iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Dre-027593

Ensembl Protein ID

ENSDARP00000112458.2

UniProt Accession

Q6PE18; A5PF25; Q52PF3; P4K2A_DANRE

Genbank Protein ID

AAY16565.1; CAN88146.1; CAN88146.1; AAH58342.1; AAX89135.1

Protein Name

Phosphatidylinositol 4-kinase type 2-alpha; Phosphatidylinositol 4-kinase type II-alpha

Genbank Nucleotide ID

AY929290; AL929041; BX119918; BC058342; AY989909

Gene Name

pi4k2a; pi4kii; si:ch211-197k17.1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000033666.7	ENSDART00000130675.3	ENSDARP00000112458.2

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
ULD/UDP/UFD/MUB	28.40	1.00e-12	71.60	IUUC-Ath-007357

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Danio rerio

Functional Description
(View)

Membrane-bound phosphatidylinositol-4 kinase (PI4-kinase) that catalyzes the phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P), a lipid that plays important roles in endocytosis, Golgi function, protein sorting and membrane trafficking. Besides, phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P) is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3).

Protein Sequence
(Fasta)

MDETSPLVSP LRDSNDFNYG PAEPTSPRGG FGSTPGSVVR LPAGSPGRSR ERQPLLDRDR 60
GASPRDPHRN EFPEDPEFRE IIRKAERAIE EGIYPERIYQ GSSGSYFVKD SAGKIIGVFK 120

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Nucleotide Sequence
(Fasta)

TGTGATTGTT TGTTGGCGAT CTGCTGTAAA GAGCCGCATC ATTTCATTAC GGCAACAAAC 60
AGGCGCTTGT CCCGGGTAAA TTCCCCCTTT ACCCACTCTC TCCCTACTCC GCCATGGACG 120

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Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0965--Cell junction
KW-1003--Cell membrane
KW-0966--Cell projection
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0967--Endosome
KW-0333--Golgi apparatus
KW-0418--Kinase
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0496--Mitochondrion
KW-0547--Nucleotide-binding
KW-0564--Palmitate
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0770--Synapse
KW-0771--Synaptosome
KW-0808--Transferase

Interpro

IPR000403--PI3/4_kinase_cat_dom

Pfam

PF00454--PI3_PI4_kinase

Gene Ontology

GO:0030054--C:cell junction
GO:0031410--C:cytoplasmic vesicle
GO:0030425--C:dendrite
GO:0005768--C:endosome
GO:0035838--C:growing cell tip
GO:0044231--C:host cell presynaptic membrane
GO:0005887--C:integral component of plasma membrane
GO:0031224--C:intrinsic component of membrane
GO:0005765--C:lysosomal membrane
GO:0045121--C:membrane raft
GO:0005739--C:mitochondrion
GO:0043005--C:neuron projection
GO:0043025--C:neuronal cell body
GO:0005886--C:plasma membrane
GO:0042734--C:presynaptic membrane
GO:0005802--C:trans-Golgi network
GO:0004430--F:1-phosphatidylinositol 4-kinase activity
GO:0035651--F:AP-3 adaptor complex binding
GO:0005524--F:ATP binding
GO:0007032--P:endosome organization
GO:0007030--P:Golgi organization
GO:0006661--P:phosphatidylinositol biosynthetic process
GO:0046854--P:phosphatidylinositol phosphorylation

KEGG

dre:406667

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aly-005869	Arabidopsis lyrata	26.67	1.00e-14	75.10
IUUC-Ath-007357	Arabidopsis thaliana	27.78	1.00e-15	78.60
IUUC-Ani-009242	Aspergillus nidulans	46.74	6.00e-44	172.00
IUUC-Ate-010366	Aspergillus terreus	33.48	2.00e-62	233.00
IUUC-Ame-011505	Astyanax mexicanus	82.82	0.00e+00	742.00
IUUC-Bci-013857	Botrytis cinerea	32.22	3.00e-63	236.00
IUUC-Cin-025197	Ciona intestinalis	61.48	1.00e-152	532.00
IUUC-Dme-032030	Drosophila melanogaster	67.40	4.00e-89	322.00
IUUC-Ete-032358	Echinops telfairi	71.27	4.00e-146	511.00
IUUC-Gmo-039406	Gadus morhua	81.86	0.00e+00	761.00
IUUC-Gga-040459	Gallus gallus	76.04	0.00e+00	717.00
IUUC-Gac-041454	Gasterosteus aculeatus	93.06	0.00e+00	817.00
IUUC-Gma-043404	Glycine max	26.18	2.00e-13	70.90
IUUC-Loc-051878	Lepisosteus oculatus	90.60	0.00e+00	812.00
IUUC-Nfi-068333	Neosartorya fischeri	34.52	9.00e-65	241.00
IUUC-Ncr-068800	Neurospora crassa	33.85	6.00e-67	249.00
IUUC-Ont-072217	Oreochromis niloticus	92.62	0.00e+00	825.00
IUUC-Pma-094719	Petromyzon marinus	71.56	1.00e-145	508.00
IUUC-Pop-099050	Populus trichocarpa	26.33	4.00e-14	73.60
IUUC-Pte-104342	Pyrenophora teres	32.81	3.00e-60	227.00
IUUC-Ssl-108516	Sclerotinia sclerotiorum	33.78	9.00e-66	245.00
IUUC-Ssc-115853	Sus scrofa	75.67	0.00e+00	717.00
IUUC-Tni-120604	Tetraodon nigroviridis	91.72	0.00e+00	819.00
IUUC-Uma-129477	Ustilago maydis	44.30	3.00e-29	124.00
IUUC-Vvi-131314	Vitis vinifera	25.62	4.00e-14	73.20

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence