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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Dme-032045
UUCD1 version UUC-DrM-00582
Ensembl Protein ID FBpp0087583
UniProt Accession Q8T0L3; Q9V5A7; Q8T0L3_DROME
Genbank Protein ID AAF58910.2; AAL39336.1
Protein Name GH24511p; Ubiquitin activating enzyme 1, isoform A
Genbank Nucleotide ID AE013599; AY069191
Gene Name Uba1; CG1782; Dmel_CG1782
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
FBgn0023143 FBtr0088499 FBpp0087583
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNARAID2
Protein-protein Interaction
IIDPINAMentha
Post-translational Modifications (PTMs)
CPLMdbPAFPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E1 4.40e-199 661.9 587 1069
Active Site
Position(s) Description Evidence
767 Glycyl thioester intermediate {ECO:0000256|PROSITE-ProRule:PRU10132}
Domain Profile

   E1
   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv....gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvnvea 92
           YD Qi+++G + qekl  +k+++vGag++GcEllKn+ ++G+    g+i v+Dmd +e+snlnrqFLfr++dv+k+K+ +aa+a+k++np vnv+a
   Q: 587  YDSQIAIFGKKFQEKLADSKWFIVGAGAIGCELLKNFGMLGLgtgnGQIFVTDMDLIEKSNLNRQFLFRPHDVQKPKSMTAADAIKRMNPEVNVTA 682
           9*********************************************************************************************** PP
   S: 93   heesiteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsddppqktiPfctlketpnaaeh 185
           +e ++ +++e+++   Ff k+d+V++aldn++ar +++r c+ +r+pl+e+gtlG+lG+v+vi++  te+ys+s+dpp+k+iP+ctlk++pna+eh
   Q: 683  YELRVGAETEKVFsedFFGKLDGVANALDNVDARIYMDRKCIFNRIPLVETGTLGTLGNVQVIVPFATESYSSSQDPPEKSIPICTLKNFPNAIEH 778
           ***********99*********************************************************************************** PP
   S: 186  tiewa............vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakttinsikqllksfecdivtksk 269
           t++wa            + +++++  +++++e+ +kl   +++e++d +k++l + ++++f+ ++e+a+  ++ ++ n+ikqll +f++d++t+s+
   Q: 779  TLQWArdafegvfkqsaENAAQYI-ADPQFTERIAKLPGIQPLEILDSIKKALIDDKPKSFAHCVEWARLYWEDQYVNQIKQLLFNFPPDQITSSG 873
           ***********9999999999999.7899999999************************************************************* PP
   S: 270  spfwv..............................................................sfcsnaealqvpekvekdeevvkasaply 303
           +pfw+                                                              + ++n++a+    ++ +d e +++    +
   Q: 874  QPFWSgpkrcpdplvfdvndpmhldfiyaaanlraevygieqvrnretiaelvqkvkvpefkprsgvKIETNEAAAAASANNFDDGELDQDRV-DK 968
           ********************************************9998888887777777777777655555555554444444444333333.68 PP
   S: 304  lllralerfekkkgrkpgelsfekddds..avdlvtaaanlraeslgiepkldddlikeiagniipaiattnavvgGlaaqEviKvvsg..kfepl 395
           +  + l++++k ++ +p  l+fekddds  ++d++ a++nlra +++i+p +d+++ k iag+iipaiatt++v++Gla++EviK++ g  + +++
   Q: 969  IISELLKNADKSSKITP--LEFEKDDDSnlHMDFIVACSNLRAANYKIPP-ADRHKSKLIAGKIIPAIATTTSVLSGLAVLEVIKLIVGhrDLVKF 1061
           88888999999999988..99999999999********************.************************************99888999* PP
   S: 396  knfflfda 403
           kn f ++a
   Q: 1062 KNGFANLA 1069
           **999877 PP
   
Organism Drosophila melanogaster
Protein Sequence
(Fasta)
MSSGQQLMAD SPACSSSDHS PLAKKRRLEL LGDGVGAMGM EEEEAGGATS SSSSNNYENH 60
DKAGGVDISG KCQSKTTSEH QLELCVSSST SDTCGVNAAA KRAEKQKLKQ SQGSGDDVST 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Dme-032045|E1,E1_ThiF|Drosophila melanogaster
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATTTCAAGAG CCGCGGCCAC ACTACTGCGA ATTCTATACT GCAACTCGAT CGTGCGTGTT 60
CTGTATTTTT GGGAGTGCGT TGTTAGAAAT TCGGCCACAA ATAGAATCCG CTGTCCTGGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Dme-032045|E1,E1_ThiF|Drosophila melanogaster
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR018074--UBQ-activ_enz_E1_CS
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like
PROSITE

PS00536--UBIQUITIN_ACTIVAT_1
PS00865--UBIQUITIN_ACTIVAT_2
Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys
PRINTS

PR01849--UBIQUITINACT
SMART

SM00985--UBA_e1_C
Gene Ontology

GO:0030425--C:dendrite
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0004839--F:ubiquitin activating enzyme activity
GO:0006914--P:autophagy
GO:0008283--P:cell proliferation
GO:0008340--P:determination of adult lifespan
GO:0035096--P:larval midgut cell programmed cell death
GO:0019915--P:lipid storage
GO:0031987--P:locomotion involved in locomotory behavior
GO:0016319--P:mushroom body development
GO:0016322--P:neuron remodeling
GO:0030707--P:ovarian follicle cell development
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0010906--P:regulation of glucose metabolic process
GO:0040008--P:regulation of growth
GO:0043067--P:regulation of programmed cell death
GO:0046578--P:regulation of Ras protein signal transduction
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000456 Aegilops tauschii 44.98 0.00e+00 834.00
IUUC-Aml-001311 Ailuropoda melanoleuca 59.75 0.00e+00 1237.00
IUUC-Atr-002684 Amborella trichopoda 44.70 0.00e+00 830.00
IUUC-Apl-004158 Anas platyrhynchos 43.47 0.00e+00 717.00
IUUC-Aca-004620 Anolis carolinensis 58.75 0.00e+00 1221.00
IUUC-Aly-005418 Arabidopsis lyrata 44.50 0.00e+00 852.00
IUUC-Ath-006992 Arabidopsis thaliana 44.40 0.00e+00 831.00
IUUC-Ago-007873 Ashbya gossypii 48.77 0.00e+00 950.00
IUUC-Acl-008181 Aspergillus clavatus 51.42 0.00e+00 997.00
IUUC-Afl-008455 Aspergillus flavus 53.04 0.00e+00 980.00
IUUC-Afu-009065 Aspergillus fumigatus 51.91 0.00e+00 1004.00
IUUC-Ani-009371 Aspergillus nidulans 51.38 0.00e+00 977.00
IUUC-Ang-009737 Aspergillus niger 52.39 0.00e+00 1014.00
IUUC-Aor-010007 Aspergillus oryzae 53.04 0.00e+00 981.00
IUUC-Ate-010466 Aspergillus terreus 52.12 0.00e+00 1010.00
IUUC-Ame-010933 Astyanax mexicanus 59.17 0.00e+00 1203.00
IUUC-Bgr-012281 Blumeria graminis 50.39 0.00e+00 971.00
IUUC-Bta-012767 Bos taurus 59.88 0.00e+00 1249.00
IUUC-Bci-013721 Botrytis cinerea 52.05 0.00e+00 954.00
IUUC-Bdi-014335 Brachypodium distachyon 44.80 0.00e+00 841.00
IUUC-Bol-015161 Brassica oleracea 43.82 0.00e+00 846.00
IUUC-Bra-017252 Brassica rapa 44.00 0.00e+00 845.00
IUUC-Cel-018260 Caenorhabditis elegans 46.32 0.00e+00 868.00
IUUC-Cja-019152 Callithrix jacchus 59.96 0.00e+00 1251.00
IUUC-Cfa-020622 Canis familiaris 59.40 0.00e+00 1215.00
IUUC-Cpo-022526 Cavia porcellus 59.67 0.00e+00 1229.00
IUUC-Cre-022702 Chlamydomonas reinhardtii 44.06 0.00e+00 794.00
IUUC-Csa-023780 Chlorocebus sabaeus 60.16 0.00e+00 1254.00
IUUC-Cho-024682 Choloepus hoffmanni 37.26 5.00e-100 358.00
IUUC-Cin-025790 Ciona intestinalis 57.73 0.00e+00 1215.00
IUUC-Csv-026084 Ciona savignyi 57.71 0.00e+00 1199.00
IUUC-Cgl-026512 Colletotrichum gloeosporioides 51.28 0.00e+00 1003.00
IUUC-Cne-026960 Cryptococcus neoformans 53.34 0.00e+00 1029.00
IUUC-Cme-027290 Cyanidioschyzon merolae 43.37 0.00e+00 790.00
IUUC-Dre-028149 Danio rerio 60.62 0.00e+00 1244.00
IUUC-Dno-028884 Dasypus novemcinctus 59.86 0.00e+00 1249.00
IUUC-Dor-030229 Dipodomys ordii 57.64 0.00e+00 1189.00
IUUC-Dse-031524 Dothistroma septosporum 50.73 0.00e+00 981.00
IUUC-Ete-033124 Echinops telfairi 43.67 3.00e-149 521.00
IUUC-Eca-033330 Equus caballus 60.08 0.00e+00 1250.00
IUUC-Eeu-034717 Erinaceus europaeus 39.29 2.00e-140 492.00
IUUC-Fca-036255 Felis catus 60.08 0.00e+00 1243.00
IUUC-Fal-037445 Ficedula albicollis 41.32 0.00e+00 743.00
IUUC-Fox-038007 Fusarium oxysporum 50.35 1.00e-147 515.00
IUUC-Fso-038339 Fusarium solani 51.08 0.00e+00 952.00
IUUC-Gmo-039338 Gadus morhua 58.00 0.00e+00 1200.00
IUUC-Ggr-039823 Gaeumannomyces graminis 51.08 0.00e+00 1006.00
IUUC-Gga-040747 Gallus gallus 42.62 0.00e+00 709.00
IUUC-Gac-041773 Gasterosteus aculeatus 58.41 0.00e+00 1206.00
IUUC-Gma-043165 Glycine max 43.81 0.00e+00 834.00
IUUC-Ggo-045336 Gorilla gorilla 60.06 0.00e+00 1233.00
IUUC-Hsa-045982 Homo sapiens 59.86 0.00e+00 1228.00
IUUC-Hvu-047418 Hordeum vulgare 45.11 0.00e+00 818.00
IUUC-Itr-048460 Ictidomys tridecemlineatus 60.35 0.00e+00 1256.00
IUUC-Kpa-049112 Komagataella pastoris 48.91 0.00e+00 937.00
IUUC-Lch-050371 Latimeria chalumnae 59.73 0.00e+00 1229.00
IUUC-Lpe-051299 Leersia perrieri 44.11 0.00e+00 831.00
IUUC-Loc-052936 Lepisosteus oculatus 60.83 0.00e+00 1244.00
IUUC-Lma-053315 Leptosphaeria maculans 50.89 0.00e+00 995.00
IUUC-Laf-053948 Loxodonta africana 58.83 0.00e+00 1204.00
IUUC-Mcc-055843 Macaca mulatta 60.06 0.00e+00 1251.00
IUUC-Meu-056258 Macropus eugenii 59.09 0.00e+00 1222.00
IUUC-Mor-057269 Magnaporthe oryzae 51.71 0.00e+00 993.00
IUUC-Mpo-057435 Magnaporthe poae 51.03 0.00e+00 972.00
IUUC-Mtr-058572 Medicago truncatula 44.18 0.00e+00 808.00
IUUC-Mla-059176 Melampsora laricipopulina 52.56 0.00e+00 1018.00
IUUC-Mga-059721 Meleagris gallopavo 43.34 0.00e+00 694.00
IUUC-Mvi-060437 Microbotryum violaceum 51.52 0.00e+00 992.00
IUUC-Mmr-061405 Microcebus murinus 59.18 0.00e+00 1206.00
IUUC-Mdo-062032 Monodelphis domestica 58.00 0.00e+00 1205.00
IUUC-Mmu-063280 Mus musculus 59.96 0.00e+00 1235.00
IUUC-Mac-065505 Musa acuminata 43.82 0.00e+00 813.00
IUUC-Mpu-066409 Mustela putorius furo 60.37 0.00e+00 1256.00
IUUC-Mlu-067217 Myotis lucifugus 59.40 0.00e+00 1226.00
IUUC-Nfi-068407 Neosartorya fischeri 52.01 0.00e+00 1005.00
IUUC-Ncr-068698 Neurospora crassa 51.06 0.00e+00 989.00
IUUC-Nle-070072 Nomascus leucogenys 57.52 0.00e+00 1154.00
IUUC-Opr-070715 Ochotona princeps 39.53 0.00e+00 645.00
IUUC-Ont-071671 Oreochromis niloticus 59.61 0.00e+00 1237.00
IUUC-Oan-073268 Ornithorhynchus anatinus 41.86 0.00e+00 646.00
IUUC-Ocu-074544 Oryctolagus cuniculus 60.64 0.00e+00 1257.00
IUUC-Oba-075120 Oryza barthii 44.34 0.00e+00 814.00
IUUC-Obr-076557 Oryza brachyantha 45.05 0.00e+00 801.00
IUUC-Ogl-077887 Oryza glaberrima 44.34 0.00e+00 815.00
IUUC-Ogu-078305 Oryza glumaepatula 43.61 0.00e+00 815.00
IUUC-Oin-080154 Oryza indica 43.61 0.00e+00 816.00
IUUC-Olo-081089 Oryza longistaminata 43.61 0.00e+00 816.00
IUUC-Ome-081942 Oryza meridionalis 44.34 0.00e+00 819.00
IUUC-Oni-082365 Oryza nivara 44.34 0.00e+00 816.00
IUUC-Opu-083977 Oryza punctata 44.95 0.00e+00 822.00
IUUC-Oru-084469 Oryza rufipogon 43.61 0.00e+00 817.00
IUUC-Osa-085949 Oryza sativa 44.44 0.00e+00 822.00
IUUC-Ola-087002 Oryzias latipes 60.16 0.00e+00 1247.00
IUUC-Olu-087687 Ostreococcus lucimarinus 42.90 0.00e+00 749.00
IUUC-Oga-088594 Otolemur garnettii 60.00 0.00e+00 1228.00
IUUC-Oar-090068 Ovis aries 59.73 0.00e+00 1240.00
IUUC-Ptr-090609 Pan troglodytes 42.11 0.00e+00 706.00
IUUC-Pan-092114 Papio anubis 60.06 0.00e+00 1250.00
IUUC-Psi-093489 Pelodiscus sinensis 40.99 0.00e+00 696.00
IUUC-Pma-094214 Petromyzon marinus 54.07 7.00e-41 158.00
IUUC-Pno-095154 Phaeosphaeria nodorum 51.12 0.00e+00 997.00
IUUC-Ppa-095227 Physcomitrella patens 46.34 0.00e+00 855.00
IUUC-Pfo-097184 Poecilia formosa 59.03 0.00e+00 1230.00
IUUC-Pab-097861 Pongo abelii 59.67 0.00e+00 1222.00
IUUC-Pop-098934 Populus trichocarpa 43.76 0.00e+00 835.00
IUUC-Pca-100347 Procavia capensis 56.53 0.00e+00 1022.00
IUUC-Ppe-102012 Prunus persica 43.14 0.00e+00 825.00
IUUC-Pva-102584 Pteropus vampyrus 59.98 0.00e+00 1264.00
IUUC-Pgr-103336 Puccinia graminis 50.96 0.00e+00 974.00
IUUC-Ptt-103939 Puccinia triticina 51.42 0.00e+00 961.00
IUUC-Pte-104200 Pyrenophora teres 51.37 0.00e+00 1015.00
IUUC-Pyt-104441 Pyrenophora triticirepentis 50.53 0.00e+00 1008.00
IUUC-Rno-105462 Rattus norvegicus 59.86 0.00e+00 1235.00
IUUC-Sce-106245 Saccharomyces cerevisiae 49.61 0.00e+00 970.00
IUUC-Sha-107142 Sarcophilus harrisii 59.67 0.00e+00 1243.00
IUUC-Sja-107841 Schizosaccharomyces japonicus 52.44 0.00e+00 1038.00
IUUC-Spo-108034 Schizosaccharomyces pombe 51.49 0.00e+00 986.00
IUUC-Ssl-108497 Sclerotinia sclerotiorum 51.12 0.00e+00 953.00
IUUC-Smo-108912 Selaginella moellendorffii 45.30 0.00e+00 842.00
IUUC-Sit-110281 Setaria italica 45.10 0.00e+00 847.00
IUUC-Sly-110914 Solanum lycopersicum 44.16 0.00e+00 842.00
IUUC-Stu-112109 Solanum tuberosum 44.26 0.00e+00 845.00
IUUC-Sar-113737 Sorex araneus 59.49 0.00e+00 1231.00
IUUC-Sbi-114520 Sorghum bicolor 44.54 0.00e+00 836.00
IUUC-Sre-115148 Sporisorium reilianum 52.78 0.00e+00 976.00
IUUC-Ssc-115777 Sus scrofa 60.06 0.00e+00 1243.00
IUUC-Tgu-116565 Taeniopygia guttata 42.50 0.00e+00 715.00
IUUC-Tru-118742 Takifugu rubripes 59.38 0.00e+00 1196.00
IUUC-Tsy-119436 Tarsius syrichta 38.45 2.00e-171 595.00
IUUC-Tni-120401 Tetraodon nigroviridis 59.79 0.00e+00 1205.00
IUUC-Tca-121672 Theobroma cacao 44.43 0.00e+00 833.00
IUUC-Tre-122009 Trichoderma reesei 51.91 0.00e+00 965.00
IUUC-Tvi-122259 Trichoderma virens 51.76 0.00e+00 980.00
IUUC-Tae-125676 Triticum aestivum 44.60 0.00e+00 840.00
IUUC-Tur-126330 Triticum urartu 44.88 0.00e+00 834.00
IUUC-Tme-127055 Tuber melanosporum 49.42 0.00e+00 901.00
IUUC-Tbe-127487 Tupaia belangeri 58.37 2.00e-162 565.00
IUUC-Ttr-128331 Tursiops truncatus 59.86 0.00e+00 1236.00
IUUC-Uma-129387 Ustilago maydis 52.10 0.00e+00 968.00
IUUC-Vda-129977 Verticillium dahliae 51.02 0.00e+00 931.00
IUUC-Vpa-130716 Vicugna pacos 40.67 0.00e+00 677.00
IUUC-Vvi-130857 Vitis vinifera 43.96 0.00e+00 832.00
IUUC-Xtr-132026 Xenopus tropicalis 48.94 0.00e+00 870.00
IUUC-Xma-133805 Xiphophorus maculatus 58.83 0.00e+00 1209.00
IUUC-Yli-134547 Yarrowia lipolytica 50.45 0.00e+00 1001.00
IUUC-Zma-135052 Zea mays 44.52 0.00e+00 835.00
Created Date 25-Jun-2017

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