iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-013403

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin-conjugating enzyme E2 variant 1

Genbank Nucleotide ID

BC103134

Gene Name

UBE2V1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000027316.2	ENSBTAT00000039155.1	ENSBTAP00000038955.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	1.00e-19	70.8	32	138
E2/UEV	7.40e-68	227.1	4	145
UBD/UBC-like/UBD_UEV	1.20e-51	174.4	2	139

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E2/UBC

   S: 16   gisakpvdesd..ltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyen.Gkv...ClsilkeeekWspalsv 98
           ++s +++d++d  lt+w  +i+Gp++t+Ye+++++l+ie+ ++YP  PP v+f+tki    v+++ G v    +s+l    kW+  +s+
   Q: 32   TVSWGLEDDEDmtLTRWTGMIIGPPRTIYENRIYSLKIECGPKYPEAPPFVRFVTKINMNGVNSSnGVVdprAISVL---AKWQNSYSI 117
           456667777776689*****************************************999999988798866668888...5******** PP
   S: 99   esvllsiqsll.aepnpespl 118
           + vl ++ +l+ ++ n++ p+
   Q: 118  KVVLQELRRLMmSKENMKLPQ 138
           *********996667777665 PP

E2/UEV

   S: 4    eselkvvvprnfrlleeleegekglgdgtvsygldDgddilllsltgtIigpertayegrIyqlklfvgkkYPekPPtvrfsskinmae 92
           ++++ v+vprnfrlleeleeg+kg+gdgtvs+gl+D++d++l+++tg+Iigp+rt ye+rIy+lk+++g+kYPe+PP+vrf++kinm++
   Q: 4    TTGSGVKVPRNFRLLEELEEGQKGVGDGTVSWGLEDDEDMTLTRWTGMIIGPPRTIYENRIYSLKIECGPKYPEAPPFVRFVTKINMNG 92
           67899************************************************************************************ PP
   S: 93   vndsnGvvdpralpvLanWkreysievvlvqlkkellskenrklqqPpeGnlf 145
           vn+snGvvdpra++vLa+W+++ysi+vvl++l++ ++sken+kl+qPpeG+++
   Q: 93   VNSSNGVVDPRAISVLAKWQNSYSIKVVLQELRRLMMSKENMKLPQPPEGQCY 145
           ***************************************************98 PP

UBD/UBC-like/UBD_UEV

   S: 1    AvsesslkkvpskykdkrltvrellnliesykslkpktasfvlnDgesreLlrltGtipvpergitynipiilwllet...YPekPPfv 86
           A++++s++kvp+++       r l++l+e++k+++++t+s++l+D+e+++L+r+tG+i++p+r+i y+++i+++++e+   YPe+PPfv
   Q: 2    AATTGSGVKVPRNF-------RLLEELEEGQKGVGDGTVSWGLEDDEDMTLTRWTGMIIGPPRTI-YENRIYSLKIECgpkYPEAPPFV 82
           7999**********.......********************************************.*********************** PP
   S: 87   svkekidmntikssnehvdpnGkialpvLhkWknpasnlvelvqelivllskeppklsrp 146
           ++++ki+mn+++ssn++vdp+   a++vL+kW+n++s++v+l++++++++ske++kl++p
   Q: 83   RFVTKINMNGVNSSNGVVDPR---AISVLAKWQNSYSIKVVLQELRRLMMSKENMKLPQP 139
           *********************...**********************************98 PP

Organism

Bos taurus

Functional Description
(View)

Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage (By similarity). Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes (By similarity).

Protein Sequence
(Fasta)

MAATTGSGVK VPRNFRLLEE LEEGQKGVGD GTVSWGLEDD EDMTLTRWTG MIIGPPRTIY 60
ENRIYSLKIE CGPKYPEAPP FVRFVTKINM NGVNSSNGVV DPRAISVLAK WQNSYSIKVV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GACAGCGACG CAAGATGGCA GCCACCACGG GCTCGGGTGA GCGGGGGCGC CGGGCCCAGC 60
CGGCCTAGGG GGCATGGGCT TGGGCCGGGG GCCGGAGACC CGCACAGGCC CCTGCTGCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0035370--C:UBC13-UEV1A complex
GO:0000151--C:ubiquitin ligase complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0006301--P:postreplication repair
GO:0070534--P:protein K63-linked ubiquitination

KEGG

bta:617771

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000910	Aegilops tauschii	54.23	4.00e-40	156.00
IUUC-Aml-001242	Ailuropoda melanoleuca	99.29	6.00e-74	270.00
IUUC-Atr-003005	Amborella trichopoda	51.75	2.00e-38	150.00
IUUC-Apl-003600	Anas platyrhynchos	100.00	2.00e-73	267.00
IUUC-Aca-005104	Anolis carolinensis	93.88	1.00e-78	284.00
IUUC-Aly-005402	Arabidopsis lyrata	53.47	7.00e-40	155.00
IUUC-Ath-007596	Arabidopsis thaliana	52.74	7.00e-39	152.00
IUUC-Ago-007810	Ashbya gossypii	52.21	2.00e-34	137.00
IUUC-Acl-008375	Aspergillus clavatus	49.28	1.00e-32	132.00
IUUC-Afl-008598	Aspergillus flavus	51.11	2.00e-34	137.00
IUUC-Afu-008838	Aspergillus fumigatus	49.63	3.00e-34	137.00
IUUC-Aor-010051	Aspergillus oryzae	51.11	2.00e-34	137.00
IUUC-Ame-010710	Astyanax mexicanus	89.12	3.00e-76	276.00
IUUC-Bgr-012010	Blumeria graminis	51.45	4.00e-33	133.00
IUUC-Bci-013649	Botrytis cinerea	51.82	5.00e-33	132.00
IUUC-Bdi-014636	Brachypodium distachyon	53.73	5.00e-38	149.00
IUUC-Bol-015323	Brassica oleracea	53.15	7.00e-41	159.00
IUUC-Bra-018041	Brassica rapa	53.15	7.00e-41	159.00
IUUC-Cel-018398	Caenorhabditis elegans	66.67	5.00e-48	182.00
IUUC-Cja-019316	Callithrix jacchus	100.00	1.00e-77	281.00
IUUC-Cfa-021118	Canis familiaris	100.00	1.00e-73	268.00
IUUC-Cre-022629	Chlamydomonas reinhardtii	49.64	7.00e-38	149.00
IUUC-Csa-024275	Chlorocebus sabaeus	99.29	6.00e-74	270.00
IUUC-Cgl-026596	Colletotrichum gloeosporioides	53.62	6.00e-37	145.00
IUUC-Cne-026817	Cryptococcus neoformans	50.00	2.00e-37	147.00
IUUC-Cme-027257	Cyanidioschyzon merolae	55.47	1.00e-28	119.00
IUUC-Dre-028019	Danio rerio	88.44	3.00e-76	276.00
IUUC-Dno-029762	Dasypus novemcinctus	100.00	4.00e-74	269.00
IUUC-Dme-031635	Drosophila melanogaster	66.90	1.00e-59	221.00
IUUC-Ete-033017	Echinops telfairi	90.78	1.00e-70	259.00
IUUC-Eca-034422	Equus caballus	100.00	5.00e-73	266.00
IUUC-Eeu-035327	Erinaceus europaeus	99.29	2.00e-74	272.00
IUUC-Fal-037350	Ficedula albicollis	96.60	2.00e-74	270.00
IUUC-Fox-037803	Fusarium oxysporum	52.17	6.00e-37	145.00
IUUC-Fso-038147	Fusarium solani	53.96	3.00e-38	150.00
IUUC-Gmo-039237	Gadus morhua	81.63	9.00e-71	258.00
IUUC-Gga-040746	Gallus gallus	97.16	3.00e-72	263.00
IUUC-Gma-043736	Glycine max	54.29	4.00e-43	166.00
IUUC-Ggo-045491	Gorilla gorilla	97.16	5.00e-70	258.00
IUUC-Hsa-045659	Homo sapiens	100.00	1.00e-77	281.00
IUUC-Hvu-047368	Hordeum vulgare	54.48	3.00e-38	150.00
IUUC-Itr-048139	Ictidomys tridecemlineatus	100.00	2.00e-73	267.00
IUUC-Kpa-049337	Komagataella pastoris	51.11	6.00e-32	129.00
IUUC-Lch-050494	Latimeria chalumnae	87.86	9.00e-73	265.00
IUUC-Lpe-050874	Leersia perrieri	54.48	2.00e-38	150.00
IUUC-Loc-052024	Lepisosteus oculatus	88.65	3.00e-73	268.00
IUUC-Laf-054176	Loxodonta africana	100.00	1.00e-77	281.00
IUUC-Mcc-055788	Macaca mulatta	99.29	6.00e-74	270.00
IUUC-Meu-056842	Macropus eugenii	85.56	1.00e-35	143.00
IUUC-Mor-056915	Magnaporthe oryzae	38.67	3.00e-21	94.40
IUUC-Mpo-057437	Magnaporthe poae	46.71	1.00e-29	122.00
IUUC-Mtr-058655	Medicago truncatula	53.79	6.00e-39	153.00
IUUC-Mga-059951	Meleagris gallopavo	98.58	2.00e-73	267.00
IUUC-Mvi-060260	Microbotryum violaceum	54.01	7.00e-37	145.00
IUUC-Mmr-061374	Microcebus murinus	93.88	2.00e-64	237.00
IUUC-Mmu-063234	Mus musculus	92.91	6.00e-69	254.00
IUUC-Mac-065220	Musa acuminata	51.72	1.00e-39	155.00
IUUC-Mpu-065775	Mustela putorius furo	100.00	1.00e-77	281.00
IUUC-Mlu-067269	Myotis lucifugus	95.21	3.00e-71	260.00
IUUC-Nfi-068400	Neosartorya fischeri	44.21	2.00e-26	110.00
IUUC-Ncr-068946	Neurospora crassa	46.36	1.00e-36	145.00
IUUC-Nle-069245	Nomascus leucogenys	100.00	1.00e-77	281.00
IUUC-Opr-070859	Ochotona princeps	87.23	1.00e-63	236.00
IUUC-Ocu-074447	Oryctolagus cuniculus	97.86	9.00e-73	265.00
IUUC-Obr-076191	Oryza brachyantha	53.47	2.00e-40	157.00
IUUC-Olo-080528	Oryza longistaminata	48.63	2.00e-35	140.00
IUUC-Oga-087972	Otolemur garnettii	100.00	2.00e-73	267.00
IUUC-Oar-090166	Ovis aries	99.29	3.00e-74	271.00
IUUC-Ptr-090866	Pan troglodytes	100.00	1.00e-77	281.00
IUUC-Pan-092804	Papio anubis	97.28	3.00e-75	273.00
IUUC-Pma-094142	Petromyzon marinus	85.71	1.00e-21	93.60
IUUC-Ppa-095500	Physcomitrella patens	53.19	5.00e-40	156.00
IUUC-Pab-098403	Pongo abelii	99.29	5.00e-74	271.00
IUUC-Pop-099786	Populus trichocarpa	53.15	6.00e-40	155.00
IUUC-Pca-100723	Procavia capensis	99.29	4.00e-74	271.00
IUUC-Ppe-101725	Prunus persica	55.71	4.00e-40	157.00
IUUC-Pva-102393	Pteropus vampyrus	97.87	1.00e-79	289.00
IUUC-Rno-106065	Rattus norvegicus	93.88	5.00e-73	266.00
IUUC-Sha-107363	Sarcophilus harrisii	95.92	3.00e-74	270.00
IUUC-Sja-107722	Schizosaccharomyces japonicus	54.01	6.00e-35	139.00
IUUC-Spo-108027	Schizosaccharomyces pombe	51.09	2.00e-33	134.00
IUUC-Ssl-108493	Sclerotinia sclerotiorum	52.82	1.00e-34	138.00
IUUC-Smo-109006	Selaginella moellendorffii	46.72	2.00e-29	120.00
IUUC-Sit-110302	Setaria italica	54.86	8.00e-42	162.00
IUUC-Sly-111205	Solanum lycopersicum	52.45	2.00e-40	157.00
IUUC-Stu-112459	Solanum tuberosum	51.75	6.00e-40	155.00
IUUC-Sar-113197	Sorex araneus	100.00	2.00e-50	192.00
IUUC-Sbi-114210	Sorghum bicolor	54.17	3.00e-41	160.00
IUUC-Sre-114909	Sporisorium reilianum	51.82	9.00e-34	135.00
IUUC-Ssc-115939	Sus scrofa	100.00	1.00e-77	281.00
IUUC-Tgu-117289	Taeniopygia guttata	99.29	3.00e-74	270.00
IUUC-Tsy-119103	Tarsius syrichta	98.92	5.00e-51	193.00
IUUC-Tca-121025	Theobroma cacao	56.43	1.00e-40	159.00
IUUC-Tre-121971	Trichoderma reesei	53.96	5.00e-37	146.00
IUUC-Tvi-122622	Trichoderma virens	54.68	2.00e-37	147.00
IUUC-Tae-123220	Triticum aestivum	54.48	3.00e-38	150.00
IUUC-Tur-126236	Triticum urartu	54.01	8.00e-39	152.00
IUUC-Tme-127171	Tuber melanosporum	48.18	6.00e-30	122.00
IUUC-Tbe-128105	Tupaia belangeri	96.40	5.00e-77	281.00
IUUC-Ttr-128790	Tursiops truncatus	99.29	4.00e-74	271.00
IUUC-Vda-129776	Verticillium dahliae	52.86	1.00e-36	145.00
IUUC-Vpa-130575	Vicugna pacos	99.28	7.00e-72	263.00
IUUC-Vvi-130831	Vitis vinifera	55.71	5.00e-41	159.00
IUUC-Xtr-132359	Xenopus tropicalis	95.24	4.00e-74	269.00
IUUC-Xma-134032	Xiphophorus maculatus	82.99	9.00e-65	238.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence