iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pno-094925

Ensembl Protein ID

SNOT_13776

UniProt Accession

Q0U388; ATG3_PHANO

Genbank Protein ID

EAT78800.1

Protein Name

Autophagy-related protein 3; Autophagy-related E2-like conjugation enzyme ATG3

Genbank Nucleotide ID

CH445352

Gene Name

ATG3; SNOG_13776

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SNOG_13776	SNOT_13776	SNOT_13776

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E2/Autophagy_C	30.33	4.00e-35	145.00	IUUC-Ath-006802
E2/Autophagy_C	34.78	3.00e-29	127.00	IUUC-Hsa-046449
E2/Autophagy_C	36.81	2.00e-53	204.00	IUUC-Sce-106172

Active Site

Position(s)	Description	Evidence
244	Glycyl thioester intermediate	{ECO:0000250}

Organism

Phaeosphaeria nodorum

Functional Description
(View)

E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt) and autophagy. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8. The ATG12-ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8 from ATG3 to phosphatidylethanolamine (PE). This step is required for the membrane association of ATG8. The formation of the ATG8-phosphatidylethanolamine conjugate is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy (By similarity).

Protein Sequence
(Fasta)

MAYNFVRSYI DTFRERTAAI SHTSTFRETG QITPEEFVLA GDFLVFKFPS WQWGDASSAG 60
KRVPYLPEGK QYLMTRGVPC HRRLDDNFAG EAGQDETIVG DGFAGSEGAD DDGWLRTGGM 120

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Nucleotide Sequence
(Fasta)

ATGGCTTACA ACTTTGTGCG ATCGTACATC GACACCTTCC GCGAGCGCAC CGCCGCCATC 60
AGCCACACTT CTACCTTTCG CGAGACGGGC CAGATTACCC CAGAGGAGTT TGTCTTAGCA 120

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Sequence Source

Ensembl

Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0833--Ubl conjugation pathway

Interpro

IPR007135--Autophagy-rel_prot_3
IPR019461--Autophagy-rel_prot_3_C
IPR007134--Autophagy-rel_prot_3_N

Pfam

PF03987--Autophagy_act_C
PF10381--Autophagy_C
PF03986--Autophagy_N

Gene Ontology

GO:0000153--C:cytoplasmic ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0019776--F:Atg8 ligase activity
GO:0000045--P:autophagosome assembly
GO:0006501--P:C-terminal protein lipidation
GO:0044805--P:late nucleophagy
GO:0000422--P:mitophagy
GO:0044804--P:nucleophagy
GO:0034727--P:piecemeal microautophagy of nucleus
GO:0006612--P:protein targeting to membrane

KEGG

pno:SNOG_13776

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001111	Aegilops tauschii	37.45	3.00e-36	143.00
IUUC-Aml-002081	Ailuropoda melanoleuca	36.09	1.00e-31	128.00
IUUC-Atr-002712	Amborella trichopoda	32.96	2.00e-31	127.00
IUUC-Apl-003956	Anas platyrhynchos	25.85	1.00e-19	88.60
IUUC-Aca-004578	Anolis carolinensis	34.78	1.00e-30	125.00
IUUC-Aly-005823	Arabidopsis lyrata	33.43	2.00e-41	160.00
IUUC-Ath-006802	Arabidopsis thaliana	33.71	4.00e-42	162.00
IUUC-Ago-007855	Ashbya gossypii	37.46	1.00e-56	211.00
IUUC-Acl-008147	Aspergillus clavatus	60.56	2.00e-104	370.00
IUUC-Afl-008483	Aspergillus flavus	57.87	1.00e-108	384.00
IUUC-Afu-008818	Aspergillus fumigatus	64.61	1.00e-117	414.00
IUUC-Ani-009481	Aspergillus nidulans	62.36	3.00e-107	379.00
IUUC-Ang-009800	Aspergillus niger	57.55	3.00e-105	372.00
IUUC-Aor-010150	Aspergillus oryzae	57.87	1.00e-108	384.00
IUUC-Ate-010545	Aspergillus terreus	58.37	5.00e-61	225.00
IUUC-Ame-011793	Astyanax mexicanus	35.45	6.00e-33	132.00
IUUC-Bgr-012167	Blumeria graminis	64.44	7.00e-109	385.00
IUUC-Bta-012695	Bos taurus	34.78	2.00e-32	130.00
IUUC-Bci-013972	Botrytis cinerea	62.53	4.00e-98	349.00
IUUC-Bdi-014756	Brachypodium distachyon	34.64	5.00e-37	146.00
IUUC-Bol-015091	Brassica oleracea	32.31	5.00e-37	146.00
IUUC-Bra-017220	Brassica rapa	33.05	3.00e-40	156.00
IUUC-Cel-018143	Caenorhabditis elegans	32.52	1.00e-33	135.00
IUUC-Cja-018991	Callithrix jacchus	36.05	8.00e-34	135.00
IUUC-Cfa-020070	Canis familiaris	34.60	1.00e-32	131.00
IUUC-Cpo-021860	Cavia porcellus	34.39	3.00e-32	130.00
IUUC-Cre-022948	Chlamydomonas reinhardtii	32.17	1.00e-36	144.00
IUUC-Csa-023881	Chlorocebus sabaeus	34.85	4.00e-32	130.00
IUUC-Cho-024852	Choloepus hoffmanni	46.59	2.00e-17	81.30
IUUC-Cin-025787	Ciona intestinalis	31.18	7.00e-38	149.00
IUUC-Csv-026369	Ciona savignyi	37.45	2.00e-34	137.00
IUUC-Cgl-026680	Colletotrichum gloeosporioides	59.08	1.00e-97	347.00
IUUC-Cne-026905	Cryptococcus neoformans	48.24	4.00e-19	87.00
IUUC-Dre-028811	Danio rerio	35.07	3.00e-33	133.00
IUUC-Dno-030081	Dasypus novemcinctus	35.71	1.00e-30	125.00
IUUC-Dor-030183	Dipodomys ordii	56.67	6.00e-16	76.30
IUUC-Dse-031539	Dothistroma septosporum	52.38	5.00e-66	242.00
IUUC-Dme-031805	Drosophila melanogaster	50.00	1.00e-17	82.40
IUUC-Ete-033171	Echinops telfairi	35.55	9.00e-33	132.00
IUUC-Eca-034083	Equus caballus	34.78	3.00e-32	130.00
IUUC-Eeu-034804	Erinaceus europaeus	35.23	9.00e-31	125.00
IUUC-Fca-036289	Felis catus	36.09	2.00e-32	130.00
IUUC-Fal-037060	Ficedula albicollis	34.47	5.00e-32	129.00
IUUC-Fox-038051	Fusarium oxysporum	60.51	4.00e-107	379.00
IUUC-Fso-038124	Fusarium solani	59.83	4.00e-92	329.00
IUUC-Gmo-039538	Gadus morhua	35.51	2.00e-34	137.00
IUUC-Ggr-039880	Gaeumannomyces graminis	57.26	9.00e-104	368.00
IUUC-Gga-041108	Gallus gallus	34.47	2.00e-32	131.00
IUUC-Gac-041558	Gasterosteus aculeatus	38.89	1.00e-34	138.00
IUUC-Gma-043969	Glycine max	31.37	7.00e-37	145.00
IUUC-Ggo-045071	Gorilla gorilla	34.85	4.00e-32	129.00
IUUC-Hsa-046449	Homo sapiens	34.85	4.00e-32	129.00
IUUC-Hvu-047451	Hordeum vulgare	33.98	1.00e-39	155.00
IUUC-Itr-048360	Ictidomys tridecemlineatus	36.19	2.00e-32	131.00
IUUC-Kpa-049096	Komagataella pastoris	39.31	4.00e-57	213.00
IUUC-Lch-049726	Latimeria chalumnae	36.47	3.00e-34	137.00
IUUC-Lpe-050734	Leersia perrieri	39.41	2.00e-41	160.00
IUUC-Loc-051983	Lepisosteus oculatus	35.74	1.00e-32	131.00
IUUC-Lma-053038	Leptosphaeria maculans	91.45	3.00e-166	575.00
IUUC-Laf-054510	Loxodonta africana	36.00	9.00e-34	135.00
IUUC-Mcc-054792	Macaca mulatta	34.85	4.00e-32	130.00
IUUC-Meu-055965	Macropus eugenii	30.33	6.00e-19	86.30
IUUC-Mor-057292	Magnaporthe oryzae	60.23	9.00e-106	374.00
IUUC-Mtr-058282	Medicago truncatula	30.90	7.00e-39	152.00
IUUC-Mla-059144	Melampsora laricipopulina	34.18	8.00e-44	169.00
IUUC-Mga-059509	Meleagris gallopavo	35.23	6.00e-33	132.00
IUUC-Mvi-060281	Microbotryum violaceum	36.92	4.00e-23	100.00
IUUC-Mmr-061788	Microcebus murinus	34.78	5.00e-33	132.00
IUUC-Mdo-062922	Monodelphis domestica	34.35	8.00e-33	132.00
IUUC-Mmu-064249	Mus musculus	33.60	6.00e-31	125.00
IUUC-Mac-064474	Musa acuminata	31.30	2.00e-36	144.00
IUUC-Mpu-065717	Mustela putorius furo	35.11	6.00e-32	129.00
IUUC-Mlu-067151	Myotis lucifugus	33.60	5.00e-28	116.00
IUUC-Nfi-068551	Neosartorya fischeri	61.97	5.00e-120	422.00
IUUC-Ncr-068846	Neurospora crassa	60.86	3.00e-101	359.00
IUUC-Nle-069790	Nomascus leucogenys	34.85	4.00e-32	129.00
IUUC-Ont-072517	Oreochromis niloticus	34.21	3.00e-32	130.00
IUUC-Oan-073285	Ornithorhynchus anatinus	45.45	3.00e-17	79.70
IUUC-Ocu-074695	Oryctolagus cuniculus	34.39	8.00e-32	129.00
IUUC-Oba-075515	Oryza barthii	34.07	2.00e-42	164.00
IUUC-Obr-076787	Oryza brachyantha	34.81	4.00e-43	166.00
IUUC-Ogl-077440	Oryza glaberrima	34.35	1.00e-42	164.00
IUUC-Ogu-078037	Oryza glumaepatula	34.63	6.00e-42	162.00
IUUC-Oin-079452	Oryza indica	34.35	1.00e-42	164.00
IUUC-Olo-080450	Oryza longistaminata	32.21	2.00e-40	157.00
IUUC-Ome-081514	Oryza meridionalis	34.35	2.00e-42	164.00
IUUC-Oni-082677	Oryza nivara	34.35	1.00e-42	164.00
IUUC-Opu-083925	Oryza punctata	33.70	2.00e-41	160.00
IUUC-Oru-084828	Oryza rufipogon	33.04	1.00e-39	155.00
IUUC-Osa-085937	Oryza sativa	34.07	9.00e-43	165.00
IUUC-Ola-086559	Oryzias latipes	33.17	7.00e-20	88.60
IUUC-Olu-087766	Ostreococcus lucimarinus	32.01	1.00e-36	144.00
IUUC-Oga-087983	Otolemur garnettii	34.25	1.00e-30	124.00
IUUC-Oar-089281	Ovis aries	34.78	2.00e-32	130.00
IUUC-Ptr-090983	Pan troglodytes	34.85	4.00e-32	129.00
IUUC-Pan-092457	Papio anubis	34.47	2.00e-31	127.00
IUUC-Psi-094046	Pelodiscus sinensis	35.50	7.00e-32	129.00
IUUC-Ppa-095487	Physcomitrella patens	31.53	3.00e-38	150.00
IUUC-Pfo-096968	Poecilia formosa	35.09	6.00e-33	132.00
IUUC-Pab-098621	Pongo abelii	34.85	5.00e-31	126.00
IUUC-Pop-100007	Populus trichocarpa	32.96	3.00e-37	147.00
IUUC-Pca-100590	Procavia capensis	46.59	3.00e-17	80.90
IUUC-Ppe-101657	Prunus persica	32.39	5.00e-37	146.00
IUUC-Pva-102446	Pteropus vampyrus	34.78	3.00e-32	130.00
IUUC-Pgr-103604	Puccinia graminis	46.88	8.00e-22	96.30
IUUC-Ptt-103941	Puccinia triticina	46.88	1.00e-21	95.50
IUUC-Pte-104252	Pyrenophora teres	90.60	6.00e-164	568.00
IUUC-Pyt-104556	Pyrenophora triticirepentis	91.17	2.00e-164	569.00
IUUC-Rno-106025	Rattus norvegicus	35.80	5.00e-32	129.00
IUUC-Sce-106172	Saccharomyces cerevisiae	36.68	2.00e-52	197.00
IUUC-Sha-106858	Sarcophilus harrisii	33.73	4.00e-31	126.00
IUUC-Sja-107905	Schizosaccharomyces japonicus	31.32	1.00e-18	84.70
IUUC-Spo-108185	Schizosaccharomyces pombe	31.34	1.00e-30	124.00
IUUC-Smo-108883	Selaginella moellendorffii	30.77	3.00e-33	133.00
IUUC-Sit-110512	Setaria italica	33.89	2.00e-34	137.00
IUUC-Sly-111238	Solanum lycopersicum	31.65	1.00e-39	154.00
IUUC-Stu-112441	Solanum tuberosum	31.37	3.00e-40	157.00
IUUC-Sar-113039	Sorex araneus	46.59	3.00e-17	80.50
IUUC-Sbi-113776	Sorghum bicolor	33.43	7.00e-39	152.00
IUUC-Sre-115074	Sporisorium reilianum	45.00	8.00e-18	83.20
IUUC-Ssc-115262	Sus scrofa	36.09	4.00e-32	129.00
IUUC-Tgu-116790	Taeniopygia guttata	34.47	2.00e-32	130.00
IUUC-Tru-118160	Takifugu rubripes	33.22	2.00e-32	131.00
IUUC-Tsy-119145	Tarsius syrichta	68.97	6.00e-07	46.20
IUUC-Tni-119937	Tetraodon nigroviridis	35.06	2.00e-29	120.00
IUUC-Tca-121323	Theobroma cacao	31.46	1.00e-37	147.00
IUUC-Tre-121993	Trichoderma reesei	54.78	5.00e-89	318.00
IUUC-Tvi-122332	Trichoderma virens	54.57	3.00e-90	323.00
IUUC-Tae-123478	Triticum aestivum	33.98	5.00e-40	156.00
IUUC-Tur-126679	Triticum urartu	33.61	1.00e-39	154.00
IUUC-Tme-127159	Tuber melanosporum	44.95	2.00e-20	90.50
IUUC-Ttr-128261	Tursiops truncatus	34.78	3.00e-32	130.00
IUUC-Uma-129572	Ustilago maydis	36.50	1.00e-25	109.00
IUUC-Vda-129966	Verticillium dahliae	63.82	9.00e-110	388.00
IUUC-Vpa-130698	Vicugna pacos	46.59	2.00e-17	81.30
IUUC-Xtr-132878	Xenopus tropicalis	35.77	2.00e-34	137.00
IUUC-Xma-134017	Xiphophorus maculatus	34.96	3.00e-32	130.00
IUUC-Yli-134373	Yarrowia lipolytica	38.95	1.00e-53	201.00
IUUC-Zma-135222	Zea mays	31.30	4.00e-37	146.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence