iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cfa-021236

Ensembl Protein ID

ENSCAFP00000021856.3

UniProt Accession

F1PG28; F1PG28_CANLF

Genbank Protein ID

ENSCAFP00000021856

Protein Name

Protein kinase C

Genbank Nucleotide ID

AAEX03017373

Gene Name

PRKCI

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000014823.3	ENSCAFT00000023541.3	ENSCAFP00000021856.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UDP/UFD/PB1	1.60e-21	76.6	132	213

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UFD/PB1

   S: 1    tvrvkvsykgeirsfaldlekpgkfedLlkavrtltelkn.sevalkYeDedGDlvtlksDedldkavslla.skksllrlliq 82
           +vrvk++y+g+i  + +++e++++fe L+++vr++++++n + +++k+ De+GD +t++s+ +l++a++l++ +k+s l ++++
   Q: 132  QVRVKAYYRGDI--MITHFEPSISFEGLCNEVRDMCSFDNeQLFTMKWIDEEGDPCTVSSQLELEEAFRLYElNKDSELLIHVF 213
           69**********..88******************************************************************98 PP

Organism

Canis familiaris

Protein Sequence
(Fasta)

MLGWSRPPSP GMCAFGAGEV GGPGGEACWA RREEPRGSGC PGQAPLGSGG PRRWPSGRPC 60
GRPSGRPSGR PSGRLCSGAR PPPPPPPPAP GAPPAASASA LGRGSREMPT QRDSSAMSHA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGGGCGCCC TTCGCGGACA GCTCTGGCCT TCCCTCAGTC GCGGGGGCCG CGGAGGCCCC 60
TCCCCGGCCC ACCGATGTGC CACCCGGCGC CGCCATCCTC CCGCCCCCCT CTCCGCGGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000961--AGC-kinase_C
IPR034661--aPKC_iota
IPR020454--DAG/PE-bd
IPR011009--Kinase-like_dom
IPR000270--PB1_dom
IPR002219--PE/DAG-bd
IPR017892--Pkinase_C
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS

PROSITE

PS51285--AGC_KINASE_CTER
PS51745--PB1
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2

Pfam

PF00130--C1_1
PF00564--PB1
PF00069--Pkinase
PF00433--Pkinase_C

PRINTS

PR00008--DAGPEDOMAIN

SMART

SM00109--C1
SM00666--PB1
SM00133--S_TK_X
SM00220--S_TKc

Gene Ontology

GO:0016324--C:apical plasma membrane
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0045171--C:intercellular bridge
GO:0005622--C:intracellular
GO:0015630--C:microtubule cytoskeleton
GO:0005634--C:nucleus
GO:0043220--C:Schmidt-Lanterman incisure
GO:0005524--F:ATP binding
GO:0046872--F:metal ion binding
GO:0005543--F:phospholipid binding
GO:0004697--F:protein kinase C activity
GO:0004674--F:protein serine/threonine kinase activity
GO:0007015--P:actin filament organization
GO:0045216--P:cell-cell junction organization
GO:0032869--P:cellular response to insulin stimulus
GO:0035089--P:establishment of apical/basal cell polarity
GO:0042462--P:eye photoreceptor cell development
GO:0035556--P:intracellular signal transduction
GO:0034351--P:negative regulation of glial cell apoptotic process
GO:0043524--P:negative regulation of neuron apoptotic process
GO:0018105--P:peptidyl-serine phosphorylation
GO:2000353--P:positive regulation of endothelial cell apoptotic process
GO:0090004--P:positive regulation of establishment of protein localization to plasma membrane
GO:0060252--P:positive regulation of glial cell proliferation
GO:0046326--P:positive regulation of glucose import
GO:0010976--P:positive regulation of neuron projection development
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001764	Ailuropoda melanoleuca	99.05	0.00e+00	1014.00
IUUC-Apl-003711	Anas platyrhynchos	95.57	0.00e+00	1066.00
IUUC-Aca-005142	Anolis carolinensis	94.60	0.00e+00	1088.00
IUUC-Ame-010977	Astyanax mexicanus	87.08	0.00e+00	1000.00
IUUC-Bta-013414	Bos taurus	98.50	0.00e+00	1176.00
IUUC-Bol-015169	Brassica oleracea	35.29	2.00e-50	194.00
IUUC-Cel-018340	Caenorhabditis elegans	56.88	0.00e+00	694.00
IUUC-Cja-019802	Callithrix jacchus	99.11	0.00e+00	1102.00
IUUC-Cpo-022127	Cavia porcellus	97.00	0.00e+00	1066.00
IUUC-Csa-023332	Chlorocebus sabaeus	98.96	0.00e+00	942.00
IUUC-Cho-025054	Choloepus hoffmanni	84.11	2.00e-70	259.00
IUUC-Cin-025740	Ciona intestinalis	59.50	0.00e+00	698.00
IUUC-Csv-026145	Ciona savignyi	78.57	2.00e-175	608.00
IUUC-Dre-028444	Danio rerio	87.92	0.00e+00	1018.00
IUUC-Dno-029228	Dasypus novemcinctus	100.00	0.00e+00	647.00
IUUC-Dme-031630	Drosophila melanogaster	79.54	3.00e-172	598.00
IUUC-Ete-032633	Echinops telfairi	73.12	0.00e+00	644.00
IUUC-Eca-033572	Equus caballus	99.11	0.00e+00	1105.00
IUUC-Eeu-035110	Erinaceus europaeus	97.96	0.00e+00	1143.00
IUUC-Fca-035559	Felis catus	98.83	0.00e+00	1171.00
IUUC-Fal-036953	Ficedula albicollis	96.26	0.00e+00	1076.00
IUUC-Gmo-039334	Gadus morhua	86.69	0.00e+00	1038.00
IUUC-Gga-040223	Gallus gallus	93.49	0.00e+00	1105.00
IUUC-Gac-042113	Gasterosteus aculeatus	87.42	0.00e+00	1039.00
IUUC-Ggo-044520	Gorilla gorilla	91.85	0.00e+00	1044.00
IUUC-Hsa-046991	Homo sapiens	98.49	0.00e+00	1176.00
IUUC-Lch-050263	Latimeria chalumnae	88.26	0.00e+00	1054.00
IUUC-Loc-052221	Lepisosteus oculatus	88.42	0.00e+00	1022.00
IUUC-Laf-053591	Loxodonta africana	98.15	0.00e+00	1169.00
IUUC-Mcc-055118	Macaca mulatta	96.14	0.00e+00	1152.00
IUUC-Mga-059886	Meleagris gallopavo	95.39	0.00e+00	1065.00
IUUC-Mmr-060926	Microcebus murinus	98.66	0.00e+00	1175.00
IUUC-Mdo-062698	Monodelphis domestica	93.55	0.00e+00	1103.00
IUUC-Mmu-063689	Mus musculus	97.82	0.00e+00	1155.00
IUUC-Mpu-066630	Mustela putorius furo	99.14	0.00e+00	1144.00
IUUC-Mlu-067416	Myotis lucifugus	94.84	0.00e+00	1115.00
IUUC-Nle-069811	Nomascus leucogenys	98.49	0.00e+00	1174.00
IUUC-Opr-070466	Ochotona princeps	86.55	0.00e+00	740.00
IUUC-Ont-072278	Oreochromis niloticus	86.68	0.00e+00	976.00
IUUC-Oan-073651	Ornithorhynchus anatinus	98.62	0.00e+00	744.00
IUUC-Ocu-074383	Oryctolagus cuniculus	98.49	0.00e+00	1172.00
IUUC-Ola-087283	Oryzias latipes	77.88	0.00e+00	791.00
IUUC-Oga-088337	Otolemur garnettii	89.42	0.00e+00	1042.00
IUUC-Oar-089954	Ovis aries	99.11	0.00e+00	1112.00
IUUC-Ptr-091673	Pan troglodytes	98.49	0.00e+00	1176.00
IUUC-Pan-092494	Papio anubis	90.46	0.00e+00	1192.00
IUUC-Psi-094044	Pelodiscus sinensis	93.25	0.00e+00	1101.00
IUUC-Pfo-096661	Poecilia formosa	86.00	0.00e+00	997.00
IUUC-Pab-097659	Pongo abelii	91.53	0.00e+00	1182.00
IUUC-Pca-101107	Procavia capensis	98.22	0.00e+00	787.00
IUUC-Rno-105790	Rattus norvegicus	97.99	0.00e+00	1160.00
IUUC-Sha-106895	Sarcophilus harrisii	97.17	0.00e+00	1070.00
IUUC-Sar-113513	Sorex araneus	98.44	3.00e-174	604.00
IUUC-Ssc-115835	Sus scrofa	98.66	0.00e+00	1016.00
IUUC-Tgu-116874	Taeniopygia guttata	93.34	0.00e+00	1106.00
IUUC-Tru-117823	Takifugu rubripes	88.21	0.00e+00	1007.00
IUUC-Tsy-119154	Tarsius syrichta	98.75	0.00e+00	1103.00
IUUC-Tni-119968	Tetraodon nigroviridis	86.12	0.00e+00	993.00
IUUC-Tbe-127238	Tupaia belangeri	79.19	0.00e+00	730.00
IUUC-Ttr-129208	Tursiops truncatus	98.66	0.00e+00	1167.00
IUUC-Vpa-130363	Vicugna pacos	88.29	0.00e+00	1001.00
IUUC-Xtr-132652	Xenopus tropicalis	86.29	0.00e+00	1033.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence