iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-034059

UUCD1 version

UUC-EqC-01067

Ensembl Protein ID

ENSECAP00000012739.1

UniProt Accession

F7C9G5; F7C9G5_HORSE

Protein Name

Ubiquitinyl hydrolase 1

Gene Name

USP5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000014532.1	ENSECAT00000015808.1	ENSECAP00000012739.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	8.60e-64	216.0	324	853
UBD/Alpha-Helix/UBA	1.10e-22	79.5	723	760

Active Site

Position(s)	Description	Evidence
333	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
816	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel....................wkskkkavs 69
           tG++NlgN+CY+NSv+Q+L++ip++++ + + k ek+ +++p++p+++++++++kl + l                    +k+ +  ++
   Q: 324  TGIRNLGNSCYLNSVVQVLFSIPDFQRKYVD-KLEKIFQNAPTDPTQDFSTQVAKLGHGLlsgeyskpaaesgdgeqvpeQKEVQDGIA 411
           7******************************.99999999********************66666666666666555443366666*** PP
   S: 70   prellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikcle 158
           pr++++ ++k ++efs+++qqDaqEf+ +l++ +e+++                             ++++  +++F++ ++++ikcl+
   Q: 412  PRMFKALIGKGHPEFSTNRQQDAQEFFLHLINMVERNC-----------------------------RSSENPNEVFRFLVEEKIKCLA 471
           **************************************.............................6788899*************** PP
   S: 159  cdnvssreepfldlslpvpgkeetkke...........................slqdcLesftkeeelegenkyycekckkkqeaekk 220
            ++v+ ++   + ++lpvp++   +ke                            +++cLe++ ++e++++   ++++  ++k+ a+k+
   Q: 472  TEKVKYTQRVDYIMQLPVPMDAALNKEelleyeekkrqaeeeklplpelvraqvPFSSCLEAYGAPEQVDD---FWSTALQAKSVAVKT 557
           **********************999989*****************************************97...*************** PP
   S: 221  lklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts.......................................... 267
           +++ ++P++L++++k+f+f  + ++++k++ ++e+p+eLd+s+   +                                          
   Q: 558  TRFASFPDYLVIQIKKFTFGLD-WVPKKLDVSIEMPEELDISQLRGTglqpgeeelpdiapplvtpdepkgslgfygnededsfcsphf 645
           *******************997.*******************98888788888888888888888888888888888888777777777 PP
   S: 268  .................................................................................peekqke. 274
                                                                                            +     + 
   Q: 646  ssptspmldesviiqlvemgfpmdacrkavyytgnsgaeaamnwvmshmddpdfanplilpgssgpgstsaaadpppedcvT-----Ti 729
           7777777777777777777777777777777777666666666666666666666666666666665555555555555550.....05 PP
   S: 275  ..................................................................kkkYeLiavvvHsG.slssGHYv 296
                                                                             + kY+L+a ++H+G s+ +GHYv
   Q: 730  vsmgfsrdqalkalratnnsleravdwifshiddldaeaamdisegrsaadsisesvpvgpkvrdgPGKYQLFAFISHMGtSTMCGHYV 818
           555555555555566666666667777777777777777777777777778888888888888888*********************** PP
   S: 297  ayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           +++k+ +g+W+ ++D+kV ++  e+  +   + +Y++fY+r
   Q: 819  CHIKK-EGRWVIYNDQKVCAS--EKPPK---DLGYIYFYQR 853
           *****.9***********999..78888...89******98 PP

UBD/Alpha-Helix/UBA

   S: 4    edkleqlveMGFdreealqaLraannnleaAveyLldg 41
           ed +  +v+MGF+r++al+aLra+nn+le+Av++++++
   Q: 723  EDCVTTIVSMGFSRDQALKALRATNNSLERAVDWIFSH 760
           889999******************************97 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

RKLSEEALLS VLPTIRVPKA GDRVHKDECA FSFDTPESEG GLYICMNTFL GFGKQYVERH 60
FNKTGQRVYL HLRRTRRPKE EDTATGTGDP PRKKPTRLAI GVEGGFDLSE EKFEYDEDVK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGAAACTGA GTGAGGAGGC GCTGCTGTCA GTGTTACCGA CGATCCGGGT CCCTAAGGCT 60
GGAGACCGGG TCCACAAAGA CGAGTGCGCC TTCTCTTTCG ACACGCCGGT AAGCCCACTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0071108--P:protein K48-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000394	Aegilops tauschii	44.31	0.00e+00	644.00
IUUC-Aml-002104	Ailuropoda melanoleuca	98.59	0.00e+00	1647.00
IUUC-Apl-003774	Anas platyrhynchos	91.68	0.00e+00	1528.00
IUUC-Aca-005368	Anolis carolinensis	86.62	0.00e+00	1503.00
IUUC-Aly-005727	Arabidopsis lyrata	47.05	0.00e+00	724.00
IUUC-Ath-006974	Arabidopsis thaliana	47.15	0.00e+00	725.00
IUUC-Ago-007890	Ashbya gossypii	29.43	3.00e-83	303.00
IUUC-Acl-008057	Aspergillus clavatus	33.61	2.00e-122	433.00
IUUC-Afl-008547	Aspergillus flavus	36.18	7.00e-116	410.00
IUUC-Afu-008805	Aspergillus fumigatus	34.32	1.00e-115	410.00
IUUC-Ani-009441	Aspergillus nidulans	32.39	3.00e-98	352.00
IUUC-Ang-009720	Aspergillus niger	33.53	1.00e-116	414.00
IUUC-Aor-010111	Aspergillus oryzae	33.87	8.00e-126	444.00
IUUC-Ate-010531	Aspergillus terreus	31.99	1.00e-102	367.00
IUUC-Ame-011893	Astyanax mexicanus	65.09	0.00e+00	982.00
IUUC-Bgr-012183	Blumeria graminis	33.57	2.00e-120	426.00
IUUC-Bta-013179	Bos taurus	98.58	0.00e+00	1650.00
IUUC-Bci-013858	Botrytis cinerea	34.73	1.00e-128	454.00
IUUC-Bdi-014904	Brachypodium distachyon	46.85	0.00e+00	707.00
IUUC-Bol-015296	Brassica oleracea	47.55	0.00e+00	740.00
IUUC-Bra-017939	Brassica rapa	47.44	0.00e+00	741.00
IUUC-Cel-018625	Caenorhabditis elegans	34.93	3.00e-134	472.00
IUUC-Cja-019063	Callithrix jacchus	97.06	0.00e+00	1617.00
IUUC-Cfa-020976	Canis familiaris	96.22	0.00e+00	1596.00
IUUC-Cpo-022265	Cavia porcellus	95.87	0.00e+00	1585.00
IUUC-Cre-022640	Chlamydomonas reinhardtii	39.07	1.00e-110	393.00
IUUC-Csa-024177	Chlorocebus sabaeus	95.43	0.00e+00	1452.00
IUUC-Cho-024702	Choloepus hoffmanni	90.00	0.00e+00	999.00
IUUC-Cin-025411	Ciona intestinalis	50.18	0.00e+00	825.00
IUUC-Csv-026347	Ciona savignyi	46.30	0.00e+00	788.00
IUUC-Cgl-026667	Colletotrichum gloeosporioides	34.45	9.00e-113	400.00
IUUC-Cne-026831	Cryptococcus neoformans	35.23	1.00e-127	450.00
IUUC-Cme-027335	Cyanidioschyzon merolae	26.18	4.00e-61	229.00
IUUC-Dre-027982	Danio rerio	67.25	0.00e+00	1092.00
IUUC-Dno-029034	Dasypus novemcinctus	98.47	0.00e+00	1662.00
IUUC-Dor-030479	Dipodomys ordii	93.91	0.00e+00	716.00
IUUC-Dse-031467	Dothistroma septosporum	35.88	8.00e-130	457.00
IUUC-Dme-032075	Drosophila melanogaster	48.68	0.00e+00	800.00
IUUC-Ete-032865	Echinops telfairi	87.03	0.00e+00	1458.00
IUUC-Eeu-035304	Erinaceus europaeus	92.92	0.00e+00	1501.00
IUUC-Fca-035515	Felis catus	99.17	0.00e+00	1659.00
IUUC-Fal-037271	Ficedula albicollis	88.30	0.00e+00	1429.00
IUUC-Fox-037745	Fusarium oxysporum	35.12	5.00e-128	451.00
IUUC-Fso-038158	Fusarium solani	36.27	1.00e-127	450.00
IUUC-Gmo-039071	Gadus morhua	64.95	0.00e+00	1069.00
IUUC-Ggr-040098	Gaeumannomyces graminis	34.13	6.00e-118	418.00
IUUC-Gga-040635	Gallus gallus	91.43	0.00e+00	1594.00
IUUC-Gac-042528	Gasterosteus aculeatus	64.17	0.00e+00	1082.00
IUUC-Gma-043614	Glycine max	46.62	0.00e+00	698.00
IUUC-Ggo-044602	Gorilla gorilla	98.82	0.00e+00	1649.00
IUUC-Hsa-045959	Homo sapiens	98.82	0.00e+00	1649.00
IUUC-Hvu-047563	Hordeum vulgare	47.37	7.00e-167	580.00
IUUC-Itr-048712	Ictidomys tridecemlineatus	98.23	0.00e+00	1645.00
IUUC-Kpa-049156	Komagataella pastoris	33.06	1.00e-112	400.00
IUUC-Lch-049648	Latimeria chalumnae	81.89	0.00e+00	1372.00
IUUC-Lpe-051523	Leersia perrieri	46.66	0.00e+00	711.00
IUUC-Loc-052520	Lepisosteus oculatus	62.93	0.00e+00	1013.00
IUUC-Lma-053216	Leptosphaeria maculans	34.44	2.00e-112	401.00
IUUC-Laf-054327	Loxodonta africana	97.99	0.00e+00	1642.00
IUUC-Mcc-055443	Macaca mulatta	98.70	0.00e+00	1647.00
IUUC-Meu-056298	Macropus eugenii	93.75	0.00e+00	1064.00
IUUC-Mor-057106	Magnaporthe oryzae	35.17	8.00e-130	457.00
IUUC-Mpo-057589	Magnaporthe poae	34.79	1.00e-122	434.00
IUUC-Mtr-058680	Medicago truncatula	48.08	0.00e+00	728.00
IUUC-Mla-058903	Melampsora laricipopulina	32.31	5.00e-119	421.00
IUUC-Mga-059669	Meleagris gallopavo	90.55	0.00e+00	1516.00
IUUC-Mvi-060476	Microbotryum violaceum	34.54	7.00e-118	418.00
IUUC-Mmr-060575	Microcebus murinus	98.58	0.00e+00	1652.00
IUUC-Mdo-062183	Monodelphis domestica	92.09	0.00e+00	1535.00
IUUC-Mmu-063592	Mus musculus	98.47	0.00e+00	1650.00
IUUC-Mac-065634	Musa acuminata	42.90	0.00e+00	682.00
IUUC-Mpu-066082	Mustela putorius furo	95.40	0.00e+00	1578.00
IUUC-Mlu-067345	Myotis lucifugus	96.47	0.00e+00	1611.00
IUUC-Nfi-068558	Neosartorya fischeri	34.93	5.00e-122	431.00
IUUC-Ncr-068960	Neurospora crassa	35.07	8.00e-116	411.00
IUUC-Nle-070173	Nomascus leucogenys	95.87	0.00e+00	1583.00
IUUC-Opr-070556	Ochotona princeps	97.40	0.00e+00	1637.00
IUUC-Ont-071502	Oreochromis niloticus	64.95	0.00e+00	1080.00
IUUC-Ocu-074861	Oryctolagus cuniculus	95.28	0.00e+00	1583.00
IUUC-Oba-075109	Oryza barthii	46.37	0.00e+00	714.00
IUUC-Obr-076292	Oryza brachyantha	47.66	0.00e+00	708.00
IUUC-Ogl-077065	Oryza glaberrima	47.66	0.00e+00	743.00
IUUC-Ogu-078776	Oryza glumaepatula	46.37	0.00e+00	726.00
IUUC-Oin-080048	Oryza indica	47.20	0.00e+00	737.00
IUUC-Olo-080711	Oryza longistaminata	44.54	0.00e+00	656.00
IUUC-Ome-081506	Oryza meridionalis	45.59	0.00e+00	668.00
IUUC-Oni-082320	Oryza nivara	45.82	0.00e+00	712.00
IUUC-Opu-083801	Oryza punctata	46.55	0.00e+00	707.00
IUUC-Oru-085139	Oryza rufipogon	45.82	0.00e+00	713.00
IUUC-Osa-085713	Oryza sativa	47.78	0.00e+00	746.00
IUUC-Ola-086951	Oryzias latipes	65.54	0.00e+00	1077.00
IUUC-Olu-087822	Ostreococcus lucimarinus	41.25	2.00e-178	619.00
IUUC-Oga-088625	Otolemur garnettii	98.00	0.00e+00	1635.00
IUUC-Oar-089995	Ovis aries	96.00	0.00e+00	1618.00
IUUC-Ptr-090640	Pan troglodytes	96.22	0.00e+00	1629.00
IUUC-Pan-091974	Papio anubis	97.76	0.00e+00	1629.00
IUUC-Psi-093957	Pelodiscus sinensis	90.05	0.00e+00	1590.00
IUUC-Pma-094242	Petromyzon marinus	71.92	1.00e-165	575.00
IUUC-Pno-094835	Phaeosphaeria nodorum	34.41	6.00e-109	388.00
IUUC-Ppa-095901	Physcomitrella patens	49.48	0.00e+00	780.00
IUUC-Pfo-097148	Poecilia formosa	66.08	0.00e+00	1092.00
IUUC-Pab-098068	Pongo abelii	91.13	0.00e+00	1473.00
IUUC-Pop-098943	Populus trichocarpa	46.62	0.00e+00	705.00
IUUC-Pca-100738	Procavia capensis	98.50	0.00e+00	1143.00
IUUC-Ppe-101315	Prunus persica	46.98	0.00e+00	717.00
IUUC-Pva-102154	Pteropus vampyrus	96.81	0.00e+00	1618.00
IUUC-Pgr-103343	Puccinia graminis	33.33	5.00e-107	382.00
IUUC-Ptt-103928	Puccinia triticina	30.37	3.00e-104	372.00
IUUC-Pte-104306	Pyrenophora teres	31.70	5.00e-105	375.00
IUUC-Pyt-104696	Pyrenophora triticirepentis	32.95	6.00e-108	385.00
IUUC-Rno-105801	Rattus norvegicus	98.11	0.00e+00	1646.00
IUUC-Sce-106304	Saccharomyces cerevisiae	28.25	3.00e-71	263.00
IUUC-Sha-107635	Sarcophilus harrisii	92.33	0.00e+00	1545.00
IUUC-Sja-107678	Schizosaccharomyces japonicus	32.25	2.00e-107	383.00
IUUC-Spo-108144	Schizosaccharomyces pombe	32.15	6.00e-112	398.00
IUUC-Smo-108848	Selaginella moellendorffii	48.07	0.00e+00	731.00
IUUC-Sit-110728	Setaria italica	48.02	0.00e+00	765.00
IUUC-Sly-111523	Solanum lycopersicum	47.50	0.00e+00	754.00
IUUC-Sbi-114419	Sorghum bicolor	47.15	0.00e+00	746.00
IUUC-Sre-115225	Sporisorium reilianum	35.28	4.00e-126	445.00
IUUC-Ssc-115686	Sus scrofa	97.64	0.00e+00	1639.00
IUUC-Tgu-117346	Taeniopygia guttata	91.09	0.00e+00	1563.00
IUUC-Tru-118350	Takifugu rubripes	65.08	0.00e+00	1105.00
IUUC-Tni-120658	Tetraodon nigroviridis	66.16	0.00e+00	1088.00
IUUC-Tca-121585	Theobroma cacao	47.39	0.00e+00	716.00
IUUC-Tre-122043	Trichoderma reesei	34.22	2.00e-117	416.00
IUUC-Tvi-122303	Trichoderma virens	34.38	3.00e-124	439.00
IUUC-Tae-125686	Triticum aestivum	47.19	0.00e+00	728.00
IUUC-Tur-126732	Triticum urartu	44.72	0.00e+00	682.00
IUUC-Tme-126909	Tuber melanosporum	33.99	2.00e-116	413.00
IUUC-Tbe-127261	Tupaia belangeri	91.68	0.00e+00	1043.00
IUUC-Uma-129599	Ustilago maydis	34.16	6.00e-130	458.00
IUUC-Vda-129688	Verticillium dahliae	33.37	1.00e-117	417.00
IUUC-Vvi-131116	Vitis vinifera	47.27	0.00e+00	700.00
IUUC-Xtr-131953	Xenopus tropicalis	79.39	0.00e+00	1350.00
IUUC-Xma-133837	Xiphophorus maculatus	66.20	0.00e+00	1093.00
IUUC-Yli-134510	Yarrowia lipolytica	35.25	2.00e-127	449.00
IUUC-Zma-135786	Zea mays	47.26	0.00e+00	714.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence