iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tre-122043

Ensembl Protein ID

EGR44317

UniProt Accession

G0RWW6; G0RWW6_HYPJQ

Genbank Protein ID

EGR44317.1

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

GL985093

Gene Name

TRIREDRAFT_82458

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
TRIREDRAFT_82458	EGR44317	EGR44317

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.00e-53	180.7	301	776
UBD/Alpha-Helix/UBA	4.30e-20	70.1	582	621

Active Site

Position(s)	Description	Evidence
310	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
731	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkk...............avsprellkalkkeaeefsg 86
           tGlkNlgN+CY+ S++QcL+ +p++re + + ++++l+    +ep ++l ++l+k+ + l++++ +                 +p +l++ +++ +eefs+
   Q: 301  TGLKNLGNSCYLASIIQCLFDLPSFRERYYS-NSNDLPIV--QEPAADLETQLRKMAHGLLSGRYSvpdneapgsevtyqrGLAPAMLKHLIGRGHEEFST 398
           7******************************.88888887..79****************5333333334444444555559******************* PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke.. 185
           ++qqDa E++++l++ ++++                            ++ +++  +  F++ l+++++cl c++v  + ++   + ++vp ++  ++e  
   Q: 399  MRQQDAFELFQHLFKLISRSP---------------------------HNGEQKDPTADFRFVLEQRLQCLGCHKVRYSSNEQDNIFIDVPLEKLDQPEes 472
           *****************9988...........................56666667888*****************9777777777888887777766688 PP
   S: 186  ..........slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefple.Ldlspfcts........ 267
                     +l++cL++ft++e++e    + c+ c +k   +k+  +k++P+vL ++  ++     +++++ki+  v +p+e + l+ ++++        
   Q: 473  gqvantykpvTLKECLDNFTAAEKVE----LTCSACGSKAGFTKQSLFKTFPNVLAVNARKM--AVVNWVPIKIDVPVIVPDEpFLLDDYLSKglqpseel 567
           99***********************9....9*******************************..6678*************************88888888 PP
   S: 268  ..........................................................................................peekqke.... 274
                                                                                                     p     +    
   Q: 568  lpdepenkapafvadataiaqleamgfprnraekalhatgnsdanaamewlfahlddadidapldlgsgsgadttdpekiemlgamgflaP-----Qakka 663
           8888777777777777777777777777777766666666666666666666666666666666666666655555555555555555550.....05555 PP
   S: 275  ...............................................kkkYeLiavvvHsG.slssGHYvayvkn...ekgk....WllfdDskVtevkee 320
                                                          + +++L ++v+H+G s++ GHYva++++      k    W+lf+D+kV e   +
   Q: 664  lketggdveravewlfshpddqgimeddaagqsgeapqkepagsatlPARFQLQSIVCHKGtSIHAGHYVAFIRKtleG--KetptWVLFNDEKVVEA--H 760
           55666666666666666666666667777777777777788888888****************************6541..24678*********988..5 PP
   S: 321  evleetgstaYvlfYkr 337
           +v+e++ + aYv+f+kr
   Q: 761  DVEEMR-KFAYVYFFKR 776
           666644.79******98 PP

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGFdreealqaLraa.nnnleaAveyLldg 41
           d  +++ql++MGF+r++a +aL a+ n +++aA+e+L+ +
   Q: 582  DATAIAQLEAMGFPRNRAEKALHATgNSDANAAMEWLFAH 621
           5679*********************************976 PP

Organism

Trichoderma reesei

Protein Sequence
(Fasta)

MSCPHLDSVE LKPPTPAQSV YKEDCTQCFD SIDSPGGLDV CLQCFNGGCT GDREHSPLHN 60
AVWSHPLALN IRRTRKTVHR DEPPAKMTKL AIAAETEEDR YDTALTAKCI ECQKELDLTN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCGTGCC CGCATCTCGA CTCTGTCGGT ACGTCAAAAT TGTTACCCCG CCACCTCGTA 60
GCTTCGCAGC TCTTTCGCAG CCATCGTCAA GTCACGGAAG CTGACCTGTT CTGTTGTCAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

tre:TRIREDRAFT_82458

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000394	Aegilops tauschii	32.87	2.00e-101	362.00
IUUC-Aml-002104	Ailuropoda melanoleuca	34.65	1.00e-127	449.00
IUUC-Atr-002580	Amborella trichopoda	34.06	2.00e-106	378.00
IUUC-Apl-003774	Anas platyrhynchos	34.90	9.00e-125	439.00
IUUC-Aca-005368	Anolis carolinensis	35.36	6.00e-134	469.00
IUUC-Aly-005727	Arabidopsis lyrata	36.24	2.00e-123	435.00
IUUC-Ath-006974	Arabidopsis thaliana	36.36	7.00e-124	436.00
IUUC-Ago-007890	Ashbya gossypii	32.40	2.00e-111	395.00
IUUC-Acl-008057	Aspergillus clavatus	55.60	0.00e+00	882.00
IUUC-Afl-008547	Aspergillus flavus	58.13	0.00e+00	788.00
IUUC-Afu-008805	Aspergillus fumigatus	53.76	0.00e+00	790.00
IUUC-Ani-009441	Aspergillus nidulans	53.03	0.00e+00	703.00
IUUC-Ang-009720	Aspergillus niger	57.00	0.00e+00	899.00
IUUC-Aor-010111	Aspergillus oryzae	58.68	0.00e+00	948.00
IUUC-Ate-010531	Aspergillus terreus	54.51	0.00e+00	829.00
IUUC-Ame-011893	Astyanax mexicanus	34.83	6.00e-107	380.00
IUUC-Bgr-012183	Blumeria graminis	61.68	0.00e+00	979.00
IUUC-Bta-013179	Bos taurus	35.04	4.00e-127	447.00
IUUC-Bci-013858	Botrytis cinerea	67.43	0.00e+00	1123.00
IUUC-Bdi-014904	Brachypodium distachyon	34.44	1.00e-108	385.00
IUUC-Bol-015536	Brassica oleracea	36.35	5.00e-124	436.00
IUUC-Bra-017939	Brassica rapa	36.57	2.00e-125	441.00
IUUC-Cel-018625	Caenorhabditis elegans	31.43	3.00e-85	307.00
IUUC-Cja-019063	Callithrix jacchus	34.15	1.00e-125	442.00
IUUC-Cfa-020976	Canis familiaris	36.04	6.00e-131	459.00
IUUC-Cpo-022265	Cavia porcellus	35.60	2.00e-130	457.00
IUUC-Cre-022640	Chlamydomonas reinhardtii	34.19	3.00e-70	257.00
IUUC-Csa-024177	Chlorocebus sabaeus	36.18	1.00e-118	418.00
IUUC-Cho-024702	Choloepus hoffmanni	32.81	1.00e-75	276.00
IUUC-Cin-025411	Ciona intestinalis	34.38	2.00e-105	375.00
IUUC-Csv-026347	Ciona savignyi	31.18	1.00e-101	362.00
IUUC-Cgl-026667	Colletotrichum gloeosporioides	75.22	0.00e+00	1142.00
IUUC-Cne-026831	Cryptococcus neoformans	46.93	0.00e+00	636.00
IUUC-Cme-027335	Cyanidioschyzon merolae	34.03	3.00e-58	218.00
IUUC-Dre-027982	Danio rerio	32.25	7.00e-104	370.00
IUUC-Dno-029034	Dasypus novemcinctus	35.35	2.00e-128	451.00
IUUC-Dor-030479	Dipodomys ordii	36.26	2.00e-58	218.00
IUUC-Dse-031467	Dothistroma septosporum	57.04	0.00e+00	878.00
IUUC-Dme-032075	Drosophila melanogaster	33.57	8.00e-111	393.00
IUUC-Ete-032865	Echinops telfairi	31.73	3.00e-106	377.00
IUUC-Eca-034059	Equus caballus	34.65	7.00e-126	442.00
IUUC-Eeu-035304	Erinaceus europaeus	35.97	7.00e-119	419.00
IUUC-Fca-035515	Felis catus	34.65	3.00e-127	447.00
IUUC-Fal-037271	Ficedula albicollis	35.85	4.00e-123	434.00
IUUC-Fox-037745	Fusarium oxysporum	80.46	0.00e+00	1266.00
IUUC-Fso-038158	Fusarium solani	81.75	0.00e+00	1284.00
IUUC-Gmo-039071	Gadus morhua	33.57	3.00e-113	400.00
IUUC-Ggr-040098	Gaeumannomyces graminis	69.27	0.00e+00	1060.00
IUUC-Gga-040635	Gallus gallus	34.66	9.00e-130	456.00
IUUC-Gac-042528	Gasterosteus aculeatus	33.96	3.00e-112	397.00
IUUC-Gma-043614	Glycine max	34.73	4.00e-116	410.00
IUUC-Ggo-044602	Gorilla gorilla	34.77	2.00e-128	451.00
IUUC-Hsa-045959	Homo sapiens	34.77	2.00e-128	451.00
IUUC-Hvu-047563	Hordeum vulgare	37.17	4.00e-104	370.00
IUUC-Itr-048712	Ictidomys tridecemlineatus	34.96	3.00e-128	451.00
IUUC-Kpa-049156	Komagataella pastoris	41.49	2.00e-176	611.00
IUUC-Lch-049648	Latimeria chalumnae	34.92	2.00e-123	434.00
IUUC-Lpe-051523	Leersia perrieri	34.18	1.00e-110	392.00
IUUC-Loc-052072	Lepisosteus oculatus	32.33	4.00e-111	394.00
IUUC-Lma-053216	Leptosphaeria maculans	64.34	0.00e+00	970.00
IUUC-Laf-054327	Loxodonta africana	34.84	5.00e-128	450.00
IUUC-Mcc-055443	Macaca mulatta	34.77	2.00e-128	451.00
IUUC-Meu-056298	Macropus eugenii	34.20	6.00e-85	306.00
IUUC-Mor-057106	Magnaporthe oryzae	71.83	0.00e+00	1149.00
IUUC-Mpo-057589	Magnaporthe poae	70.03	0.00e+00	1073.00
IUUC-Mtr-058680	Medicago truncatula	36.06	3.00e-122	431.00
IUUC-Mla-058903	Melampsora laricipopulina	43.26	1.00e-178	618.00
IUUC-Mga-059669	Meleagris gallopavo	34.40	3.00e-123	434.00
IUUC-Mvi-060476	Microbotryum violaceum	42.96	2.00e-176	611.00
IUUC-Mmr-060575	Microcebus murinus	34.88	3.00e-128	451.00
IUUC-Mdo-062183	Monodelphis domestica	34.56	5.00e-126	443.00
IUUC-Mmu-063592	Mus musculus	34.88	5.00e-129	453.00
IUUC-Mac-065634	Musa acuminata	32.65	1.00e-107	382.00
IUUC-Mpu-066082	Mustela putorius furo	35.92	8.00e-131	459.00
IUUC-Mlu-067345	Myotis lucifugus	34.22	2.00e-128	451.00
IUUC-Nfi-068558	Neosartorya fischeri	56.56	0.00e+00	853.00
IUUC-Ncr-068960	Neurospora crassa	71.09	0.00e+00	1073.00
IUUC-Nle-070173	Nomascus leucogenys	35.80	7.00e-131	459.00
IUUC-Opr-070556	Ochotona princeps	34.77	1.00e-128	452.00
IUUC-Ont-071502	Oreochromis niloticus	34.52	3.00e-116	410.00
IUUC-Oan-072959	Ornithorhynchus anatinus	40.77	3.00e-46	176.00
IUUC-Ocu-074861	Oryctolagus cuniculus	36.23	3.00e-131	460.00
IUUC-Oba-075109	Oryza barthii	34.57	3.00e-114	404.00
IUUC-Obr-076292	Oryza brachyantha	34.72	3.00e-109	387.00
IUUC-Ogl-077065	Oryza glaberrima	35.01	7.00e-121	426.00
IUUC-Ogu-078776	Oryza glumaepatula	34.47	5.00e-118	416.00
IUUC-Oin-080048	Oryza indica	35.52	1.00e-120	425.00
IUUC-Olo-080711	Oryza longistaminata	33.93	3.00e-106	377.00
IUUC-Ome-081506	Oryza meridionalis	34.68	2.00e-107	381.00
IUUC-Oni-082320	Oryza nivara	33.73	1.00e-112	398.00
IUUC-Opu-083801	Oryza punctata	34.69	9.00e-109	386.00
IUUC-Oru-085139	Oryza rufipogon	33.73	2.00e-112	398.00
IUUC-Osa-085713	Oryza sativa	35.14	1.00e-121	429.00
IUUC-Ola-086951	Oryzias latipes	32.63	7.00e-107	380.00
IUUC-Olu-087822	Ostreococcus lucimarinus	32.20	3.00e-100	357.00
IUUC-Oga-088625	Otolemur garnettii	34.53	2.00e-127	448.00
IUUC-Oar-089995	Ovis aries	34.69	8.00e-127	446.00
IUUC-Ptr-090640	Pan troglodytes	35.57	4.00e-131	460.00
IUUC-Pan-091974	Papio anubis	34.49	1.00e-128	452.00
IUUC-Psi-093957	Pelodiscus sinensis	34.81	6.00e-133	466.00
IUUC-Pma-094242	Petromyzon marinus	39.12	6.00e-70	256.00
IUUC-Pno-094835	Phaeosphaeria nodorum	62.25	0.00e+00	871.00
IUUC-Ppa-095901	Physcomitrella patens	37.72	1.00e-133	468.00
IUUC-Pfo-097148	Poecilia formosa	34.01	3.00e-117	414.00
IUUC-Pab-098068	Pongo abelii	32.28	3.00e-108	384.00
IUUC-Pop-098943	Populus trichocarpa	35.23	6.00e-117	413.00
IUUC-Pca-100738	Procavia capensis	35.35	2.00e-93	335.00
IUUC-Ppe-101315	Prunus persica	34.77	4.00e-117	414.00
IUUC-Pva-102154	Pteropus vampyrus	34.19	3.00e-125	441.00
IUUC-Pgr-103343	Puccinia graminis	44.21	5.00e-151	526.00
IUUC-Ptt-103928	Puccinia triticina	38.63	3.00e-148	517.00
IUUC-Pte-104306	Pyrenophora teres	63.65	0.00e+00	924.00
IUUC-Pyt-104696	Pyrenophora triticirepentis	62.27	0.00e+00	937.00
IUUC-Rno-105801	Rattus norvegicus	34.77	1.00e-128	452.00
IUUC-Sce-106304	Saccharomyces cerevisiae	33.25	6.00e-115	406.00
IUUC-Sha-107635	Sarcophilus harrisii	34.89	3.00e-127	447.00
IUUC-Sja-107678	Schizosaccharomyces japonicus	43.63	7.00e-179	619.00
IUUC-Spo-108144	Schizosaccharomyces pombe	42.55	5.00e-177	612.00
IUUC-Smo-108703	Selaginella moellendorffii	38.25	6.00e-123	433.00
IUUC-Sit-110728	Setaria italica	35.30	2.00e-120	425.00
IUUC-Sly-111523	Solanum lycopersicum	36.67	4.00e-129	453.00
IUUC-Sar-113733	Sorex araneus	34.79	6.00e-57	214.00
IUUC-Sbi-114419	Sorghum bicolor	34.81	9.00e-116	409.00
IUUC-Sre-115225	Sporisorium reilianum	45.45	0.00e+00	638.00
IUUC-Ssc-115686	Sus scrofa	34.77	1.00e-127	449.00
IUUC-Tgu-117346	Taeniopygia guttata	34.19	6.00e-126	443.00
IUUC-Tru-118350	Takifugu rubripes	32.99	2.00e-113	401.00
IUUC-Tsy-119278	Tarsius syrichta	31.16	2.00e-88	318.00
IUUC-Tni-120658	Tetraodon nigroviridis	33.02	8.00e-107	379.00
IUUC-Tca-121585	Theobroma cacao	35.29	7.00e-118	416.00
IUUC-Tvi-122303	Trichoderma virens	90.90	0.00e+00	1420.00
IUUC-Tae-125848	Triticum aestivum	34.79	2.00e-115	408.00
IUUC-Tur-126732	Triticum urartu	32.65	7.00e-106	376.00
IUUC-Tme-126909	Tuber melanosporum	61.65	0.00e+00	936.00
IUUC-Tbe-127261	Tupaia belangeri	31.53	2.00e-73	268.00
IUUC-Ttr-129119	Tursiops truncatus	35.87	4.00e-59	221.00
IUUC-Uma-129599	Ustilago maydis	44.46	0.00e+00	663.00
IUUC-Vda-129688	Verticillium dahliae	74.97	0.00e+00	1147.00
IUUC-Vpa-130170	Vicugna pacos	34.44	1.00e-47	183.00
IUUC-Vvi-131116	Vitis vinifera	35.65	1.00e-113	402.00
IUUC-Xtr-131953	Xenopus tropicalis	33.91	1.00e-112	399.00
IUUC-Xma-133837	Xiphophorus maculatus	33.77	1.00e-116	412.00
IUUC-Yli-134510	Yarrowia lipolytica	44.93	4.00e-178	616.00
IUUC-Zma-135786	Zea mays	35.42	4.00e-109	387.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence