iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mac-065446

Ensembl Protein ID

GSMUA_Achr8P33120_001

UniProt Accession

M0TVR4; M0TVR4_MUSAM

Protein Name

Ubiquitinyl hydrolase 1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
GSMUA_Achr8G33120_001	GSMUA_Achr8T33120_001	GSMUA_Achr8P33120_001

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.10e-45	157.2	490	847
UBD/Alpha-Helix/UBA	5.30e-13	49.5	725	764

Active Site

Position(s)	Description	Evidence
317	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
811	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 142  isdlFqgqlksqikclecdnvs.sreepfldlslpvpgkeetkke...........................slqdcLesftkeeele 201
            s+ F++ ++++++c++ +  + +r +  l+l++p+++ ++ +++                            l+ cL+ f+++ee++
   Q: 490  PSRSFKFIIEERLQCPSGKVAYnKRSDYILSLTIPLHKATNGEQLeafdklkaekklegkdiargeivrprvPLEACLDCFSAPEEVH 577
           5788************999888566666777777777777665559*****************************************9 PP
   S: 202  genkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts...................... 267
           +   +y++  ++k++a k+ +l+++P++L+lh+++f + ee+++++k++ ++++p+ +d++++ ++                      
   Q: 578  D---FYSSALNAKTTAIKTAGLSTFPDYLVLHMQKF-VLEEGWVPKKLDVYIDVPDVIDITHMRSKglqpgeellpetgpcevepthf 661
           7...********************************.66889*******************999999999999998888888888888 PP
   S: 268  .....................................................................peekqke............ 274
                                                                                +     +            
   Q: 662  vasedivsklaamgfnyvhcqkaaintanagveeamtwllshmndsdiddpisqnphtmelqsvdeasvE-----Tlisfgfqegvak 744
           8888888888888888888877777777777777777777777776666666666666655555555550.....0555555555555 PP
   S: 275  ..............................................kkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVt 315
                                                         + +Y+L+a v+H G s+++GHYva+v++ +g+W+ f+D+kV 
   Q: 745  kalkasggdiekatdwifnhpeasssvdteltssgvqaddpavpdgSGRYKLMALVSHIGtSTQCGHYVAHVYK-DGRWVIFNDNKVG 831
           5566666666666666666666666777888888888899999999****************************.9***********9 PP
   S: 316  evkeeevleetgstaYvlfYk 336
           ++   +  +   + +Y++f+ 
   Q: 832  AS--IDPPK---DMGYLYFFS 847
           87..45666...777888776 PP

UBD/Alpha-Helix/UBA

   S: 2    ededkleqlveMGFdreealqaLraannnleaAveyLldg 41
            de  +e l++ GF +  a++aL a+++++e A+++++++
   Q: 725  VDEASVETLISFGFQEGVAKKALKASGGDIEKATDWIFNH 764
           58899*********************************97 PP

Organism

Musa acuminata

Protein Sequence
(Fasta)

MELLRSHLSR VRIPEPTNRI YKTECCISFD TPRSEGGLYV DLSSFIAFGK EGVGWNYEKS 60
GNPVYLHIQQ RPKPVPEDRP LKKPTLLAIG VDGGFDHEET EYEETYSIVM LPDYMSLPFP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGCTCC TCCGCTCGCA CCTCTCCAGG GTTCGGATCC CGGAGCCCAC CAACCGCATC 60
TACAAGACGG AGTGCTGCAT CTCGTTCGAC ACCCCGGTAG CCTCCCTTCT GATCTCTTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aly-005727	Arabidopsis lyrata	65.39	0.00e+00	1092.00
IUUC-Ath-006974	Arabidopsis thaliana	65.27	0.00e+00	1091.00
IUUC-Afl-008547	Aspergillus flavus	32.44	1.00e-95	343.00
IUUC-Aor-010111	Aspergillus oryzae	30.76	2.00e-102	366.00
IUUC-Bdi-014904	Brachypodium distachyon	63.83	0.00e+00	1034.00
IUUC-Cel-018625	Caenorhabditis elegans	30.22	8.00e-93	334.00
IUUC-Dno-029034	Dasypus novemcinctus	41.93	0.00e+00	659.00
IUUC-Ggr-040098	Gaeumannomyces graminis	30.20	4.00e-89	322.00
IUUC-Gma-043614	Glycine max	67.41	0.00e+00	1086.00
IUUC-Lch-049648	Latimeria chalumnae	42.78	0.00e+00	672.00
IUUC-Lma-053216	Leptosphaeria maculans	31.79	3.00e-92	333.00
IUUC-Mpo-057589	Magnaporthe poae	31.03	5.00e-91	328.00
IUUC-Mtr-058680	Medicago truncatula	67.29	0.00e+00	1125.00
IUUC-Mvi-060476	Microbotryum violaceum	31.30	2.00e-84	306.00
IUUC-Mlu-067345	Myotis lucifugus	41.40	0.00e+00	647.00
IUUC-Ncr-068960	Neurospora crassa	29.97	7.00e-88	318.00
IUUC-Oan-072959	Ornithorhynchus anatinus	53.51	2.00e-66	244.00
IUUC-Pno-094835	Phaeosphaeria nodorum	33.94	2.00e-91	329.00
IUUC-Pop-098855	Populus trichocarpa	68.38	0.00e+00	1119.00
IUUC-Ppe-101315	Prunus persica	68.93	0.00e+00	1122.00
IUUC-Pva-102154	Pteropus vampyrus	41.38	0.00e+00	652.00
IUUC-Pte-104306	Pyrenophora teres	30.52	9.00e-86	311.00
IUUC-Pyt-104696	Pyrenophora triticirepentis	31.77	1.00e-90	327.00
IUUC-Sly-111523	Solanum lycopersicum	65.33	0.00e+00	1135.00
IUUC-Ssc-115686	Sus scrofa	41.05	0.00e+00	651.00
IUUC-Tur-126732	Triticum urartu	61.66	0.00e+00	1043.00
IUUC-Uma-129599	Ustilago maydis	30.43	1.00e-96	347.00
IUUC-Vvi-131116	Vitis vinifera	70.51	0.00e+00	1117.00
IUUC-Xtr-131953	Xenopus tropicalis	40.79	4.00e-177	614.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence