iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ago-007842

Ensembl Protein ID

AAS50847

UniProt Accession

Q75DE9; DEF1_ASHGO

Genbank Protein ID

AAS50847.2

Protein Name

RNA polymerase II degradation factor 1

Genbank Nucleotide ID

AE016815

Gene Name

DEF1; ABR077C

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AGOS_ABR077C	AAS50847	AAS50847

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/CUE	57.97	2.00e-20	95.50	IUUC-Sce-106424

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Ashbya gossypii

Functional Description
(View)

RNA polymerase II degradation factor recruits the ubiquitination machinery to the RNA polymerase II for polyubiquitination, removal and degradation, when RAD26 fails to efficiently displace stalled RNA polymerase II. Also involved in telomere length regulation (By similarity).

Protein Sequence
(Fasta)

MSQQYSRRGG GKAKRTQVDA EKKFKLDTLT ELFPDWTNED LIDLVHEFED LETIIDKITT 60
GAVTKWDEVK KPSKKDRQQK EPAGDVEHIH AGSAAAAFGA SAQAQGAPAS LQRSHHSAGH 120

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Nucleotide Sequence
(Fasta)

ATGTCACAGC AGTATAGCAG AAGAGGTGGC GGTAAAGCCA AGCGGACGCA GGTGGACGCG 60
GAGAAGAAGT TCAAGCTTGA TACGCTGACA GAGCTGTTCC CAGACTGGAC GAACGAGGAC 120

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Sequence Source

Ensembl

Keyword

KW-0158--Chromosome
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0238--DNA-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0779--Telomere
KW-0833--Ubl conjugation pathway

Gene Ontology

GO:0000781--C:chromosome, telomeric region
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0006281--P:DNA repair

KEGG

ago:AGOS_ABR077C

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aca-004593	Anolis carolinensis	30.23	2.70e-01	26.60
IUUC-Acl-008346	Aspergillus clavatus	46.55	1.00e-09	56.60
IUUC-Afu-008947	Aspergillus fumigatus	51.06	9.00e-10	57.00
IUUC-Ani-009287	Aspergillus nidulans	48.28	8.00e-11	60.50
IUUC-Ang-009672	Aspergillus niger	51.06	1.00e-07	48.10
IUUC-Aor-010169	Aspergillus oryzae	50.00	3.00e-11	62.00
IUUC-Ate-010403	Aspergillus terreus	42.65	8.00e-08	50.10
IUUC-Bgr-012096	Blumeria graminis	35.85	3.00e-08	51.60
IUUC-Bta-013452	Bos taurus	38.89	1.70e-01	27.30
IUUC-Bci-013969	Botrytis cinerea	36.36	8.00e-10	57.40
IUUC-Cel-018295	Caenorhabditis elegans	43.59	2.20e-02	30.40
IUUC-Cgl-026768	Colletotrichum gloeosporioides	30.23	2.00e-03	32.30
IUUC-Cne-026987	Cryptococcus neoformans	36.84	5.60e-02	31.20
IUUC-Dse-031419	Dothistroma septosporum	35.71	3.00e-09	55.50
IUUC-Fal-037120	Ficedula albicollis	30.23	2.50e-01	26.90
IUUC-Fox-038044	Fusarium oxysporum	33.33	5.00e-05	40.80
IUUC-Fso-038371	Fusarium solani	30.43	2.00e-04	38.90
IUUC-Ggr-040008	Gaeumannomyces graminis	35.19	3.00e-06	45.40
IUUC-Kpa-049227	Komagataella pastoris	43.24	7.00e-12	63.50
IUUC-Laf-054335	Loxodonta africana	37.84	8.30e-02	28.10
IUUC-Mor-057258	Magnaporthe oryzae	30.16	3.00e-05	42.40
IUUC-Mpo-057575	Magnaporthe poae	35.71	6.00e-07	47.80
IUUC-Mla-058869	Melampsora laricipopulina	44.19	8.00e-06	41.20
IUUC-Mvi-060545	Microbotryum violaceum	39.06	2.00e-06	46.20
IUUC-Nfi-068569	Neosartorya fischeri	53.19	4.00e-10	58.20
IUUC-Ncr-068873	Neurospora crassa	28.89	1.00e-04	40.40
IUUC-Pno-095140	Phaeosphaeria nodorum	45.65	6.00e-08	51.20
IUUC-Pgr-103269	Puccinia graminis	43.48	4.00e-06	45.40
IUUC-Ptt-103757	Puccinia triticina	44.44	1.00e-03	36.60
IUUC-Pte-104043	Pyrenophora teres	46.55	3.00e-10	58.50
IUUC-Pyt-104760	Pyrenophora triticirepentis	48.28	3.00e-10	58.90
IUUC-Sce-106424	Saccharomyces cerevisiae	56.72	1.00e-19	89.70
IUUC-Sja-107853	Schizosaccharomyces japonicus	43.14	2.00e-07	48.90
IUUC-Spo-108061	Schizosaccharomyces pombe	40.58	4.00e-07	48.50
IUUC-Ssl-108511	Sclerotinia sclerotiorum	35.71	6.50e+00	23.50
IUUC-Sre-115033	Sporisorium reilianum	36.00	9.00e-07	47.00
IUUC-Tgu-117270	Taeniopygia guttata	30.23	2.70e-01	26.60
IUUC-Tre-121872	Trichoderma reesei	32.61	2.00e-04	38.90
IUUC-Tvi-122493	Trichoderma virens	30.43	6.00e-04	37.70
IUUC-Tur-126119	Triticum urartu	35.56	1.80e-01	27.70
IUUC-Tme-127134	Tuber melanosporum	29.09	3.00e-04	38.90
IUUC-Tbe-127558	Tupaia belangeri	50.00	6.90e-01	25.40
IUUC-Uma-129410	Ustilago maydis	33.33	4.00e-05	41.60
IUUC-Vda-129677	Verticillium dahliae	29.27	2.80e-01	28.90
IUUC-Yli-134616	Yarrowia lipolytica	42.22	5.20e-01	27.70

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence