iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Apl-003774

Ensembl Protein ID

ENSAPLP00000002978.1

UniProt Accession

U3I6V7; U3I6V7_ANAPL

Genbank Protein ID

ENSAPLP00000002978

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

ADON01052855

Gene Name

USP5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAPLG00000003443.1	ENSAPLT00000003572.1	ENSAPLP00000002978.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.40e-62	210.8	285	812
UBD/Alpha-Helix/UBA	6.00e-23	80.0	681	719

Active Site

Position(s)	Description	Evidence
294	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
775	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel..................wkskkkavspr 71
           tG++NlgN+CY+NSv+Q+L++ip++++ + + k ek+ +++p++p+++++++++kl + l                  +k+ ++ ++pr
   Q: 285  TGIRNLGNSCYLNSVMQVLFSIPDFQRKYVD-KLEKIFQSAPSDPTQDFSTQVAKLGHGLlsgeyskpvsaegeqqpdQKGVQNGIAPR 372
           7******************************.99999999********************666666666655554433366666***** PP
   S: 72   ellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecd 160
           ++++ ++k ++efs+++qqDaqEf+ ++++ +e+++                             ++++  +++F++ +++++kcl+ +
   Q: 373  MFKSLIGKGHPEFSTNRQQDAQEFFLHFINMVERNC-----------------------------RSSENPNEVFRFLVEEKLKCLATE 432
           ************************************.............................6788899***************** PP
   S: 161  nvssreepfldlslpvpgkeetkke...........................slqdcLesftkeeelegenkyycekckkkqeaekklk 222
           +v+ ++   + ++lpvp++   +k                             +++cLe++ ++e++++   ++++  ++k+ a k+++
   Q: 433  KVKYTQRVDYIMQLPVPMDAALNKDelleyeekkrqaeeekqplpelvrakvPFSSCLEAYGAPEQVDD---FWSTALQAKSVALKTTR 518
           ******************998877799****************************************97...***************** PP
   S: 223  lkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts............................................ 267
           + ++P++L++++k+f+f  + ++++k++ ++e+p+eLd+s    +                                            
   Q: 519  FASFPDYLVIQIKKFTFGLD-WVPKKLDVSIEMPEELDISALQGTglqdgeeempdiapplvtpdepkgslgfygnedddsfcsphfss 606
           *****************997.*******************8766667777777777777777777777777777777777777777766 PP
   S: 268  .........................................................................peekqke......... 274
                                                                                    p     +         
   Q: 607  ptspmldesviiqlvemgfpmdacrkavyytgnsgveaamnwvmshmddpdfanplvlpgssgpgstiacpdpP-----Sedsvativs 690
           66666666666666666666666666666666666666666666666666555555555555555555555550.....0555555666 PP
   S: 275  ................................................................kkkYeLiavvvHsG.slssGHYvay 298
                                                                           + kY+L+a ++H+G s+ +GHYv++
   Q: 691  mgfsrdqamkalratnnsleravdwifshiddldaeaamdisegrsaadsisesvpvgpkvrdgPGKYQLFAFISHMGtSTMCGHYVCH 779
           6666666666666666666677777777777777777777888888888888888889999999************************* PP
   S: 299  vknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           +k+ +g+W+ ++D+kV ++  e+  +   + +Y++fY+r
   Q: 780  IKK-DGRWVIYNDQKVCAS--EKPPK---DLGYIYFYQR 812
           ***.9***********999..78888...89******98 PP

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGFdreealqaLraannnleaAveyLldg 41
           +ed ++ +v+MGF+r++a +aLra+nn+le+Av++++++
   Q: 681  SEDSVATIVSMGFSRDQAMKALRATNNSLERAVDWIFSH 719
           699**********************************97 PP

Organism

Anas platyrhynchos

Protein Sequence
(Fasta)

GLYICMNTFL GFGKHYVERH FQKTGQRVYL HLKRTRKPKE EDANSSAGDP PRKKPTRLAI 60
GVEGGFDITE EKFEYDEDVK IVILPEHLDI PRDGLEGLPD MVRDRIASAV EAILTADSAS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGCTGTACA TCTGCATGAA CACCTTCCTG GGCTTCGGCA AGCACTACGT GGAGAGGCAC 60
TTCCAGAAGA CAGGCCAGAG GGTCTACCTG CACCTCAAGC GGACGCGCAA GCCGGTAAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0071108--P:protein K48-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000394	Aegilops tauschii	44.70	0.00e+00	660.00
IUUC-Aml-002104	Ailuropoda melanoleuca	91.09	0.00e+00	1488.00
IUUC-Atr-002580	Amborella trichopoda	46.16	0.00e+00	709.00
IUUC-Aca-005368	Anolis carolinensis	91.29	0.00e+00	1524.00
IUUC-Aly-005727	Arabidopsis lyrata	47.45	0.00e+00	720.00
IUUC-Ath-006974	Arabidopsis thaliana	47.69	0.00e+00	721.00
IUUC-Ago-007890	Ashbya gossypii	29.27	4.00e-78	285.00
IUUC-Acl-008057	Aspergillus clavatus	34.57	3.00e-124	439.00
IUUC-Afl-008547	Aspergillus flavus	35.87	1.00e-117	416.00
IUUC-Afu-008805	Aspergillus fumigatus	34.65	3.00e-118	419.00
IUUC-Ani-009441	Aspergillus nidulans	33.29	6.00e-100	357.00
IUUC-Ang-009720	Aspergillus niger	34.45	1.00e-113	404.00
IUUC-Aor-010111	Aspergillus oryzae	34.45	6.00e-124	437.00
IUUC-Ate-010531	Aspergillus terreus	32.50	4.00e-100	358.00
IUUC-Ame-011893	Astyanax mexicanus	63.86	0.00e+00	932.00
IUUC-Bgr-012183	Blumeria graminis	34.13	5.00e-120	425.00
IUUC-Bta-013179	Bos taurus	91.43	0.00e+00	1494.00
IUUC-Bci-013858	Botrytis cinerea	34.25	5.00e-126	444.00
IUUC-Bdi-014904	Brachypodium distachyon	47.75	0.00e+00	695.00
IUUC-Bol-015296	Brassica oleracea	48.23	0.00e+00	732.00
IUUC-Bra-017619	Brassica rapa	48.23	0.00e+00	734.00
IUUC-Cel-018625	Caenorhabditis elegans	35.54	7.00e-130	457.00
IUUC-Cja-019063	Callithrix jacchus	90.00	0.00e+00	1466.00
IUUC-Cfa-020976	Canis familiaris	88.86	0.00e+00	1439.00
IUUC-Cpo-022265	Cavia porcellus	88.51	0.00e+00	1430.00
IUUC-Cre-022640	Chlamydomonas reinhardtii	39.45	3.00e-117	415.00
IUUC-Csa-024177	Chlorocebus sabaeus	88.13	0.00e+00	1305.00
IUUC-Cho-024702	Choloepus hoffmanni	85.61	0.00e+00	948.00
IUUC-Cin-025411	Ciona intestinalis	50.48	0.00e+00	810.00
IUUC-Csv-026347	Ciona savignyi	46.07	0.00e+00	755.00
IUUC-Cgl-026667	Colletotrichum gloeosporioides	35.30	6.00e-110	391.00
IUUC-Cne-026831	Cryptococcus neoformans	35.18	2.00e-125	442.00
IUUC-Dre-027982	Danio rerio	66.67	0.00e+00	1049.00
IUUC-Dno-029034	Dasypus novemcinctus	91.55	0.00e+00	1507.00
IUUC-Dor-030479	Dipodomys ordii	88.58	0.00e+00	676.00
IUUC-Dse-031467	Dothistroma septosporum	35.62	8.00e-128	451.00
IUUC-Dme-032075	Drosophila melanogaster	50.66	0.00e+00	795.00
IUUC-Ete-032865	Echinops telfairi	81.64	0.00e+00	1313.00
IUUC-Eca-034059	Equus caballus	91.68	0.00e+00	1495.00
IUUC-Eeu-035304	Erinaceus europaeus	90.89	0.00e+00	1386.00
IUUC-Fca-035515	Felis catus	91.43	0.00e+00	1496.00
IUUC-Fal-037271	Ficedula albicollis	95.19	0.00e+00	1549.00
IUUC-Fox-037745	Fusarium oxysporum	35.53	9.00e-126	444.00
IUUC-Fso-038158	Fusarium solani	35.86	1.00e-123	436.00
IUUC-Gmo-039071	Gadus morhua	64.38	0.00e+00	1020.00
IUUC-Ggr-040098	Gaeumannomyces graminis	33.89	2.00e-117	416.00
IUUC-Gga-040635	Gallus gallus	98.90	0.00e+00	1658.00
IUUC-Gac-042528	Gasterosteus aculeatus	63.69	0.00e+00	1031.00
IUUC-Gma-043614	Glycine max	47.03	0.00e+00	691.00
IUUC-Ggo-044602	Gorilla gorilla	91.55	0.00e+00	1494.00
IUUC-Hsa-045959	Homo sapiens	91.55	0.00e+00	1494.00
IUUC-Hvu-047563	Hordeum vulgare	47.95	2.00e-172	598.00
IUUC-Itr-048712	Ictidomys tridecemlineatus	90.46	0.00e+00	1493.00
IUUC-Kpa-049156	Komagataella pastoris	33.69	7.00e-111	394.00
IUUC-Lch-049648	Latimeria chalumnae	80.74	0.00e+00	1329.00
IUUC-Lpe-051523	Leersia perrieri	46.82	0.00e+00	694.00
IUUC-Loc-052520	Lepisosteus oculatus	62.05	0.00e+00	967.00
IUUC-Lma-053216	Leptosphaeria maculans	34.80	2.00e-113	404.00
IUUC-Laf-054327	Loxodonta africana	90.70	0.00e+00	1485.00
IUUC-Mcc-055443	Macaca mulatta	91.43	0.00e+00	1491.00
IUUC-Meu-056298	Macropus eugenii	90.11	0.00e+00	971.00
IUUC-Mor-057106	Magnaporthe oryzae	36.40	3.00e-127	449.00
IUUC-Mpo-057589	Magnaporthe poae	34.65	3.00e-122	432.00
IUUC-Mtr-058680	Medicago truncatula	48.01	0.00e+00	706.00
IUUC-Mla-058903	Melampsora laricipopulina	32.58	7.00e-119	421.00
IUUC-Mga-059669	Meleagris gallopavo	98.41	0.00e+00	1645.00
IUUC-Mvi-060476	Microbotryum violaceum	35.02	2.00e-117	416.00
IUUC-Mmr-060575	Microcebus murinus	91.55	0.00e+00	1499.00
IUUC-Mdo-062183	Monodelphis domestica	88.86	0.00e+00	1427.00
IUUC-Mmu-063592	Mus musculus	91.43	0.00e+00	1496.00
IUUC-Mac-065634	Musa acuminata	43.46	0.00e+00	673.00
IUUC-Mpu-066082	Mustela putorius furo	88.37	0.00e+00	1429.00
IUUC-Mlu-067345	Myotis lucifugus	88.90	0.00e+00	1464.00
IUUC-Nfi-068558	Neosartorya fischeri	35.31	9.00e-127	447.00
IUUC-Ncr-068960	Neurospora crassa	35.00	7.00e-111	394.00
IUUC-Nle-070173	Nomascus leucogenys	88.74	0.00e+00	1433.00
IUUC-Opr-070556	Ochotona princeps	90.94	0.00e+00	1501.00
IUUC-Ont-071502	Oreochromis niloticus	64.27	0.00e+00	1031.00
IUUC-Ocu-074861	Oryctolagus cuniculus	88.37	0.00e+00	1446.00
IUUC-Oba-075109	Oryza barthii	46.64	0.00e+00	699.00
IUUC-Obr-076292	Oryza brachyantha	47.99	0.00e+00	696.00
IUUC-Ogl-077065	Oryza glaberrima	47.99	0.00e+00	726.00
IUUC-Ogu-078776	Oryza glumaepatula	46.52	0.00e+00	707.00
IUUC-Oin-080048	Oryza indica	47.50	0.00e+00	721.00
IUUC-Olo-080711	Oryza longistaminata	45.25	0.00e+00	680.00
IUUC-Ome-081506	Oryza meridionalis	46.31	0.00e+00	692.00
IUUC-Oni-082320	Oryza nivara	46.06	0.00e+00	693.00
IUUC-Opu-083801	Oryza punctata	47.13	0.00e+00	690.00
IUUC-Oru-085139	Oryza rufipogon	45.94	0.00e+00	697.00
IUUC-Osa-085713	Oryza sativa	48.11	0.00e+00	729.00
