iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-012944

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin-conjugating enzyme E2 Q2; E2 ubiquitin-conjugating enzyme Q2; Ubiquitin carrier protein Q2; Ubiquitin-protein ligase Q2

Genbank Nucleotide ID

BC109798

Gene Name

UBE2Q2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000004024.5	ENSBTAT00000005257.5	ENSBTAP00000005257.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	5.70e-18	65.1	175	327

Active Site

Position(s)	Description	Evidence
271	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388}

Domain Profile

E2/UBC

   S: 1    Rlkkelkelekdpp..eg.isakpvdesdltewevlilG.pedtpYeg...........gvFkleiefpedYPfkPPkvkfltkifhPn 74
           Rl+kel ++ ++++  +g +s+++ ++  l++w+v++    +d+p +            ++  l+++f++++Pf+PP v+++ +++++ 
   Q: 175  RLMKELRDIYRSQSykTGiYSVELIND-SLYDWHVKLQKvDPDSPLHSdlqilkekegiEYILLNFSFKDNFPFDPPFVRVVLPVLSGG 262
           778888888665552233145666666.5888888886544555554312222222222346799***********************9 PP
   S: 75   vyen.GkvClsilkeeekWspalsvesvllsiqsll..aepnpesplneeaaellkknreeykkkvr 138
           +    G++C+++l +++ Ws+a+s+esv+++i+++l   +++++ ++n+++++l +++++ y+++v+
   Q: 263  YVLGgGALCMELL-TKQGWSSAYSIESVIMQINATLvkGKARVQFGANKNQYNLARAQQS-YNSIVQ 327
           99998********.59********************87789************9999998.999885 PP

Organism

Bos taurus

Functional Description
(View)

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination.

Protein Sequence
(Fasta)

MSVSGLKAEL KFLASIFDKN HERFRIVSWK LDELHCQFLV PPPAPPGSPH SPPPPLTLHC 60
NITESYPSSS PIWFVDSDDP NLTSVLERLE DTKNNNSNGT TEEVTSEEEE EEEMAEDIED 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTTTCCAGC CCCGATCCGA CGCGGGCCGC GGCGGCGAGG AGAGGCGGAG CCGCGAGAGC 60
GCGGCCCGGG CCGGCCCCGC GGGGCGGTCG CGGCCGTGAC GGCGGCTCCG GGCCCGGCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005524--F:ATP binding
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0070936--P:protein K48-linked ubiquitination

KEGG

bta:511631

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Afl-008523	Aspergillus flavus	31.69	5.00e-17	83.60
IUUC-Afu-009025	Aspergillus fumigatus	35.17	2.00e-15	78.20
IUUC-Ang-009729	Aspergillus niger	31.15	5.00e-21	97.10
IUUC-Aor-010200	Aspergillus oryzae	33.95	5.00e-17	83.60
IUUC-Ate-010283	Aspergillus terreus	35.47	1.00e-17	85.50
IUUC-Bci-013792	Botrytis cinerea	33.52	2.00e-16	82.00
IUUC-Cfa-020582	Canis familiaris	86.74	2.00e-166	578.00
IUUC-Cpo-022469	Cavia porcellus	85.68	4.00e-167	580.00
IUUC-Csa-023724	Chlorocebus sabaeus	86.24	1.00e-171	595.00
IUUC-Cgl-026471	Colletotrichum gloeosporioides	34.93	9.00e-19	89.70
IUUC-Dno-029081	Dasypus novemcinctus	99.59	1.00e-131	461.00
IUUC-Dse-031418	Dothistroma septosporum	32.98	2.00e-18	88.60
IUUC-Ete-032744	Echinops telfairi	64.01	5.00e-88	317.00
IUUC-Eca-033376	Equus caballus	90.45	2.00e-175	608.00
IUUC-Fca-036101	Felis catus	88.10	3.00e-167	581.00
IUUC-Fso-038245	Fusarium solani	29.19	1.00e-13	72.80
IUUC-Gmo-039720	Gadus morhua	84.26	1.00e-157	548.00
IUUC-Ggr-039776	Gaeumannomyces graminis	31.03	1.00e-15	79.70
IUUC-Gac-041836	Gasterosteus aculeatus	83.63	4.00e-158	550.00
IUUC-Hsa-046577	Homo sapiens	85.19	9.00e-169	585.00
IUUC-Lma-052975	Leptosphaeria maculans	31.52	8.00e-22	99.80
IUUC-Mor-057265	Magnaporthe oryzae	30.20	5.00e-12	67.40
IUUC-Mpo-057298	Magnaporthe poae	31.97	2.00e-13	72.00
IUUC-Mvi-060299	Microbotryum violaceum	30.05	2.00e-14	75.50
IUUC-Mmr-061213	Microcebus murinus	89.92	1.00e-173	602.00
IUUC-Mmu-063747	Mus musculus	86.77	4.00e-170	590.00
IUUC-Mpu-066198	Mustela putorius furo	89.92	8.00e-173	599.00
IUUC-Nfi-068376	Neosartorya fischeri	34.48	2.00e-15	78.60
IUUC-Nle-069221	Nomascus leucogenys	85.71	4.00e-171	593.00
IUUC-Ocu-074097	Oryctolagus cuniculus	87.00	4.00e-169	587.00
IUUC-Olu-087612	Ostreococcus lucimarinus	29.41	7.00e-11	60.10
IUUC-Oga-089115	Otolemur garnettii	89.39	1.00e-171	595.00
IUUC-Ptr-090599	Pan troglodytes	85.71	1.00e-171	595.00
IUUC-Pan-092455	Papio anubis	86.51	1.00e-172	598.00
IUUC-Pno-095082	Phaeosphaeria nodorum	34.22	3.00e-17	84.70
IUUC-Pva-102975	Pteropus vampyrus	88.22	3.00e-145	507.00
IUUC-Pte-104028	Pyrenophora teres	35.20	3.00e-19	91.30
IUUC-Pyt-104588	Pyrenophora triticirepentis	35.20	3.00e-18	88.20
IUUC-Rno-105714	Rattus norvegicus	84.35	1.00e-159	555.00
IUUC-Ssl-108486	Sclerotinia sclerotiorum	34.09	2.00e-17	81.60
IUUC-Sar-113657	Sorex araneus	86.62	4.00e-141	493.00
IUUC-Ssc-116046	Sus scrofa	86.77	4.00e-167	580.00
IUUC-Tsy-118894	Tarsius syrichta	85.99	4.00e-104	370.00
IUUC-Tre-122084	Trichoderma reesei	31.25	1.00e-16	82.80
IUUC-Tvi-122420	Trichoderma virens	32.97	3.00e-14	74.70
IUUC-Tme-127145	Tuber melanosporum	39.58	2.00e-18	88.60
IUUC-Ttr-128707	Tursiops truncatus	90.19	1.00e-174	605.00
IUUC-Vda-129662	Verticillium dahliae	30.00	9.00e-12	66.20
IUUC-Vpa-130455	Vicugna pacos	88.22	8.00e-146	509.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence