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Tag Content
iUUCD ID IUUC-Sha-107190
Ensembl Protein ID ENSSHAP00000021163.1
UniProt Accession G3X0F8; G3X0F8_SARHA
Genbank Protein ID ENSSHAP00000021163
Protein Name Eukaryotic translation initiation factor 3 subunit F; Eukaryotic translation initiation factor 3 subunit 5; eIF-3-epsilon; eIF3 p47
Genbank Nucleotide ID AEFK01220861
Gene Name EIF3F; EIF3S5
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSSHAG00000017942.1 ENSSHAT00000021333.1 ENSSHAP00000021163.1
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
DUB/JAMM 94.64 1.00e-145 513.00 IUUC-Hsa-046860
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Sarcophilus harrisii
Functional Description
(View)

Functional Description



     Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
Protein Sequence
(Fasta)
LGTSEVFSFP EADSWPITAE KEVSYPRLHL WPGCPSLGLP PLLTSASPSF LSRFDNMAAT 60
TAASGPSPPS TPAPTPAPVS NPDPAPASAP APAPAPPVIL ASIVDSYERR NEGAGRVIGT 120
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Protein Fasta Sequence



>IUUC-Sha-107190|DUB,JAMM|Sarcophilus harrisii
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Nucleotide Sequence
(Fasta)
CTGGGAACTA GCGAGGTCTT CTCGTTTCCC GAGGCCGATT CTTGGCCAAT AACCGCCGAG 60
AAGGAAGTGT CGTACCCACG GCTGCACCTA TGGCCGGGCT GCCCTTCCTT GGGCCTGCCT 120
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Nucleotide Fasta Sequence



>IUUC-Sha-107190|DUB,JAMM|Sarcophilus harrisii
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0396--Initiation factor
KW-0597--Phosphoprotein
KW-0648--Protein biosynthesis
KW-1185--Reference proteome

Interpro

IPR027531--eIF3f
IPR000555--JAMM/MPN+_dom
IPR024969--Rpn11/EIF3F_C

Pfam

PF01398--JAB
PF13012--MitMem_reg

SMART

SM00232--JAB_MPN

Gene Ontology

GO:0016282--C:eukaryotic 43S preinitiation complex
GO:0033290--C:eukaryotic 48S preinitiation complex
GO:0071541--C:eukaryotic translation initiation factor 3 complex, eIF3m
GO:0016020--C:membrane
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0003743--F:translation initiation factor activity
GO:0001731--P:formation of translation preinitiation complex
GO:0075522--P:IRES-dependent viral translational initiation
GO:0016579--P:protein deubiquitination
GO:0006446--P:regulation of translational initiation

Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001150 Aegilops tauschii 36.65 2.00e-46 179.00
IUUC-Aml-001527 Ailuropoda melanoleuca 94.64 3.00e-147 514.00
IUUC-Atr-002686 Amborella trichopoda 40.54 3.00e-47 181.00
IUUC-Apl-003977 Anas platyrhynchos 93.30 2.00e-125 441.00
IUUC-Aca-004335 Anolis carolinensis 91.19 3.00e-144 504.00
IUUC-Aly-005945 Arabidopsis lyrata 37.84 2.00e-47 182.00
IUUC-Ath-007045 Arabidopsis thaliana 37.84 2.00e-46 179.00
IUUC-Acl-008365 Aspergillus clavatus 34.96 9.00e-42 163.00
IUUC-Afl-008742 Aspergillus flavus 35.07 1.00e-39 157.00
IUUC-Afu-009030 Aspergillus fumigatus 34.59 2.00e-41 162.00
IUUC-Ani-009212 Aspergillus nidulans 35.45 2.00e-41 162.00
IUUC-Ang-009712 Aspergillus niger 34.33 3.00e-40 158.00
IUUC-Aor-009885 Aspergillus oryzae 35.07 2.00e-41 162.00
IUUC-Ate-010315 Aspergillus terreus 35.45 5.00e-40 157.00
IUUC-Ame-010801 Astyanax mexicanus 54.58 4.00e-65 241.00
IUUC-Bgr-011982 Blumeria graminis 35.45 7.00e-41 160.00
IUUC-Bta-012804 Bos taurus 95.02 4.00e-147 513.00
IUUC-Bci-013891 Botrytis cinerea 35.07 1.00e-35 143.00
IUUC-Bdi-014328 Brachypodium distachyon 39.46 1.00e-48 186.00
IUUC-Bol-015446 Brassica oleracea 38.22 3.00e-48 184.00
IUUC-Bra-016862 Brassica rapa 38.61 9.00e-49 186.00
IUUC-Cel-018171 Caenorhabditis elegans 34.52 6.00e-44 170.00
IUUC-Cja-019335 Callithrix jacchus 94.64 7.00e-147 513.00
IUUC-Cfa-020138 Canis familiaris 94.25 1.00e-146 512.00
IUUC-Cpo-022109 Cavia porcellus 83.21 4.00e-126 443.00
IUUC-Cre-022664 Chlamydomonas reinhardtii 38.40 2.00e-56 212.00
IUUC-Csa-023994 Chlorocebus sabaeus 94.64 1.00e-146 512.00
IUUC-Cho-024351 Choloepus hoffmanni 72.03 2.00e-101 361.00
IUUC-Cin-025801 Ciona intestinalis 55.17 2.00e-84 305.00
IUUC-Csv-025805 Ciona savignyi 54.41 1.00e-82 299.00
IUUC-Cgl-026643 Colletotrichum gloeosporioides 32.09 9.00e-36 144.00
IUUC-Cne-026868 Cryptococcus neoformans 29.06 7.00e-27 114.00
IUUC-Cme-027328 Cyanidioschyzon merolae 25.99 2.00e-22 99.00
IUUC-Dre-028085 Danio rerio 80.84 3.00e-126 444.00
IUUC-Dno-030099 Dasypus novemcinctus 94.25 8.00e-147 512.00
IUUC-Dor-030324 Dipodomys ordii 85.82 8.00e-129 452.00
IUUC-Dse-031314 Dothistroma septosporum 36.33 3.00e-44 171.00
IUUC-Dme-031926 Drosophila melanogaster 47.92 8.00e-74 270.00
IUUC-Ete-032569 Echinops telfairi 87.36 3.00e-133 467.00
IUUC-Eca-033502 Equus caballus 89.66 4.00e-136 477.00
IUUC-Eeu-034883 Erinaceus europaeus 78.92 4.00e-79 286.00
IUUC-Fca-035873 Felis catus 94.64 5.00e-147 513.00
IUUC-Fal-036921 Ficedula albicollis 93.10 1.00e-146 511.00
IUUC-Fox-037765 Fusarium oxysporum 33.08 2.00e-30 126.00
IUUC-Fso-038240 Fusarium solani 33.83 3.00e-33 135.00
IUUC-Gmo-038864 Gadus morhua 80.46 3.00e-128 450.00
IUUC-Ggr-039862 Gaeumannomyces graminis 30.34 3.00e-29 122.00
IUUC-Gga-040952 Gallus gallus 93.10 4.00e-146 510.00
IUUC-Gac-041677 Gasterosteus aculeatus 80.46 1.00e-127 448.00
IUUC-Gma-043061 Glycine max 39.38 9.00e-46 176.00
IUUC-Ggo-045591 Gorilla gorilla 94.64 4.00e-147 513.00
IUUC-Hsa-046860 Homo sapiens 94.64 1.00e-146 512.00
IUUC-Hvu-047410 Hordeum vulgare 30.41 1.00e-20 91.70
IUUC-Itr-048211 Ictidomys tridecemlineatus 94.25 1.00e-146 512.00
IUUC-Lch-049410 Latimeria chalumnae 73.74 4.00e-84 303.00
IUUC-Lpe-051102 Leersia perrieri 38.82 4.00e-47 181.00
IUUC-Loc-052016 Lepisosteus oculatus 74.33 3.00e-112 397.00
IUUC-Lma-053157 Leptosphaeria maculans 35.09 3.00e-43 168.00
IUUC-Laf-054568 Loxodonta africana 94.25 2.00e-146 511.00
IUUC-Mcc-054613 Macaca mulatta 94.64 4.00e-147 513.00
IUUC-Meu-056832 Macropus eugenii 77.62 3.00e-88 317.00
IUUC-Mor-057104 Magnaporthe oryzae 31.25 6.00e-30 124.00
IUUC-Mtr-058445 Medicago truncatula 39.00 4.00e-54 204.00
IUUC-Mla-059038 Melampsora laricipopulina 30.82 3.00e-31 129.00
IUUC-Mga-059548 Meleagris gallopavo 93.64 5.00e-133 466.00
IUUC-Mvi-060520 Microbotryum violaceum 27.85 2.00e-21 96.30
IUUC-Mdo-062376 Monodelphis domestica 99.62 3.00e-155 540.00
IUUC-Mmu-063254 Mus musculus 93.87 9.00e-146 509.00
IUUC-Mac-065635 Musa acuminata 39.11 2.00e-49 189.00
IUUC-Mpu-066314 Mustela putorius furo 94.64 4.00e-147 513.00
IUUC-Mlu-067512 Myotis lucifugus 94.25 2.00e-146 511.00
IUUC-Nfi-068262 Neosartorya fischeri 34.59 2.00e-41 162.00
IUUC-Ncr-068872 Neurospora crassa 32.09 6.00e-33 134.00
IUUC-Nle-070118 Nomascus leucogenys 94.64 4.00e-147 514.00
IUUC-Opr-071228 Ochotona princeps 94.89 2.00e-133 467.00
IUUC-Ont-072600 Oreochromis niloticus 82.38 9.00e-131 458.00
IUUC-Oan-073584 Ornithorhynchus anatinus 96.61 5.00e-135 472.00
IUUC-Ocu-074542 Oryctolagus cuniculus 95.02 7.00e-148 516.00
IUUC-Oba-075923 Oryza barthii 39.38 2.00e-49 189.00
IUUC-Obr-076313 Oryza brachyantha 39.61 1.00e-49 189.00
IUUC-Ogl-076932 Oryza glaberrima 39.38 2.00e-49 189.00
IUUC-Ogu-078152 Oryza glumaepatula 39.38 2.00e-49 189.00
IUUC-Oin-079528 Oryza indica 39.38 2.00e-49 189.00
IUUC-Olo-080401 Oryza longistaminata 39.38 2.00e-49 189.00
IUUC-Ome-081553 Oryza meridionalis 39.77 7.00e-50 190.00
IUUC-Oni-082090 Oryza nivara 39.38 2.00e-49 189.00
IUUC-Opu-083583 Oryza punctata 39.61 3.00e-49 188.00
IUUC-Oru-084492 Oryza rufipogon 39.38 2.00e-49 189.00
IUUC-Osa-085383 Oryza sativa 39.38 2.00e-49 189.00
IUUC-Ola-086835 Oryzias latipes 80.08 3.00e-127 447.00
IUUC-Olu-087716 Ostreococcus lucimarinus 28.20 6.00e-27 114.00
IUUC-Oga-088886 Otolemur garnettii 95.02 9.00e-148 516.00
IUUC-Oar-090079 Ovis aries 95.02 5.00e-147 513.00
IUUC-Ptr-091457 Pan troglodytes 94.64 1.00e-146 512.00
IUUC-Pan-092317 Papio anubis 94.05 7.00e-101 359.00
IUUC-Psi-093129 Pelodiscus sinensis 86.87 3.00e-133 467.00
IUUC-Pma-094488 Petromyzon marinus 76.63 1.00e-121 428.00
IUUC-Pno-095049 Phaeosphaeria nodorum 35.09 3.00e-43 169.00
IUUC-Ppa-095341 Physcomitrella patens 39.53 4.00e-58 218.00
IUUC-Pfo-096286 Poecilia formosa 80.46 8.00e-128 449.00
IUUC-Pab-097765 Pongo abelii 94.64 1.00e-146 512.00
IUUC-Pop-099131 Populus trichocarpa 39.00 8.00e-51 193.00
IUUC-Pca-100524 Procavia capensis 79.91 3.00e-104 370.00
IUUC-Ppe-101934 Prunus persica 40.15 1.00e-55 209.00
IUUC-Pva-102577 Pteropus vampyrus 93.87 3.00e-146 511.00
IUUC-Pgr-103521 Puccinia graminis 29.29 2.00e-29 122.00
IUUC-Pte-104304 Pyrenophora teres 35.85 6.00e-44 171.00
IUUC-Pyt-104563 Pyrenophora triticirepentis 35.85 5.00e-44 171.00
IUUC-Rno-105717 Rattus norvegicus 94.25 2.00e-146 511.00
IUUC-Sja-107918 Schizosaccharomyces japonicus 34.93 2.00e-43 169.00
IUUC-Spo-108355 Schizosaccharomyces pombe 35.27 4.00e-45 174.00
IUUC-Smo-109374 Selaginella moellendorffii 43.08 9.00e-64 236.00
IUUC-Sit-110119 Setaria italica 39.00 9.00e-49 186.00
IUUC-Sly-111570 Solanum lycopersicum 36.68 1.00e-43 169.00
IUUC-Stu-112308 Solanum tuberosum 38.63 4.00e-50 191.00
IUUC-Sar-113515 Sorex araneus 90.43 5.00e-48 183.00
IUUC-Sbi-114605 Sorghum bicolor 38.61 2.00e-48 186.00
IUUC-Sre-114906 Sporisorium reilianum 39.03 1.00e-50 193.00
IUUC-Tgu-117087 Taeniopygia guttata 92.37 1.00e-130 457.00
IUUC-Tru-117700 Takifugu rubripes 79.69 6.00e-127 446.00
IUUC-Tni-120470 Tetraodon nigroviridis 81.61 1.00e-128 452.00
IUUC-Tca-121109 Theobroma cacao 39.00 1.00e-45 176.00
IUUC-Tre-122095 Trichoderma reesei 33.70 3.00e-32 132.00
IUUC-Tvi-122580 Trichoderma virens 33.33 2.00e-31 129.00
IUUC-Tae-125129 Triticum aestivum 39.46 6.00e-51 194.00
IUUC-Tur-126658 Triticum urartu 35.69 2.00e-43 169.00
IUUC-Tme-127043 Tuber melanosporum 37.83 2.00e-48 186.00
IUUC-Tbe-127927 Tupaia belangeri 94.64 5.00e-147 513.00
IUUC-Ttr-129231 Tursiops truncatus 95.02 2.00e-147 514.00
IUUC-Uma-129578 Ustilago maydis 38.66 1.00e-49 189.00
IUUC-Vda-129730 Verticillium dahliae 32.84 6.00e-38 151.00
IUUC-Vpa-130677 Vicugna pacos 61.31 1.00e-39 156.00
IUUC-Vvi-130968 Vitis vinifera 41.31 5.00e-52 197.00
IUUC-Xtr-132203 Xenopus tropicalis 85.82 2.00e-134 471.00
IUUC-Xma-133972 Xiphophorus maculatus 80.08 1.00e-127 448.00
IUUC-Yli-134553 Yarrowia lipolytica 36.33 6.00e-41 160.00
IUUC-Zma-134941 Zea mays 39.46 1.00e-44 173.00
Created Date 25-Jun-2017

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