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Tag Content
iUUCD ID IUUC-Gga-040690
Ensembl Protein ID ENSGALP00000007240.3
UniProt Accession Q5ZHN3; WIPI2_CHICK
Genbank Protein ID CAG32760.1
Protein Name WD repeat domain phosphoinositide-interacting protein 2
Genbank Nucleotide ID AJ721101
Gene Name WIPI2; RCJMB04_35d18
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSGALG00000004557.5 ENSGALT00000007252.4 ENSGALP00000007240.3
ENSGALG00000004557.5 ENSGALT00000088934.1 ENSGALP00000062260.1
ENSGALG00000004557.5 ENSGALT00000086572.1 ENSGALP00000059438.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 2.80e-07 31.0 183 217
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf..sdtllvsGsdDgt.ikvWDlrtg 33
           H ++  +laf  s+t l+++s  gt i+v+++ +g
   Q: 183  HDSPLAALAFdaSGTKLATASEKGTvIRVFSIPEG 217
           9999999***9877***********9999987665 PP
   
Organism Gallus gallus
Functional Description
(View)

Functional Description


     Early component of the autophagy machinery being involved in formation of preautophagosomal structures and their maturation into mature phagosomes in response to phosphatidylinositol 3-phosphate (PtdIns3P). Recruits the ATG12-ATG5-ATG16L1 complex to omegasomes, resulting in ATG8 family proteins lipidation and starvation-induced autophagy. Omegasomes are derived from ER and serve as intermediates for genesis of isolation membrane (also called preautophagosome) from ER cisternae membranes.
 Early component of the autophagy machinery being involved in formation of preautophagosomal structures and their maturation into mature phagosomes in response to phosphatidylinositol 3-phosphate (PtdIns3P). Recruits the ATG12-ATG5-ATG16L1 complex to omegasomes, resulting in ATG8 family proteins lipidation and starvation-induced autophagy. Omegasomes are derived from ER and serve as intermediates for genesis of isolation membrane (also called preautophagosome) from ER cisternae membranes.
Protein Sequence
(Fasta)
MNLAGQSGDA GSGHLLFANF NQDNTSLAVG SKSGYKFFSL SSVDKLEQIY ECTDTEDVCI 60
VERLFSSSLV AIVSLKAPRK LKVCHFKKGT EICNYSYSNT ILAVKLNRQR LIVCLEESLY 120
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Protein Fasta Sequence


>IUUC-Gga-040690|E3,WD_repeat|Gallus gallus
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Nucleotide Sequence
(Fasta)
GGGGCCTCTC CGCCGCCCGC AGCGTAAACA AGGCGCTGGC GGCGATGAGG AGGCCGCGGG 60
CGTGCGGAGC GGACCGGGGC CGCCGGGCTT GAGCTGCTCT GCCTGCTGGA GGCGTCCCCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Gga-040690|E3,WD_repeat|Gallus gallus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
IPR032911--WIPI2
SMART

SM00320--WD40
Gene Ontology

GO:0005829--C:cytosol
GO:0034045--C:pre-autophagosomal structure membrane
GO:0043234--C:protein complex
GO:0080025--F:phosphatidylinositol-3,5-bisphosphate binding
GO:0032266--F:phosphatidylinositol-3-phosphate binding
GO:0000045--P:autophagosome assembly
KEGG gga:416481
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001842 Ailuropoda melanoleuca 94.16 0.00e+00 766.00
IUUC-Apl-003390 Anas platyrhynchos 100.00 0.00e+00 857.00
IUUC-Aca-004975 Anolis carolinensis 95.41 0.00e+00 871.00
IUUC-Ago-007948 Ashbya gossypii 31.85 4.00e-27 115.00
IUUC-Acl-008148 Aspergillus clavatus 44.15 2.00e-55 209.00
IUUC-Afl-008562 Aspergillus flavus 35.55 3.00e-62 231.00
IUUC-Afu-008936 Aspergillus fumigatus 35.46 2.00e-59 223.00
IUUC-Ani-009254 Aspergillus nidulans 35.15 2.00e-62 233.00
IUUC-Ang-009798 Aspergillus niger 35.71 1.00e-64 239.00
IUUC-Aor-010066 Aspergillus oryzae 35.55 3.00e-62 231.00
IUUC-Ate-010266 Aspergillus terreus 34.53 4.00e-59 221.00
IUUC-Ame-010727 Astyanax mexicanus 88.07 0.00e+00 803.00
IUUC-Bta-012655 Bos taurus 92.20 0.00e+00 815.00
IUUC-Bci-013627 Botrytis cinerea 34.49 2.00e-63 236.00
IUUC-Cel-018503 Caenorhabditis elegans 43.94 4.00e-83 301.00
IUUC-Cja-018829 Callithrix jacchus 89.65 0.00e+00 803.00
IUUC-Cfa-020858 Canis familiaris 88.86 0.00e+00 811.00
IUUC-Cpo-022235 Cavia porcellus 93.35 0.00e+00 816.00
IUUC-Cre-022613 Chlamydomonas reinhardtii 31.53 4.00e-32 132.00
IUUC-Csa-023963 Chlorocebus sabaeus 88.33 0.00e+00 786.00
IUUC-Cho-024328 Choloepus hoffmanni 84.33 0.00e+00 665.00
IUUC-Cin-025343 Ciona intestinalis 57.87 6.00e-138 483.00
IUUC-Csv-025920 Ciona savignyi 68.89 4.00e-149 520.00
IUUC-Cgl-026425 Colletotrichum gloeosporioides 46.45 2.00e-29 123.00
IUUC-Cne-026947 Cryptococcus neoformans 35.90 9.00e-63 233.00
IUUC-Dre-027490 Danio rerio 88.30 0.00e+00 804.00
IUUC-Dno-030057 Dasypus novemcinctus 86.31 0.00e+00 749.00
IUUC-Dor-030472 Dipodomys ordii 85.90 0.00e+00 769.00
IUUC-Dse-031215 Dothistroma septosporum 37.55 4.00e-47 182.00
IUUC-Ete-032362 Echinops telfairi 81.46 0.00e+00 744.00
IUUC-Eca-034362 Equus caballus 92.14 0.00e+00 795.00
IUUC-Fca-036230 Felis catus 94.13 0.00e+00 759.00
IUUC-Fal-036782 Ficedula albicollis 99.51 0.00e+00 853.00
IUUC-Fox-037797 Fusarium oxysporum 42.32 5.00e-53 201.00
IUUC-Fso-038174 Fusarium solani 43.07 4.00e-54 205.00
IUUC-Gmo-039706 Gadus morhua 58.45 3.00e-137 481.00
IUUC-Ggr-040113 Gaeumannomyces graminis 42.70 5.00e-53 201.00
IUUC-Gac-041360 Gasterosteus aculeatus 88.07 0.00e+00 777.00
IUUC-Gma-043876 Glycine max 35.92 1.00e-39 156.00
IUUC-Hsa-046782 Homo sapiens 91.19 0.00e+00 820.00
IUUC-Itr-048693 Ictidomys tridecemlineatus 90.09 0.00e+00 816.00
IUUC-Kpa-049378 Komagataella pastoris 41.16 1.00e-55 210.00
IUUC-Lch-050413 Latimeria chalumnae 84.13 0.00e+00 739.00
IUUC-Lma-052948 Leptosphaeria maculans 34.77 9.00e-62 230.00
IUUC-Laf-054007 Loxodonta africana 93.03 0.00e+00 857.00
IUUC-Mor-057125 Magnaporthe oryzae 41.95 6.00e-52 197.00
IUUC-Mga-059795 Meleagris gallopavo 97.66 0.00e+00 869.00
IUUC-Mvi-060219 Microbotryum violaceum 39.93 8.00e-46 177.00
IUUC-Mmr-061096 Microcebus murinus 89.43 0.00e+00 829.00
IUUC-Mdo-061815 Monodelphis domestica 93.41 0.00e+00 877.00
IUUC-Mmu-063787 Mus musculus 90.79 0.00e+00 844.00
IUUC-Mpu-066019 Mustela putorius furo 86.39 0.00e+00 752.00
IUUC-Mlu-068016 Myotis lucifugus 92.66 0.00e+00 820.00
IUUC-Nfi-068424 Neosartorya fischeri 35.32 3.00e-60 225.00
IUUC-Ncr-068833 Neurospora crassa 34.88 9.00e-61 227.00
IUUC-Opr-070933 Ochotona princeps 75.77 1.00e-179 622.00
IUUC-Ont-072495 Oreochromis niloticus 86.29 0.00e+00 768.00
IUUC-Oan-073084 Ornithorhynchus anatinus 88.54 0.00e+00 793.00
IUUC-Ocu-074689 Oryctolagus cuniculus 92.33 0.00e+00 799.00
IUUC-Oga-088894 Otolemur garnettii 90.76 0.00e+00 754.00
IUUC-Oar-089850 Ovis aries 93.43 0.00e+00 801.00
IUUC-Ptr-090456 Pan troglodytes 88.99 0.00e+00 793.00
IUUC-Pan-092111 Papio anubis 92.81 0.00e+00 823.00
IUUC-Psi-094095 Pelodiscus sinensis 99.03 0.00e+00 851.00
IUUC-Pno-095015 Phaeosphaeria nodorum 41.95 1.00e-47 183.00
IUUC-Pfo-096987 Poecilia formosa 87.44 0.00e+00 767.00
IUUC-Pab-097754 Pongo abelii 95.38 0.00e+00 785.00
IUUC-Pva-103047 Pteropus vampyrus 82.38 0.00e+00 761.00
IUUC-Pte-104139 Pyrenophora teres 35.24 4.00e-58 218.00
IUUC-Pyt-104488 Pyrenophora triticirepentis 34.85 1.00e-57 216.00
IUUC-Rno-105990 Rattus norvegicus 91.24 0.00e+00 847.00
IUUC-Sha-106581 Sarcophilus harrisii 97.57 0.00e+00 843.00
IUUC-Sja-107913 Schizosaccharomyces japonicus 35.50 4.00e-53 201.00
IUUC-Spo-108068 Schizosaccharomyces pombe 36.46 4.00e-50 191.00
IUUC-Ssl-108418 Sclerotinia sclerotiorum 35.87 4.00e-67 248.00
IUUC-Sre-115219 Sporisorium reilianum 42.01 2.00e-49 189.00
IUUC-Ssc-116360 Sus scrofa 92.66 0.00e+00 800.00
IUUC-Tgu-116951 Taeniopygia guttata 97.37 0.00e+00 845.00
IUUC-Tru-117889 Takifugu rubripes 85.14 0.00e+00 769.00
IUUC-Tre-121895 Trichoderma reesei 41.95 1.00e-56 213.00
IUUC-Tvi-122311 Trichoderma virens 41.57 1.00e-56 213.00
IUUC-Uma-129438 Ustilago maydis 44.57 2.00e-44 172.00
IUUC-Vda-129782 Verticillium dahliae 46.28 6.00e-38 151.00
IUUC-Xma-133370 Xiphophorus maculatus 87.44 0.00e+00 767.00
IUUC-Yli-134337 Yarrowia lipolytica 37.38 2.00e-55 209.00
Created Date 25-Jun-2017

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