IUUC-Ola-086951	Oryzias latipes	64.88	0.00e+00	1024.00
IUUC-Olu-087822	Ostreococcus lucimarinus	40.50	1.00e-173	603.00
IUUC-Oga-088625	Otolemur garnettii	90.34	0.00e+00	1474.00
IUUC-Oar-089995	Ovis aries	88.78	0.00e+00	1467.00
IUUC-Ptr-090640	Pan troglodytes	89.23	0.00e+00	1488.00
IUUC-Pan-091974	Papio anubis	90.49	0.00e+00	1472.00
IUUC-Psi-093957	Pelodiscus sinensis	94.86	0.00e+00	1629.00
IUUC-Pma-094242	Petromyzon marinus	71.50	1.00e-169	588.00
IUUC-Pno-094835	Phaeosphaeria nodorum	34.36	5.00e-109	388.00
IUUC-Ppa-095901	Physcomitrella patens	49.46	0.00e+00	764.00
IUUC-Pfo-097148	Poecilia formosa	65.45	0.00e+00	1035.00
IUUC-Pab-098068	Pongo abelii	84.60	0.00e+00	1330.00
IUUC-Pop-098943	Populus trichocarpa	46.90	0.00e+00	695.00
IUUC-Pca-100738	Procavia capensis	83.48	0.00e+00	1335.00
IUUC-Pva-102154	Pteropus vampyrus	90.55	0.00e+00	1472.00
IUUC-Pgr-103343	Puccinia graminis	33.92	2.00e-102	366.00
IUUC-Ptt-103928	Puccinia triticina	30.14	1.00e-99	357.00
IUUC-Pte-104306	Pyrenophora teres	32.15	9.00e-101	360.00
IUUC-Pyt-104696	Pyrenophora triticirepentis	33.89	2.00e-104	373.00
IUUC-Rno-105801	Rattus norvegicus	91.43	0.00e+00	1498.00
IUUC-Sce-106304	Saccharomyces cerevisiae	29.38	8.00e-73	268.00
IUUC-Sha-107635	Sarcophilus harrisii	88.62	0.00e+00	1432.00
IUUC-Sja-107678	Schizosaccharomyces japonicus	31.29	2.00e-101	363.00
IUUC-Spo-108144	Schizosaccharomyces pombe	33.21	2.00e-109	390.00
IUUC-Smo-108848	Selaginella moellendorffii	47.86	0.00e+00	724.00
IUUC-Sit-110728	Setaria italica	48.24	0.00e+00	744.00
IUUC-Sly-111523	Solanum lycopersicum	48.18	0.00e+00	750.00
IUUC-Sbi-114419	Sorghum bicolor	47.75	0.00e+00	730.00
IUUC-Sre-115225	Sporisorium reilianum	34.10	7.00e-118	417.00
IUUC-Ssc-115686	Sus scrofa	89.36	0.00e+00	1481.00
IUUC-Tgu-117346	Taeniopygia guttata	97.92	0.00e+00	1617.00
IUUC-Tru-118350	Takifugu rubripes	64.77	0.00e+00	1058.00
IUUC-Tni-120658	Tetraodon nigroviridis	65.90	0.00e+00	1043.00
IUUC-Tca-121585	Theobroma cacao	47.52	0.00e+00	704.00
IUUC-Tre-122043	Trichoderma reesei	34.58	6.00e-114	404.00
IUUC-Tvi-122303	Trichoderma virens	34.54	5.00e-118	418.00
IUUC-Tae-125686	Triticum aestivum	47.51	0.00e+00	711.00
IUUC-Tur-126732	Triticum urartu	44.82	0.00e+00	665.00
IUUC-Tme-126909	Tuber melanosporum	34.76	5.00e-113	401.00
IUUC-Tbe-127261	Tupaia belangeri	86.36	0.00e+00	989.00
IUUC-Uma-129599	Ustilago maydis	33.48	1.00e-124	440.00
IUUC-Vda-129688	Verticillium dahliae	33.78	3.00e-114	405.00
IUUC-Vvi-131116	Vitis vinifera	47.64	0.00e+00	686.00
IUUC-Xtr-131953	Xenopus tropicalis	80.17	0.00e+00	1322.00
IUUC-Xma-133837	Xiphophorus maculatus	65.57	0.00e+00	1037.00
IUUC-Yli-134510	Yarrowia lipolytica	35.19	8.00e-123	434.00
IUUC-Zma-135786	Zea mays	47.62	0.00e+00	699.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence