iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ptr-091039

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AACZ03038602

Gene Name

FBXW11

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000017526.5	ENSPTRT00000032395.3	ENSPTRP00000029931.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	4.20e-57	187.5	441	475
UBD/Beta-Prp	2.00e-69	234.0	354	519

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclafsd.tllvsGsdDgtikvWDlrtgvl 35
           gH++ v+c++f d +++vsG++Dg+ikvWDl    +
   Q: 441  GHEELVRCIRF-DnKRIVSGAYDGKIKVWDLQAALD 475
           8**********.44****************977665 PP

UBD/Beta-Prp

   S: 43   kllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqclee 131
           +l r l gh a+v+ v+f+++  ++v++s Drtikvw+ st++ v+tl+gh++ + +l++      +vsGs+d+tir+wd+e g cl+ 
   Q: 354  TLRRVLVGHRAAVNVVDFDDK--YIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRD--RLVVSGSSDNTIRLWDIECGACLR- 437
           4556679*************9..8**************************************..************************. PP
   S: 132  tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl.........ktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdl 209
           +l+gh+++v+c++++   + +vsG++D+++++Wdl         ++  +lrtl + h ++v  l+fd+  ++++s s+d t+ +wd+
   Q: 438  VLEGHEELVRCIRFDN--KRIVSGAYDGKIKVWDLqaaldprapASTLCLRTLVE-HSGRVFRLQFDE--FQIISSSHDDTILIWDF 519
           ***************9..***********************************99.************..99**************7 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MEPDSVIEDK TIELMCSVPR SLWLGCANLV ESMCALSCLQ SMPSVRCLQI SNGTSSVIVS 60
RKRPSEGNYQ KEKDLCIKYF DQWSESDQVE FVEHLISRMC HYQHGHINSY LKPMLQRDFI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTAGTCGTGG CGCTCTCGAG GCCCTACCAT GAGCAAGCTC TTAACTCTTC AGGTCTGCAC 60
GTCCTACGTC CACAGTCCAG TGCTACTCTC AGCTCGGAGT TCAGCTTCGG GCTGCCAAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR021977--Beta-TrCP_D
IPR001810--F-box_dom
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12125--Beta-TrCP_D
PF12937--F-box-like
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM01028--Beta-TrCP_D
SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:0005813--C:centrosome
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0042347--P:negative regulation of NF-kappaB import into nucleus
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0042753--P:positive regulation of circadian rhythm
GO:0045862--P:positive regulation of proteolysis
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006470--P:protein dephosphorylation
GO:0031648--P:protein destabilization
GO:0000209--P:protein polyubiquitination
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001397	Ailuropoda melanoleuca	99.82	0.00e+00	1118.00
IUUC-Apl-003449	Anas platyrhynchos	94.58	0.00e+00	1067.00
IUUC-Ame-011174	Astyanax mexicanus	83.92	0.00e+00	984.00
IUUC-Bta-012920	Bos taurus	99.80	0.00e+00	1021.00
IUUC-Bci-013685	Botrytis cinerea	30.72	5.00e-54	205.00
IUUC-Cel-018392	Caenorhabditis elegans	63.16	0.00e+00	634.00
IUUC-Cja-018879	Callithrix jacchus	99.82	0.00e+00	1118.00
IUUC-Cfa-020021	Canis familiaris	99.82	0.00e+00	1118.00
IUUC-Cpo-022151	Cavia porcellus	99.39	0.00e+00	1013.00
IUUC-Csa-024095	Chlorocebus sabaeus	99.80	0.00e+00	1020.00
IUUC-Cho-024658	Choloepus hoffmanni	99.62	9.00e-156	543.00
IUUC-Cin-025188	Ciona intestinalis	80.42	0.00e+00	824.00
IUUC-Csv-026020	Ciona savignyi	78.75	0.00e+00	781.00
IUUC-Dre-028160	Danio rerio	92.34	0.00e+00	953.00
IUUC-Dno-029485	Dasypus novemcinctus	88.96	0.00e+00	890.00
IUUC-Dor-030498	Dipodomys ordii	99.24	0.00e+00	1081.00
IUUC-Dme-031885	Drosophila melanogaster	80.63	0.00e+00	810.00
IUUC-Ete-032978	Echinops telfairi	70.43	0.00e+00	735.00
IUUC-Eca-033804	Equus caballus	99.80	0.00e+00	1035.00
IUUC-Fca-035887	Felis catus	94.11	0.00e+00	1037.00
IUUC-Fal-036783	Ficedula albicollis	95.29	0.00e+00	1036.00
IUUC-Fox-037978	Fusarium oxysporum	33.56	2.00e-60	227.00
IUUC-Fso-038077	Fusarium solani	32.52	1.00e-55	211.00
IUUC-Gmo-038590	Gadus morhua	88.03	0.00e+00	975.00
IUUC-Gga-040628	Gallus gallus	94.92	0.00e+00	1031.00
IUUC-Gac-041305	Gasterosteus aculeatus	88.58	0.00e+00	992.00
IUUC-Ggo-044604	Gorilla gorilla	99.82	0.00e+00	1118.00
IUUC-Hsa-046139	Homo sapiens	99.82	0.00e+00	1118.00
IUUC-Itr-047872	Ictidomys tridecemlineatus	88.49	0.00e+00	827.00
IUUC-Lch-050460	Latimeria chalumnae	97.37	0.00e+00	997.00
IUUC-Loc-052686	Lepisosteus oculatus	88.51	0.00e+00	925.00
IUUC-Laf-053968	Loxodonta africana	96.09	0.00e+00	1107.00
IUUC-Mcc-055822	Macaca mulatta	91.40	0.00e+00	1061.00
IUUC-Meu-056078	Macropus eugenii	79.10	0.00e+00	764.00
IUUC-Mga-059225	Meleagris gallopavo	98.79	0.00e+00	1006.00
IUUC-Mvi-060284	Microbotryum violaceum	44.95	1.00e-69	258.00
IUUC-Mmr-060746	Microcebus murinus	99.82	0.00e+00	1118.00
IUUC-Mdo-062005	Monodelphis domestica	99.19	0.00e+00	1015.00
IUUC-Mmu-063851	Mus musculus	96.09	0.00e+00	1107.00
IUUC-Mpu-065716	Mustela putorius furo	99.80	0.00e+00	1021.00
IUUC-Mlu-067001	Myotis lucifugus	99.80	0.00e+00	1020.00
IUUC-Nle-069788	Nomascus leucogenys	93.54	0.00e+00	1031.00
IUUC-Opr-071229	Ochotona princeps	99.63	0.00e+00	1117.00
IUUC-Ont-071792	Oreochromis niloticus	89.57	0.00e+00	998.00
IUUC-Oan-072782	Ornithorhynchus anatinus	95.29	0.00e+00	1036.00
IUUC-Ocu-074894	Oryctolagus cuniculus	96.09	0.00e+00	1107.00
IUUC-Ola-086985	Oryzias latipes	85.87	0.00e+00	998.00
IUUC-Oga-088604	Otolemur garnettii	99.60	0.00e+00	1018.00
IUUC-Oar-090412	Ovis aries	95.86	0.00e+00	1041.00
IUUC-Pan-092770	Papio anubis	95.93	0.00e+00	1059.00
IUUC-Psi-093887	Pelodiscus sinensis	94.01	0.00e+00	1061.00
IUUC-Pma-094315	Petromyzon marinus	83.23	0.00e+00	845.00
IUUC-Pno-094808	Phaeosphaeria nodorum	29.50	2.00e-45	177.00
IUUC-Pfo-096783	Poecilia formosa	86.22	0.00e+00	1003.00
IUUC-Pva-102547	Pteropus vampyrus	99.63	0.00e+00	1104.00
IUUC-Ptt-103853	Puccinia triticina	32.75	2.00e-60	226.00
IUUC-Rno-105246	Rattus norvegicus	95.86	0.00e+00	1042.00
IUUC-Sha-107339	Sarcophilus harrisii	99.19	0.00e+00	1015.00
IUUC-Sja-107743	Schizosaccharomyces japonicus	35.38	3.00e-74	272.00
IUUC-Spo-108200	Schizosaccharomyces pombe	31.92	2.00e-66	246.00
IUUC-Ssc-115490	Sus scrofa	87.90	0.00e+00	918.00
IUUC-Tgu-116541	Taeniopygia guttata	94.57	0.00e+00	1068.00
IUUC-Tru-117671	Takifugu rubripes	85.16	0.00e+00	989.00
IUUC-Tsy-118983	Tarsius syrichta	81.10	0.00e+00	876.00
IUUC-Tni-120359	Tetraodon nigroviridis	85.79	0.00e+00	939.00
IUUC-Tbe-127418	Tupaia belangeri	93.55	0.00e+00	1004.00
IUUC-Ttr-129131	Tursiops truncatus	99.82	0.00e+00	1117.00
IUUC-Vpa-130668	Vicugna pacos	99.44	0.00e+00	1106.00
IUUC-Xtr-132861	Xenopus tropicalis	76.90	0.00e+00	929.00
IUUC-Xma-133187	Xiphophorus maculatus	95.36	8.00e-158	548.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence