iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO	FFGED
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	dbPTM	UniProt
PHOSIDA	BioGRID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Other/Other	57.53	5.00e-67	251.00	IUUC-Hsa-046907

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Saccharomyces cerevisiae

Functional Description
(View)

GTP shows a positive allosteric effect, and tetrahydrobiopterin inhibits the enzyme activity.

Protein Sequence
(Fasta)

MHNIQLVQEI ERHETPLNIR PTSPYTLNPP VERDGFSWPS VGTRQRAEET EEEEKERIQR 60
ISGAIKTILT ELGEDVNREG LLDTPQRYAK AMLYFTKGYQ TNIMDDVIKN AVFEEDHDEM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCATAACA TCCAATTAGT GCAAGAGATA GAAAGACATG AAACCCCGTT AAACATTAGA 60
CCTACCTCTC CATACACTTT AAACCCTCCT GTCGAGAGAG ATGGGTTTTC TTGGCCAAGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0021--Allosteric enzyme
KW-0181--Complete proteome
KW-0289--Folate biosynthesis
KW-0342--GTP-binding
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0862--Zinc

Interpro

IPR001474--GTP_CycHdrlase_I
IPR018234--GTP_CycHdrlase_I_CS
IPR020602--GTP_CycHdrlase_I_dom

PROSITE

PS00859--GTP_CYCLOHYDROL_1_1
PS00860--GTP_CYCLOHYDROL_1_2

Pfam

PF01227--GTP_cyclohydroI

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005525--F:GTP binding
GO:0003934--F:GTP cyclohydrolase I activity
GO:0046872--F:metal ion binding
GO:0035998--P:7,8-dihydroneopterin 3'-triphosphate biosynthetic process
GO:0046656--P:folic acid biosynthetic process
GO:0009396--P:folic acid-containing compound biosynthetic process
GO:0046654--P:tetrahydrofolate biosynthetic process

KEGG

sce:YGR267C

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Atr-002530	Amborella trichopoda	41.56	1.00e-28	119.00
IUUC-Apl-004135	Anas platyrhynchos	70.00	2.00e-64	236.00
IUUC-Aca-005252	Anolis carolinensis	64.80	4.00e-66	241.00
IUUC-Aly-006454	Arabidopsis lyrata	41.76	4.00e-29	120.00
IUUC-Ath-006744	Arabidopsis thaliana	41.21	6.00e-29	119.00
IUUC-Ago-007744	Ashbya gossypii	79.83	1.00e-101	359.00
IUUC-Acl-008058	Aspergillus clavatus	66.98	3.00e-85	306.00
IUUC-Afl-008668	Aspergillus flavus	68.06	1.00e-86	310.00
IUUC-Afu-008935	Aspergillus fumigatus	66.97	3.00e-86	309.00
IUUC-Ani-009207	Aspergillus nidulans	67.13	1.00e-84	304.00
IUUC-Ang-009686	Aspergillus niger	67.71	6.00e-86	308.00
IUUC-Aor-010202	Aspergillus oryzae	68.61	5.00e-91	325.00
IUUC-Ate-010518	Aspergillus terreus	68.16	3.00e-90	322.00
IUUC-Ame-010958	Astyanax mexicanus	59.62	1.00e-69	253.00
IUUC-Bgr-012060	Blumeria graminis	57.48	6.00e-71	258.00
IUUC-Bta-012416	Bos taurus	65.36	4.00e-67	245.00
IUUC-Bci-013811	Botrytis cinerea	56.39	1.00e-74	270.00
IUUC-Bdi-014794	Brachypodium distachyon	39.51	8.00e-24	102.00
IUUC-Bol-015182	Brassica oleracea	42.20	2.00e-30	124.00
IUUC-Bra-016764	Brassica rapa	41.38	2.00e-29	121.00
IUUC-Cel-018345	Caenorhabditis elegans	65.95	6.00e-72	261.00
IUUC-Cja-019848	Callithrix jacchus	69.85	5.00e-56	207.00
IUUC-Cfa-020630	Canis familiaris	66.48	1.00e-68	250.00
IUUC-Cpo-021420	Cavia porcellus	69.46	9.00e-67	243.00
IUUC-Cre-022618	Chlamydomonas reinhardtii	43.48	1.00e-36	144.00
IUUC-Csa-023403	Chlorocebus sabaeus	61.08	9.00e-54	201.00
IUUC-Cho-024907	Choloepus hoffmanni	66.48	8.00e-69	251.00
IUUC-Cin-025120	Ciona intestinalis	63.39	6.00e-61	224.00
IUUC-Csv-026259	Ciona savignyi	62.64	6.00e-68	247.00
IUUC-Cgl-026508	Colletotrichum gloeosporioides	61.97	2.00e-78	283.00
IUUC-Cne-026810	Cryptococcus neoformans	61.24	2.00e-72	264.00
IUUC-Cme-027139	Cyanidioschyzon merolae	54.05	9.00e-53	197.00
IUUC-Dre-028815	Danio rerio	66.48	1.00e-68	250.00
IUUC-Dno-029017	Dasypus novemcinctus	67.80	3.00e-69	252.00
IUUC-Dor-030417	Dipodomys ordii	69.92	7.00e-55	203.00
IUUC-Dse-031187	Dothistroma septosporum	64.19	1.00e-85	307.00
IUUC-Dme-031615	Drosophila melanogaster	62.01	1.00e-56	210.00
IUUC-Ete-032727	Echinops telfairi	46.76	7.00e-30	121.00
IUUC-Eca-033487	Equus caballus	70.59	1.00e-55	206.00
IUUC-Eeu-034696	Erinaceus europaeus	68.86	2.00e-66	243.00
IUUC-Fca-035975	Felis catus	69.74	2.00e-26	107.00
IUUC-Fal-037439	Ficedula albicollis	70.27	6.00e-60	220.00
IUUC-Fox-037781	Fusarium oxysporum	64.32	6.00e-72	261.00
IUUC-Fso-038377	Fusarium solani	63.38	4.00e-74	269.00
IUUC-Gmo-038945	Gadus morhua	64.29	2.00e-65	239.00
IUUC-Ggr-039834	Gaeumannomyces graminis	61.03	2.00e-76	276.00
IUUC-Gga-040495	Gallus gallus	67.60	4.00e-69	251.00
IUUC-Gac-042306	Gasterosteus aculeatus	65.92	6.00e-68	248.00
IUUC-Gma-043539	Glycine max	41.14	4.00e-31	127.00
IUUC-Ggo-045597	Gorilla gorilla	55.69	4.00e-50	188.00
IUUC-Hsa-046907	Homo sapiens	68.26	5.00e-66	241.00
IUUC-Hvu-047298	Hordeum vulgare	36.68	8.00e-30	122.00
IUUC-Itr-048997	Ictidomys tridecemlineatus	65.92	3.00e-68	248.00
IUUC-Kpa-049319	Komagataella pastoris	75.98	3.00e-102	362.00
IUUC-Lch-049771	Latimeria chalumnae	67.04	1.00e-69	253.00
IUUC-Lpe-050904	Leersia perrieri	39.33	6.00e-28	116.00
IUUC-Loc-052063	Lepisosteus oculatus	67.60	3.00e-69	252.00
IUUC-Lma-053280	Leptosphaeria maculans	52.14	2.00e-61	228.00
IUUC-Laf-054214	Loxodonta africana	59.24	6.00e-69	251.00
IUUC-Mcc-054778	Macaca mulatta	68.26	4.00e-66	242.00
IUUC-Meu-056598	Macropus eugenii	68.66	5.00e-21	92.40
IUUC-Mor-056989	Magnaporthe oryzae	62.44	2.00e-76	276.00
IUUC-Mpo-057591	Magnaporthe poae	61.50	2.00e-76	276.00
IUUC-Mtr-057924	Medicago truncatula	44.52	4.00e-33	133.00
IUUC-Mla-058931	Melampsora laricipopulina	64.32	2.00e-69	253.00
IUUC-Mga-060001	Meleagris gallopavo	70.59	2.00e-56	208.00
IUUC-Mvi-060513	Microbotryum violaceum	59.91	5.00e-73	265.00
IUUC-Mmr-061725	Microcebus murinus	66.48	1.00e-68	250.00
IUUC-Mdo-062715	Monodelphis domestica	66.48	1.00e-68	251.00
IUUC-Mmu-063203	Mus musculus	68.86	2.00e-66	243.00
IUUC-Mac-065392	Musa acuminata	44.38	2.00e-34	136.00
IUUC-Mpu-066174	Mustela putorius furo	66.48	9.00e-69	251.00
IUUC-Mlu-067883	Myotis lucifugus	69.85	4.00e-56	207.00
IUUC-Nfi-068317	Neosartorya fischeri	66.97	3.00e-86	309.00
IUUC-Ncr-068822	Neurospora crassa	63.77	8.00e-76	275.00
IUUC-Nle-069231	Nomascus leucogenys	68.26	4.00e-66	241.00
IUUC-Opr-070417	Ochotona princeps	70.68	9.00e-55	203.00
IUUC-Ont-072168	Oreochromis niloticus	64.80	2.00e-67	246.00
IUUC-Oan-072690	Ornithorhynchus anatinus	71.05	1.00e-26	108.00
IUUC-Ocu-074537	Oryctolagus cuniculus	66.48	6.00e-68	248.00
IUUC-Oba-075333	Oryza barthii	39.74	2.00e-28	118.00
IUUC-Obr-076255	Oryza brachyantha	41.10	4.00e-27	112.00
IUUC-Ogl-077792	Oryza glaberrima	39.33	2.00e-28	117.00
IUUC-Ogu-078354	Oryza glumaepatula	39.33	5.00e-28	116.00
IUUC-Oin-079934	Oryza indica	34.85	8.00e-28	115.00
IUUC-Olo-080643	Oryza longistaminata	39.88	1.00e-25	108.00
IUUC-Ome-081632	Oryza meridionalis	35.90	3.00e-28	117.00
IUUC-Oni-083004	Oryza nivara	34.85	7.00e-28	116.00
IUUC-Opu-083899	Oryza punctata	35.35	8.00e-29	119.00
IUUC-Oru-084386	Oryza rufipogon	34.85	6.00e-28	116.00
IUUC-Osa-085665	Oryza sativa	39.88	5.00e-26	109.00
IUUC-Ola-086577	Oryzias latipes	67.57	1.00e-70	257.00
IUUC-Olu-087867	Ostreococcus lucimarinus	47.62	7.00e-44	167.00
IUUC-Oga-088652	Otolemur garnettii	68.86	1.00e-65	240.00
IUUC-Oar-089965	Ovis aries	65.92	3.00e-68	249.00
IUUC-Ptr-090833	Pan troglodytes	68.26	5.00e-66	241.00
IUUC-Psi-093542	Pelodiscus sinensis	68.00	5.00e-59	218.00
IUUC-Pma-094423	Petromyzon marinus	66.42	5.00e-53	197.00
IUUC-Pno-095091	Phaeosphaeria nodorum	66.96	5.00e-83	298.00
IUUC-Ppa-096013	Physcomitrella patens	42.48	5.00e-29	120.00
IUUC-Pfo-097146	Poecilia formosa	65.92	3.00e-68	249.00
IUUC-Pab-098744	Pongo abelii	68.26	5.00e-66	241.00
IUUC-Pop-099917	Populus trichocarpa	43.51	2.00e-30	124.00
IUUC-Pca-100111	Procavia capensis	66.48	1.00e-68	250.00
IUUC-Ppe-101984	Prunus persica	40.91	5.00e-28	116.00
IUUC-Pva-103078	Pteropus vampyrus	64.84	3.00e-67	246.00
IUUC-Pgr-103438	Puccinia graminis	62.70	3.00e-67	246.00
IUUC-Ptt-103875	Puccinia triticina	61.73	3.00e-67	246.00
IUUC-Pte-104180	Pyrenophora teres	66.81	1.00e-81	294.00
IUUC-Pyt-104552	Pyrenophora triticirepentis	64.05	2.00e-82	296.00
IUUC-Rno-105506	Rattus norvegicus	65.92	3.00e-68	249.00
IUUC-Sha-107585	Sarcophilus harrisii	67.65	8.00e-55	203.00
IUUC-Sja-107871	Schizosaccharomyces japonicus	63.00	2.00e-80	289.00
IUUC-Spo-108282	Schizosaccharomyces pombe	62.45	1.00e-80	290.00
IUUC-Smo-109561	Selaginella moellendorffii	43.09	1.00e-33	135.00
IUUC-Sit-110577	Setaria italica	37.79	4.00e-26	110.00
IUUC-Sly-111719	Solanum lycopersicum	41.56	2.00e-30	124.00
IUUC-Stu-112752	Solanum tuberosum	41.67	2.00e-31	128.00
IUUC-Sar-113701	Sorex araneus	64.13	3.00e-68	249.00
IUUC-Sbi-114308	Sorghum bicolor	35.64	7.00e-29	119.00
IUUC-Sre-115125	Sporisorium reilianum	58.99	4.00e-74	270.00
IUUC-Tgu-117039	Taeniopygia guttata	70.59	2.00e-56	208.00
IUUC-Tru-117939	Takifugu rubripes	58.04	8.00e-70	254.00
IUUC-Tsy-118852	Tarsius syrichta	58.65	2.00e-42	162.00
IUUC-Tni-120356	Tetraodon nigroviridis	65.36	9.00e-68	247.00
IUUC-Tca-121422	Theobroma cacao	42.86	2.00e-31	128.00
IUUC-Tre-122035	Trichoderma reesei	62.74	1.00e-77	280.00
IUUC-Tvi-122649	Trichoderma virens	63.68	2.00e-78	283.00
IUUC-Tae-124146	Triticum aestivum	36.18	4.00e-30	123.00
IUUC-Tme-127015	Tuber melanosporum	65.33	8.00e-84	301.00
IUUC-Tbe-128024	Tupaia belangeri	58.65	2.00e-42	162.00
IUUC-Ttr-128474	Tursiops truncatus	57.73	4.00e-69	252.00
IUUC-Uma-129655	Ustilago maydis	59.35	2.00e-74	271.00
IUUC-Vda-129970	Verticillium dahliae	58.12	4.00e-77	279.00
IUUC-Vpa-130564	Vicugna pacos	70.68	4.00e-55	204.00
IUUC-Vvi-131597	Vitis vinifera	43.17	7.00e-33	132.00
IUUC-Xtr-132201	Xenopus tropicalis	62.38	1.00e-69	253.00
IUUC-Xma-133679	Xiphophorus maculatus	65.92	3.00e-68	249.00
IUUC-Yli-134489	Yarrowia lipolytica	77.63	1.00e-101	360.00
IUUC-Zma-135058	Zea mays	35.32	1.00e-28	118.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence