iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oan-073187

UUCD1 version

UUC-OrA-00698

Ensembl Protein ID

ENSOANP00000007759.1

UniProt Accession

F7FU40; F7FU40_ORNAN

Protein Name

Uncharacterized protein

Gene Name

DDB1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOANG00000004897.2	ENSOANT00000007761.1	ENSOANP00000007759.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DDB1	0	1629.4	1	1032

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DDB1

   S: 110  lDdigrssdsGlinviepkirlialelyqglfklIvldndikelkafnirleelnvsdvkflilltqptgrvlviyqdddgkhlkty 196
           +D+igr+s++G+i++i+p++r+i+l+ly+glfk+I+ld+d+kelkafnirleel+v+dvkfl+++++pt  ++++yqd++g+h+kty
   Q: 1    QDRIGRPSETGIIGIIDPECRMIGLRLYDGLFKVIPLDRDNKELKAFNIRLEELQVIDVKFLYGCQAPT--ICFVYQDPQGRHVKTY 85
           6********************************************************************..**************** PP
   S: 197  elslkdKeFvkis.kqesiekeaellipvpsqlvgvlvlgeesivyksadnykdvdPylirqstairyervdnngirylLgdfdGel 282
           e+sl++KeF+k++ kqe++e+ea+++i+vp++++g++++g+esi+y+++d+y +++P++i+qst+++++rvd ng+rylLgd++G+l
   Q: 86   EVSLREKEFNKGPwKQENVEAEASMVIAVPEPFGGAIIIGQESITYHNGDKYLAIAPPIIKQSTIVCHNRVDPNGSRYLLGDMEGRL 172
           *************************************************************************************** PP
   S: 283  kllllsaeeemsG.vevkslkielLgeisiaesisyldngllfvgsrfgdsQlvklisestgkgsyvvilerfknlkpIvdlvvvdl 368
           ++lll++ee+m+G v++k+l++elLge+siae+++yldng++fvgsr+gdsQlvkl+++s+++gsyvv++e+f+nl+pIvd++vvdl
   Q: 173  FMLLLEKEEQMDGaVTLKDLRVELLGETSIAECLTYLDNGVVFVGSRLGDSQLVKLNVDSNEQGSYVVAMETFTNLGPIVDMCVVDL 259
           *************************************************************************************** PP
   S: 369  drrgqgqvvtvsgaskdGslRvirlgigieelasvdlkgvigllslkstidestdnslvlafvsetkvlnlntgeeledtelsgvls 455
           +r+gqgq+vt+sga+k+GslR+ir+gigi+e+as+dl+g++gl++l+s+++++td++lvl+fv++t+vl+ln gee+e+tel+g+++
   Q: 260  ERQGQGQLVTCSGAFKEGSLRIIRNGIGIHEHASIDLPGIKGLWPLRSNSNRETDDTLVLSFVGQTRVLMLN-GEEVEETELTGFVD 345
           ************************************************************************.************** PP
   S: 456  dlqtlltqdvidykqllqvTsqsvrLvssqikrllkeWkaknleiigvassNteqvliaatsndlvyleigdgeldltstttlenev 542
           ++qt+++ +v +++ql+q+Ts+svrLv ++ k+l++eWk++++++i+vas+N++qv++a+ +++l+yl+i++ el+++s+t++e+ev
   Q: 346  NQQTFFCGNV-AHQQLIQITSASVRLVTQEPKALVSEWKEPQGKNISVASCNSSQVVVAV-GRALYYLQIHPRELRQISHTEMEHEV 430
           **********.************************************************9.************************** PP
   S: 543  avldlinieddpnlsdleavglltdiskrililpdletiykeklggeiipRsilltefEnvtYlLialgdGalvsyildidtgdesd 629
           a+ld+++++d++ +s l+a+gl+tdis+ril+lp++e+++ke+lggeiipRsil+t+fE+ +YlL+algdGal+++ l i+tg +sd
   Q: 431  ACLDITPLGDSHGMSPLCAIGLWTDISARILKLPSFELLHKEMLGGEIIPRSILMTTFESSHYLLCALGDGALFYFGLSIETGLLSD 517
           *************************************************************************************** PP
   S: 630  akksnlgtspgtlktfkslsttqvfassDrPtvIyssskkLvfSnVnlkeVqylCsldseaypdslalanngslvigtvddiqklki 716
           +kk++lgt+p++l+tf+slstt+vfa+sDrPtvIyss++kLvfSnVnlkeV+y+C+l+s++ypdslalann++l+igt+d+iqkl+i
   Q: 518  RKKVTLGTQPTVLRTFRSLSTTNVFACSDRPTVIYSSNHKLVFSNVNLKEVNYMCPLNSDGYPDSLALANNSTLTIGTIDEIQKLHI 604
           *************************************************************************************** PP
   S: 717  Rsiplgeslrriayqesvitfgvisdrreldf.klklkalrnnasilalvpdiennklfsdglrilelseleenevnfllvlDkntf 802
           R++pl+es+r+i+yqe +++fgv+s+r+e+++ +++++alr++ s++al+++++++klfs++++ +e+s++ee+ev++ll++D++tf
   Q: 605  RTVPLYESPRKICYQEGSQCFGVLSSRIEVQDaSGGTTALRPSGSTQALSSSVSSSKLFSSSTAPHETSFGEEVEVHNLLIIDQHTF 691
           ********************************9****************************************************** PP
   S: 803  elllaqdlrewEtavsllSqklkdDseeyyvvktalvlpeenelkkgrilvfsvedslklkLltvaekkvkgavidlvklNgkllaa 889
           e+l+a+++ ++E+a+sl+S+kl++D ++y++v+ta+v+pee+e+k+gri+vf+++d+   kL+tvaek+vkgav+++v++Ngklla+
   Q: 692  EVLHAHQFLQNEYALSLVSCKLGKDANTYFIVGTAMVYPEEAEPKQGRIVVFQYSDG---KLQTVAEKEVKGAVYSMVEFNGKLLAS 775
           *********************************************************...*************************** PP
   S: 890  inseirlyewkvmgtdekelrkeCernntilaLtlktrkdfivVgDlmrsvtLllykdlegsfeEsardynlewmsaveilnddifl 976
           ins++rlyew    t ekelr+eC+++n+i+aL+lkt++dfi+VgDlmrsv Ll+yk +eg+feE+ard+n++wmsaveil+dd+fl
   Q: 776  INSTVRLYEW----TAEKELRTECNHYNNIMALYLKTKGDFILVGDLMRSVLLLAYKPMEGNFEEIARDFNPNWMSAVEILDDDNFL 858
           **********....************************************************************************* PP
   S: 977  gaencgNlfvvkkdikagltdeerslleevgefrlgefvevfrfgtlvlqdvgerevnrssevifgtengeigvilrlrrellkflr 1063
           gaen++Nlfv++kd +a++tdeer++l+evg f+lgefv+vf++g+lv+q++ge++++++++v+fgt+ng+ig++++l+++++++l 
   Q: 859  GAENAFNLFVCQKD-SAATTDEERQHLQEVGLFHLGEFVNVFCHGSLVMQNLGETSTPTQGSVLFGTVNGMIGLVTSLSESWYNLLL 944
           **************.************************************************************************ PP
   S: 1064 nlestlkkvikrvakieHssyRsFetekrterasgfvdgdLiesilDlsrdkavdilkvl.yekrwnskkevsveeivKlveelkrl 1149
           +++++l+kvik+v+kieHs++RsF+te++te+a+gf+dgdLies+lD+sr+k+++++++l  ++++++k+e++v++++K+veel+r+
   Q: 945  DMQNRLNKVIKSVGKIEHSFWRSFHTERKTEPATGFIDGDLIESFLDISRPKMQEVVANLqIDDGSGMKREATVDDLIKIVEELTRI 1031
           ************************************************************6699**********************9 PP
   S: 1150 h 1150
           h
   Q: 1032 H 1032
           8 PP

Organism

Ornithorhynchus anatinus

Protein Sequence
(Fasta)

QDRIGRPSET GIIGIIDPEC RMIGLRLYDG LFKVIPLDRD NKELKAFNIR LEELQVIDVK 60
FLYGCQAPTI CFVYQDPQGR HVKTYEVSLR EKEFNKGPWK QENVEAEASM VIAVPEPFGG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGGACCGGA TCGGCCGTCC CTCCGAGACG GGCATCATCG GCATCATCGA CCCCGAGTGC 60
CGAATGATCG GGCTGCGCCT CTACGACGGC CTCTTCAAGG TCATCCCCCT CGACCGAGAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR004871--Cleavage/polyA-sp_fac_asu_C
IPR031297--DDB1
IPR011047--Quinoprotein_ADH-like_supfam
IPR015943--WD40/YVTN_repeat-like_dom

Pfam

PF03178--CPSF_A

Gene Ontology

GO:0031464--C:Cul4A-RING E3 ubiquitin ligase complex
GO:0031465--C:Cul4B-RING E3 ubiquitin ligase complex
GO:0031461--C:cullin-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005615--C:extracellular space
GO:0000784--C:nuclear chromosome, telomeric region
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0003684--F:damaged DNA binding
GO:0035518--P:histone H2A monoubiquitination
GO:0051702--P:interaction with symbiont
GO:0043066--P:negative regulation of apoptotic process
GO:0006289--P:nucleotide-excision repair
GO:0046726--P:positive regulation by virus of viral protein levels in host cell
GO:0045070--P:positive regulation of viral genome replication
GO:1902188--P:positive regulation of viral release from host cell
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:1901990--P:regulation of mitotic cell cycle phase transition
GO:0070914--P:UV-damage excision repair
GO:0016055--P:Wnt signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000120	Aegilops tauschii	51.95	0.00e+00	1046.00
IUUC-Aml-002096	Ailuropoda melanoleuca	98.16	0.00e+00	2053.00
IUUC-Atr-002742	Amborella trichopoda	52.45	0.00e+00	1072.00
IUUC-Apl-003624	Anas platyrhynchos	97.20	0.00e+00	2029.00
IUUC-Aca-005085	Anolis carolinensis	97.09	0.00e+00	2029.00
IUUC-Aly-005857	Arabidopsis lyrata	52.89	0.00e+00	1073.00
IUUC-Ath-006658	Arabidopsis thaliana	52.79	0.00e+00	1071.00
IUUC-Acl-008149	Aspergillus clavatus	27.02	1.00e-93	337.00
IUUC-Afl-008549	Aspergillus flavus	27.85	2.00e-100	360.00
IUUC-Afu-009076	Aspergillus fumigatus	27.21	2.00e-105	376.00
IUUC-Ani-009302	Aspergillus nidulans	26.99	7.00e-79	288.00
IUUC-Ang-009636	Aspergillus niger	27.97	7.00e-84	305.00
IUUC-Aor-010073	Aspergillus oryzae	27.85	1.00e-100	360.00
IUUC-Ate-010422	Aspergillus terreus	26.87	2.00e-92	333.00
IUUC-Ame-011643	Astyanax mexicanus	80.10	0.00e+00	1632.00
IUUC-Bgr-012164	Blumeria graminis	29.09	9.00e-65	241.00
IUUC-Bta-012494	Bos taurus	98.16	0.00e+00	2055.00
IUUC-Bci-013957	Botrytis cinerea	26.18	2.00e-80	294.00
IUUC-Bdi-014186	Brachypodium distachyon	52.99	0.00e+00	1072.00
IUUC-Bol-015922	Brassica oleracea	53.56	0.00e+00	1085.00
IUUC-Bra-017300	Brassica rapa	53.56	0.00e+00	1080.00
IUUC-Cel-018239	Caenorhabditis elegans	37.60	0.00e+00	709.00
IUUC-Cja-019165	Callithrix jacchus	98.06	0.00e+00	2052.00
IUUC-Cfa-020406	Canis familiaris	98.16	0.00e+00	2053.00
IUUC-Cpo-022154	Cavia porcellus	97.58	0.00e+00	2040.00
IUUC-Cre-022557	Chlamydomonas reinhardtii	40.60	0.00e+00	698.00
IUUC-Csa-024061	Chlorocebus sabaeus	98.06	0.00e+00	2052.00
IUUC-Cho-024554	Choloepus hoffmanni	91.67	0.00e+00	929.00
IUUC-Cin-025466	Ciona intestinalis	61.46	0.00e+00	1318.00
IUUC-Csv-026370	Ciona savignyi	60.48	0.00e+00	1264.00
IUUC-Cgl-026595	Colletotrichum gloeosporioides	26.51	7.00e-89	322.00
IUUC-Cme-027342	Cyanidioschyzon merolae	27.95	4.00e-114	405.00
IUUC-Dre-027448	Danio rerio	92.09	0.00e+00	1028.00
IUUC-Dno-029794	Dasypus novemcinctus	97.83	0.00e+00	1916.00
IUUC-Dor-030789	Dipodomys ordii	84.07	0.00e+00	972.00
IUUC-Dse-031491	Dothistroma septosporum	28.70	3.00e-107	382.00
IUUC-Dme-031940	Drosophila melanogaster	60.87	0.00e+00	1236.00
IUUC-Ete-032913	Echinops telfairi	79.46	0.00e+00	844.00
IUUC-Eca-033777	Equus caballus	97.38	0.00e+00	2029.00
IUUC-Eeu-034900	Erinaceus europaeus	95.96	0.00e+00	1108.00
IUUC-Fca-035869	Felis catus	98.16	0.00e+00	2053.00
IUUC-Fal-036777	Ficedula albicollis	97.20	0.00e+00	2031.00
IUUC-Fox-037954	Fusarium oxysporum	26.64	8.00e-93	334.00
IUUC-Fso-038292	Fusarium solani	25.77	3.00e-96	346.00
IUUC-Gmo-038815	Gadus morhua	82.33	0.00e+00	969.00
IUUC-Ggr-039907	Gaeumannomyces graminis	26.68	6.00e-91	328.00
IUUC-Gga-040995	Gallus gallus	97.38	0.00e+00	2034.00
IUUC-Gac-042390	Gasterosteus aculeatus	89.93	0.00e+00	1786.00
IUUC-Gma-042904	Glycine max	52.31	0.00e+00	1030.00
IUUC-Ggo-044891	Gorilla gorilla	97.68	0.00e+00	2044.00
IUUC-Hsa-046709	Homo sapiens	98.06	0.00e+00	2052.00
IUUC-Hvu-047504	Hordeum vulgare	52.79	0.00e+00	1053.00
IUUC-Itr-048678	Ictidomys tridecemlineatus	98.06	0.00e+00	2053.00
IUUC-Lch-050565	Latimeria chalumnae	93.71	0.00e+00	1968.00
IUUC-Lpe-051260	Leersia perrieri	53.28	0.00e+00	1071.00
IUUC-Loc-052091	Lepisosteus oculatus	82.81	0.00e+00	1486.00
IUUC-Lma-053246	Leptosphaeria maculans	25.74	2.00e-100	359.00
IUUC-Laf-053502	Loxodonta africana	97.87	0.00e+00	2049.00
IUUC-Mcc-054802	Macaca mulatta	98.14	0.00e+00	2036.00
IUUC-Meu-056808	Macropus eugenii	95.51	0.00e+00	1273.00
IUUC-Mor-057253	Magnaporthe oryzae	26.09	7.00e-73	268.00
IUUC-Mpo-057562	Magnaporthe poae	26.02	6.00e-87	315.00
IUUC-Mtr-057743	Medicago truncatula	51.73	0.00e+00	1049.00
IUUC-Mla-059154	Melampsora laricipopulina	25.41	6.00e-71	262.00
IUUC-Mga-059824	Meleagris gallopavo	96.81	0.00e+00	2022.00
IUUC-Mvi-060279	Microbotryum violaceum	27.48	1.00e-104	374.00
IUUC-Mmr-061215	Microcebus murinus	97.48	0.00e+00	2033.00
IUUC-Mdo-062028	Monodelphis domestica	96.70	0.00e+00	1877.00
IUUC-Mmu-064327	Mus musculus	97.97	0.00e+00	2051.00
IUUC-Mac-065445	Musa acuminata	52.88	0.00e+00	1047.00
IUUC-Mpu-065814	Mustela putorius furo	94.57	0.00e+00	1957.00
IUUC-Mlu-067136	Myotis lucifugus	98.06	0.00e+00	2046.00
IUUC-Nfi-068355	Neosartorya fischeri	27.21	6.00e-99	355.00
IUUC-Ncr-068620	Neurospora crassa	25.64	2.00e-79	290.00
IUUC-Nle-069566	Nomascus leucogenys	97.95	0.00e+00	2021.00
IUUC-Opr-070915	Ochotona princeps	89.43	0.00e+00	1836.00
IUUC-Ont-071753	Oreochromis niloticus	91.28	0.00e+00	1908.00
IUUC-Ocu-074619	Oryctolagus cuniculus	98.06	0.00e+00	2051.00
IUUC-Oba-075091	Oryza barthii	44.88	0.00e+00	838.00
IUUC-Obr-076425	Oryza brachyantha	53.61	0.00e+00	1072.00
IUUC-Ogu-078794	Oryza glumaepatula	53.47	0.00e+00	1076.00
IUUC-Oin-079725	Oryza indica	53.28	0.00e+00	1061.00
IUUC-Olo-080842	Oryza longistaminata	51.59	0.00e+00	1051.00
IUUC-Ome-081818	Oryza meridionalis	53.56	0.00e+00	1080.00
IUUC-Oni-082879	Oryza nivara	52.70	0.00e+00	1055.00
IUUC-Opu-083361	Oryza punctata	52.71	0.00e+00	1069.00
IUUC-Oru-084781	Oryza rufipogon	53.47	0.00e+00	1077.00
IUUC-Osa-086293	Oryza sativa	53.47	0.00e+00	1077.00
IUUC-Ola-086881	Oryzias latipes	90.06	0.00e+00	1881.00
IUUC-Olu-087674	Ostreococcus lucimarinus	45.46	0.00e+00	873.00
IUUC-Oga-089056	Otolemur garnettii	98.26	0.00e+00	2053.00
IUUC-Oar-089457	Ovis aries	98.33	0.00e+00	2020.00
IUUC-Ptr-091179	Pan troglodytes	98.06	0.00e+00	2051.00
IUUC-Pan-092019	Papio anubis	97.49	0.00e+00	2038.00
IUUC-Psi-093407	Pelodiscus sinensis	97.58	0.00e+00	2038.00
IUUC-Pma-094272	Petromyzon marinus	86.24	0.00e+00	1675.00
IUUC-Pno-094864	Phaeosphaeria nodorum	26.61	1.00e-104	374.00
IUUC-Ppa-095885	Physcomitrella patens	53.79	0.00e+00	1061.00
IUUC-Pfo-096083	Poecilia formosa	90.51	0.00e+00	1890.00
IUUC-Pab-098652	Pongo abelii	92.77	0.00e+00	1902.00
IUUC-Pop-099593	Populus trichocarpa	52.89	0.00e+00	1024.00
IUUC-Pca-100189	Procavia capensis	97.76	0.00e+00	1308.00
IUUC-Ppe-101987	Prunus persica	52.50	0.00e+00	1026.00
IUUC-Pva-102605	Pteropus vampyrus	97.97	0.00e+00	2049.00
IUUC-Pgr-103659	Puccinia graminis	24.45	9.00e-68	251.00
IUUC-Ptt-103884	Puccinia triticina	23.59	4.00e-56	213.00
IUUC-Pte-104233	Pyrenophora teres	26.92	2.00e-102	366.00
IUUC-Pyt-104454	Pyrenophora triticirepentis	27.29	9.00e-101	361.00
IUUC-Rno-106004	Rattus norvegicus	97.97	0.00e+00	2050.00
IUUC-Sha-106726	Sarcophilus harrisii	96.03	0.00e+00	1990.00
IUUC-Sja-107864	Schizosaccharomyces japonicus	24.43	5.00e-70	258.00
IUUC-Spo-108029	Schizosaccharomyces pombe	26.80	2.00e-92	333.00
IUUC-Ssl-108441	Sclerotinia sclerotiorum	25.49	1.00e-71	264.00
IUUC-Smo-108808	Selaginella moellendorffii	53.04	0.00e+00	1100.00
IUUC-Sit-109735	Setaria italica	53.51	0.00e+00	1067.00
IUUC-Sly-111520	Solanum lycopersicum	52.55	0.00e+00	1050.00
IUUC-Sar-113606	Sorex araneus	94.61	1.00e-134	473.00
IUUC-Sbi-114539	Sorghum bicolor	52.34	0.00e+00	1053.00
IUUC-Sre-114936	Sporisorium reilianum	25.65	3.00e-66	246.00
IUUC-Ssc-116038	Sus scrofa	97.97	0.00e+00	2050.00
IUUC-Tgu-117512	Taeniopygia guttata	97.00	0.00e+00	2021.00
IUUC-Tru-117593	Takifugu rubripes	89.35	0.00e+00	1871.00
IUUC-Tsy-119513	Tarsius syrichta	94.63	0.00e+00	1181.00
IUUC-Tni-120551	Tetraodon nigroviridis	85.23	0.00e+00	1703.00
IUUC-Tca-121505	Theobroma cacao	52.99	0.00e+00	1041.00
IUUC-Tre-122136	Trichoderma reesei	26.44	2.00e-92	333.00
IUUC-Tvi-122512	Trichoderma virens	25.42	8.00e-88	318.00
IUUC-Tae-122891	Triticum aestivum	52.79	0.00e+00	1054.00
IUUC-Tur-126451	Triticum urartu	52.70	0.00e+00	1049.00
IUUC-Tme-127057	Tuber melanosporum	29.95	1.00e-103	370.00
IUUC-Ttr-128891	Tursiops truncatus	93.21	0.00e+00	1459.00
IUUC-Uma-129583	Ustilago maydis	25.31	9.00e-56	212.00
IUUC-Vda-129870	Verticillium dahliae	25.09	2.00e-81	296.00
IUUC-Vpa-130117	Vicugna pacos	92.82	0.00e+00	1539.00
IUUC-Vvi-131033	Vitis vinifera	52.12	0.00e+00	1048.00
IUUC-Xtr-131987	Xenopus tropicalis	92.76	0.00e+00	1926.00
IUUC-Xma-134117	Xiphophorus maculatus	90.32	0.00e+00	1882.00
IUUC-Zma-134758	Zea mays	53.37	0.00e+00	1071.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence