iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-061856

UUCD1 version

UUC-MoD-01114

Ensembl Protein ID

ENSMODP00000027866.1

UniProt Accession

F6UYE0; F6UYE0_MONDO

Protein Name

Uncharacterized protein

Gene Name

USP19

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000013305.3	ENSMODT00000016945.3	ENSMODP00000016640.3
ENSMODG00000013305.3	ENSMODT00000029403.1	ENSMODP00000027866.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.70e-114	382.7	527	1250

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsg 86
           tGl NlgNtC+mNSv+Q+Lsn++elr+++++ +++ ++n +np ++ g+l+  ++ l+++lwk++++a++p++l+++++++a++f+g
   Q: 527  TGLVNLGNTCFMNSVIQSLSNTRELRDYFHDrSFEAEINYSNPLGTGGRLAIGFAVLLRALWKGTHHAFQPSKLKAIVASKANQFTG 613
           7******************************99****************************************************** PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdnvssreep 168
           y+q+DaqEf+aflld+l+e+l++ +nkp++e+ ++d   ++de     a++++k++n+s+i+dlFqgq+ks+++c+ c + s +++p
   Q: 614  YAQHDAQEFMAFLLDGLHEDLNRIQNKPYTETVDSD--GRPDEvvaqeAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCSKLSITFDP 698
           ********************************9999..6666666777*************************************** PP
   S: 169  fldlslpvpgkeetkke...................................................................... 185
           fl+l++p+p+k++  +                                                                       
   Q: 699  FLYLPVPLPQKQKVLTVyyfakephkkpvkflvsiskenssamevldslaqsvhvkpeslrlaeviknrfhrvflpshsldtvsptd 785
           ************87555********************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 786  lllcfevlspelakervvvlqvqqrpqvpsvpiakcaacqkkqqsedeklkrctrcyrvgycnqvcqkthwpdhkglcrpenigfpf 872
           *************************************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 873  fisvpesrltyarlaqllegyarysvsvfqppfqlgrvspeqspqvlssstppvpstleagdgdrdlrpspesqvsptvaelgdtgs 959
           *************************************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 960  srsrapsdrnavpsldtglsestvsipgeggfskdtvgerllrpeaavpgyqhsadvlsahpppffinkidstnkeqkledkgetpl 1046
           *************************************************************************************** PP
   S: 186  ...............................................slqdcLesftkeeelegenkyycekckkkqeaekklklkk 225
                                                          +l++cL+ ftk+e l  e+++yc+kck+++ea+k+l+l++
   Q: 1047 elsddcslalvwknnerlkefvlvgskelecvedpssaseaaraghfTLEQCLNLFTKPEVLAPEEAWYCPKCKQHREASKQLMLWR 1133
           *************************************************************************************** PP
   S: 226  lPevLilhLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk...... 305
           lP+v+i++LkRfsf++  +++ kin+ vefp + Ldls+fc+ ++++  +  +Y+L+av++H+G++ +GHY+ay++  ++k      
   Q: 1134 LPNVFIIQLKRFSFRSFIWRD-KINDMVEFPVRnLDLSKFCIGQKDDR-QLPTYDLYAVINHYGGMIGGHYTAYARLPSDKnsqrsd 1218
           *****************8886.**********9**********77665.6**************************94444445677 PP
   S: 306  ..WllfdDskVtevkeeevleetgstaYvlfYkrr 338
             W lfdDs+Vt v+e++v++   + aYvlfY+rr
   Q: 1219 vgWRLFDDSTVTIVDESQVVT---RYAYVLFYRRR 1250
           88*******************...********996 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

FLRSFVPHWK VWPQRVAKIA GPGRKRRTPD PDSITDPGGF WVSSKRLKMS GGASATGQRR 60
CPQGLEDATN KKKQKDRVNQ ESKDGEPKRV LPLLIPSRTV QGKILSKPSN DIEMGVVNTR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTCCTTAGGT CATTTGTTCC TCACTGGAAA GTTTGGCCAC AGAGAGTCGC CAAGATAGCT 60
GGGCCAGGAA GAAAACGTCG AACCCCTGAC CCAGACTCCA TCACTGACCC CGGTGGATTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR007052--CS_dom
IPR008978--HSP20-like_chaperone
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR002893--Znf_MYND

PROSITE

PS51203--CS
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS01360--ZF_MYND_1
PS50865--ZF_MYND_2

Pfam

PF04969--CS
PF00443--UCH
PF01753--zf-MYND

Gene Ontology

GO:0005829--C:cytosol
GO:0005789--C:endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1901799--P:negative regulation of proteasomal protein catabolic process
GO:0048642--P:negative regulation of skeletal muscle tissue development
GO:0050821--P:protein stabilization
GO:1900037--P:regulation of cellular response to hypoxia
GO:1904292--P:regulation of ERAD pathway
GO:0030433--P:ubiquitin-dependent ERAD pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001999	Ailuropoda melanoleuca	79.28	0.00e+00	1605.00
IUUC-Apl-003368	Anas platyrhynchos	79.74	0.00e+00	1544.00
IUUC-Aca-004267	Anolis carolinensis	79.90	0.00e+00	1537.00
IUUC-Ame-010970	Astyanax mexicanus	72.39	0.00e+00	1357.00
IUUC-Bta-012905	Bos taurus	81.41	0.00e+00	1592.00
IUUC-Cel-018257	Caenorhabditis elegans	43.42	9.00e-89	322.00
IUUC-Cja-018789	Callithrix jacchus	79.86	0.00e+00	1687.00
IUUC-Cfa-021004	Canis familiaris	78.59	0.00e+00	1591.00
IUUC-Cpo-021529	Cavia porcellus	77.87	0.00e+00	1625.00
IUUC-Csa-024035	Chlorocebus sabaeus	82.65	0.00e+00	1633.00
IUUC-Cho-025036	Choloepus hoffmanni	79.22	0.00e+00	706.00
IUUC-Cin-025451	Ciona intestinalis	42.22	9.00e-84	305.00
IUUC-Dre-028556	Danio rerio	66.39	0.00e+00	1347.00
IUUC-Dno-029240	Dasypus novemcinctus	75.32	0.00e+00	1556.00
IUUC-Dor-030495	Dipodomys ordii	79.83	0.00e+00	1087.00
IUUC-Ete-032741	Echinops telfairi	81.33	0.00e+00	1562.00
IUUC-Eca-033661	Equus caballus	82.19	0.00e+00	1691.00
IUUC-Eeu-034648	Erinaceus europaeus	68.43	0.00e+00	879.00
IUUC-Fca-035646	Felis catus	78.59	0.00e+00	1589.00
IUUC-Fal-037094	Ficedula albicollis	78.65	0.00e+00	1664.00
IUUC-Gmo-038869	Gadus morhua	66.83	0.00e+00	1255.00
IUUC-Gga-041170	Gallus gallus	77.80	0.00e+00	1626.00
IUUC-Gac-041901	Gasterosteus aculeatus	62.70	0.00e+00	1433.00
IUUC-Ggo-044708	Gorilla gorilla	79.86	0.00e+00	1713.00
IUUC-Hsa-046791	Homo sapiens	74.34	0.00e+00	1854.00
IUUC-Itr-048892	Ictidomys tridecemlineatus	78.14	0.00e+00	1600.00
IUUC-Lch-050456	Latimeria chalumnae	67.64	0.00e+00	1171.00
IUUC-Loc-052861	Lepisosteus oculatus	63.87	0.00e+00	1133.00
IUUC-Laf-053788	Loxodonta africana	80.82	0.00e+00	1665.00
IUUC-Mcc-055693	Macaca mulatta	80.14	0.00e+00	1638.00
IUUC-Meu-055921	Macropus eugenii	94.64	0.00e+00	1572.00
IUUC-Mga-059879	Meleagris gallopavo	77.95	0.00e+00	1613.00
IUUC-Mmr-060802	Microcebus murinus	79.73	0.00e+00	1661.00
IUUC-Mmu-063874	Mus musculus	81.99	0.00e+00	1675.00
IUUC-Mpu-066166	Mustela putorius furo	78.79	0.00e+00	1584.00
IUUC-Nle-070161	Nomascus leucogenys	79.40	0.00e+00	1683.00
IUUC-Opr-071015	Ochotona princeps	73.13	0.00e+00	1790.00
IUUC-Ont-072308	Oreochromis niloticus	71.83	0.00e+00	1382.00
IUUC-Oan-072723	Ornithorhynchus anatinus	73.84	0.00e+00	1597.00
IUUC-Ocu-073938	Oryctolagus cuniculus	82.12	0.00e+00	1582.00
IUUC-Ola-086375	Oryzias latipes	70.13	0.00e+00	1369.00
IUUC-Oga-088297	Otolemur garnettii	79.84	0.00e+00	1653.00
IUUC-Oar-089675	Ovis aries	82.16	0.00e+00	1407.00
IUUC-Ptr-091621	Pan troglodytes	73.89	0.00e+00	1845.00
IUUC-Pan-092118	Papio anubis	79.98	0.00e+00	1630.00
IUUC-Pfo-097246	Poecilia formosa	70.03	0.00e+00	935.00
IUUC-Pab-098551	Pongo abelii	73.59	0.00e+00	1821.00
IUUC-Pca-100158	Procavia capensis	73.36	0.00e+00	1571.00
IUUC-Pva-103160	Pteropus vampyrus	75.86	0.00e+00	1626.00
IUUC-Rno-105355	Rattus norvegicus	82.62	0.00e+00	1662.00
IUUC-Sha-107057	Sarcophilus harrisii	93.13	0.00e+00	1864.00
IUUC-Sar-113011	Sorex araneus	73.17	0.00e+00	1219.00
IUUC-Ssc-115761	Sus scrofa	78.20	0.00e+00	1588.00
IUUC-Tgu-116956	Taeniopygia guttata	64.62	0.00e+00	889.00
IUUC-Tru-118739	Takifugu rubripes	70.40	0.00e+00	1358.00
IUUC-Tsy-118827	Tarsius syrichta	79.01	0.00e+00	761.00
IUUC-Tni-119921	Tetraodon nigroviridis	71.16	0.00e+00	1322.00
IUUC-Tbe-128017	Tupaia belangeri	78.43	0.00e+00	1640.00
IUUC-Ttr-128869	Tursiops truncatus	78.21	0.00e+00	1660.00
IUUC-Uma-129498	Ustilago maydis	30.67	3.00e-92	334.00
IUUC-Vpa-130427	Vicugna pacos	77.99	0.00e+00	750.00
IUUC-Xtr-132734	Xenopus tropicalis	74.49	0.00e+00	1448.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence