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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046528
UUCD1 version UUC-HoS-00042
Ensembl Protein ID ENSP00000418287.1
UniProt Accession O76071; A0MNN9; Q53FM5; CIAO1_HUMAN
Genbank Protein ID AAC24948.1; ABK41108.1; AAC23493.1; CAG33083.1; BAD96977.1; AAH01395.1; AAH32812.1
Protein Name Probable cytosolic iron-sulfur protein assembly protein CIAO1; WD repeat-containing protein 39
Genbank Nucleotide ID U63810; EF011618; AC004020; CR456802; AK223257; BC001395; BC032812
Gene Name CIAO1; WDR39
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000144021.2 ENST00000488633.1 ENSP00000418287.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDBioGRIDmUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD WD_repeat 17588513
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 5.30e-44 147.9 192 222
UBD/Beta-Prp 3.90e-61 208.5 13 221
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWD 29
           gH++ v++laf ++  +l+s+sdD t+++W+
   Q: 192  GHESTVWSLAFdPSgQRLASCSDDRTVRIWR 222
           8***********6669**************8 PP
   

   UBD/Beta-Prp
   S: 7    ghhksvitcvkfspdksllatgsrdgtikvwdvttgkl..lrsl.sgheaevtavkfspdgkilvtgseDrtikvw..dlstgkcvhtlkgh 93
           +h++s++  +++ p ++lla+ + d++i++w ++  +    + l +gh+ +v+ v +sp g++l+++s D+t ++w  + ++++cv tl+gh
   Q: 13   AHPDSRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSWicKSVLsEGHQRTVRKVAWSPCGNYLASASFDATTCIWkkNQDDFECVTTLEGH 104
           688999999999*********************9877654566689******************************99999*********** PP
   S: 94   edsvlslsfspsgdklvsGshdrtirvwdletgqclee..tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgk..llrtltgghtd 181
           e++v s+++ psg+ l++ s+d+ + vw+++++ ++e   +l+ h++ v +vv+hp++ ll+s+s+D tv+l++ + ++  +  tl+g h++
   Q: 105  ENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECvsVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDwvCCATLEG-HES 195
           ******************************9987776566*********************************9977754499****9.*** PP
   S: 182  svyslsfdsngkelvsgsldgtvklw 207
            v sl+fd++g++l+s+s+d+tv++w
   Q: 196  TVWSLAFDPSGQRLASCSDDRTVRIW 221
           ************************** PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.
 Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.
Protein Sequence
(Fasta)
MKDSLVLLGR VPAHPDSRCW FLAWNPAGTL LASCGGDRRI RIWGTEGDSW ICKSVLSEGH 60
QRTVRKVAWS PCGNYLASAS FDATTCIWKK NQDDFECVTT LEGHENEVKS VAWAPSGNLL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046528|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CCCTGCCGAG GTGAGGGGAG CGACTACAAC TCCCAGAGGG TATGGCGGCC GCAGCAGTGG 60
GCAGTTGAGT TTCCGGGGCG ACCCAGGTCC TCCGGCGGAA GCGGGAGCCT CTGTCGGCCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046528|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0159--Chromosome partition
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR028608--CIAO1/Cia1
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0097361--C:CIA complex
GO:0071817--C:MMXD complex
GO:0007059--P:chromosome segregation
GO:0016226--P:iron-sulfur cluster assembly
GO:0008284--P:positive regulation of cell proliferation
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
KEGG hsa:9391
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000874 Aegilops tauschii 48.00 1.00e-66 248.00
IUUC-Aml-001317 Ailuropoda melanoleuca 96.76 0.00e+00 634.00
IUUC-Atr-003029 Amborella trichopoda 51.91 3.00e-94 338.00
IUUC-Apl-004042 Anas platyrhynchos 76.52 1.00e-56 211.00
IUUC-Aly-006458 Arabidopsis lyrata 48.41 7.00e-86 310.00
IUUC-Ath-006671 Arabidopsis thaliana 48.41 2.00e-85 309.00
IUUC-Ago-007820 Ashbya gossypii 40.59 7.00e-60 224.00
IUUC-Acl-008042 Aspergillus clavatus 31.57 4.00e-50 192.00
IUUC-Afl-008639 Aspergillus flavus 32.38 6.00e-53 201.00
IUUC-Afu-008899 Aspergillus fumigatus 35.51 5.00e-49 188.00
IUUC-Ani-009453 Aspergillus nidulans 32.38 5.00e-51 195.00
IUUC-Ang-009758 Aspergillus niger 34.66 3.00e-51 196.00
IUUC-Aor-010212 Aspergillus oryzae 32.38 6.00e-53 201.00
IUUC-Ate-010314 Aspergillus terreus 32.37 2.00e-52 200.00
IUUC-Ame-010676 Astyanax mexicanus 77.25 2.00e-157 548.00
IUUC-Bgr-012095 Blumeria graminis 30.46 2.00e-38 153.00
IUUC-Bta-012884 Bos taurus 93.51 6.00e-177 613.00
IUUC-Bci-013622 Botrytis cinerea 32.56 1.00e-37 150.00
IUUC-Bdi-014614 Brachypodium distachyon 48.82 1.00e-85 310.00
IUUC-Bol-016439 Brassica oleracea 47.35 4.00e-83 301.00
IUUC-Bra-016830 Brassica rapa 46.61 5.00e-82 297.00
IUUC-Cel-018709 Caenorhabditis elegans 39.76 3.00e-63 235.00
IUUC-Cja-019822 Callithrix jacchus 98.53 0.00e+00 647.00
IUUC-Cfa-020823 Canis familiaris 97.35 0.00e+00 638.00
IUUC-Cre-022811 Chlamydomonas reinhardtii 47.41 9.00e-81 293.00
IUUC-Csa-023754 Chlorocebus sabaeus 100.00 0.00e+00 654.00
IUUC-Cin-025395 Ciona intestinalis 57.31 2.00e-116 411.00
IUUC-Csv-025943 Ciona savignyi 55.26 5.00e-112 397.00
IUUC-Cgl-026435 Colletotrichum gloeosporioides 33.67 2.00e-36 147.00
IUUC-Cne-026939 Cryptococcus neoformans 32.59 2.00e-49 189.00
IUUC-Cme-027239 Cyanidioschyzon merolae 40.93 2.00e-44 173.00
IUUC-Dre-028172 Danio rerio 76.95 1.00e-155 542.00
IUUC-Dno-029472 Dasypus novemcinctus 95.56 1.00e-153 535.00
IUUC-Dor-031134 Dipodomys ordii 85.25 5.00e-154 536.00
IUUC-Dse-031535 Dothistroma septosporum 30.09 4.00e-47 182.00
IUUC-Dme-032020 Drosophila melanogaster 59.09 7.00e-118 416.00
IUUC-Eca-033700 Equus caballus 97.94 0.00e+00 642.00
IUUC-Eeu-035010 Erinaceus europaeus 94.40 1.00e-177 615.00
IUUC-Fca-036309 Felis catus 88.82 2.00e-172 598.00
IUUC-Fal-037243 Ficedula albicollis 73.95 3.00e-86 310.00
IUUC-Fox-038058 Fusarium oxysporum 32.82 2.00e-43 171.00
IUUC-Fso-038459 Fusarium solani 35.43 2.00e-39 156.00
IUUC-Gmo-039375 Gadus morhua 75.52 1.00e-140 492.00
IUUC-Ggr-040002 Gaeumannomyces graminis 35.67 1.00e-40 160.00
IUUC-Gga-040294 Gallus gallus 77.98 6.00e-130 456.00
IUUC-Gac-042499 Gasterosteus aculeatus 74.78 5.00e-139 487.00
IUUC-Gma-043543 Glycine max 48.97 3.00e-87 315.00
IUUC-Ggo-045181 Gorilla gorilla 100.00 0.00e+00 654.00
IUUC-Hvu-047341 Hordeum vulgare 57.45 9.00e-56 209.00
IUUC-Itr-048790 Ictidomys tridecemlineatus 97.94 0.00e+00 642.00
IUUC-Kpa-049353 Komagataella pastoris 37.39 6.00e-57 214.00
IUUC-Lch-049763 Latimeria chalumnae 80.24 2.00e-160 558.00
IUUC-Lpe-051500 Leersia perrieri 44.74 2.00e-81 296.00
IUUC-Loc-052021 Lepisosteus oculatus 80.54 2.00e-153 535.00
IUUC-Lma-053331 Leptosphaeria maculans 35.00 1.00e-55 211.00
IUUC-Laf-054558 Loxodonta africana 95.28 2.00e-180 624.00
IUUC-Mcc-055374 Macaca mulatta 99.71 0.00e+00 651.00
IUUC-Meu-056042 Macropus eugenii 77.24 3.00e-112 397.00
IUUC-Mor-057187 Magnaporthe oryzae 35.48 1.00e-38 154.00
IUUC-Mtr-058072 Medicago truncatula 48.51 1.00e-86 313.00
IUUC-Mla-059108 Melampsora laricipopulina 31.59 1.00e-51 197.00
IUUC-Mga-059370 Meleagris gallopavo 63.93 3.00e-101 361.00
IUUC-Mvi-060495 Microbotryum violaceum 36.81 7.00e-58 218.00
IUUC-Mmr-060902 Microcebus murinus 97.64 0.00e+00 638.00
IUUC-Mdo-062510 Monodelphis domestica 92.92 3.00e-171 594.00
IUUC-Mmu-063575 Mus musculus 94.99 0.00e+00 625.00
IUUC-Mac-065322 Musa acuminata 50.74 2.00e-91 328.00
IUUC-Mpu-065925 Mustela putorius furo 96.76 0.00e+00 634.00
IUUC-Mlu-067755 Myotis lucifugus 96.76 0.00e+00 632.00
IUUC-Nfi-068327 Neosartorya fischeri 31.22 9.00e-49 187.00
IUUC-Ncr-068845 Neurospora crassa 33.23 7.00e-33 135.00
IUUC-Nle-069406 Nomascus leucogenys 97.35 0.00e+00 633.00
IUUC-Opr-070416 Ochotona princeps 75.81 6.00e-133 467.00
IUUC-Ont-071936 Oreochromis niloticus 75.67 2.00e-142 498.00
IUUC-Oan-073452 Ornithorhynchus anatinus 92.73 3.00e-76 277.00
IUUC-Ocu-074791 Oryctolagus cuniculus 95.87 0.00e+00 630.00
IUUC-Oba-075636 Oryza barthii 49.55 7.00e-89 320.00
IUUC-Obr-076742 Oryza brachyantha 48.60 3.00e-77 281.00
IUUC-Ogl-077766 Oryza glaberrima 49.55 7.00e-89 320.00
IUUC-Ogu-079039 Oryza glumaepatula 49.55 3.00e-89 321.00
IUUC-Oin-079315 Oryza indica 49.32 6.00e-78 284.00
IUUC-Olo-080669 Oryza longistaminata 44.01 6.00e-81 294.00
IUUC-Ome-081490 Oryza meridionalis 49.55 5.00e-89 320.00
IUUC-Oni-082572 Oryza nivara 49.55 7.00e-89 320.00
IUUC-Opu-083732 Oryza punctata 49.70 6.00e-89 320.00
IUUC-Oru-084763 Oryza rufipogon 49.55 7.00e-89 320.00
IUUC-Osa-085372 Oryza sativa 49.55 7.00e-89 320.00
IUUC-Ola-087379 Oryzias latipes 73.53 1.00e-138 485.00
IUUC-Olu-087801 Ostreococcus lucimarinus 36.01 1.00e-44 173.00
IUUC-Oga-089076 Otolemur garnettii 97.05 0.00e+00 635.00
IUUC-Oar-090022 Ovis aries 93.22 4.00e-176 610.00
IUUC-Ptr-090809 Pan troglodytes 100.00 0.00e+00 654.00
IUUC-Pan-091685 Papio anubis 100.00 0.00e+00 661.00
IUUC-Psi-093046 Pelodiscus sinensis 88.13 1.00e-168 585.00
IUUC-Pma-094181 Petromyzon marinus 63.80 8.00e-132 462.00
IUUC-Pno-094882 Phaeosphaeria nodorum 35.19 7.00e-56 211.00
IUUC-Ppa-095172 Physcomitrella patens 47.67 5.00e-86 311.00
IUUC-Pfo-096396 Poecilia formosa 72.11 8.00e-139 486.00
IUUC-Pab-098427 Pongo abelii 99.41 0.00e+00 646.00
IUUC-Pop-100016 Populus trichocarpa 51.63 2.00e-90 326.00
IUUC-Pca-101048 Procavia capensis 95.58 0.00e+00 625.00
IUUC-Ppe-102050 Prunus persica 47.71 2.00e-86 312.00
IUUC-Pva-103117 Pteropus vampyrus 96.17 0.00e+00 630.00
IUUC-Pgr-103307 Puccinia graminis 34.25 1.00e-56 214.00
IUUC-Ptt-103938 Puccinia triticina 38.06 6.00e-49 187.00
IUUC-Pte-104315 Pyrenophora teres 34.05 1.00e-56 214.00
IUUC-Pyt-104825 Pyrenophora triticirepentis 33.33 1.00e-55 210.00
IUUC-Rno-105523 Rattus norvegicus 94.40 7.00e-180 622.00
IUUC-Sce-106297 Saccharomyces cerevisiae 42.27 3.00e-65 241.00
IUUC-Sha-106981 Sarcophilus harrisii 92.15 6.00e-143 499.00
IUUC-Sja-107715 Schizosaccharomyces japonicus 39.31 7.00e-56 211.00
IUUC-Spo-108214 Schizosaccharomyces pombe 41.16 1.00e-57 217.00
IUUC-Smo-109034 Selaginella moellendorffii 45.33 5.00e-82 297.00
IUUC-Sit-110663 Setaria italica 50.44 4.00e-90 324.00
IUUC-Sly-110898 Solanum lycopersicum 47.38 1.00e-82 300.00
IUUC-Stu-112647 Solanum tuberosum 50.37 5.00e-70 257.00
IUUC-Sbi-114288 Sorghum bicolor 48.09 8.00e-86 310.00
IUUC-Sre-115065 Sporisorium reilianum 43.18 2.00e-75 276.00
IUUC-Ssc-115960 Sus scrofa 89.61 2.00e-179 621.00
IUUC-Tru-118382 Takifugu rubripes 71.22 2.00e-147 514.00
IUUC-Tsy-119585 Tarsius syrichta 89.09 3.00e-164 571.00
IUUC-Tni-120133 Tetraodon nigroviridis 74.85 3.00e-143 501.00
IUUC-Tca-121167 Theobroma cacao 49.26 1.00e-81 296.00
IUUC-Tre-122119 Trichoderma reesei 29.10 3.00e-40 159.00
IUUC-Tvi-122407 Trichoderma virens 32.84 7.00e-40 158.00
IUUC-Tae-125748 Triticum aestivum 48.09 4.00e-82 298.00
IUUC-Tur-126682 Triticum urartu 48.52 3.00e-67 248.00
IUUC-Tme-127095 Tuber melanosporum 35.95 7.00e-61 228.00
IUUC-Tbe-128004 Tupaia belangeri 97.05 0.00e+00 637.00
IUUC-Ttr-129284 Tursiops truncatus 91.52 1.00e-170 592.00
IUUC-Uma-129527 Ustilago maydis 42.78 3.00e-74 272.00
IUUC-Vda-129854 Verticillium dahliae 31.52 1.00e-37 150.00
IUUC-Vpa-130681 Vicugna pacos 97.41 9.00e-50 190.00
IUUC-Vvi-131004 Vitis vinifera 53.45 1.00e-87 316.00
IUUC-Xtr-131928 Xenopus tropicalis 81.31 3.00e-155 541.00
IUUC-Xma-134290 Xiphophorus maculatus 70.92 2.00e-135 474.00
IUUC-Yli-134364 Yarrowia lipolytica 43.73 2.00e-67 249.00
IUUC-Zma-135658 Zea mays 49.55 9.00e-87 313.00
Created Date 25-Jun-2017

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