iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Gac-042117

UUCD1 version

UUC-GaA-00704

Ensembl Protein ID

ENSGACP00000018233.1

UniProt Accession

G3PKV3; G3PKV3_GASAC

Protein Name

Ribosome biogenesis protein WDR12; WD repeat-containing protein 12

Gene Name

wdr12; WDR12

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGACG00000013778.1	ENSGACT00000018268.1	ENSGACP00000018233.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	7.60e-41	136.7	341	376
UBD/Beta-Prp	7.20e-48	163.7	246	414

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf..sd.tllvsGsdDgtikvWDlrtgv 34
           Ht++vt++++  s    lvsGs D+ +k+WD+r+++
   Q: 341  HTGWVTAVKWapSHeYQLVSGSLDNLVKLWDTRSCK 376
           ***********644577**************99876 PP

UBD/Beta-Prp

   S: 83   tgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl..ktg 169
           t+++++tl+gh++ v s+ +   ++ + s+s+d tir+wd+etg     tl+g + v nc++++p ++ l+sGs+Dr +rlWd   k g
   Q: 246  TRTPLMTLSGHNEAVSSVLWTD-SEEVCSASWDHTIRIWDIETGGMKT-TLTGSK-VFNCISYSPLCRRLASGSTDRHIRLWDPrtKDG 331
           67899****************9.8999*******************98.999987.99*************************955556 PP
   S: 170  kllrtl.tgghtdsvyslsfdsng.kelvsgsldgtvklwdlq.tgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdl 251
           +l++   t+ ht+ v+ +++ ++   +lvsgsld+ vklwd +  +  ++ l +h+d v +v+ + ++ +++sg++D+ ++ + +
   Q: 332  SLVQLSlTS-HTGWVTAVKWAPSHeYQLVSGSLDNLVKLWDTRsCKAPLYDLAAHEDKVFCVDWT-ESGLMLSGGADNKLYTYRC 414
           777755365.**********9988799****************54566****************9.99**********9988755 PP

Organism

Gasterosteus aculeatus

Functional Description
(View)

Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.

Protein Sequence
(Fasta)

MSQLQARFFT ENKRYVVDDV PFSIPAASEV LELSNVINKL LEAKNASHSK VEFDFLVRGQ 60
FLRTSLATHM ETEGISTEDV VEIEYVERIT APEAEECMMH DDWISAVDAD AEWILTGSYD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTCACTGCA CGAGAGTCGT TCGTGTTATG AAGGAGCAGA TTAACTAGGT AGCCATATCC 60
CAGATTTCTA TTGCTTTTGG TACGTTGGGG AAATATATAC ATTTACCAAA ATGTCACAAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0690--Ribosome biogenesis
KW-0698--rRNA processing
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR012972--NLE
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR028599--WDR12/Ytm1

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08154--NLE
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0030687--C:preribosome, large subunit precursor
GO:0043021--F:ribonucleoprotein complex binding
GO:0000466--P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000463--P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000532	Aegilops tauschii	32.78	9.00e-64	237.00
IUUC-Aml-001997	Ailuropoda melanoleuca	75.61	1.00e-177	615.00
IUUC-Atr-002544	Amborella trichopoda	35.00	4.00e-63	235.00
IUUC-Apl-003981	Anas platyrhynchos	76.52	3.00e-170	590.00
IUUC-Aca-004370	Anolis carolinensis	75.29	0.00e+00	666.00
IUUC-Aly-006455	Arabidopsis lyrata	35.40	1.00e-65	243.00
IUUC-Ath-006669	Arabidopsis thaliana	35.32	2.00e-60	226.00
IUUC-Ago-007864	Ashbya gossypii	32.95	5.00e-50	191.00
IUUC-Acl-008177	Aspergillus clavatus	29.18	4.00e-41	162.00
IUUC-Afl-008617	Aspergillus flavus	29.52	1.00e-40	160.00
IUUC-Afu-008752	Aspergillus fumigatus	27.49	2.00e-38	153.00
IUUC-Ani-009136	Aspergillus nidulans	29.82	2.00e-41	163.00
IUUC-Ang-009701	Aspergillus niger	27.75	3.00e-40	159.00
IUUC-Aor-009884	Aspergillus oryzae	29.52	5.00e-41	162.00
IUUC-Ame-011432	Astyanax mexicanus	82.03	0.00e+00	702.00
IUUC-Bgr-012218	Blumeria graminis	29.03	4.00e-40	159.00
IUUC-Bta-012829	Bos taurus	75.41	0.00e+00	641.00
IUUC-Bci-013953	Botrytis cinerea	30.23	6.00e-41	161.00
IUUC-Bdi-014351	Brachypodium distachyon	34.82	2.00e-62	233.00
IUUC-Bol-016190	Brassica oleracea	34.68	2.00e-62	233.00
IUUC-Bra-018095	Brassica rapa	34.94	2.00e-63	236.00
IUUC-Cel-018569	Caenorhabditis elegans	32.30	7.00e-52	197.00
IUUC-Cja-019468	Callithrix jacchus	74.47	4.00e-179	620.00
IUUC-Cfa-020471	Canis familiaris	75.41	5.00e-180	623.00
IUUC-Cpo-022260	Cavia porcellus	74.94	0.00e+00	628.00
IUUC-Cre-022614	Chlamydomonas reinhardtii	32.66	2.00e-45	176.00
IUUC-Csa-023989	Chlorocebus sabaeus	74.23	3.00e-179	620.00
IUUC-Cho-024426	Choloepus hoffmanni	73.65	5.00e-135	474.00
IUUC-Cin-025789	Ciona intestinalis	44.24	1.00e-106	379.00
IUUC-Cne-027063	Cryptococcus neoformans	26.07	5.00e-16	79.00
IUUC-Dre-027907	Danio rerio	82.98	0.00e+00	717.00
IUUC-Dno-029225	Dasypus novemcinctus	74.23	0.00e+00	634.00
IUUC-Dor-031082	Dipodomys ordii	61.70	3.00e-135	474.00
IUUC-Dse-031308	Dothistroma septosporum	28.35	4.00e-43	168.00
IUUC-Dme-032189	Drosophila melanogaster	42.82	3.00e-101	361.00
IUUC-Ete-032247	Echinops telfairi	71.16	1.00e-169	589.00
IUUC-Eca-034285	Equus caballus	74.70	0.00e+00	636.00
IUUC-Eeu-035322	Erinaceus europaeus	69.10	3.00e-158	551.00
IUUC-Fca-036114	Felis catus	75.41	0.00e+00	640.00
IUUC-Fal-036891	Ficedula albicollis	77.97	1.00e-159	555.00
IUUC-Fox-037965	Fusarium oxysporum	26.01	5.00e-40	158.00
IUUC-Fso-038244	Fusarium solani	27.82	4.00e-40	159.00
IUUC-Gmo-039040	Gadus morhua	85.34	0.00e+00	742.00
IUUC-Ggr-040093	Gaeumannomyces graminis	26.05	8.00e-15	75.10
IUUC-Gga-040610	Gallus gallus	76.12	0.00e+00	659.00
IUUC-Gma-043146	Glycine max	37.41	3.00e-71	262.00
IUUC-Ggo-045179	Gorilla gorilla	74.23	2.00e-178	618.00
IUUC-Hsa-046114	Homo sapiens	74.70	4.00e-179	620.00
IUUC-Hvu-047331	Hordeum vulgare	33.42	4.00e-60	225.00
IUUC-Itr-048275	Ictidomys tridecemlineatus	74.94	0.00e+00	640.00
IUUC-Kpa-049304	Komagataella pastoris	31.71	3.00e-50	192.00
IUUC-Lch-050655	Latimeria chalumnae	72.54	8.00e-137	479.00
IUUC-Lpe-051675	Leersia perrieri	34.92	2.00e-66	246.00
IUUC-Loc-052868	Lepisosteus oculatus	81.09	0.00e+00	693.00
IUUC-Lma-053258	Leptosphaeria maculans	26.92	2.00e-39	158.00
IUUC-Laf-053993	Loxodonta africana	75.65	0.00e+00	639.00
IUUC-Mcc-055128	Macaca mulatta	60.99	4.00e-139	487.00
IUUC-Meu-056501	Macropus eugenii	66.22	2.00e-142	498.00
IUUC-Mor-057114	Magnaporthe oryzae	26.65	1.00e-32	134.00
IUUC-Mtr-058367	Medicago truncatula	37.32	2.00e-65	243.00
IUUC-Mla-059107	Melampsora laricipopulina	26.67	2.00e-37	149.00
IUUC-Mga-059745	Meleagris gallopavo	75.12	0.00e+00	633.00
IUUC-Mvi-060362	Microbotryum violaceum	26.67	3.00e-36	146.00
IUUC-Mdo-062257	Monodelphis domestica	74.11	0.00e+00	655.00
IUUC-Mmu-063546	Mus musculus	75.18	0.00e+00	639.00
IUUC-Mac-065540	Musa acuminata	33.17	3.00e-64	239.00
IUUC-Mpu-066284	Mustela putorius furo	75.18	0.00e+00	640.00
IUUC-Mlu-067241	Myotis lucifugus	74.70	0.00e+00	635.00
IUUC-Nfi-068260	Neosartorya fischeri	27.75	3.00e-40	159.00
IUUC-Ncr-068719	Neurospora crassa	26.89	5.00e-32	132.00
IUUC-Nle-068981	Nomascus leucogenys	74.47	3.00e-175	607.00
IUUC-Opr-071218	Ochotona princeps	68.84	1.00e-162	565.00
IUUC-Ont-071646	Oreochromis niloticus	89.79	0.00e+00	748.00
IUUC-Oan-073453	Ornithorhynchus anatinus	77.54	0.00e+00	709.00
IUUC-Ocu-074008	Oryctolagus cuniculus	74.94	0.00e+00	639.00
IUUC-Oba-075712	Oryza barthii	30.62	2.00e-49	190.00
IUUC-Obr-076721	Oryza brachyantha	34.92	4.00e-66	245.00
IUUC-Ogl-077229	Oryza glaberrima	34.92	6.00e-66	244.00
IUUC-Ogu-078977	Oryza glumaepatula	30.62	7.00e-50	191.00
IUUC-Oin-079683	Oryza indica	34.92	1.00e-66	246.00
IUUC-Olo-080291	Oryza longistaminata	29.24	7.00e-33	134.00
IUUC-Ome-081834	Oryza meridionalis	35.15	2.00e-67	250.00
IUUC-Oni-082507	Oryza nivara	33.57	7.00e-62	231.00
IUUC-Opu-083396	Oryza punctata	34.20	1.00e-65	244.00
IUUC-Oru-085220	Oryza rufipogon	33.81	9.00e-62	230.00
IUUC-Osa-085767	Oryza sativa	34.92	1.00e-66	246.00
IUUC-Ola-087420	Oryzias latipes	88.89	0.00e+00	748.00
IUUC-Olu-087740	Ostreococcus lucimarinus	29.74	3.00e-42	166.00
IUUC-Oga-088264	Otolemur garnettii	73.52	4.00e-179	620.00
IUUC-Oar-089335	Ovis aries	74.94	0.00e+00	637.00
IUUC-Ptr-091320	Pan troglodytes	74.70	4.00e-179	620.00
IUUC-Pan-092833	Papio anubis	74.47	1.00e-178	618.00
IUUC-Psi-093504	Pelodiscus sinensis	77.30	0.00e+00	669.00
IUUC-Pma-094189	Petromyzon marinus	65.57	2.00e-163	568.00
IUUC-Pno-094929	Phaeosphaeria nodorum	26.50	3.00e-38	152.00
IUUC-Ppa-095429	Physcomitrella patens	37.09	6.00e-71	261.00
IUUC-Pfo-096337	Poecilia formosa	89.36	0.00e+00	774.00
IUUC-Pab-097571	Pongo abelii	74.47	7.00e-179	619.00
IUUC-Pop-099977	Populus trichocarpa	36.32	4.00e-70	258.00
IUUC-Pca-100394	Procavia capensis	71.64	2.00e-160	558.00
IUUC-Ppe-101848	Prunus persica	37.02	1.00e-69	257.00
IUUC-Pva-102921	Pteropus vampyrus	71.26	3.00e-89	322.00
IUUC-Pgr-103637	Puccinia graminis	29.70	7.00e-45	174.00
IUUC-Ptt-103781	Puccinia triticina	29.09	2.00e-44	173.00
IUUC-Pte-104135	Pyrenophora teres	27.83	5.00e-38	153.00
IUUC-Pyt-104609	Pyrenophora triticirepentis	26.32	4.00e-37	149.00
IUUC-Rno-105114	Rattus norvegicus	75.41	0.00e+00	642.00
IUUC-Sce-106401	Saccharomyces cerevisiae	31.87	8.00e-50	191.00
IUUC-Sha-107122	Sarcophilus harrisii	73.76	0.00e+00	625.00
IUUC-Sja-107766	Schizosaccharomyces japonicus	33.26	4.00e-57	215.00
IUUC-Spo-108134	Schizosaccharomyces pombe	30.11	5.00e-47	181.00
IUUC-Ssl-108398	Sclerotinia sclerotiorum	31.38	1.00e-43	170.00
IUUC-Smo-108720	Selaginella moellendorffii	35.17	9.00e-62	230.00
IUUC-Sit-110311	Setaria italica	35.44	1.00e-64	239.00
IUUC-Sly-111178	Solanum lycopersicum	36.07	2.00e-67	249.00
IUUC-Stu-112778	Solanum tuberosum	36.99	3.00e-71	262.00
IUUC-Sar-113596	Sorex araneus	61.47	3.00e-141	494.00
IUUC-Sbi-114193	Sorghum bicolor	36.83	3.00e-66	245.00
IUUC-Sre-115002	Sporisorium reilianum	25.86	7.00e-18	85.50
IUUC-Ssc-116066	Sus scrofa	75.41	0.00e+00	639.00
IUUC-Tgu-117048	Taeniopygia guttata	76.78	2.00e-169	588.00
IUUC-Tsy-119573	Tarsius syrichta	47.37	8.00e-103	367.00
IUUC-Tni-119820	Tetraodon nigroviridis	87.94	0.00e+00	738.00
IUUC-Tca-121605	Theobroma cacao	36.60	2.00e-68	253.00
IUUC-Tre-121947	Trichoderma reesei	27.99	1.00e-41	164.00
IUUC-Tvi-122481	Trichoderma virens	28.48	1.00e-42	167.00
IUUC-Tae-125861	Triticum aestivum	33.02	4.00e-65	242.00
IUUC-Tur-126586	Triticum urartu	33.42	4.00e-62	231.00
IUUC-Tme-126900	Tuber melanosporum	31.44	4.00e-53	202.00
IUUC-Tbe-127736	Tupaia belangeri	55.53	6.00e-120	424.00
IUUC-Ttr-129041	Tursiops truncatus	65.48	1.00e-155	542.00
IUUC-Uma-129628	Ustilago maydis	28.57	1.00e-12	68.20
IUUC-Vpa-130260	Vicugna pacos	75.18	0.00e+00	641.00
IUUC-Vvi-131009	Vitis vinifera	36.26	4.00e-69	255.00
IUUC-Xtr-132083	Xenopus tropicalis	73.05	0.00e+00	630.00
IUUC-Xma-133094	Xiphophorus maculatus	88.65	0.00e+00	771.00
IUUC-Yli-134531	Yarrowia lipolytica	25.41	1.00e-29	124.00
IUUC-Zma-135509	Zea mays	35.24	9.00e-67	247.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence