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Tag Content
UUCD2 ID IUUC-Gga-040244
UUCD1 version UUC-GaG-00835
Ensembl Protein ID ENSGALP00000051055.1
UniProt Accession Q5ZKY2; ATG7_CHICK
Genbank Protein ID CAG31611.1
Protein Name Ubiquitin-like modifier-activating enzyme ATG7; ATG12-activating enzyme E1 ATG7; Autophagy-related protein 7
Genbank Nucleotide ID AJ719952
Gene Name ATG7; APG7L; RCJMB04_8l10
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSGALG00000004932.6 ENSGALT00000047265.2 ENSGALP00000051055.1
ENSGALG00000004932.6 ENSGALT00000036275.3 ENSGALP00000035497.3
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E1 37.45 3.00e-119 424.00 IUUC-Sce-106413
Active Site
Position(s) Description Evidence
578 Glycyl thioester intermediate {ECO:0000250}
Organism Gallus gallus
Functional Description
(View)

Functional Description


     E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress (By similarity).
 E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress (By similarity).
Protein Sequence
(Fasta)
MAAVSNESQN PVDPGSSKLQ FAPFSSALNV GFWHELTQKK LNEYRLDETP KVIKGYYYNG 60
DPSGFPARLT LEYSAFDINA SIPARCCPAF GTLYNTNTFE TFKSCDKKSL LEKEANEIWE 120
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Protein Fasta Sequence


>IUUC-Gga-040244|E1,E1_ThiF|Gallus gallus
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Nucleotide Sequence
(Fasta)
GTACTGCGCG CTGGAGCCGG TGAGCGGCCG CGCGCGGTCG GGGGCCGTCT GGCGTGAGGA 60
GGCGGTGGTG GCTGAGGGGC ATGGAGGATG TCGGCTGCCT TCGGGCTCCG GCTGCGTACC 120
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Nucleotide Fasta Sequence


>IUUC-Gga-040244|E1,E1_ThiF|Gallus gallus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0833--Ubl conjugation pathway
Interpro

IPR006285--Atg7
IPR032197--Atg7_N
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
Pfam

PF16420--ATG7_N
PF00899--ThiF
Gene Ontology

GO:0000407--C:pre-autophagosomal structure
GO:0019778--F:Atg12 activating enzyme activity
GO:0071455--P:cellular response to hyperoxia
GO:0009267--P:cellular response to starvation
GO:0051607--P:defense response to virus
GO:0016236--P:macroautophagy
GO:0000422--P:mitophagy
GO:0043065--P:positive regulation of apoptotic process
GO:0010508--P:positive regulation of autophagy
GO:0045732--P:positive regulation of protein catabolic process
GO:0031401--P:positive regulation of protein modification process
GO:0006497--P:protein lipidation
GO:0015031--P:protein transport
GO:0039521--P:suppression by virus of host autophagy
KEGG gga:415961
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000588 Aegilops tauschii 35.70 2.00e-103 370.00
IUUC-Aml-002316 Ailuropoda melanoleuca 83.92 0.00e+00 1083.00
IUUC-Atr-002579 Amborella trichopoda 46.92 8.00e-171 593.00
IUUC-Apl-003805 Anas platyrhynchos 93.42 0.00e+00 1353.00
IUUC-Aca-004618 Anolis carolinensis 84.80 0.00e+00 1035.00
IUUC-Aly-005670 Arabidopsis lyrata 44.54 1.00e-139 489.00
IUUC-Ath-007499 Arabidopsis thaliana 45.78 6.00e-143 501.00
IUUC-Ago-007838 Ashbya gossypii 39.12 6.00e-116 410.00
IUUC-Acl-008093 Aspergillus clavatus 41.88 8.00e-147 513.00
IUUC-Afl-008663 Aspergillus flavus 44.18 6.00e-139 487.00
IUUC-Afu-008926 Aspergillus fumigatus 39.72 1.00e-137 483.00
IUUC-Ani-009156 Aspergillus nidulans 43.24 3.00e-146 511.00
IUUC-Ang-009853 Aspergillus niger 45.35 9.00e-55 206.00
IUUC-Aor-010055 Aspergillus oryzae 39.45 1.00e-145 509.00
IUUC-Ate-010281 Aspergillus terreus 44.01 8.00e-110 390.00
IUUC-Ame-010939 Astyanax mexicanus 76.50 0.00e+00 1132.00
IUUC-Bgr-012006 Blumeria graminis 40.19 1.00e-141 496.00
IUUC-Bta-012336 Bos taurus 83.36 0.00e+00 1163.00
IUUC-Bci-013598 Botrytis cinerea 39.97 3.00e-139 488.00
IUUC-Bdi-014170 Brachypodium distachyon 34.97 1.00e-100 361.00
IUUC-Bol-015357 Brassica oleracea 45.17 4.00e-151 528.00
IUUC-Bra-016835 Brassica rapa 45.54 1.00e-151 530.00
IUUC-Cel-018172 Caenorhabditis elegans 39.71 2.00e-133 469.00
IUUC-Cja-019544 Callithrix jacchus 84.63 0.00e+00 1218.00
IUUC-Cfa-021043 Canis familiaris 84.22 0.00e+00 1217.00
IUUC-Cpo-022366 Cavia porcellus 82.93 0.00e+00 1194.00
IUUC-Cre-022945 Chlamydomonas reinhardtii 43.26 3.00e-107 382.00
IUUC-Csa-023373 Chlorocebus sabaeus 84.65 0.00e+00 1228.00
IUUC-Cho-024965 Choloepus hoffmanni 68.47 1.00e-173 603.00
IUUC-Cin-025710 Ciona intestinalis 51.63 0.00e+00 709.00
IUUC-Cgl-026542 Colletotrichum gloeosporioides 40.76 3.00e-141 495.00
IUUC-Cne-027083 Cryptococcus neoformans 42.84 1.00e-134 473.00
IUUC-Dre-028740 Danio rerio 69.50 0.00e+00 988.00
IUUC-Dno-029637 Dasypus novemcinctus 84.65 0.00e+00 1108.00
IUUC-Dor-030492 Dipodomys ordii 83.95 0.00e+00 1208.00
IUUC-Dse-031267 Dothistroma septosporum 42.73 5.00e-115 408.00
IUUC-Dme-032084 Drosophila melanogaster 40.41 3.00e-143 501.00
IUUC-Ete-032616 Echinops telfairi 79.63 0.00e+00 1118.00
IUUC-Eca-033991 Equus caballus 84.26 0.00e+00 1209.00
IUUC-Eeu-035126 Erinaceus europaeus 82.05 4.00e-113 402.00
IUUC-Fca-035472 Felis catus 84.07 0.00e+00 1218.00
IUUC-Fal-037178 Ficedula albicollis 91.95 0.00e+00 1288.00
IUUC-Fox-037901 Fusarium oxysporum 41.21 6.00e-144 504.00
IUUC-Fso-038279 Fusarium solani 42.42 2.00e-145 509.00
IUUC-Gmo-039329 Gadus morhua 69.78 0.00e+00 983.00
IUUC-Ggr-040061 Gaeumannomyces graminis 41.96 7.00e-137 481.00
IUUC-Gac-041880 Gasterosteus aculeatus 66.16 0.00e+00 934.00
IUUC-Gma-043235 Glycine max 45.96 1.00e-159 556.00
IUUC-Ggo-045428 Gorilla gorilla 84.36 0.00e+00 1227.00
IUUC-Hsa-046183 Homo sapiens 84.36 0.00e+00 1225.00
IUUC-Hvu-047509 Hordeum vulgare 35.98 1.00e-101 363.00
IUUC-Itr-048165 Ictidomys tridecemlineatus 84.06 0.00e+00 1125.00
IUUC-Kpa-049142 Komagataella pastoris 39.10 8.00e-128 450.00
IUUC-Lch-049601 Latimeria chalumnae 67.40 0.00e+00 836.00
IUUC-Lpe-051496 Leersia perrieri 35.61 1.00e-100 360.00
IUUC-Loc-051751 Lepisosteus oculatus 76.48 0.00e+00 1148.00
IUUC-Lma-053203 Leptosphaeria maculans 40.37 6.00e-115 407.00
IUUC-Laf-053424 Loxodonta africana 83.64 0.00e+00 1211.00
IUUC-Mcc-054633 Macaca mulatta 84.36 0.00e+00 1225.00
IUUC-Meu-056523 Macropus eugenii 75.25 0.00e+00 1033.00
IUUC-Mor-056983 Magnaporthe oryzae 41.63 9.00e-145 507.00
IUUC-Mpo-057615 Magnaporthe poae 42.40 2.00e-144 506.00
IUUC-Mtr-058366 Medicago truncatula 45.65 5.00e-156 544.00
IUUC-Mla-058826 Melampsora laricipopulina 43.97 6.00e-165 574.00
IUUC-Mga-059447 Meleagris gallopavo 98.31 0.00e+00 1459.00
IUUC-Mvi-060537 Microbotryum violaceum 42.74 1.00e-149 523.00
IUUC-Mmr-060676 Microcebus murinus 84.07 0.00e+00 1217.00
IUUC-Mdo-062967 Monodelphis domestica 81.81 0.00e+00 1174.00
IUUC-Mmu-063217 Mus musculus 83.64 0.00e+00 1208.00
IUUC-Mac-065527 Musa acuminata 43.27 2.00e-146 513.00
IUUC-Mpu-066417 Mustela putorius furo 83.45 0.00e+00 1191.00
IUUC-Mlu-067195 Myotis lucifugus 84.47 0.00e+00 1224.00
IUUC-Nfi-068576 Neosartorya fischeri 40.05 5.00e-145 508.00
IUUC-Ncr-068867 Neurospora crassa 42.26 2.00e-144 505.00
IUUC-Nle-069447 Nomascus leucogenys 89.29 0.00e+00 659.00
IUUC-Opr-070737 Ochotona princeps 71.79 0.00e+00 1045.00
IUUC-Ont-071260 Oreochromis niloticus 73.26 0.00e+00 1068.00
IUUC-Oan-073622 Ornithorhynchus anatinus 81.60 0.00e+00 845.00
IUUC-Ocu-074584 Oryctolagus cuniculus 83.36 0.00e+00 1234.00
IUUC-Oba-075483 Oryza barthii 34.94 8.00e-96 345.00
IUUC-Obr-076786 Oryza brachyantha 35.25 5.00e-105 375.00
IUUC-Ogl-077388 Oryza glaberrima 34.74 6.00e-94 338.00
IUUC-Ogu-078618 Oryza glumaepatula 35.19 7.00e-101 362.00
IUUC-Oin-080007 Oryza indica 35.19 2.00e-97 350.00
IUUC-Olo-080994 Oryza longistaminata 35.98 1.00e-92 334.00
IUUC-Ome-081735 Oryza meridionalis 34.94 5.00e-96 345.00
IUUC-Oni-082153 Oryza nivara 34.99 1.00e-96 347.00
IUUC-Opu-083146 Oryza punctata 34.73 6.00e-95 342.00
IUUC-Oru-084919 Oryza rufipogon 34.99 2.00e-96 347.00
IUUC-Osa-086182 Oryza sativa 35.14 2.00e-97 350.00
IUUC-Ola-086441 Oryzias latipes 74.54 0.00e+00 1095.00
IUUC-Olu-087664 Ostreococcus lucimarinus 42.18 4.00e-135 474.00
IUUC-Oga-089074 Otolemur garnettii 82.66 0.00e+00 1110.00
IUUC-Oar-090159 Ovis aries 83.28 0.00e+00 1144.00
IUUC-Ptr-091105 Pan troglodytes 84.99 0.00e+00 1048.00
IUUC-Pan-092446 Papio anubis 84.51 0.00e+00 1225.00
IUUC-Psi-093372 Pelodiscus sinensis 85.13 0.00e+00 1147.00
IUUC-Pma-094661 Petromyzon marinus 59.77 0.00e+00 709.00
IUUC-Pno-094813 Phaeosphaeria nodorum 38.04 2.00e-114 405.00
IUUC-Ppa-095224 Physcomitrella patens 45.35 3.00e-154 538.00
IUUC-Pfo-096565 Poecilia formosa 76.01 0.00e+00 1063.00
IUUC-Pop-099702 Populus trichocarpa 45.98 2.00e-169 588.00
IUUC-Pca-100324 Procavia capensis 63.03 0.00e+00 846.00
IUUC-Ppe-101416 Prunus persica 46.73 8.00e-165 573.00
IUUC-Pva-102589 Pteropus vampyrus 79.05 0.00e+00 1117.00
IUUC-Pgr-103497 Puccinia graminis 43.18 3.00e-160 558.00
IUUC-Ptt-103718 Puccinia triticina 43.45 7.00e-159 554.00
IUUC-Pte-104206 Pyrenophora teres 39.02 6.00e-108 384.00
IUUC-Pyt-104767 Pyrenophora triticirepentis 37.88 2.00e-119 422.00
IUUC-Rno-105911 Rattus norvegicus 83.64 0.00e+00 1204.00
IUUC-Sce-106413 Saccharomyces cerevisiae 37.45 7.00e-120 424.00
IUUC-Sha-106679 Sarcophilus harrisii 82.23 0.00e+00 1200.00
IUUC-Sja-107928 Schizosaccharomyces japonicus 37.66 3.00e-127 449.00
IUUC-Spo-108107 Schizosaccharomyces pombe 40.72 5.00e-127 448.00
IUUC-Ssl-108570 Sclerotinia sclerotiorum 41.73 5.00e-147 514.00
IUUC-Smo-109677 Selaginella moellendorffii 42.47 1.00e-143 503.00
IUUC-Sit-110319 Setaria italica 33.09 6.00e-82 298.00
IUUC-Sly-111215 Solanum lycopersicum 46.70 8.00e-162 563.00
IUUC-Stu-112442 Solanum tuberosum 46.55 9.00e-157 546.00
IUUC-Sar-113370 Sorex araneus 84.60 0.00e+00 660.00
IUUC-Sbi-114261 Sorghum bicolor 33.62 2.00e-90 327.00
IUUC-Sre-114997 Sporisorium reilianum 40.78 5.00e-145 508.00
IUUC-Ssc-115304 Sus scrofa 82.97 0.00e+00 1135.00
IUUC-Tgu-117235 Taeniopygia guttata 91.64 0.00e+00 1295.00
IUUC-Tru-118374 Takifugu rubripes 74.25 0.00e+00 1066.00
IUUC-Tsy-118966 Tarsius syrichta 72.78 0.00e+00 997.00
IUUC-Tni-120269 Tetraodon nigroviridis 69.78 0.00e+00 905.00
IUUC-Tca-121245 Theobroma cacao 46.51 2.00e-166 578.00
IUUC-Tre-121966 Trichoderma reesei 41.24 2.00e-140 493.00
IUUC-Tvi-122360 Trichoderma virens 42.62 3.00e-140 492.00
IUUC-Tae-125251 Triticum aestivum 35.71 2.00e-104 373.00
IUUC-Tur-126294 Triticum urartu 35.71 1.00e-99 357.00
IUUC-Tme-127117 Tuber melanosporum 39.40 1.00e-137 483.00
IUUC-Tbe-127662 Tupaia belangeri 55.56 2.00e-115 409.00
IUUC-Ttr-129054 Tursiops truncatus 83.79 0.00e+00 1214.00
IUUC-Uma-129526 Ustilago maydis 39.82 4.00e-149 521.00
IUUC-Vda-129878 Verticillium dahliae 40.19 4.00e-138 484.00
IUUC-Vpa-130264 Vicugna pacos 66.23 0.00e+00 900.00
IUUC-Vvi-131163 Vitis vinifera 45.43 9.00e-166 577.00
IUUC-Xtr-132328 Xenopus tropicalis 50.98 0.00e+00 647.00
IUUC-Xma-133015 Xiphophorus maculatus 73.74 0.00e+00 1034.00
IUUC-Yli-134468 Yarrowia lipolytica 38.02 9.00e-119 420.00
IUUC-Zma-134871 Zea mays 34.11 4.00e-97 349.00
Created Date 25-Jun-2017

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