iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ggo-044936

UUCD1 version

UUC-GoG-00775

Ensembl Protein ID

ENSGGOP00000020445.1

UniProt Accession

G3RXA9; G3RXA9_GORGO

Protein Name

Ribosome biogenesis protein WDR12; WD repeat-containing protein 12

Gene Name

WDR12

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000024046.1	ENSGGOT00000033210.1	ENSGGOP00000020445.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	5.90e-26	89.9	327	361

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 3    tdsvtclaf..sd.tllvsGsdDgtikvWDlrtgv 34
           t++vt +++  +    l+sGs D+ +k+WD+r+++
   Q: 327  TGWVTLVKWspTHeQQLISGSLDNIVKLWDTRSCD 361
           79*******9533678**************99876 PP

Organism

Gorilla gorilla

Functional Description
(View)

Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.

Protein Sequence
(Fasta)

MAQLQTHFYT DNKKYAVNDV SFSIPAASEF ADLSNIINKL LKDKNEFHKH MEFYFLIKGQ 60
FLRMSLVKHM ELENMSSEVL VEIEYVKYTA PQPEQCMFHD DWILSVKGAK EWILTGSYDK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCTCAGC TCCAAACACA TTTCTACACC GATAACAAGA AATATGCTGT AAATGATGTT 60
TCCTTCTCAA TCCCTGCCGC CTCTGAATTT GCTGACCTTA GTAACATCAT CAATAAATTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0690--Ribosome biogenesis
KW-0698--rRNA processing
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR020472--G-protein_beta_WD-40_rep
IPR012972--NLE
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR028599--WDR12/Ytm1

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08154--NLE
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0030687--C:preribosome, large subunit precursor
GO:0043021--F:ribonucleoprotein complex binding
GO:0000466--P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000463--P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Sre-115002	Sporisorium reilianum	27.59	8.00e-16	78.60

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence