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Tag Content
UUCD2 ID IUUC-Ola-086815
UUCD1 version UUC-OrL-00132
Ensembl Protein ID ENSORLP00000003392.1
UniProt Accession H2LBW3; H2LBW3_ORYLA
Genbank Protein ID ENSORLP00000003392
Protein Name Lissencephaly-1 homolog
Genbank Nucleotide ID BAAF04066294
Gene Name pafah1b1b (1 of many); LOC101158788; LIS1; PAFAH1B1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSORLG00000002718.1 ENSORLT00000003393.1 ENSORLP00000003392.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 4.50e-56 184.6 336 374
UBD/Beta-Prp 2.40e-92 309.6 105 410
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
    gH ++v+++ f ++ +++vs++dD+ti++WD++ ++ k
   Q: 336 GHDNWVRGVLFhPGgRFIVSCADDKTIRIWDFKNKRCMK 374
    8***********9989***************99998876 PP
   


   UBD/Beta-Prp

   S: 7    ghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghed 95
    + h +++t v f+p s+++t+s+d+tikvwd++ g++ r+l+gh++ v++v+f+++gk+l+++s D+ ik+wd++ ++c++t++gh++
   Q: 105 SGHRAPVTRVIFHPVFSVMVTASEDATIKVWDYEAGDFERTLKGHTDSVQDVSFDQTGKLLASCSADMSIKLWDFQGFECIRTMHGHDH 193
    558889999******************************************************************************** PP
   S: 96 svlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvy 184
    +v s++++p+gd++vs+s+d+ti++w++ tg+c++ t++gh+++v++v+ ++dg+ll+s+s+D+tvr+W ++++++ +l++ h++ v+
   Q: 194 NVSSVAIMPNGDHIVSASRDKTIKMWEVATGYCVK-TFTGHREWVRMVRPNQDGSLLASCSNDQTVRVWVVSSKECKAELRE-HEHVVE 280
    ***********************************.*********************************************9.****** PP
   S: 185 slsfdsng....................kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrs 253
    ++++ +++ ++l+sgs+d+t+k+wd++ g c++tl gh+++v+ v f+p + ++vs+++D++iriWd ++
   Q: 281 CIAWAPDSahptileatgseskksgkpgPFLLSGSRDKTIKMWDVSIGICLMTLVGHDNWVRGVLFHPGGRFIVSCADDKTIRIWDFKN 369
    ***************************************************************************************** PP
   S: 254 gdllktlqlhnssvisvavlsfgdnvlvlgsedskvniwklk 295
    + ++ktl+ h++ v+s ++ + + +++v+gs d++v++w+++
   Q: 370 KRCMKTLSAHEHFVTSLDF-HKSAPYVVTGSVDQTVKVWECR 410
    *******************.99*****************985 PP
   

Organism Oryzias latipes
Functional Description
(View)

Functional Description



     Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration.
Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration.
Protein Sequence
(Fasta)
MVLSQRQRDE LNRAIADYLR SNGYEEAYST FKKEAELDMN EDVDKKYAGL LEKKWTSVIR 60
LQKKVMELES KLNEAKEEMT HGGPVGQKRD PKEWIPRPPE RYAMSGHRAP VTRVIFHPVF 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Ola-086815|E3,WD_repeat;UBD,Beta-Prp|Oryzias latipes
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TGAAAGGCCA AAAGCTGAGA AGCTGAGGAA TCGACTTATT CAGACATCAT TTTTCCCAAT 60
CGGAGTATCC CTCTTTACCT CATCTTCACC TCCCTAAGAG GGAGAGAGCA GCAGCCACCA 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Ola-086815|E3,WD_repeat;UBD,Beta-Prp|Oryzias latipes
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0493--Microtubule
KW-0498--Mitosis
KW-0524--Neurogenesis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR017252--Dynein_regulator_LIS1
IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08513--LisH
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00667--LisH
SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005874--C:microtubule
GO:0005875--C:microtubule associated complex
GO:0005815--C:microtubule organizing center
GO:0030154--P:cell differentiation
GO:0051301--P:cell division
GO:0000132--P:establishment of mitotic spindle orientation
GO:0007067--P:mitotic nuclear division
GO:0007399--P:nervous system development
GO:0006810--P:transport

KEGG ola:101158788
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ago-007862 Ashbya gossypii 26.13 5.00e-39 155.00
IUUC-Acl-008360 Aspergillus clavatus 46.29 4.00e-105 374.00
IUUC-Afl-008502 Aspergillus flavus 45.71 2.00e-94 339.00
IUUC-Afu-008848 Aspergillus fumigatus 47.43 2.00e-106 379.00
IUUC-Ani-009173 Aspergillus nidulans 43.00 1.00e-90 326.00
IUUC-Aor-009973 Aspergillus oryzae 44.47 5.00e-92 331.00
IUUC-Ate-010523 Aspergillus terreus 42.32 3.00e-90 325.00
IUUC-Bci-013615 Botrytis cinerea 44.82 7.00e-100 357.00
IUUC-Cre-022578 Chlamydomonas reinhardtii 36.71 6.00e-52 197.00
IUUC-Cne-027087 Cryptococcus neoformans 50.64 3.00e-111 395.00
IUUC-Dse-031164 Dothistroma septosporum 43.83 8.00e-102 363.00
IUUC-Dme-031745 Drosophila melanogaster 71.05 2.00e-175 607.00
IUUC-Fox-037996 Fusarium oxysporum 45.11 3.00e-103 368.00
IUUC-Fso-038160 Fusarium solani 43.36 7.00e-98 350.00
IUUC-Gmo-039166 Gadus morhua 96.59 0.00e+00 835.00
IUUC-Ggr-040051 Gaeumannomyces graminis 45.58 4.00e-99 355.00
IUUC-Gac-041363 Gasterosteus aculeatus 97.07 0.00e+00 839.00
IUUC-Kpa-049351 Komagataella pastoris 29.27 1.00e-45 177.00
IUUC-Lma-053170 Leptosphaeria maculans 46.19 1.00e-99 356.00
IUUC-Mor-056962 Magnaporthe oryzae 44.87 7.00e-99 353.00
IUUC-Mpo-057583 Magnaporthe poae 45.75 2.00e-94 338.00
IUUC-Mla-058819 Melampsora laricipopulina 48.76 3.00e-119 421.00
IUUC-Ncr-068895 Neurospora crassa 47.68 7.00e-105 374.00
IUUC-Ont-071905 Oreochromis niloticus 97.56 0.00e+00 843.00
IUUC-Pno-094815 Phaeosphaeria nodorum 46.54 6.00e-103 367.00
IUUC-Pfo-096228 Poecilia formosa 96.59 0.00e+00 839.00
IUUC-Pte-104261 Pyrenophora teres 47.02 3.00e-103 368.00
IUUC-Pyt-104780 Pyrenophora triticirepentis 47.26 1.00e-103 370.00
IUUC-Ssl-108571 Sclerotinia sclerotiorum 44.95 2.00e-100 359.00
IUUC-Sre-115003 Sporisorium reilianum 50.46 7.00e-126 443.00
IUUC-Tru-118179 Takifugu rubripes 96.59 0.00e+00 836.00
IUUC-Tni-120288 Tetraodon nigroviridis 96.34 0.00e+00 830.00
IUUC-Tre-121977 Trichoderma reesei 42.95 5.00e-101 361.00
IUUC-Tvi-122661 Trichoderma virens 43.66 1.00e-100 360.00
IUUC-Tme-127031 Tuber melanosporum 47.39 4.00e-103 368.00
IUUC-Uma-129347 Ustilago maydis 49.09 4.00e-124 437.00
IUUC-Xma-133469 Xiphophorus maculatus 96.83 0.00e+00 840.00
IUUC-Yli-134403 Yarrowia lipolytica 39.29 3.00e-75 275.00
Created Date 25-Jun-2017

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