iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Post-translational Modifications (PTMs)
dbPAF	dbPTM	Phospho.ELM	UniProt
PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.30e-21	75.8	214	247

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWDlrt 32
           gH d+v +++f   ++++vs++ D+++k+W l t
   Q: 214  GHRDEVLSIDFnmRGDRIVSSGMDHSLKLWCLNT 247
           8**********776699*************9866 PP

Organism

Drosophila melanogaster

Functional Description
(View)

Polycomb group (PcG) protein. While PcG proteins are generally required to maintain the transcriptionally repressive state of homeotic genes throughout development, this protein is specifically required during the first 6 hours of embryogenesis to establish the repressed state. Component of the Esc/E(z) complex, which methylates 'Lys-9' and 'Lys-27' residues of histone H3, leading to transcriptional repression of the affected target gene. The Esc/E(z) complex is necessary but not sufficient for the repression of homeotic target genes, suggesting that the recruitment of the distinct PRC1 complex is also required.

Protein Sequence
(Fasta)

MSSDKVKNGN EPEESEESCG DESASYTTNS TTSRSKSPSS STRSKRRGRR STKSKPKSRA 60
AYKYDTHVKE NHGANIFGVA FNTLLGKDEP QVFATAGSNR VTVYECPRQG GMQLLHCYAD 120

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Nucleotide Sequence
(Fasta)

CTGGGTATTT TACGCGATCC GTGACTGGGG TCACACCATT GCCGCCAAAA AAAAACATTT 60
TCATTCGCCT CGTTATTTAA ACATTTAAAA AAAGCATTAT CGAATAGTTC ATTGAAGTCG 120

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Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0853--WD repeat

Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0035098--C:ESC/E(Z) complex
GO:0035097--C:histone methyltransferase complex
GO:0000790--C:nuclear chromatin
GO:0005634--C:nucleus
GO:0005700--C:polytene chromosome
GO:0008047--F:enzyme activator activity
GO:0042802--F:identical protein binding
GO:0006342--P:chromatin silencing
GO:0048096--P:chromatin-mediated maintenance of transcription
GO:0048813--P:dendrite morphogenesis
GO:0016458--P:gene silencing
GO:0070734--P:histone H3-K27 methylation
GO:0051567--P:histone H3-K9 methylation
GO:0016571--P:histone methylation
GO:0007517--P:muscle organ development
GO:0048666--P:neuron development
GO:0031062--P:positive regulation of histone methylation
GO:0006351--P:transcription, DNA-templated

KEGG

dme:Dmel_CG14941

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000689	Aegilops tauschii	38.08	2.00e-67	248.00
IUUC-Atr-002496	Amborella trichopoda	38.57	4.00e-66	244.00
IUUC-Aly-005980	Arabidopsis lyrata	38.74	5.00e-74	270.00
IUUC-Ath-006579	Arabidopsis thaliana	39.29	6.00e-75	273.00
IUUC-Bdi-014553	Brachypodium distachyon	39.53	2.00e-70	258.00
IUUC-Bol-016522	Brassica oleracea	38.19	6.00e-74	270.00
IUUC-Bra-017137	Brassica rapa	38.19	4.00e-74	270.00
IUUC-Cel-018494	Caenorhabditis elegans	26.51	5.00e-31	127.00
IUUC-Dse-031324	Dothistroma septosporum	25.30	1.00e-27	117.00
IUUC-Hvu-047228	Hordeum vulgare	33.68	3.00e-28	117.00
IUUC-Ogl-077522	Oryza glaberrima	40.41	2.00e-72	265.00
IUUC-Opu-083537	Oryza punctata	38.65	5.00e-71	260.00
IUUC-Olu-087788	Ostreococcus lucimarinus	30.63	1.00e-49	189.00
IUUC-Pno-095072	Phaeosphaeria nodorum	23.77	2.00e-18	85.90
IUUC-Pop-098930	Populus trichocarpa	38.74	1.00e-73	269.00
IUUC-Pgr-103619	Puccinia graminis	26.60	2.00e-20	92.40
IUUC-Smo-109638	Selaginella moellendorffii	39.39	3.00e-73	268.00
IUUC-Sbi-114023	Sorghum bicolor	39.53	4.00e-73	267.00
IUUC-Tca-121787	Theobroma cacao	38.86	2.00e-74	271.00
IUUC-Tae-124694	Triticum aestivum	38.08	3.00e-67	248.00
IUUC-Zma-135593	Zea mays	39.83	1.00e-73	269.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence