iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000077721.15	ENST00000371558.6	ENSP00000360613.2
ENSG00000077721.15	ENST00000346330.6	ENSP00000335027.4
ENSG00000077721.15	ENST00000625938.2	ENSP00000486599.1
ENSG00000077721.15	ENST00000631185.2	ENSP00000486153.1
ENSG00000077721.15	ENST00000629303.2	ENSP00000486347.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	miRWalk
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
ClinVar	GWASdb	GWAS Central	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E2/UBC	E2_UBC	20675655; 17462990

Classification

Family	E-value	Score	Start	End
E2/UBC	1.20e-54	185.5	8	142

Active Site

Position(s)	Description	Evidence
88	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkeeekW 92
           Rl++++k+l++dpp+g+s  p+++ +++ w+++i+Gpe+tp+e+g+Fkl+ief+e+YP kPP+v+f++k+fhPnvy++G++Cl+il+  ++W
   Q: 8    RLMRDFKRLQEDPPAGVSGAPSEN-NIMVWNAVIFGPEGTPFEDGTFKLTIEFTEEYPNKPPTVRFVSKMFHPNVYADGSICLDILQ--NRW 96
           9**********************9.9************************************************************9..*** PP
   S: 93   spalsvesvllsiqsllaepnpesplneeaaellkknreeykkkvr 138
           sp+++v+s+l+siqsll+epnp+sp+n++aa+l+++n++ey+k+v+
   Q: 97   SPTYDVSSILTSIQSLLDEPNPNSPANSQAAQLYQENKREYEKRVS 142
           *******************************************996 PP

Organism

Homo sapiens

Functional Description
(View)

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11', as well as 'Lys-48'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA.

Protein Sequence
(Fasta)

MSTPARRRLM RDFKRLQEDP PAGVSGAPSE NNIMVWNAVI FGPEGTPFED GTFKLTIEFT 60
EEYPNKPPTV RFVSKMFHPN VYADGSICLD ILQNRWSPTY DVSSILTSIQ SLLDEPNPNS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTACGGCCTG TCCGGCGCTC GACGTTCCAC CCCCCTCTCT CTGCTCTCAG GTTGGTTCAG 60
CCCCCGTCTA CACTGGGGTG GTGCTTAGCC GGCGCCAGAC CGACCCTCGA CTTCGGAGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0227--DNA damage
KW-0234--DNA repair
KW-0991--Mental retardation
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0000785--C:chromatin
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0033503--C:HULC complex
GO:0000790--C:nuclear chromatin
GO:0005654--C:nucleoplasm
GO:0001741--C:XY body
GO:0005524--F:ATP binding
GO:0043130--F:ubiquitin binding
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006281--P:DNA repair
GO:0033522--P:histone H2A ubiquitination
GO:0001701--P:in utero embryonic development
GO:0060135--P:maternal process involved in female pregnancy
GO:0008284--P:positive regulation of cell proliferation
GO:0006301--P:postreplication repair
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0070979--P:protein K11-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0009411--P:response to UV
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:7319

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001001	Aegilops tauschii	75.84	1.00e-69	255.00
IUUC-Atr-002862	Amborella trichopoda	79.19	8.00e-72	262.00
IUUC-Aly-005584	Arabidopsis lyrata	77.18	9.00e-71	258.00
IUUC-Ath-007149	Arabidopsis thaliana	77.18	9.00e-71	258.00
IUUC-Ago-007745	Ashbya gossypii	69.80	9.00e-63	232.00
IUUC-Afl-008551	Aspergillus flavus	68.87	2.00e-63	234.00
IUUC-Afu-008980	Aspergillus fumigatus	68.87	2.00e-63	234.00
IUUC-Ang-009554	Aspergillus niger	68.87	2.00e-63	234.00
IUUC-Aor-010242	Aspergillus oryzae	68.87	2.00e-63	234.00
IUUC-Ate-010390	Aspergillus terreus	68.87	2.00e-63	234.00
IUUC-Ame-011594	Astyanax mexicanus	100.00	1.00e-88	318.00
IUUC-Bgr-012039	Blumeria graminis	66.91	2.00e-56	211.00
IUUC-Bci-013919	Botrytis cinerea	69.54	1.00e-64	238.00
IUUC-Bdi-015010	Brachypodium distachyon	78.52	5.00e-71	259.00
IUUC-Bol-016084	Brassica oleracea	78.52	1.00e-71	261.00
IUUC-Bra-016643	Brassica rapa	78.52	1.00e-71	261.00
IUUC-Cel-018244	Caenorhabditis elegans	85.91	9.00e-78	282.00
IUUC-Cja-018783	Callithrix jacchus	100.00	1.00e-88	318.00
IUUC-Cfa-020646	Canis familiaris	100.00	3.00e-87	314.00
IUUC-Cpo-021323	Cavia porcellus	99.34	2.00e-88	317.00
IUUC-Csa-023588	Chlorocebus sabaeus	100.00	1.00e-88	318.00
IUUC-Cin-025537	Ciona intestinalis	82.89	8.00e-63	232.00
IUUC-Csv-025846	Ciona savignyi	83.89	2.00e-67	247.00
IUUC-Cgl-026381	Colletotrichum gloeosporioides	68.87	4.00e-64	236.00
IUUC-Cne-026864	Cryptococcus neoformans	71.81	4.00e-65	239.00
IUUC-Cme-027284	Cyanidioschyzon merolae	67.33	2.00e-54	205.00
IUUC-Dre-028358	Danio rerio	100.00	1.00e-88	318.00
IUUC-Dse-031487	Dothistroma septosporum	68.87	8.00e-64	235.00
IUUC-Dme-031863	Drosophila melanogaster	88.08	5.00e-78	283.00
IUUC-Eca-033562	Equus caballus	98.05	7.00e-87	311.00
IUUC-Eeu-035191	Erinaceus europaeus	79.22	2.00e-64	238.00
IUUC-Fca-036581	Felis catus	100.00	1.00e-88	318.00
IUUC-Fal-037474	Ficedula albicollis	100.00	1.00e-68	251.00
IUUC-Gmo-038517	Gadus morhua	100.00	1.00e-88	318.00
IUUC-Gga-040588	Gallus gallus	100.00	1.00e-88	318.00
IUUC-Gac-041504	Gasterosteus aculeatus	99.34	3.00e-88	316.00
IUUC-Gma-043883	Glycine max	79.19	6.00e-72	262.00
IUUC-Ggo-044896	Gorilla gorilla	100.00	1.00e-88	318.00
IUUC-Hvu-047054	Hordeum vulgare	75.84	1.00e-69	255.00
IUUC-Itr-048507	Ictidomys tridecemlineatus	100.00	1.00e-88	318.00
IUUC-Lch-049964	Latimeria chalumnae	100.00	1.00e-88	318.00
IUUC-Lpe-051301	Leersia perrieri	79.19	8.00e-72	262.00
IUUC-Loc-051731	Lepisosteus oculatus	100.00	1.00e-88	318.00
IUUC-Laf-053680	Loxodonta africana	100.00	1.00e-88	318.00
IUUC-Mcc-055546	Macaca mulatta	100.00	3.00e-88	317.00
IUUC-Meu-056231	Macropus eugenii	100.00	1.00e-88	318.00
IUUC-Mpo-057498	Magnaporthe poae	69.13	3.00e-63	234.00
IUUC-Mtr-058305	Medicago truncatula	79.19	6.00e-72	263.00
IUUC-Mvi-060330	Microbotryum violaceum	74.17	2.00e-59	221.00
IUUC-Mmr-060956	Microcebus murinus	98.03	5.00e-85	306.00
IUUC-Mdo-062292	Monodelphis domestica	100.00	1.00e-88	318.00
IUUC-Mmu-063680	Mus musculus	100.00	1.00e-88	318.00
IUUC-Mac-064774	Musa acuminata	79.19	1.00e-71	261.00
IUUC-Nfi-068580	Neosartorya fischeri	68.87	2.00e-63	234.00
IUUC-Ncr-068913	Neurospora crassa	68.87	3.00e-64	236.00
IUUC-Nle-069121	Nomascus leucogenys	100.00	1.00e-88	318.00
IUUC-Ont-071335	Oreochromis niloticus	98.03	9.00e-87	311.00
IUUC-Ocu-074550	Oryctolagus cuniculus	100.00	3.00e-88	317.00
IUUC-Oba-075896	Oryza barthii	78.52	3.00e-71	260.00
IUUC-Obr-076713	Oryza brachyantha	79.19	8.00e-72	262.00
IUUC-Ogl-077116	Oryza glaberrima	79.19	8.00e-72	262.00
IUUC-Ogu-078696	Oryza glumaepatula	79.19	8.00e-72	262.00
IUUC-Oin-079099	Oryza indica	79.19	8.00e-72	262.00
IUUC-Olo-081018	Oryza longistaminata	67.27	3.00e-62	231.00
IUUC-Ome-081285	Oryza meridionalis	79.19	8.00e-72	262.00
IUUC-Oni-082088	Oryza nivara	79.19	8.00e-72	262.00
IUUC-Opu-083310	Oryza punctata	79.19	8.00e-72	262.00
IUUC-Oru-084449	Oryza rufipogon	79.19	8.00e-72	262.00
IUUC-Osa-085923	Oryza sativa	79.19	8.00e-72	262.00
IUUC-Ola-086407	Oryzias latipes	100.00	1.00e-88	318.00
IUUC-Olu-087830	Ostreococcus lucimarinus	79.87	2.00e-62	230.00
IUUC-Oga-088659	Otolemur garnettii	100.00	1.00e-88	318.00
IUUC-Ptr-091305	Pan troglodytes	100.00	1.00e-88	318.00
IUUC-Pan-092740	Papio anubis	100.00	3.00e-88	317.00
IUUC-Psi-094094	Pelodiscus sinensis	100.00	1.00e-88	318.00
IUUC-Pma-094376	Petromyzon marinus	96.03	2.00e-85	307.00
IUUC-Ppa-095689	Physcomitrella patens	79.19	9.00e-63	232.00
IUUC-Pfo-096656	Poecilia formosa	99.34	2.00e-88	317.00
IUUC-Pab-097972	Pongo abelii	100.00	1.00e-88	318.00
IUUC-Pop-099517	Populus trichocarpa	79.19	6.00e-72	262.00
IUUC-Pca-100906	Procavia capensis	93.42	1.00e-80	291.00
IUUC-Ppe-101949	Prunus persica	79.19	1.00e-71	262.00
IUUC-Pva-102380	Pteropus vampyrus	98.68	1.00e-85	307.00
IUUC-Rno-105577	Rattus norvegicus	93.83	2.00e-86	310.00
IUUC-Sja-107790	Schizosaccharomyces japonicus	72.48	7.00e-59	219.00
IUUC-Spo-108073	Schizosaccharomyces pombe	72.48	4.00e-59	219.00
IUUC-Ssl-108432	Sclerotinia sclerotiorum	69.54	1.00e-64	238.00
IUUC-Smo-109512	Selaginella moellendorffii	79.19	4.00e-72	263.00
IUUC-Sit-110731	Setaria italica	79.19	8.00e-72	262.00
IUUC-Sly-111506	Solanum lycopersicum	78.52	2.00e-71	261.00
IUUC-Stu-112080	Solanum tuberosum	78.52	2.00e-71	261.00
IUUC-Sbi-114289	Sorghum bicolor	79.19	8.00e-72	262.00
IUUC-Sre-115106	Sporisorium reilianum	72.85	8.00e-60	223.00
IUUC-Ssc-116265	Sus scrofa	100.00	1.00e-88	318.00
IUUC-Tgu-117383	Taeniopygia guttata	100.00	1.00e-88	318.00
IUUC-Tru-117924	Takifugu rubripes	90.74	5.00e-81	293.00
IUUC-Tni-119743	Tetraodon nigroviridis	96.05	2.00e-84	303.00
IUUC-Tca-121827	Theobroma cacao	78.52	9.00e-72	261.00
IUUC-Tre-122002	Trichoderma reesei	68.87	8.00e-64	235.00
IUUC-Tvi-122331	Trichoderma virens	68.87	8.00e-64	235.00
IUUC-Tae-124461	Triticum aestivum	77.85	3.00e-71	261.00
IUUC-Tur-126866	Triticum urartu	77.85	5.00e-71	259.00
IUUC-Tme-127148	Tuber melanosporum	70.39	3.00e-65	240.00
IUUC-Ttr-129050	Tursiops truncatus	99.34	1.00e-85	308.00
IUUC-Vda-129711	Verticillium dahliae	68.87	4.00e-64	236.00
IUUC-Vvi-131547	Vitis vinifera	79.19	7.00e-72	263.00
IUUC-Xtr-132301	Xenopus tropicalis	100.00	1.00e-88	318.00
IUUC-Xma-133937	Xiphophorus maculatus	100.00	1.00e-88	318.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence