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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046880
UUCD1 version UUC-HoS-00048
Ensembl Protein ID ENSP00000343001.6
UniProt Accession O95155; A8K8S9; G0ZJH6; O75169; O95338; Q5SZ12; Q5SZ16; Q96QD4; Q9BYI7; UBE4B_HUMAN
Genbank Protein ID AAD02233.1; BAB40446.1; AAK69622.1; AEK06331.1; BAA31659.3; BAF85133.1; CAI14687.1; CAI14687.1; CAI14688.1; CAI14688.1; CAI21859.1; CAI21859.1; CAI21860.1; CAI21860.1; AAH93696.1; AAC72962.1
Protein Name Ubiquitin conjugation factor E4 B; Homozygously deleted in neuroblastoma 1; RING-type E3 ubiquitin transferase E4 B; Ubiquitin fusion degradation protein 2
Genbank Nucleotide ID AF043117; AB028839; AF331520; JF289274; AB014584; AK292444; AL590639; AL096841; AL590639; AL096841; AL096841; AL590639; AL096841; AL590639; BC093696; AF091093
Gene Name UBE4B; HDNB1; KIAA0684; UFD2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000130939.18 ENST00000253251.12 ENSP00000253251.8
ENSG00000130939.18 ENST00000377153.5 ENSP00000366358.1
ENSG00000130939.18 ENST00000343090.10 ENSP00000343001.6
ENSG00000130939.18 ENST00000470736.1 ENSP00000467258.1
ENSG00000130939.18 ENST00000488228.1 ENSP00000468178.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkTargetScanRepTarmiRNAMap
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbGWAS CentralOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosSNPPhosphositePlus
dbPTMHPRDPhospho.ELMUniProt
PHOSIDABioGRIDmUbiSiDa
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/U-box U-box 16484223; 21317885; 20696387
Classification
Family E-value Score Start End
E3 activity/RING/U-box 1.40e-21 78.0 1228 1299
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/U-box
   S: 2    vpeeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrliqawceenss 74
            p+ef++p++ +lM+dPv lpsG  +drs I ++l ++ + +P++rq+lte++l P  +l++ iqaw+ e+++
   Q: 1228 APDEFRDPLMDTLMTDPVRLPSGTIMDRSIILRHLLNSPT-DPFNRQTLTESMLEPVPELKEQIQAWMREKQN 1299
           79**********************************9998.***************************99986 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase.
 Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase.
Protein Sequence
(Fasta)
MEELSADEIR RRRLARLAGG QTSQPTTPLT SPQRENPPGP PIAASAPGPS QSLGLNVHNM 60
TPATSPIGAS GVAHRSQSSE GVSSLSSSPS NSLETQSQSL SRSQSMDIDG VSCEKSMSQV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046880|E3,U-box|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GACGGGGTGG GACGGAGGCG GGGAGAGGAC GCAGGCGAGA GGAACTCGGC GGCGCGGCGC 60
CCGCGGCCTA TTGGCTGCCA CGTCCCGGCG CCAGAAGCCC CGCCTCCCTG ACGGGGGTCA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046880|E3,U-box|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR019474--Ub_conjug_fac_E4_core
IPR003613--Ubox_domain
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51698--U_BOX
Pfam

PF04564--U-box
PF10408--Ufd2P_core
SMART

SM00504--Ubox
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0000151--C:ubiquitin ligase complex
GO:0005524--F:ATP binding
GO:0019899--F:enzyme binding
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0008626--P:granzyme-mediated apoptotic signaling pathway
GO:0031175--P:neuron projection development
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0009411--P:response to UV
GO:0030433--P:ubiquitin-dependent ERAD pathway
GO:0003222--P:ventricular trabecula myocardium morphogenesis
KEGG hsa:10277
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000585 Aegilops tauschii 33.03 6.00e-95 342.00
IUUC-Aml-002396 Ailuropoda melanoleuca 98.88 0.00e+00 1734.00
IUUC-Atr-002479 Amborella trichopoda 32.02 7.00e-99 355.00
IUUC-Apl-003747 Anas platyrhynchos 94.05 0.00e+00 1671.00
IUUC-Aca-004866 Anolis carolinensis 93.93 0.00e+00 1657.00
IUUC-Aly-006300 Arabidopsis lyrata 30.65 2.00e-89 323.00
IUUC-Ath-006962 Arabidopsis thaliana 30.62 9.00e-87 315.00
IUUC-Ago-007880 Ashbya gossypii 29.30 2.00e-76 281.00
IUUC-Acl-008289 Aspergillus clavatus 30.41 1.00e-97 351.00
IUUC-Afl-008711 Aspergillus flavus 30.49 3.00e-102 367.00
IUUC-Afu-008766 Aspergillus fumigatus 30.87 1.00e-102 368.00
IUUC-Ani-009126 Aspergillus nidulans 30.44 2.00e-99 357.00
IUUC-Ang-009837 Aspergillus niger 30.33 2.00e-97 350.00
IUUC-Aor-009919 Aspergillus oryzae 30.06 7.00e-98 352.00
IUUC-Ate-010300 Aspergillus terreus 31.29 2.00e-104 374.00
IUUC-Ame-011355 Astyanax mexicanus 84.83 0.00e+00 1565.00
IUUC-Bgr-011995 Blumeria graminis 30.44 2.00e-100 360.00
IUUC-Bta-013056 Bos taurus 99.11 0.00e+00 1738.00
IUUC-Bci-013605 Botrytis cinerea 28.38 8.00e-86 312.00
IUUC-Bdi-015032 Brachypodium distachyon 30.52 1.00e-88 321.00
IUUC-Bol-016124 Brassica oleracea 30.75 6.00e-96 345.00
IUUC-Bra-017426 Brassica rapa 30.60 4.00e-96 346.00
IUUC-Cel-018606 Caenorhabditis elegans 30.81 1.00e-98 354.00
IUUC-Cja-018872 Callithrix jacchus 98.92 0.00e+00 2279.00
IUUC-Cfa-020045 Canis familiaris 98.77 0.00e+00 1732.00
IUUC-Cpo-022309 Cavia porcellus 98.21 0.00e+00 1728.00
IUUC-Cre-022726 Chlamydomonas reinhardtii 29.20 4.00e-49 189.00
IUUC-Csa-024003 Chlorocebus sabaeus 98.78 0.00e+00 1115.00
IUUC-Cho-025092 Choloepus hoffmanni 93.58 0.00e+00 1050.00
IUUC-Cin-025533 Ciona intestinalis 47.51 0.00e+00 825.00
IUUC-Csv-026081 Ciona savignyi 63.98 2.00e-60 224.00
IUUC-Cgl-026710 Colletotrichum gloeosporioides 30.98 1.00e-103 371.00
IUUC-Cne-027098 Cryptococcus neoformans 29.61 1.00e-103 372.00
IUUC-Cme-027352 Cyanidioschyzon merolae 32.64 1.00e-86 315.00
IUUC-Dre-027979 Danio rerio 84.25 0.00e+00 1506.00
IUUC-Dno-029282 Dasypus novemcinctus 98.99 0.00e+00 1735.00
IUUC-Dor-030904 Dipodomys ordii 81.36 0.00e+00 1084.00
IUUC-Dse-031393 Dothistroma septosporum 29.20 1.00e-94 341.00
IUUC-Dme-031666 Drosophila melanogaster 41.82 0.00e+00 681.00
IUUC-Ete-032519 Echinops telfairi 87.26 0.00e+00 722.00
IUUC-Eca-033778 Equus caballus 98.44 0.00e+00 1722.00
IUUC-Eeu-035315 Erinaceus europaeus 87.15 0.00e+00 1219.00
IUUC-Fca-035658 Felis catus 98.55 0.00e+00 1725.00
IUUC-Fal-037638 Ficedula albicollis 83.35 0.00e+00 1981.00
IUUC-Fox-037909 Fusarium oxysporum 29.06 6.00e-93 335.00
IUUC-Fso-038406 Fusarium solani 29.92 2.00e-94 341.00
IUUC-Gmo-039379 Gadus morhua 84.22 0.00e+00 1509.00
IUUC-Ggr-039851 Gaeumannomyces graminis 31.76 7.00e-104 372.00
IUUC-Gga-041136 Gallus gallus 94.14 0.00e+00 1674.00
IUUC-Gac-041910 Gasterosteus aculeatus 84.40 0.00e+00 1518.00
IUUC-Gma-043587 Glycine max 31.20 5.00e-92 332.00
IUUC-Ggo-045354 Gorilla gorilla 93.21 0.00e+00 1603.00
IUUC-Hvu-047157 Hordeum vulgare 33.20 1.00e-90 327.00
IUUC-Itr-048213 Ictidomys tridecemlineatus 98.80 0.00e+00 643.00
IUUC-Kpa-049211 Komagataella pastoris 27.80 9.00e-75 275.00
IUUC-Lch-050534 Latimeria chalumnae 87.98 0.00e+00 1607.00
IUUC-Lpe-051022 Leersia perrieri 31.14 2.00e-90 327.00
IUUC-Loc-052622 Lepisosteus oculatus 86.55 0.00e+00 1538.00
IUUC-Lma-053241 Leptosphaeria maculans 29.96 2.00e-94 340.00
IUUC-Laf-053646 Loxodonta africana 95.19 0.00e+00 2180.00
IUUC-Mcc-055588 Macaca mulatta 99.89 0.00e+00 1755.00
IUUC-Meu-055999 Macropus eugenii 74.28 0.00e+00 1627.00
IUUC-Mor-057064 Magnaporthe oryzae 30.68 3.00e-103 370.00
IUUC-Mpo-057452 Magnaporthe poae 31.98 7.00e-106 379.00
IUUC-Mtr-058016 Medicago truncatula 29.67 9.00e-99 355.00
IUUC-Mla-058887 Melampsora laricipopulina 33.05 8.00e-108 385.00
IUUC-Mga-059497 Meleagris gallopavo 93.92 0.00e+00 1667.00
IUUC-Mvi-060343 Microbotryum violaceum 34.39 5.00e-110 392.00
IUUC-Mmr-061173 Microcebus murinus 89.13 0.00e+00 1862.00
IUUC-Mdo-062102 Monodelphis domestica 95.50 0.00e+00 1682.00
IUUC-Mmu-063223 Mus musculus 97.77 0.00e+00 1724.00
IUUC-Mac-065531 Musa acuminata 31.21 3.00e-94 340.00
IUUC-Mpu-066624 Mustela putorius furo 66.78 0.00e+00 1051.00
IUUC-Mlu-068018 Myotis lucifugus 97.88 0.00e+00 1718.00
IUUC-Nfi-068590 Neosartorya fischeri 31.30 8.00e-104 372.00
IUUC-Ncr-068901 Neurospora crassa 32.54 5.00e-100 359.00
IUUC-Nle-069605 Nomascus leucogenys 98.56 0.00e+00 1738.00
IUUC-Opr-071011 Ochotona princeps 84.67 0.00e+00 853.00
IUUC-Ont-072304 Oreochromis niloticus 83.79 0.00e+00 1492.00
IUUC-Oan-073410 Ornithorhynchus anatinus 97.73 0.00e+00 1092.00
IUUC-Ocu-074910 Oryctolagus cuniculus 95.09 0.00e+00 2123.00
IUUC-Oba-075073 Oryza barthii 30.98 2.00e-96 347.00
IUUC-Obr-076452 Oryza brachyantha 31.27 4.00e-95 343.00
IUUC-Ogl-077141 Oryza glaberrima 30.98 9.00e-97 348.00
IUUC-Ogu-078116 Oryza glumaepatula 30.98 6.00e-97 349.00
IUUC-Oin-079066 Oryza indica 31.11 4.00e-97 349.00
IUUC-Olo-080253 Oryza longistaminata 29.02 5.00e-83 302.00
IUUC-Ome-081263 Oryza meridionalis 30.86 7.00e-96 345.00
IUUC-Oni-082019 Oryza nivara 31.11 6.00e-97 349.00
IUUC-Opu-083558 Oryza punctata 31.02 2.00e-97 350.00
IUUC-Oru-085002 Oryza rufipogon 30.98 1.00e-96 348.00
IUUC-Osa-085980 Oryza sativa 31.11 5.00e-97 349.00
IUUC-Ola-086323 Oryzias latipes 80.91 0.00e+00 1439.00
IUUC-Olu-087901 Ostreococcus lucimarinus 31.53 2.00e-97 350.00
IUUC-Oga-087969 Otolemur garnettii 94.74 0.00e+00 1637.00
IUUC-Oar-090020 Ovis aries 88.50 0.00e+00 2013.00
IUUC-Ptr-091589 Pan troglodytes 99.77 0.00e+00 2268.00
IUUC-Pan-091718 Papio anubis 100.00 0.00e+00 868.00
IUUC-Psi-093013 Pelodiscus sinensis 85.18 0.00e+00 2046.00
IUUC-Pma-094627 Petromyzon marinus 74.62 0.00e+00 629.00
IUUC-Pno-094840 Phaeosphaeria nodorum 29.93 8.00e-102 365.00
IUUC-Ppa-095989 Physcomitrella patens 29.34 3.00e-96 346.00
IUUC-Pfo-096436 Poecilia formosa 84.71 0.00e+00 1545.00
IUUC-Pab-098275 Pongo abelii 85.19 0.00e+00 1434.00
IUUC-Pop-098797 Populus trichocarpa 30.19 3.00e-100 360.00
IUUC-Pca-100478 Procavia capensis 80.35 0.00e+00 904.00
IUUC-Ppe-101230 Prunus persica 30.90 3.00e-101 363.00
IUUC-Pva-102459 Pteropus vampyrus 92.78 0.00e+00 2003.00
IUUC-Pgr-103485 Puccinia graminis 32.81 4.00e-108 386.00
IUUC-Ptt-104001 Puccinia triticina 42.17 2.00e-45 177.00
IUUC-Pte-104084 Pyrenophora teres 32.13 1.00e-109 391.00
IUUC-Pyt-104484 Pyrenophora triticirepentis 31.85 8.00e-109 388.00
IUUC-Rno-105719 Rattus norvegicus 97.87 0.00e+00 1721.00
IUUC-Sce-106135 Saccharomyces cerevisiae 36.49 1.00e-72 268.00
IUUC-Sha-106760 Sarcophilus harrisii 95.50 0.00e+00 1676.00
IUUC-Sja-107698 Schizosaccharomyces japonicus 32.66 9.00e-112 398.00
IUUC-Spo-108076 Schizosaccharomyces pombe 33.09 2.00e-106 380.00
IUUC-Ssl-108624 Sclerotinia sclerotiorum 29.19 2.00e-97 351.00
IUUC-Smo-109042 Selaginella moellendorffii 29.00 5.00e-89 322.00
IUUC-Sit-109949 Setaria italica 31.30 2.00e-92 334.00
IUUC-Sly-110973 Solanum lycopersicum 31.06 7.00e-84 305.00
IUUC-Stu-112372 Solanum tuberosum 30.03 2.00e-100 360.00
IUUC-Sar-113469 Sorex araneus 89.77 0.00e+00 1011.00
IUUC-Sbi-113828 Sorghum bicolor 31.47 8.00e-96 345.00
IUUC-Sre-114967 Sporisorium reilianum 32.25 3.00e-101 363.00
IUUC-Ssc-115655 Sus scrofa 97.74 0.00e+00 1107.00
IUUC-Tgu-117290 Taeniopygia guttata 93.60 0.00e+00 1624.00
IUUC-Tru-118193 Takifugu rubripes 74.76 0.00e+00 1768.00
IUUC-Tsy-118926 Tarsius syrichta 94.70 0.00e+00 2177.00
IUUC-Tni-120862 Tetraodon nigroviridis 85.46 0.00e+00 1504.00
IUUC-Tca-121096 Theobroma cacao 31.51 2.00e-100 360.00
IUUC-Tre-122104 Trichoderma reesei 30.47 2.00e-97 351.00
IUUC-Tvi-122345 Trichoderma virens 30.65 6.00e-101 363.00
IUUC-Tae-124607 Triticum aestivum 33.03 3.00e-95 343.00
IUUC-Tur-126056 Triticum urartu 33.03 8.00e-95 341.00
IUUC-Tme-127074 Tuber melanosporum 32.77 3.00e-97 350.00
IUUC-Tbe-127533 Tupaia belangeri 93.77 0.00e+00 1893.00
IUUC-Ttr-128757 Tursiops truncatus 93.25 0.00e+00 2138.00
IUUC-Uma-129550 Ustilago maydis 32.17 2.00e-102 367.00
IUUC-Vda-129901 Verticillium dahliae 30.29 9.00e-100 358.00
IUUC-Vpa-130636 Vicugna pacos 97.48 0.00e+00 1035.00
IUUC-Vvi-130891 Vitis vinifera 31.28 3.00e-100 360.00
IUUC-Xtr-132364 Xenopus tropicalis 87.27 0.00e+00 1576.00
IUUC-Xma-133772 Xiphophorus maculatus 84.60 0.00e+00 1543.00
IUUC-Yli-134506 Yarrowia lipolytica 30.68 1.00e-80 295.00
IUUC-Zma-135695 Zea mays 30.77 4.00e-87 316.00
Created Date 25-Jun-2017

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