	Dipodomys ordii	69.01	4.00e-116	411.00
IUUC-Dse-031536	Dothistroma septosporum	35.29	4.00e-85	308.00
IUUC-Dme-031683	Drosophila melanogaster	44.47	1.00e-127	449.00
IUUC-Ete-032420	Echinops telfairi	83.33	0.00e+00	888.00
IUUC-Eca-033992	Equus caballus	98.20	0.00e+00	920.00
IUUC-Eeu-034713	Erinaceus europaeus	80.31	1.00e-118	419.00
IUUC-Fca-036548	Felis catus	96.82	0.00e+00	1078.00
IUUC-Fal-037600	Ficedula albicollis	80.84	0.00e+00	888.00
IUUC-Fox-038037	Fusarium oxysporum	33.70	1.00e-76	280.00
IUUC-Fso-038387	Fusarium solani	34.59	2.00e-78	286.00
IUUC-Gmo-038562	Gadus morhua	71.40	0.00e+00	824.00
IUUC-Ggr-040005	Gaeumannomyces graminis	34.48	8.00e-74	271.00
IUUC-Gga-041129	Gallus gallus	84.30	0.00e+00	940.00
IUUC-Gac-042558	Gasterosteus aculeatus	72.69	0.00e+00	835.00
IUUC-Gma-043610	Glycine max	41.44	2.00e-120	425.00
IUUC-Ggo-045611	Gorilla gorilla	99.07	0.00e+00	1104.00
IUUC-Hsa-046563	Homo sapiens	99.63	0.00e+00	1107.00
IUUC-Hvu-047790	Hordeum vulgare	38.11	3.00e-77	281.00
IUUC-Itr-048066	Ictidomys tridecemlineatus	97.94	0.00e+00	1091.00
IUUC-Kpa-049309	Komagataella pastoris	35.86	7.00e-84	304.00
IUUC-Lch-050038	Latimeria chalumnae	76.60	0.00e+00	857.00
IUUC-Lpe-051535	Leersia perrieri	41.45	2.00e-111	395.00
IUUC-Loc-051917	Lepisosteus oculatus	69.56	0.00e+00	795.00
IUUC-Lma-053112	Leptosphaeria maculans	35.51	4.00e-87	315.00
IUUC-Laf-053690	Loxodonta africana	96.63	0.00e+00	1084.00
IUUC-Mcc-055117	Macaca mulatta	97.03	0.00e+00	1079.00
IUUC-Meu-056761	Macropus eugenii	77.18	0.00e+00	829.00
IUUC-Mor-057230	Magnaporthe oryzae	33.63	6.00e-78	284.00
IUUC-Mpo-057514	Magnaporthe poae	33.63	8.00e-72	264.00
IUUC-Mtr-058551	Medicago truncatula	40.74	4.00e-117	415.00
IUUC-Mla-059183	Melampsora laricipopulina	36.98	2.00e-96	346.00
IUUC-Mga-060144	Meleagris gallopavo	83.14	0.00e+00	917.00
IUUC-Mvi-060221	Microbotryum violaceum	35.62	2.00e-81	296.00
IUUC-Mmr-061325	Microcebus murinus	95.16	0.00e+00	1061.00
IUUC-Mdo-062532	Monodelphis domestica	91.74	0.00e+00	1030.00
IUUC-Mmu-063956	Mus musculus	97.19	0.00e+00	1085.00
IUUC-Mac-064521	Musa acuminata	40.75	3.00e-123	435.00
IUUC-Mpu-066716	Mustela putorius furo	97.01	0.00e+00	1023.00
IUUC-Mlu-067459	Myotis lucifugus	95.71	0.00e+00	1065.00
IUUC-Nfi-068245	Neosartorya fischeri	34.05	8.00e-82	297.00
IUUC-Ncr-068910	Neurospora crassa	34.30	1.00e-76	280.00
IUUC-Nle-070034	Nomascus leucogenys	96.38	0.00e+00	1051.00
IUUC-Opr-070552	Ochotona princeps	87.62	0.00e+00	889.00
IUUC-Ont-071426	Oreochromis niloticus	73.35	0.00e+00	853.00
IUUC-Oan-073389	Ornithorhynchus anatinus	83.82	0.00e+00	779.00
IUUC-Ocu-074911	Oryctolagus cuniculus	96.44	0.00e+00	1084.00
IUUC-Oba-075437	Oryza barthii	42.94	2.00e-118	419.00
IUUC-Obr-076684	Oryza brachyantha	43.13	1.00e-113	403.00
IUUC-Ogl-077170	Oryza glaberrima	42.94	2.00e-118	419.00
IUUC-Ogu-078844	Oryza glumaepatula	43.71	2.00e-111	396.00
IUUC-Oin-079105	Oryza indica	42.94	6.00e-118	417.00
IUUC-Olo-080943	Oryza longistaminata	40.44	3.00e-106	378.00
IUUC-Oni-082891	Oryza nivara	40.08	7.00e-112	397.00
IUUC-Opu-083457	Oryza punctata	42.94	8.00e-118	417.00
IUUC-Oru-084960	Oryza rufipogon	40.44	3.00e-106	379.00
IUUC-Osa-085358	Oryza sativa	43.13	1.00e-118	419.00
IUUC-Ola-086420	Oryzias latipes	71.31	9.00e-169	585.00
IUUC-Olu-087625	Ostreococcus lucimarinus	30.85	1.00e-60	227.00
IUUC-Oga-088810	Otolemur garnettii	96.25	0.00e+00	1078.00
IUUC-Oar-089196	Ovis aries	97.39	0.00e+00	1089.00
IUUC-Pan-092761	Papio anubis	99.06	0.00e+00	1101.00
IUUC-Psi-093191	Pelodiscus sinensis	86.85	0.00e+00	965.00
IUUC-Pma-094380	Petromyzon marinus	62.07	0.00e+00	663.00
IUUC-Pno-095084	Phaeosphaeria nodorum	32.61	3.00e-74	273.00
IUUC-Ppa-095875	Physcomitrella patens	40.04	1.00e-119	422.00
IUUC-Pfo-096467	Poecilia formosa	72.59	0.00e+00	834.00
IUUC-Pab-098255	Pongo abelii	98.65	0.00e+00	915.00
IUUC-Pop-099722	Populus trichocarpa	41.03	3.00e-124	438.00
IUUC-Pca-100807	Procavia capensis	78.87	4.00e-118	417.00
IUUC-Ppe-101280	Prunus persica	40.68	3.00e-123	435.00
IUUC-Pva-102333	Pteropus vampyrus	92.92	0.00e+00	1025.00
IUUC-Pgr-103401	Puccinia graminis	32.30	6.00e-82	298.00
IUUC-Ptt-103889	Puccinia triticina	27.67	9.00e-59	221.00
IUUC-Pte-104355	Pyrenophora teres	36.48	2.00e-90	326.00
IUUC-Pyt-104545	Pyrenophora triticirepentis	36.19	3.00e-91	329.00
IUUC-Rno-105810	Rattus norvegicus	96.63	0.00e+00	1080.00
IUUC-Sce-106397	Saccharomyces cerevisiae	26.02	3.00e-37	149.00
IUUC-Sha-106770	Sarcophilus harrisii	90.11	5.00e-154	536.00
IUUC-Sja-107926	Schizosaccharomyces japonicus	32.95	2.00e-77	283.00
IUUC-Spo-108276	Schizosaccharomyces pombe	35.02	1.00e-83	303.00
IUUC-Ssl-108387	Sclerotinia sclerotiorum	32.36	3.00e-67	249.00
IUUC-Smo-109296	Selaginella moellendorffii	42.42	5.00e-123	434.00
IUUC-Sit-110157	Setaria italica	44.40	8.00e-135	473.00
IUUC-Sly-111105	Solanum lycopersicum	40.19	9.00e-122	430.00
IUUC-Stu-112469	Solanum tuberosum	40.71	1.00e-123	436.00
IUUC-Sar-113083	Sorex araneus	73.45	0.00e+00	754.00
IUUC-Sbi-113813	Sorghum bicolor	44.40	5.00e-134	471.00
IUUC-Sre-115058	Sporisorium reilianum	38.89	2.00e-85	310.00
IUUC-Tgu-116772	Taeniopygia guttata	80.46	0.00e+00	887.00
IUUC-Tru-118686	Takifugu rubripes	71.64	0.00e+00	836.00
IUUC-Tsy-119111	Tarsius syrichta	89.05	8.00e-149	520.00
IUUC-Tni-120231	Tetraodon nigroviridis	66.42	0.00e+00	754.00
IUUC-Tca-121491	Theobroma cacao	40.72	2.00e-116	412.00
IUUC-Tre-122103	Trichoderma reesei	37.00	9.00e-84	304.00
IUUC-Tvi-122672	Trichoderma virens	36.88	1.00e-75	276.00
IUUC-Tae-125679	Triticum aestivum	43.13	8.00e-128	450.00
IUUC-Tur-126487	Triticum urartu	41.41	4.00e-121	428.00
IUUC-Tme-127097	Tuber melanosporum	38.73	5.00e-95	341.00
IUUC-Ttr-128465	Tursiops truncatus	90.32	0.00e+00	997.00
IUUC-Uma-129645	Ustilago maydis	33.67	5.00e-90	325.00
IUUC-Vda-129989	Verticillium dahliae	30.68	4.00e-56	212.00
IUUC-Vpa-130529	Vicugna pacos	92.92	0.00e+00	1032.00
IUUC-Vvi-131059	Vitis vinifera	41.63	8.00e-122	430.00
IUUC-Xtr-132002	Xenopus tropicalis	78.75	0.00e+00	905.00
IUUC-Xma-133930	Xiphophorus maculatus	73.00	0.00e+00	839.00
IUUC-Yli-134505	Yarrowia lipolytica	34.86	2.00e-85	309.00
IUUC-Zma-135895	Zea mays	44.66	3.00e-133	468.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence