iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Dme-032097

UUCD1 version

UUC-DrM-00551

Ensembl Protein ID

FBpp0305066

UniProt Accession

P35128; A9YHJ7; Q9VY67; UBE2N_DROME

Genbank Protein ID

AAA28392.1; AAB30753.1; ABW92183.1; ABW92184.1; ABW92185.1; ABW92186.1; ABW92187.1; ABW92188.1; ABW92189.1; ABW92190.1; ABW92191.1; ABW92192.1; ABW92193.1; ABW92194.1; AAF48338.1; AAL39672.1

Protein Name

Ubiquitin-conjugating enzyme E2 N; E2 ubiquitin-conjugating enzyme N; Protein bendless; Ubiquitin carrier protein N; Ubiquitin-conjugating enzyme E2-17 kDa; Ubiquitin-protein ligase D3; Ubiquitin-protein ligase N

Genbank Nucleotide ID

L20126; S70118; EU217226; EU217227; EU217228; EU217229; EU217230; EU217231; EU217232; EU217233; EU217234; EU217235; EU217236; EU217237; AE014298; AY069527

Gene Name

ben; UbcD3; CG18319

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
FBgn0000173	FBtr0332843	FBpp0305066

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	PINA
Post-translational Modifications (PTMs)
CPLM
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E2/UBC	E2_UBC	19141674

Classification

Family	E-value	Score	Start	End
E2/UBC	6.50e-47	158.8	7	141

Active Site

Position(s)	Description	Evidence
87	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkeeekWspalsv 98
           R+ ke+++l+++p++gi a p+++ +   ++v ++Gp+d+p+eggvFkle+ +pedYP+++Pkv+f+tki+hPn+++ G++Cl++lk  +kWspal++
   Q: 7    RIIKETQRLMQEPVPGINAIPDEN-NARYFHVIVTGPNDSPFEGGVFKLELFLPEDYPMSAPKVRFITKIYHPNIDRLGRICLDVLK--DKWSPALQI 101
           899*******************99.9************************************************************9..********* PP
   S: 99   esvllsiqsllaepnpesplneeaaellkknreeykkkvr 138
           +++llsiq+ll+ pnp++pl +++ael+k n++e  +++r
   Q: 102  RTILLSIQALLSAPNPDDPLANDVAELWKVNEAEAIRNAR 141
           ******************************9998777665 PP

Organism

Drosophila melanogaster

Functional Description
(View)

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.

Protein Sequence
(Fasta)

MSSLPRRIIK ETQRLMQEPV PGINAIPDEN NARYFHVIVT GPNDSPFEGG VFKLELFLPE 60
DYPMSAPKVR FITKIYHPNI DRLGRICLDV LKDKWSPALQ IRTILLSIQA LLSAPNPDDP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGTTAGTCAC AGCAACGCAC ACACACACTA CCAAACGGCT ACATTTTTTT TCGAGTGTGT 60
TCGACATTCA TAATTTTTGT GGTGGAGCTG CCTGCAAAAT CGAATTTTAT CAGTTTGCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0035370--C:UBC13-UEV1A complex
GO:0005524--F:ATP binding
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0007412--P:axon target recognition
GO:0007409--P:axonogenesis
GO:0007629--P:flight behavior
GO:0007625--P:grooming behavior
GO:0007630--P:jump response
GO:0061057--P:peptidoglycan recognition protein signaling pathway
GO:0008594--P:photoreceptor cell morphogenesis
GO:0010942--P:positive regulation of cell death
GO:0046330--P:positive regulation of JNK cascade
GO:0045977--P:positive regulation of mitotic cell cycle, embryonic
GO:1902916--P:positive regulation of protein polyubiquitination
GO:0006301--P:postreplication repair
GO:0070534--P:protein K63-linked ubiquitination
GO:0000209--P:protein polyubiquitination
GO:0072347--P:response to anesthetic
GO:0006979--P:response to oxidative stress
GO:0060074--P:synapse maturation
GO:0051124--P:synaptic growth at neuromuscular junction

KEGG

dme:Dmel_CG18319

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000100	Aegilops tauschii	76.19	6.00e-67	244.00
IUUC-Aml-001889	Ailuropoda melanoleuca	80.14	4.00e-68	248.00
IUUC-Atr-002818	Amborella trichopoda	74.83	4.00e-67	245.00
IUUC-Apl-003469	Anas platyrhynchos	78.62	2.00e-69	253.00
IUUC-Aca-005051	Anolis carolinensis	80.13	9.00e-73	264.00
IUUC-Aly-005804	Arabidopsis lyrata	76.19	2.00e-67	247.00
IUUC-Ath-007639	Arabidopsis thaliana	76.19	2.00e-67	246.00
IUUC-Ago-007837	Ashbya gossypii	74.40	8.00e-53	198.00
IUUC-Acl-008263	Aspergillus clavatus	74.15	4.00e-65	238.00
IUUC-Afl-008733	Aspergillus flavus	74.83	3.00e-65	239.00
IUUC-Afu-008946	Aspergillus fumigatus	74.15	4.00e-65	238.00
IUUC-Ani-009482	Aspergillus nidulans	72.48	1.00e-64	237.00
IUUC-Ang-009678	Aspergillus niger	74.83	5.00e-65	238.00
IUUC-Aor-010025	Aspergillus oryzae	74.83	3.00e-65	239.00
IUUC-Ate-010254	Aspergillus terreus	74.15	3.00e-64	236.00
IUUC-Ame-010742	Astyanax mexicanus	81.76	2.00e-72	263.00
IUUC-Bgr-012156	Blumeria graminis	65.79	2.00e-55	206.00
IUUC-Bta-012636	Bos taurus	80.13	9.00e-73	264.00
IUUC-Bci-013761	Botrytis cinerea	73.15	1.00e-64	237.00
IUUC-Bdi-014796	Brachypodium distachyon	77.55	9.00e-68	247.00
IUUC-Bol-015775	Brassica oleracea	77.55	3.00e-68	249.00
IUUC-Bra-016982	Brassica rapa	76.87	8.00e-68	248.00
IUUC-Cel-018119	Caenorhabditis elegans	80.27	4.00e-71	258.00
IUUC-Cja-019108	Callithrix jacchus	80.13	9.00e-73	264.00
IUUC-Cfa-020561	Canis familiaris	79.47	3.00e-72	263.00
IUUC-Cpo-022280	Cavia porcellus	76.67	6.00e-69	251.00
IUUC-Cre-022978	Chlamydomonas reinhardtii	75.51	2.00e-65	240.00
IUUC-Csa-023860	Chlorocebus sabaeus	73.51	3.00e-66	242.00
IUUC-Cho-024459	Choloepus hoffmanni	80.13	9.00e-73	264.00
IUUC-Cin-025278	Ciona intestinalis	77.03	2.00e-67	246.00
IUUC-Csv-025952	Ciona savignyi	70.47	6.00e-61	224.00
IUUC-Cgl-026752	Colletotrichum gloeosporioides	73.47	4.00e-64	235.00
IUUC-Cne-026809	Cryptococcus neoformans	73.68	5.00e-57	211.00
IUUC-Dre-027931	Danio rerio	81.76	2.00e-72	263.00
IUUC-Dno-030059	Dasypus novemcinctus	78.81	4.00e-71	259.00
IUUC-Dor-030269	Dipodomys ordii	82.95	4.00e-64	235.00
IUUC-Dse-031505	Dothistroma septosporum	72.11	2.00e-61	227.00
IUUC-Ete-032369	Echinops telfairi	80.13	9.00e-73	264.00
IUUC-Eca-033230	Equus caballus	80.13	9.00e-73	264.00
IUUC-Fca-036161	Felis catus	77.48	4.00e-70	255.00
IUUC-Fal-036781	Ficedula albicollis	76.82	3.00e-70	255.00
IUUC-Fox-037840	Fusarium oxysporum	72.60	1.00e-62	230.00
IUUC-Fso-038118	Fusarium solani	73.29	3.00e-63	232.00
IUUC-Gmo-039561	Gadus morhua	82.43	2.00e-72	263.00
IUUC-Ggr-039807	Gaeumannomyces graminis	75.51	2.00e-65	239.00
IUUC-Gga-041024	Gallus gallus	80.13	9.00e-73	264.00
IUUC-Gac-042026	Gasterosteus aculeatus	81.21	2.00e-73	266.00
IUUC-Gma-043485	Glycine max	76.87	4.00e-68	248.00
IUUC-Ggo-044660	Gorilla gorilla	79.47	3.00e-72	262.00
IUUC-Hsa-045881	Homo sapiens	80.13	9.00e-73	264.00
IUUC-Hvu-047346	Hordeum vulgare	76.19	3.00e-67	246.00
IUUC-Itr-048778	Ictidomys tridecemlineatus	80.15	6.00e-65	238.00
IUUC-Kpa-049285	Komagataella pastoris	72.67	2.00e-64	236.00
IUUC-Lch-050548	Latimeria chalumnae	75.00	2.00e-68	249.00
IUUC-Lpe-051394	Leersia perrieri	76.19	1.00e-67	247.00
IUUC-Loc-052205	Lepisosteus oculatus	81.76	1.00e-72	264.00
IUUC-Lma-053056	Leptosphaeria maculans	76.03	2.00e-65	239.00
IUUC-Laf-053540	Loxodonta africana	80.14	5.00e-68	248.00
IUUC-Mcc-054863	Macaca mulatta	80.13	9.00e-73	264.00
IUUC-Meu-056482	Macropus eugenii	80.14	5.00e-68	248.00
IUUC-Mor-057014	Magnaporthe oryzae	72.11	3.00e-63	233.00
IUUC-Mpo-057586	Magnaporthe poae	75.51	2.00e-65	240.00
IUUC-Mtr-058552	Medicago truncatula	68.32	1.00e-63	234.00
IUUC-Mla-058920	Melampsora laricipopulina	71.43	2.00e-62	230.00
IUUC-Mga-059649	Meleagris gallopavo	76.16	6.00e-69	251.00
IUUC-Mvi-060483	Microbotryum violaceum	75.51	2.00e-66	243.00
IUUC-Mmr-061167	Microcebus murinus	80.13	9.00e-73	264.00
IUUC-Mdo-062701	Monodelphis domestica	80.13	9.00e-73	264.00
IUUC-Mmu-064070	Mus musculus	80.13	9.00e-73	264.00
IUUC-Mac-064742	Musa acuminata	76.19	6.00e-68	248.00
IUUC-Mpu-066401	Mustela putorius furo	80.13	1.00e-72	264.00
IUUC-Mlu-067229	Myotis lucifugus	79.45	2.00e-69	253.00
IUUC-Nfi-068526	Neosartorya fischeri	73.47	1.00e-64	237.00
IUUC-Ncr-068643	Neurospora crassa	73.47	2.00e-64	236.00
IUUC-Nle-070146	Nomascus leucogenys	80.13	9.00e-73	264.00
IUUC-Opr-070232	Ochotona princeps	64.24	9.00e-53	197.00
IUUC-Ont-071741	Oreochromis niloticus	80.41	4.00e-72	262.00
IUUC-Oan-073174	Ornithorhynchus anatinus	78.91	2.00e-69	253.00
IUUC-Ocu-074712	Oryctolagus cuniculus	80.13	9.00e-73	264.00
IUUC-Oba-075408	Oryza barthii	76.19	1.00e-67	247.00
IUUC-Obr-076881	Oryza brachyantha	76.19	1.00e-67	247.00
IUUC-Ogl-077242	Oryza glaberrima	76.19	1.00e-67	247.00
IUUC-Ogu-078465	Oryza glumaepatula	76.19	1.00e-67	247.00
IUUC-Oin-080035	Oryza indica	75.36	4.00e-63	232.00
IUUC-Olo-080555	Oryza longistaminata	76.19	1.00e-67	247.00
IUUC-Ome-081653	Oryza meridionalis	76.19	1.00e-67	247.00
IUUC-Oni-082400	Oryza nivara	76.19	1.00e-67	247.00
IUUC-Opu-083130	Oryza punctata	77.94	5.00e-63	233.00
IUUC-Oru-084649	Oryza rufipogon	76.19	1.00e-67	247.00
IUUC-Osa-085629	Oryza sativa	76.19	1.00e-67	247.00
IUUC-Ola-087083	Oryzias latipes	81.76	9.00e-72	261.00
IUUC-Olu-087886	Ostreococcus lucimarinus	70.07	3.00e-59	219.00
IUUC-Oga-088983	Otolemur garnettii	76.00	1.00e-68	251.00
IUUC-Oar-090440	Ovis aries	79.47	3.00e-72	262.00
IUUC-Ptr-090572	Pan troglodytes	80.13	9.00e-73	264.00
IUUC-Pan-092503	Papio anubis	78.15	4.00e-71	258.00
IUUC-Psi-093419	Pelodiscus sinensis	80.60	8.00e-65	238.00
IUUC-Pma-094136	Petromyzon marinus	77.38	5.00e-38	147.00
IUUC-Pno-094838	Phaeosphaeria nodorum	74.32	2.00e-65	240.00
IUUC-Ppa-095892	Physcomitrella patens	76.19	9.00e-68	248.00
IUUC-Pfo-096111	Poecilia formosa	81.76	8.00e-73	264.00
IUUC-Pab-097778	Pongo abelii	80.13	9.00e-73	264.00
IUUC-Pop-099707	Populus trichocarpa	75.51	3.00e-67	246.00
IUUC-Pca-100334	Procavia capensis	68.87	1.00e-61	227.00
IUUC-Ppe-101149	Prunus persica	76.19	1.00e-67	247.00
IUUC-Pva-102979	Pteropus vampyrus	80.13	9.00e-73	264.00
IUUC-Pgr-103654	Puccinia graminis	72.79	1.00e-62	231.00
IUUC-Ptt-103752	Puccinia triticina	70.83	1.00e-59	220.00
IUUC-Pte-104137	Pyrenophora teres	75.34	5.00e-65	238.00
IUUC-Pyt-104513	Pyrenophora triticirepentis	75.34	5.00e-65	238.00
IUUC-Rno-105927	Rattus norvegicus	80.13	1.00e-72	263.00
IUUC-Sce-106178	Saccharomyces cerevisiae	70.95	4.00e-61	225.00
IUUC-Sha-107493	Sarcophilus harrisii	80.13	9.00e-73	264.00
IUUC-Sja-107878	Schizosaccharomyces japonicus	67.35	5.00e-58	216.00
IUUC-Spo-108062	Schizosaccharomyces pombe	67.35	9.00e-58	214.00
IUUC-Ssl-108395	Sclerotinia sclerotiorum	72.79	7.00e-63	231.00
IUUC-Smo-109587	Selaginella moellendorffii	70.00	1.00e-61	227.00
IUUC-Sit-110069	Setaria italica	76.19	1.00e-67	247.00
IUUC-Sly-111322	Solanum lycopersicum	76.19	2.00e-67	247.00
IUUC-Stu-112254	Solanum tuberosum	75.51	5.00e-67	245.00
IUUC-Sar-113464	Sorex araneus	80.14	5.00e-68	248.00
IUUC-Sbi-114864	Sorghum bicolor	76.87	1.00e-67	247.00
IUUC-Sre-114927	Sporisorium reilianum	75.34	3.00e-65	239.00
IUUC-Ssc-116096	Sus scrofa	80.13	9.00e-73	264.00
IUUC-Tgu-117266	Taeniopygia guttata	80.14	5.00e-68	248.00
IUUC-Tru-117903	Takifugu rubripes	81.76	2.00e-72	263.00
IUUC-Tsy-118952	Tarsius syrichta	80.14	5.00e-68	248.00
IUUC-Tni-120038	Tetraodon nigroviridis	81.76	2.00e-72	263.00
IUUC-Tca-121752	Theobroma cacao	75.18	3.00e-63	233.00
IUUC-Tre-121979	Trichoderma reesei	75.34	1.00e-64	237.00
IUUC-Tvi-122515	Trichoderma virens	73.97	1.00e-63	233.00
IUUC-Tae-124984	Triticum aestivum	77.55	7.00e-68	248.00
IUUC-Tur-126865	Triticum urartu	76.26	7.00e-63	231.00
IUUC-Tme-127129	Tuber melanosporum	74.66	3.00e-64	236.00
IUUC-Tbe-127846	Tupaia belangeri	80.14	5.00e-68	248.00
IUUC-Ttr-128808	Tursiops truncatus	78.15	8.00e-70	254.00
IUUC-Uma-129548	Ustilago maydis	76.03	6.00e-66	241.00
IUUC-Vda-129810	Verticillium dahliae	72.60	2.00e-63	233.00
IUUC-Vpa-130221	Vicugna pacos	74.82	2.00e-59	219.00
IUUC-Vvi-131158	Vitis vinifera	75.69	3.00e-64	236.00
IUUC-Xtr-132366	Xenopus tropicalis	79.08	4.00e-71	258.00
IUUC-Xma-133961	Xiphophorus maculatus	81.76	8.00e-73	264.00
IUUC-Yli-134605	Yarrowia lipolytica	74.32	2.00e-64	236.00
IUUC-Zma-135587	Zea mays	72.55	8.00e-65	238.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence