iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-033205

UUCD1 version

UUC-EqC-00742

Ensembl Protein ID

ENSECAP00000005641.1

UniProt Accession

F7BU84; F7BU84_HORSE

Protein Name

Uncharacterized protein

Gene Name

FBXO18

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000006839.1	ENSECAT00000007671.1	ENSECAP00000005641.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/SCF/F-box	92.07	0.00e+00	2002.00	IUUC-Hsa-046650
E3 adaptor/Cullin RING/SCF/F-box	29.10	3.00e-43	171.00	IUUC-Spo-108147

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Equus caballus

Protein Sequence
(Fasta)

VRRFKRKHLL AIDCQHLARS HLAVAQPFGQ RWTNRDPNHG LYPRPRTKRG TRGQGCQRRI 60
TEFFLAGRQR CTNDMAKSNS VGRDSSKDSE GEMIFAAESN CALPQEGDGE ARLGSSGSAL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGAGACGGT TTAAGCGGAA GCATCTTCTA GCCATCGACT GCCAACATTT GGCTCGGAGT 60
CACTTGGCTG TGGCCCAGCC CTTCGGTCAA AGATGGACAA ACAGAGATCC GAACCACGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR014017--DNA_helicase_UvrD-like_C
IPR000212--DNA_helicase_UvrD/REP
IPR001810--F-box_dom
IPR027417--P-loop_NTPase

PROSITE

PS50181--FBOX

Pfam

PF12937--F-box-like
PF13361--UvrD_C

SMART

SM00256--FBOX

Gene Ontology

GO:0000785--C:chromatin
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0043138--F:3'-5' DNA helicase activity
GO:0005524--F:ATP binding
GO:0004003--F:ATP-dependent DNA helicase activity
GO:0015616--F:DNA translocase activity
GO:0003690--F:double-stranded DNA binding
GO:0003697--F:single-stranded DNA binding
GO:0008219--P:cell death
GO:0006974--P:cellular response to DNA damage stimulus
GO:0000737--P:DNA catabolic process, endonucleolytic
GO:0035562--P:negative regulation of chromatin binding
GO:2000042--P:negative regulation of double-strand break repair via homologous recombination
GO:1902231--P:positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:0001934--P:positive regulation of protein phosphorylation
GO:0016567--P:protein ubiquitination
GO:0031297--P:replication fork processing
GO:0048478--P:replication fork protection
GO:0072429--P:response to intra-S DNA damage checkpoint signaling

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000424	Aegilops tauschii	25.25	2.00e-04	42.00
IUUC-Aml-001396	Ailuropoda melanoleuca	95.03	0.00e+00	2012.00
IUUC-Atr-002826	Amborella trichopoda	40.00	6.00e-04	40.00
IUUC-Apl-003317	Anas platyrhynchos	48.21	0.00e+00	939.00
IUUC-Aca-004498	Anolis carolinensis	54.63	0.00e+00	954.00
IUUC-Aly-006174	Arabidopsis lyrata	34.43	1.00e-03	35.40
IUUC-Ath-007293	Arabidopsis thaliana	37.68	4.00e-03	37.40
IUUC-Ago-007983	Ashbya gossypii	35.71	1.80e+00	28.90
IUUC-Ani-009226	Aspergillus nidulans	31.67	2.00e-06	48.10
IUUC-Ate-010526	Aspergillus terreus	39.71	7.00e-04	39.70
IUUC-Ame-011808	Astyanax mexicanus	58.65	5.00e-135	474.00
IUUC-Bta-013250	Bos taurus	90.82	0.00e+00	1931.00
IUUC-Bol-015348	Brassica oleracea	37.68	3.00e-03	37.70
IUUC-Cja-019638	Callithrix jacchus	92.16	0.00e+00	2001.00
IUUC-Cfa-020195	Canis familiaris	96.30	0.00e+00	1928.00
IUUC-Cpo-022269	Cavia porcellus	86.71	0.00e+00	1807.00
IUUC-Cre-022611	Chlamydomonas reinhardtii	40.28	4.00e-08	53.90
IUUC-Csa-024060	Chlorocebus sabaeus	93.11	0.00e+00	1781.00
IUUC-Cho-025003	Choloepus hoffmanni	89.90	0.00e+00	714.00
IUUC-Cin-025694	Ciona intestinalis	26.78	2.00e-28	119.00
IUUC-Dre-028083	Danio rerio	45.17	0.00e+00	868.00
IUUC-Dno-029203	Dasypus novemcinctus	88.54	0.00e+00	1806.00
IUUC-Dor-030477	Dipodomys ordii	97.19	0.00e+00	794.00
IUUC-Ete-032861	Echinops telfairi	88.72	0.00e+00	1883.00
IUUC-Eeu-034784	Erinaceus europaeus	86.79	0.00e+00	1208.00
IUUC-Fca-035797	Felis catus	94.94	0.00e+00	2019.00
IUUC-Gmo-038855	Gadus morhua	46.18	2.00e-122	433.00
IUUC-Gga-040326	Gallus gallus	50.86	0.00e+00	991.00
IUUC-Gac-042240	Gasterosteus aculeatus	42.06	0.00e+00	732.00
IUUC-Ggo-045050	Gorilla gorilla	88.79	0.00e+00	1838.00
IUUC-Hsa-046650	Homo sapiens	91.49	0.00e+00	1930.00
IUUC-Itr-047965	Ictidomys tridecemlineatus	96.64	0.00e+00	778.00
IUUC-Lch-050231	Latimeria chalumnae	42.58	5.00e-160	558.00
IUUC-Loc-051884	Lepisosteus oculatus	50.00	0.00e+00	983.00
IUUC-Lma-053267	Leptosphaeria maculans	25.45	4.00e-03	37.40
IUUC-Laf-053843	Loxodonta africana	92.26	0.00e+00	1968.00
IUUC-Mcc-055570	Macaca mulatta	92.35	0.00e+00	1956.00
IUUC-Meu-056798	Macropus eugenii	66.67	4.00e-150	525.00
IUUC-Mtr-057915	Medicago truncatula	35.21	6.00e-04	40.40
IUUC-Mga-059648	Meleagris gallopavo	51.64	0.00e+00	949.00
IUUC-Mmr-060757	Microcebus murinus	89.38	0.00e+00	1857.00
IUUC-Mdo-061913	Monodelphis domestica	70.37	0.00e+00	1396.00
IUUC-Mmu-064337	Mus musculus	89.10	0.00e+00	1930.00
IUUC-Mpu-066483	Mustela putorius furo	92.83	0.00e+00	2004.00
IUUC-Mlu-068204	Myotis lucifugus	88.27	0.00e+00	1882.00
IUUC-Ncr-068735	Neurospora crassa	37.50	4.00e-03	37.40
IUUC-Nle-070053	Nomascus leucogenys	92.35	0.00e+00	1909.00
IUUC-Opr-070588	Ochotona princeps	85.95	0.00e+00	1811.00
IUUC-Ont-072655	Oreochromis niloticus	47.22	0.00e+00	758.00
IUUC-Oan-073351	Ornithorhynchus anatinus	62.57	0.00e+00	1311.00
IUUC-Ocu-074465	Oryctolagus cuniculus	91.15	0.00e+00	1872.00
IUUC-Oin-079176	Oryza indica	23.33	1.00e-05	44.30
IUUC-Opu-083155	Oryza punctata	50.00	2.00e-03	37.70
IUUC-Olu-087831	Ostreococcus lucimarinus	31.66	5.00e-64	240.00
IUUC-Oga-089088	Otolemur garnettii	89.20	0.00e+00	1854.00
IUUC-Oar-089870	Ovis aries	90.25	0.00e+00	1888.00
IUUC-Ptr-090957	Pan troglodytes	92.27	0.00e+00	1904.00
IUUC-Pan-092632	Papio anubis	92.35	0.00e+00	1909.00
IUUC-Psi-093035	Pelodiscus sinensis	55.30	0.00e+00	1129.00
IUUC-Pno-094870	Phaeosphaeria nodorum	24.56	1.00e-03	38.90
IUUC-Ppa-095660	Physcomitrella patens	38.36	5.00e-04	40.40
IUUC-Pfo-096902	Poecilia formosa	44.87	0.00e+00	682.00
IUUC-Pab-098206	Pongo abelii	92.42	0.00e+00	1801.00
IUUC-Pop-098801	Populus trichocarpa	34.72	6.00e-04	40.00
IUUC-Pca-100238	Procavia capensis	86.23	0.00e+00	1815.00
IUUC-Ppe-101748	Prunus persica	35.94	9.00e-03	36.20
IUUC-Pva-103182	Pteropus vampyrus	91.68	0.00e+00	1899.00
IUUC-Pte-104033	Pyrenophora teres	23.92	7.00e-03	36.60
IUUC-Pyt-104599	Pyrenophora triticirepentis	25.00	3.00e-03	37.40
IUUC-Rno-105141	Rattus norvegicus	89.01	0.00e+00	1925.00
IUUC-Sce-106341	Saccharomyces cerevisiae	25.76	3.00e-03	37.40
IUUC-Sha-106827	Sarcophilus harrisii	68.54	0.00e+00	1462.00
IUUC-Sja-107882	Schizosaccharomyces japonicus	28.36	1.00e-41	164.00
IUUC-Spo-108147	Schizosaccharomyces pombe	29.10	5.00e-43	169.00
IUUC-Ssl-108584	Sclerotinia sclerotiorum	26.19	8.00e-04	39.30
IUUC-Sly-111170	Solanum lycopersicum	33.33	5.40e-02	32.70
IUUC-Sre-115025	Sporisorium reilianum	33.02	1.00e-38	155.00
IUUC-Ssc-116188	Sus scrofa	95.99	0.00e+00	1282.00
IUUC-Tgu-116612	Taeniopygia guttata	57.05	4.00e-156	544.00
IUUC-Tsy-119560	Tarsius syrichta	82.26	2.00e-116	414.00
IUUC-Tni-120734	Tetraodon nigroviridis	45.66	0.00e+00	711.00
IUUC-Tca-121338	Theobroma cacao	30.36	1.00e-02	36.20
IUUC-Tre-122089	Trichoderma reesei	40.74	2.00e-04	40.80
IUUC-Tme-127009	Tuber melanosporum	24.37	1.00e-03	38.90
IUUC-Tbe-127431	Tupaia belangeri	90.44	0.00e+00	1648.00
IUUC-Ttr-128744	Tursiops truncatus	90.35	0.00e+00	1892.00
IUUC-Uma-129536	Ustilago maydis	32.77	2.00e-41	164.00
IUUC-Vpa-130123	Vicugna pacos	81.82	2.00e-112	399.00
IUUC-Vvi-131025	Vitis vinifera	37.50	4.00e-03	37.40
IUUC-Xtr-132902	Xenopus tropicalis	59.12	0.00e+00	1008.00
IUUC-Xma-133978	Xiphophorus maculatus	45.92	3.00e-151	528.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence