iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bta-013320

Ensembl Protein ID

ENSBTAP00000026497.4

UniProt Accession

F1N3C8; F1N3C8_BOVIN

Genbank Protein ID

ENSBTAP00000026497

Protein Name

Protein HIRA

Genbank Nucleotide ID

DAAA02045759

Gene Name

HIRA

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000019888.4	ENSBTAT00000026497.4	ENSBTAP00000026497.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.40e-20	71.5	66	95

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWD 29
           H + v+c+++ ++  +l+sG+dD+ i+vW 
   Q: 66   HLACVNCVRWsNGgMYLASGGDDKLIMVWK 95
           8899******877899*************7 PP

Organism

Bos taurus

Functional Description
(View)

Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.

Protein Sequence
(Fasta)

TMCLSPLFPG KPIFSVDIHP DGTKFATGGQ GQDSGKVVIW NMSPVLQEDD EKDENVPKML 60
CQMDNHLACV NCVRWSNGGM YLASGGDDKL IMVWKRATYI GPSTVFGSGG KLANVEQWRC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACCATGTGTC TCTCTCCTCT GTTCCCAGGC AAACCAATTT TTTCAGTTGA TATTCACCCG 60
GACGGGACCA AGTTCGCAAC TGGAGGGCAA GGTAGGTTCT GGGGAGCAGC GGGGCGCTGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0853--WD repeat

Interpro

IPR031120--HIR1
IPR011494--Hira
IPR019015--HIRA_B_motif
IPR002469--Peptidase_S9B_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF07569--Hira
PF09453--HIRA_B
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0000790--C:nuclear chromatin
GO:0043234--C:protein complex
GO:0031491--F:nucleosome binding
GO:0003714--F:transcription corepressor activity
GO:0016569--P:covalent chromatin modification
GO:0006336--P:DNA replication-independent nucleosome assembly
GO:0007369--P:gastrulation
GO:0042692--P:muscle cell differentiation
GO:0001649--P:osteoblast differentiation
GO:0031935--P:regulation of chromatin silencing
GO:0006351--P:transcription, DNA-templated

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001039	Aegilops tauschii	39.86	3.00e-85	310.00
IUUC-Aml-001723	Ailuropoda melanoleuca	92.30	0.00e+00	1702.00
IUUC-Atr-003132	Amborella trichopoda	41.49	2.00e-84	307.00
IUUC-Apl-003197	Anas platyrhynchos	82.33	0.00e+00	1574.00
IUUC-Aca-004733	Anolis carolinensis	81.52	0.00e+00	1526.00
IUUC-Aly-005446	Arabidopsis lyrata	40.05	6.00e-78	285.00
IUUC-Ath-007627	Arabidopsis thaliana	41.30	4.00e-81	296.00
IUUC-Ago-007766	Ashbya gossypii	31.30	2.00e-56	214.00
IUUC-Acl-008104	Aspergillus clavatus	30.24	2.00e-60	227.00
IUUC-Afl-008591	Aspergillus flavus	33.42	2.00e-59	224.00
IUUC-Afu-008781	Aspergillus fumigatus	33.33	3.00e-58	220.00
IUUC-Ani-009272	Aspergillus nidulans	29.50	3.00e-53	204.00
IUUC-Ang-009655	Aspergillus niger	33.51	3.00e-61	230.00
IUUC-Aor-010119	Aspergillus oryzae	33.42	3.00e-59	224.00
IUUC-Ate-010530	Aspergillus terreus	31.28	2.00e-53	204.00
IUUC-Ame-011147	Astyanax mexicanus	84.09	2.00e-45	173.00
IUUC-Bgr-012237	Blumeria graminis	33.86	2.00e-58	221.00
IUUC-Bci-013795	Botrytis cinerea	34.21	7.00e-63	235.00
IUUC-Bdi-014075	Brachypodium distachyon	42.45	6.00e-88	318.00
IUUC-Bol-016440	Brassica oleracea	40.84	2.00e-83	304.00
IUUC-Bra-016651	Brassica rapa	40.31	3.00e-83	303.00
IUUC-Cel-018692	Caenorhabditis elegans	38.26	1.00e-73	271.00
IUUC-Cja-018987	Callithrix jacchus	89.90	0.00e+00	1586.00
IUUC-Cfa-020132	Canis familiaris	92.09	0.00e+00	1697.00
IUUC-Cpo-021484	Cavia porcellus	90.30	0.00e+00	1660.00
IUUC-Cre-022846	Chlamydomonas reinhardtii	36.00	2.00e-58	221.00
IUUC-Csa-023081	Chlorocebus sabaeus	90.69	0.00e+00	1662.00
IUUC-Cin-025182	Ciona intestinalis	55.04	1.00e-148	521.00
IUUC-Csv-026154	Ciona savignyi	55.97	2.00e-146	513.00
IUUC-Cgl-026655	Colletotrichum gloeosporioides	32.08	3.00e-64	240.00
IUUC-Cne-026891	Cryptococcus neoformans	41.24	4.00e-80	293.00
IUUC-Cme-027349	Cyanidioschyzon merolae	29.60	3.00e-52	200.00
IUUC-Dre-027655	Danio rerio	67.29	0.00e+00	1288.00
IUUC-Dno-029557	Dasypus novemcinctus	81.60	0.00e+00	1039.00
IUUC-Dor-030687	Dipodomys ordii	83.30	0.00e+00	700.00
IUUC-Dse-031334	Dothistroma septosporum	31.19	8.00e-59	222.00
IUUC-Dme-031746	Drosophila melanogaster	54.96	3.00e-151	529.00
IUUC-Ete-032384	Echinops telfairi	84.14	0.00e+00	1547.00
IUUC-Eca-033430	Equus caballus	91.68	0.00e+00	1681.00
IUUC-Fca-036121	Felis catus	92.00	0.00e+00	1695.00
IUUC-Fal-036817	Ficedula albicollis	81.48	0.00e+00	1574.00
IUUC-Fox-037906	Fusarium oxysporum	35.09	2.00e-65	244.00
IUUC-Fso-038409	Fusarium solani	33.83	2.00e-63	238.00
IUUC-Gmo-039151	Gadus morhua	85.79	0.00e+00	674.00
IUUC-Ggr-040016	Gaeumannomyces graminis	35.20	5.00e-66	246.00
IUUC-Gga-040936	Gallus gallus	82.94	0.00e+00	1628.00
IUUC-Gac-041405	Gasterosteus aculeatus	62.48	0.00e+00	1150.00
IUUC-Gma-044252	Glycine max	36.38	1.00e-86	315.00
IUUC-Ggo-045430	Gorilla gorilla	90.70	0.00e+00	1661.00
IUUC-Hsa-046442	Homo sapiens	90.40	0.00e+00	1657.00
IUUC-Hvu-047587	Hordeum vulgare	36.31	3.00e-79	290.00
IUUC-Itr-048910	Ictidomys tridecemlineatus	99.00	5.00e-174	602.00
IUUC-Kpa-049145	Komagataella pastoris	30.85	4.00e-58	219.00
IUUC-Lch-050474	Latimeria chalumnae	74.95	0.00e+00	1368.00
IUUC-Lpe-051209	Leersia perrieri	34.86	2.00e-79	290.00
IUUC-Loc-052119	Lepisosteus oculatus	71.12	0.00e+00	1306.00
IUUC-Lma-053237	Leptosphaeria maculans	33.47	3.00e-64	240.00
IUUC-Laf-053718	Loxodonta africana	90.10	0.00e+00	1666.00
IUUC-Mcc-055621	Macaca mulatta	90.49	0.00e+00	1596.00
IUUC-Meu-055914	Macropus eugenii	76.26	0.00e+00	1378.00
IUUC-Mor-057090	Magnaporthe oryzae	34.09	2.00e-63	237.00
IUUC-Mpo-057364	Magnaporthe poae	35.71	1.00e-67	251.00
IUUC-Mtr-057744	Medicago truncatula	37.33	2.00e-86	313.00
IUUC-Mla-058914	Melampsora laricipopulina	40.85	9.00e-80	291.00
IUUC-Mga-060181	Meleagris gallopavo	81.38	0.00e+00	1598.00
IUUC-Mvi-060432	Microbotryum violaceum	38.52	2.00e-73	270.00
IUUC-Mmr-060871	Microcebus murinus	90.50	0.00e+00	1709.00
IUUC-Mdo-062301	Monodelphis domestica	83.73	0.00e+00	1541.00
IUUC-Mmu-063888	Mus musculus	89.60	0.00e+00	1645.00
IUUC-Mac-065137	Musa acuminata	38.23	1.00e-84	308.00
IUUC-Mpu-066732	Mustela putorius furo	91.75	0.00e+00	1732.00
IUUC-Mlu-067542	Myotis lucifugus	91.56	0.00e+00	1662.00
IUUC-Nfi-068396	Neosartorya fischeri	33.99	3.00e-58	220.00
IUUC-Ncr-068842	Neurospora crassa	30.63	1.00e-64	241.00
IUUC-Nle-070156	Nomascus leucogenys	90.50	0.00e+00	1672.00
IUUC-Opr-070808	Ochotona princeps	89.66	0.00e+00	1335.00
IUUC-Ont-072105	Oreochromis niloticus	67.38	0.00e+00	1278.00
IUUC-Ocu-074962	Oryctolagus cuniculus	90.52	0.00e+00	1689.00
IUUC-Oba-075178	Oryza barthii	41.93	7.00e-87	315.00
IUUC-Obr-076399	Oryza brachyantha	36.19	1.00e-87	318.00
IUUC-Ogu-078797	Oryza glumaepatula	41.93	7.00e-87	315.00
IUUC-Oin-080085	Oryza indica	40.80	8.00e-78	285.00
IUUC-Olo-081048	Oryza longistaminata	41.04	5.00e-66	246.00
IUUC-Ome-081324	Oryza meridionalis	41.93	9.00e-87	315.00
IUUC-Oni-082548	Oryza nivara	41.93	7.00e-87	315.00
IUUC-Opu-084008	Oryza punctata	41.93	8.00e-87	315.00
IUUC-Oru-084339	Oryza rufipogon	41.67	2.00e-86	313.00
IUUC-Osa-085782	Oryza sativa	41.67	2.00e-86	313.00
IUUC-Ola-087302	Oryzias latipes	70.82	0.00e+00	766.00
IUUC-Olu-087611	Ostreococcus lucimarinus	39.34	9.00e-84	305.00
IUUC-Oga-087935	Otolemur garnettii	90.14	0.00e+00	1651.00
IUUC-Oar-089229	Ovis aries	75.30	0.00e+00	1095.00
IUUC-Ptr-090715	Pan troglodytes	90.50	0.00e+00	1659.00
IUUC-Pan-092318	Papio anubis	90.63	0.00e+00	1664.00
IUUC-Psi-094053	Pelodiscus sinensis	82.03	0.00e+00	1578.00
IUUC-Pno-094985	Phaeosphaeria nodorum	33.95	7.00e-57	215.00
IUUC-Ppa-095819	Physcomitrella patens	39.49	2.00e-84	307.00
IUUC-Pfo-096857	Poecilia formosa	66.44	0.00e+00	1236.00
IUUC-Pab-098047	Pongo abelii	90.69	0.00e+00	1662.00
IUUC-Pop-099587	Populus trichocarpa	37.73	3.00e-85	310.00
IUUC-Pca-100558	Procavia capensis	88.24	0.00e+00	696.00
IUUC-Ppe-101261	Prunus persica	38.41	3.00e-85	310.00
IUUC-Pva-102683	Pteropus vampyrus	92.08	0.00e+00	1710.00
IUUC-Pgr-103660	Puccinia graminis	40.92	2.00e-73	270.00
IUUC-Ptt-103900	Puccinia triticina	42.24	4.00e-75	276.00
IUUC-Pte-104209	Pyrenophora teres	34.15	2.00e-61	231.00
IUUC-Pyt-104802	Pyrenophora triticirepentis	34.15	2.00e-60	228.00
IUUC-Rno-105137	Rattus norvegicus	89.39	0.00e+00	1670.00
IUUC-Sce-106291	Saccharomyces cerevisiae	32.64	4.00e-59	223.00
IUUC-Sha-107514	Sarcophilus harrisii	78.86	0.00e+00	1441.00
IUUC-Sja-107833	Schizosaccharomyces japonicus	35.59	6.00e-78	285.00
IUUC-Spo-108162	Schizosaccharomyces pombe	39.61	1.00e-76	281.00
IUUC-Smo-109186	Selaginella moellendorffii	40.57	7.00e-85	308.00
IUUC-Sit-109980	Setaria italica	37.95	8.00e-89	322.00
IUUC-Sly-111547	Solanum lycopersicum	38.19	7.00e-89	322.00
IUUC-Stu-112705	Solanum tuberosum	38.19	4.00e-89	323.00
IUUC-Sar-113222	Sorex araneus	85.27	0.00e+00	1470.00
IUUC-Sbi-114272	Sorghum bicolor	36.67	2.00e-88	320.00
IUUC-Sre-115061	Sporisorium reilianum	27.45	7.00e-89	322.00
IUUC-Ssc-116364	Sus scrofa	91.71	0.00e+00	1797.00
IUUC-Tgu-116645	Taeniopygia guttata	81.82	0.00e+00	1596.00
IUUC-Tru-117590	Takifugu rubripes	66.25	0.00e+00	1259.00
IUUC-Tsy-119212	Tarsius syrichta	85.59	0.00e+00	932.00
IUUC-Tni-119915	Tetraodon nigroviridis	66.26	0.00e+00	1222.00
IUUC-Tca-121765	Theobroma cacao	37.17	2.00e-88	320.00
IUUC-Tre-121887	Trichoderma reesei	34.02	5.00e-56	213.00
IUUC-Tvi-122262	Trichoderma virens	34.02	6.00e-56	213.00
IUUC-Tae-124148	Triticum aestivum	44.57	1.00e-34	141.00
IUUC-Tur-126483	Triticum urartu	43.23	3.00e-89	323.00
IUUC-Tme-127202	Tuber melanosporum	31.74	3.00e-55	210.00
IUUC-Tbe-127350	Tupaia belangeri	80.68	2.00e-179	623.00
IUUC-Ttr-129077	Tursiops truncatus	89.30	0.00e+00	1739.00
IUUC-Uma-129465	Ustilago maydis	35.71	3.00e-75	277.00
IUUC-Vda-129844	Verticillium dahliae	34.70	5.00e-63	236.00
IUUC-Vvi-131397	Vitis vinifera	38.18	7.00e-88	318.00
IUUC-Xtr-132057	Xenopus tropicalis	73.69	0.00e+00	1376.00
IUUC-Xma-134139	Xiphophorus maculatus	68.05	0.00e+00	789.00
IUUC-Yli-134424	Yarrowia lipolytica	31.96	4.00e-63	236.00
IUUC-Zma-135839	Zea mays	42.19	8.00e-88	318.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence