iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ame-010740

Ensembl Protein ID

ENSAMXP00000020823.1

UniProt Accession

W5LLW1; W5LLW1_ASTMX

Genbank Protein ID

ENSAMXP00000020823

Protein Name

Ubiquitin thioesterase

Genbank Nucleotide ID

APWO01120524

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMXG00000020226.1	ENSAMXT00000020823.1	ENSAMXP00000020823.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	1.60e-46	158.4	79	269

Active Site

Position(s)	Description	Evidence
86	N/A	{ECO:0000256\|PIRSR:PIRSR013503-1}
89	Nucleophile	{ECO:0000256\|PIRSR:PIRSR013503-1}
263		{ECO:0000256\|PIRSR:PIRSR013503-1}

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqs..........................................................llgvfdddslsd 32
            i+kt++DGnC++rA+++s                                                          ll++f+++s+sd
   Q: 79   FIRKTRPDGNCFYRAFGFSylesllddskelhrfkavaakskmdlvsqgfteftiedfhntfmdlievcdkqpsvgeLLNSFNEQSVSD 167
           699************************************************************************************** PP
   S: 33   alveaLreltseylqkesdffsefieekedekefcqklvepeak.geeihifaLaqiLsrpiivvdvdsleskvggillpllfpeeklk 120
           +lv++Lr+ ts +lq+e+dff++fie+++++ efcq++vep++k +++ihi+aLaq+L++ i v+++d++e   gg++++++fpe+  +
   Q: 168  YLVVYLRLVTSGFLQREEDFFQHFIEGGRTVREFCQQEVEPMSKeSDHIHIIALAQALNVCILVEYMDRGE---GGTVNHHIFPEDG-D 252
           **********************************************************************9...9************.* PP
   S: 121  kpivLlYrsgHYdaLva 137
           +++ LlYr+gHYd+L++
   Q: 253  PKVFLLYRPGHYDILYK 269
           ***************96 PP

Organism

Astyanax mexicanus

Protein Sequence
(Fasta)

MAEEEQQQEG MAQKEADGLN CLAYDEAIIA QQDRIQQEIA TSISLVSDQQ DLAILKKEYA 60
EDDTIYQQKI RDLQKKYTFI RKTRPDGNCF YRAFGFSYLE SLLDDSKELH RFKAVAAKSK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTTATACAC ATAATCCCAG TTATGTAGGA GTATTTTCAA TTGGAACTAT ACATTTTGGT 60
AGTTGAGGGG TTAAAGCTGA ACTCAATTTA GTATATTTGT AATAAAACGC TTCAGAAACT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR003323--OTU_dom
IPR030298--OTUB1
IPR016615--Otubain
IPR019400--Peptidase_C65_otubain

PROSITE

PS50802--OTU

Pfam

PF10275--Peptidase_C65

Gene Ontology

GO:0005634--C:nucleus
GO:0019784--F:NEDD8-specific protease activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0071108--P:protein K48-linked deubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ath-007112	Arabidopsis thaliana	43.51	9.00e-53	200.00
IUUC-Cre-022997	Chlamydomonas reinhardtii	40.00	1.00e-45	176.00
IUUC-Cin-025507	Ciona intestinalis	47.78	7.00e-48	183.00
IUUC-Csv-026273	Ciona savignyi	49.80	2.00e-68	252.00
IUUC-Dre-027843	Danio rerio	88.48	2.00e-143	501.00
IUUC-Eeu-034775	Erinaceus europaeus	47.37	2.00e-60	224.00
IUUC-Gma-043712	Glycine max	41.94	6.00e-52	197.00
IUUC-Opr-070761	Ochotona princeps	40.12	3.00e-30	124.00
IUUC-Oan-072922	Ornithorhynchus anatinus	47.58	3.00e-61	228.00
IUUC-Ocu-074643	Oryctolagus cuniculus	47.37	4.00e-61	227.00
IUUC-Oni-082026	Oryza nivara	31.02	1.00e-15	77.80
IUUC-Oru-084761	Oryza rufipogon	31.02	1.00e-15	77.80
IUUC-Pan-091969	Papio anubis	46.93	3.00e-61	228.00
IUUC-Pca-100252	Procavia capensis	44.44	8.00e-21	93.60
IUUC-Sar-113295	Sorex araneus	47.81	4.00e-60	224.00
IUUC-Tca-121467	Theobroma cacao	41.18	4.00e-50	191.00
IUUC-Uma-129443	Ustilago maydis	31.96	1.00e-25	110.00
IUUC-Vvi-131389	Vitis vinifera	43.01	7.00e-52	197.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence