iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/BCR/BTB_3-box	BTB_3-box	13679922; 17878235; 19361490

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	1.70e-16	60.6	201	265
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	4.90e-06	25.9	303	325

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmele.esksklmveikdvqpevfrallkFlYtgkl 65
           +D  ++v+g+ ++ahk+vLaa+S+vF+a+++++   e k ++m+ i+d++++v  +++ ++Y+g+ 
   Q: 201  CDFAINVNGKIIRAHKAVLAARSPVFNAMLTHQDTdEAK-SSMMYINDMDYDVIYEMVYYIYCGRC 265
           8999**************************998886877.************************97 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 2    eNclgilrfAdlydcpdLkdaal 24
           eN++++l ++dly++p+L+++a+
   Q: 303  ENACSLLIIGDLYSAPKLRKRAV 325
           8********************97 PP

Organism

Caenorhabditis elegans

Functional Description
(View)

Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14528312, PubMed:13679922). Controls degradation of microtubule severing protein mei-1 (PubMed:14528312). In body wall muscles, involved in the organization of myosin thick filaments, likely by regulating the degradation of mei-1 downstream of unc-89 (PubMed:22621901).

Protein Sequence
(Fasta)

MEPRIDGGVF IGGIGNSGNE MCSNGVPALG VSSQTEIKVE KVQHTWTVKN FSHCYQEYLE 60
NFVYLQRGDE QLTWSIKIYP KGNGENNKDF VFLCLNRVIN NNVKAGKIGF KSQFKLRTAE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGGAAATGGA ACCACGAATC GATGGAGGAG TATTCATCGG AGGAATCGGA AATTCGGGAA 60
ATGAAATGTG TAGTAATGGA GTACCGGCAC TCGGGGTTTC ATCTCAAACT GAGATTAAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR000210--BTB/POZ_dom
IPR002083--MATH/TRAF_dom
IPR011333--SKP1/BTB/POZ
IPR034089--SPOP_C
IPR008974--TRAF-like

PROSITE

PS50097--BTB
PS50144--MATH

Pfam

PF00651--BTB

SMART

SM00225--BTB
SM00061--MATH

Gene Ontology

GO:0005938--C:cell cortex
GO:0032154--C:cleavage furrow
GO:0000793--C:condensed chromosome
GO:0005737--C:cytoplasm
GO:0031674--C:I band
GO:0031430--C:M band
GO:0016020--C:membrane
GO:0019005--C:SCF ubiquitin ligase complex
GO:0042802--F:identical protein binding
GO:0030674--F:protein binding, bridging
GO:0019901--F:protein kinase binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0044257--P:cellular protein catabolic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030162--P:regulation of proteolysis
GO:0071688--P:striated muscle myosin thick filament assembly

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Atr-002746	Amborella trichopoda	33.54	3.00e-22	97.10
IUUC-Aly-005780	Arabidopsis lyrata	36.69	2.00e-18	85.50
IUUC-Ate-010319	Aspergillus terreus	21.66	7.00e-04	39.30
IUUC-Bra-017656	Brassica rapa	36.67	4.00e-20	90.90
IUUC-Gma-043365	Glycine max	33.12	5.00e-19	87.00
IUUC-Mla-059110	Melampsora laricipopulina	25.76	3.00e-03	36.20
IUUC-Mvi-060215	Microbotryum violaceum	25.69	4.00e-06	45.80
IUUC-Pop-099250	Populus trichocarpa	33.72	5.00e-19	87.00
IUUC-Ppe-102104	Prunus persica	33.72	1.00e-19	89.00
IUUC-Pte-104211	Pyrenophora teres	21.43	7.00e-06	43.50
IUUC-Sly-111459	Solanum lycopersicum	36.69	4.00e-19	87.40
IUUC-Stu-112229	Solanum tuberosum	37.41	2.00e-19	88.20
IUUC-Tca-121101	Theobroma cacao	34.53	8.00e-18	83.20

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence