iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
iRefIndex	Mentha
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	4.40e-08	34.3	71	135
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	1.90e-06	27.2	175	205

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 1    aDvilvvg.geeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgkl 65
           aDv+++ + g+ + ah  +L ++S v + ++++  + +k   ++ i++v ++++r++++FlY++  
   Q: 71   ADVVIYTDnGSIIYAHANILGTASTVIKGMLKQAKRHGK-WHTISIRGVPHDAVRVFIRFLYSSCY 135
           79************************************9.**********************9876 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 2    eNclgilrfAdlydcpdLkdaaldfilkhFk 32
           eN+++++++A l+d p+L +  +++i khF+
   Q: 175  ENVVDVFQLALLCDFPRLSLISHRMIMKHFN 205
           9*****************************6 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Protein Sequence
(Fasta)

MQGREDKLNK RMVTGCVDLH QSFKSADSSS VPIPPPLPSK SDGLKKKLGH SSVSTATRDM 60
WDRLFNDGYK ADVVIYTDNG SIIYAHANIL GTASTVIKGM LKQAKRHGKW HTISIRGVPH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCTGTGGTCT GAATCTTTTC AAGGTATATA TGTCGGAACA AATTAGAGCA TTGATTGATT 60
CTTGTTCTTA CATTTTCTAT CGATCTGTTT CAAGAATTCT TGTTATTTCT GATTGATATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ
IPR034089--SPOP_C
IPR000197--Znf_TAZ

PROSITE

PS50097--BTB

Pfam

PF00651--BTB
PF02135--zf-TAZ

SMART

SM00225--BTB
SM00551--ZnF_TAZ

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0005774--C:vacuolar membrane
GO:0005516--F:calmodulin binding
GO:0004402--F:histone acetyltransferase activity
GO:0003712--F:transcription cofactor activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0008270--F:zinc ion binding
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030162--P:regulation of proteolysis
GO:0006355--P:regulation of transcription, DNA-templated
GO:0009733--P:response to auxin
GO:0009739--P:response to gibberellin
GO:0042542--P:response to hydrogen peroxide
GO:0009753--P:response to jasmonic acid
GO:0009751--P:response to salicylic acid
GO:0009651--P:response to salt stress
GO:0009611--P:response to wounding

KEGG

ath:AT5G67480

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000841	Aegilops tauschii	48.88	9.00e-89	321.00
IUUC-Atr-002763	Amborella trichopoda	57.46	7.00e-112	396.00
IUUC-Aly-005497	Arabidopsis lyrata	95.16	0.00e+00	706.00
IUUC-Bol-015364	Brassica oleracea	86.47	1.00e-177	615.00
IUUC-Bra-017513	Brassica rapa	86.17	5.00e-177	612.00
IUUC-Gma-042947	Glycine max	65.15	2.00e-124	438.00
IUUC-Hvu-047808	Hordeum vulgare	51.30	1.00e-92	332.00
IUUC-Mtr-058697	Medicago truncatula	69.60	4.00e-140	490.00
IUUC-Mla-059158	Melampsora laricipopulina	27.78	3.80e+00	25.80
IUUC-Mac-064670	Musa acuminata	61.88	9.00e-121	426.00
IUUC-Ppa-095315	Physcomitrella patens	50.15	6.00e-94	337.00
IUUC-Smo-109030	Selaginella moellendorffii	50.48	4.00e-91	327.00
IUUC-Stu-112261	Solanum tuberosum	58.49	6.00e-120	423.00
IUUC-Tca-121307	Theobroma cacao	72.46	2.00e-150	524.00
IUUC-Tae-122738	Triticum aestivum	50.14	7.00e-94	336.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence