iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089526

Ensembl Protein ID

ENSOARP00000009742.1

UniProt Accession

W5PH25; W5PH25_SHEEP

Genbank Protein ID

ENSOARP00000009742

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AMGL01066649

Gene Name

USP14

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000009076.1	ENSOART00000009884.1	ENSOARP00000009742.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	9.30e-65	219.2	105	480
ULD/UDP/UBQ/UBQ_Other	1.20e-08	34.9	6	74

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs.... 85
           +Gl+NlgNtCYmN+++Qc+ ++pel+++l++ +  +l+++ +  + + ++ +l++lf ++ +++++++ p  ll+ l+++ ++f     
   Q: 105  CGLTNLGNTCYMNATVQCIRSVPELKDALKR-YAGALRASGEMASAQYITAALRDLFDSM-DKTSSSIPPIILLQFLHMAFPQFAekge 191
           7******************************.****************************.99999******************999*9 PP
   S: 86   ..gyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldl 172
             +y qqDa+E++ +++  l+++l+  ++ +++e+ ++       +a+  +++k+ksli++ F++++++++kc e +++ +++ +  +l
   Q: 192  qgQYLQQDANECWVQMMRVLQQKLEAIEDDTVKETDSS-------SASAVTPSKKKSLIDQFFGVEFETTMKCTESEEEEVTKGKESQL 273
           999*********************66555555554333.......47788999*********************999999888777777 PP
   S: 173  slpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdl 261
           +l+   ++e   + l   L+   +ee  +     ++++ +++    k+ k+++lP +L++++ Rf ++e+++++ k+ k v+fpl+Ld+
   Q: 274  QLSCFINQEV--KYLFTGLKLRLQEEITK-----QSPTLQRNALYIKSSKISRLPAYLTIQMVRFFYKEKESVNAKVLKDVKFPLMLDV 355
           7777766643..57999999999999998.....58899999999******************************************** PP
   S: 262  spfcts........................peekqke...........................kkkYeLiavvvHsG.slssGHYvay 298
            + ct                         p     +                           +  Y+L av+ H+G s+ssGHYv++
   Q: 356  YELCTPelqekmvsfrskfkdledkkvnqqP-----KtgdknsspqkevkyepfsfaddigsnnCGYYDLQAVLTHQGrSSSSGHYVSW 439
           ******6666666666666666555555551.....0555556666667777777777777777************************* PP
   S: 299  vknekgkWllfdDskVtevkeeevleetg....staYvlfY 335
           vk + ++W++fdD+kV+ v+ e++l+ +g    + aYvl+Y
   Q: 440  VKRKPDEWIKFDDDKVSIVTPEDILRLSGggdwHIAYVLLY 480
           **************************988************ PP

ULD/UDP/UBQ/UBQ_Other

   S: 3    vtvksldgseltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiLeddktLadyglkdgstihllek 72
           vtvk+ + +  ++++n +++  ++K +++ ++g++p++q+ ++kG  L+dd ++++ ++k+g+t++++ +
   Q: 6    VTVKWGKEKFEGVELNTDEPPMVFKAQLFALTGVQPARQKVMVKGGTLKDD-DWGNIKMKNGMTVLMMGS 74
           89*******99*************************************999.9**************965 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

YGLFAVTVKW GKEKFEGVEL NTDEPPMVFK AQLFALTGVQ PARQKVMVKG GTLKDDDWGN 60
IKMKNGMTVL MMGSADALPE EPSAKTVFVE DMTEEQLASA MELPCGLTNL GNTCYMNATV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TATGGTTTGT TTGCAGTTAC TGTGAAATGG GGAAAGGAGA AATTTGAAGG TGTAGAATTG 60
AATACTGATG AACCTCCGAT GGTGTTCAAG GCTCAGCTTT TTGCACTGAC TGGAGTCCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR029071--Ubiquitin-rel_dom
IPR019954--Ubiquitin_CS
IPR000626--Ubiquitin_dom
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00299--UBIQUITIN_1
PS50053--UBIQUITIN_2
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

SMART

SM00213--UBQ

Gene Ontology

GO:0009986--C:cell surface
GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0045202--C:synapse
GO:0004866--F:endopeptidase inhibitor activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0007268--P:chemical synaptic transmission
GO:1903070--P:negative regulation of ER-associated ubiquitin-dependent protein catabolic process
GO:0016579--P:protein deubiquitination
GO:0050920--P:regulation of chemotaxis
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000893	Aegilops tauschii	30.66	9.00e-65	241.00
IUUC-Aml-002053	Ailuropoda melanoleuca	97.96	0.00e+00	930.00
IUUC-Atr-002725	Amborella trichopoda	41.80	2.00e-101	362.00
IUUC-Apl-004031	Anas platyrhynchos	91.26	0.00e+00	898.00
IUUC-Aca-004361	Anolis carolinensis	89.25	0.00e+00	907.00
IUUC-Aly-006078	Arabidopsis lyrata	41.78	6.00e-112	397.00
IUUC-Ath-007623	Arabidopsis thaliana	42.38	2.00e-112	399.00
IUUC-Ago-007796	Ashbya gossypii	32.64	5.00e-59	221.00
IUUC-Acl-008258	Aspergillus clavatus	37.41	4.00e-67	249.00
IUUC-Afl-008732	Aspergillus flavus	34.15	5.00e-79	288.00
IUUC-Afu-008755	Aspergillus fumigatus	35.29	1.00e-82	300.00
IUUC-Ani-009148	Aspergillus nidulans	39.11	9.00e-73	267.00
IUUC-Ang-009878	Aspergillus niger	38.21	2.00e-67	250.00
IUUC-Aor-010239	Aspergillus oryzae	34.15	5.00e-79	288.00
IUUC-Ate-010243	Aspergillus terreus	34.74	2.00e-79	289.00
IUUC-Ame-011327	Astyanax mexicanus	50.60	2.00e-127	448.00
IUUC-Bgr-012231	Blumeria graminis	34.26	1.00e-80	294.00
IUUC-Bta-012553	Bos taurus	98.98	0.00e+00	966.00
IUUC-Bci-013606	Botrytis cinerea	40.21	1.00e-70	261.00
IUUC-Bdi-014567	Brachypodium distachyon	43.97	7.00e-113	400.00
IUUC-Bol-016127	Brassica oleracea	42.40	3.00e-114	405.00
IUUC-Bra-017501	Brassica rapa	42.20	2.00e-113	402.00
IUUC-Cel-018140	Caenorhabditis elegans	42.51	3.00e-100	358.00
IUUC-Cja-019516	Callithrix jacchus	96.36	0.00e+00	942.00
IUUC-Cfa-020808	Canis familiaris	97.76	0.00e+00	958.00
IUUC-Cpo-021688	Cavia porcellus	96.76	0.00e+00	944.00
IUUC-Cre-022663	Chlamydomonas reinhardtii	37.70	1.00e-82	300.00
IUUC-Csa-023429	Chlorocebus sabaeus	97.15	0.00e+00	923.00
IUUC-Cho-024347	Choloepus hoffmanni	96.33	0.00e+00	946.00
IUUC-Cin-025198	Ciona intestinalis	55.01	1.00e-152	533.00
IUUC-Csv-026007	Ciona savignyi	53.43	3.00e-153	534.00
IUUC-Cgl-026757	Colletotrichum gloeosporioides	38.68	4.00e-64	239.00
IUUC-Cne-026963	Cryptococcus neoformans	34.68	1.00e-75	276.00
IUUC-Cme-027240	Cyanidioschyzon merolae	31.15	8.00e-61	228.00
IUUC-Dre-027647	Danio rerio	82.79	0.00e+00	828.00
IUUC-Dno-029967	Dasypus novemcinctus	96.34	0.00e+00	922.00
IUUC-Dor-030886	Dipodomys ordii	91.36	0.00e+00	757.00
IUUC-Dse-031466	Dothistroma septosporum	35.56	9.00e-58	218.00
IUUC-Dme-032079	Drosophila melanogaster	55.28	3.00e-158	551.00
IUUC-Ete-032351	Echinops telfairi	84.96	0.00e+00	846.00
IUUC-Eca-033461	Equus caballus	96.95	0.00e+00	996.00
IUUC-Eeu-035220	Erinaceus europaeus	73.57	0.00e+00	692.00
IUUC-Fca-036210	Felis catus	97.97	0.00e+00	960.00
IUUC-Fal-037528	Ficedula albicollis	90.61	0.00e+00	873.00
IUUC-Fox-037805	Fusarium oxysporum	39.95	3.00e-71	262.00
IUUC-Fso-038177	Fusarium solani	38.42	3.00e-68	253.00
IUUC-Gmo-038953	Gadus morhua	77.51	0.00e+00	764.00
IUUC-Ggr-039972	Gaeumannomyces graminis	34.84	1.00e-75	277.00
IUUC-Gga-040462	Gallus gallus	89.84	0.00e+00	883.00
IUUC-Gac-041312	Gasterosteus aculeatus	82.27	0.00e+00	799.00
IUUC-Gma-043255	Glycine max	42.83	1.00e-108	386.00
IUUC-Ggo-045458	Gorilla gorilla	81.41	0.00e+00	788.00
IUUC-Hsa-045706	Homo sapiens	97.36	0.00e+00	926.00
IUUC-Hvu-047821	Hordeum vulgare	46.30	2.00e-57	215.00
IUUC-Itr-048654	Ictidomys tridecemlineatus	96.54	0.00e+00	948.00
IUUC-Lch-050464	Latimeria chalumnae	82.86	0.00e+00	830.00
IUUC-Lpe-051419	Leersia perrieri	42.95	2.00e-108	386.00
IUUC-Loc-052732	Lepisosteus oculatus	81.87	0.00e+00	843.00
IUUC-Lma-053177	Leptosphaeria maculans	41.56	2.00e-71	263.00
IUUC-Laf-053822	Loxodonta africana	97.96	0.00e+00	957.00
IUUC-Mcc-055893	Macaca mulatta	97.35	0.00e+00	924.00
IUUC-Meu-056307	Macropus eugenii	81.84	0.00e+00	794.00
IUUC-Mor-057171	Magnaporthe oryzae	39.90	3.00e-68	252.00
IUUC-Mpo-057415	Magnaporthe poae	37.00	4.00e-81	295.00
IUUC-Mtr-057901	Medicago truncatula	42.77	1.00e-111	396.00
IUUC-Mla-058897	Melampsora laricipopulina	40.16	1.00e-75	276.00
IUUC-Mga-060016	Meleagris gallopavo	91.06	0.00e+00	895.00
IUUC-Mvi-060562	Microbotryum violaceum	39.57	3.00e-68	252.00
IUUC-Mmr-060624	Microcebus murinus	96.95	0.00e+00	994.00
IUUC-Mdo-061809	Monodelphis domestica	92.31	0.00e+00	892.00
IUUC-Mmu-063869	Mus musculus	96.34	0.00e+00	943.00
IUUC-Mac-064876	Musa acuminata	39.68	2.00e-95	343.00
IUUC-Mpu-066480	Mustela putorius furo	97.36	0.00e+00	955.00
IUUC-Mlu-067866	Myotis lucifugus	96.75	0.00e+00	962.00
IUUC-Nfi-068393	Neosartorya fischeri	37.65	4.00e-67	249.00
IUUC-Ncr-068815	Neurospora crassa	36.17	4.00e-83	301.00
IUUC-Nle-070121	Nomascus leucogenys	97.21	4.00e-138	483.00
IUUC-Opr-070712	Ochotona princeps	76.92	7.00e-174	603.00
IUUC-Ont-071544	Oreochromis niloticus	82.21	0.00e+00	767.00
IUUC-Oan-073635	Ornithorhynchus anatinus	91.36	0.00e+00	750.00
IUUC-Ocu-074926	Oryctolagus cuniculus	95.33	0.00e+00	915.00
IUUC-Oba-075633	Oryza barthii	42.00	4.00e-109	388.00
IUUC-Obr-076423	Oryza brachyantha	42.86	2.00e-111	396.00
IUUC-Ogl-077913	Oryza glaberrima	41.84	3.00e-111	395.00
IUUC-Ogu-078435	Oryza glumaepatula	42.00	4.00e-109	388.00
IUUC-Oin-080072	Oryza indica	41.94	3.00e-109	389.00
IUUC-Olo-080535	Oryza longistaminata	39.24	6.00e-93	334.00
IUUC-Ome-081309	Oryza meridionalis	42.00	4.00e-109	388.00
IUUC-Oni-083113	Oryza nivara	42.00	4.00e-109	388.00
IUUC-Opu-083168	Oryza punctata	41.04	9.00e-104	370.00
IUUC-Oru-084253	Oryza rufipogon	42.00	4.00e-109	388.00
IUUC-Osa-085554	Oryza sativa	41.84	2.00e-111	395.00
IUUC-Ola-086998	Oryzias latipes	81.06	0.00e+00	791.00
IUUC-Olu-087818	Ostreococcus lucimarinus	36.16	1.00e-70	259.00
IUUC-Oga-088571	Otolemur garnettii	97.15	0.00e+00	946.00
IUUC-Ptr-091433	Pan troglodytes	97.35	0.00e+00	924.00
IUUC-Pan-091966	Papio anubis	97.15	0.00e+00	923.00
IUUC-Psi-093458	Pelodiscus sinensis	88.58	0.00e+00	847.00
IUUC-Pma-094343	Petromyzon marinus	69.69	4.00e-122	430.00
IUUC-Pno-095109	Phaeosphaeria nodorum	39.90	1.00e-66	247.00
IUUC-Ppa-095756	Physcomitrella patens	43.33	4.00e-112	398.00
IUUC-Pfo-096514	Poecilia formosa	82.62	0.00e+00	784.00
IUUC-Pab-098477	Pongo abelii	85.53	0.00e+00	736.00
IUUC-Pop-099221	Populus trichocarpa	41.48	1.00e-103	370.00
IUUC-Pca-100791	Procavia capensis	79.95	7.00e-180	623.00
IUUC-Ppe-101812	Prunus persica	42.05	3.00e-107	382.00
IUUC-Pva-102462	Pteropus vampyrus	92.77	0.00e+00	776.00
IUUC-Pgr-103623	Puccinia graminis	40.74	2.00e-75	276.00
IUUC-Ptt-103767	Puccinia triticina	39.40	9.00e-68	251.00
IUUC-Pte-104109	Pyrenophora teres	39.69	6.00e-71	261.00
IUUC-Pyt-104766	Pyrenophora triticirepentis	40.31	3.00e-71	263.00
IUUC-Rno-105351	Rattus norvegicus	96.34	0.00e+00	900.00
IUUC-Sce-106168	Saccharomyces cerevisiae	33.00	6.00e-63	234.00
IUUC-Sha-107491	Sarcophilus harrisii	92.49	0.00e+00	912.00
IUUC-Sja-107769	Schizosaccharomyces japonicus	34.24	1.00e-78	287.00
IUUC-Spo-108174	Schizosaccharomyces pombe	37.00	4.00e-80	291.00
IUUC-Ssl-108659	Sclerotinia sclerotiorum	35.35	4.00e-84	305.00
IUUC-Smo-108805	Selaginella moellendorffii	43.45	4.00e-109	388.00
IUUC-Sit-110361	Setaria italica	42.97	2.00e-114	405.00
IUUC-Sly-110965	Solanum lycopersicum	40.58	6.00e-108	384.00
IUUC-Sar-113355	Sorex araneus	83.92	0.00e+00	662.00
IUUC-Sbi-114778	Sorghum bicolor	44.29	3.00e-114	405.00
IUUC-Sre-115011	Sporisorium reilianum	36.71	6.00e-63	234.00
IUUC-Ssc-116273	Sus scrofa	97.36	0.00e+00	950.00
IUUC-Tgu-117063	Taeniopygia guttata	90.04	0.00e+00	874.00
IUUC-Tru-118381	Takifugu rubripes	79.80	0.00e+00	793.00
IUUC-Tsy-119076	Tarsius syrichta	81.78	4.00e-117	414.00
IUUC-Tni-119941	Tetraodon nigroviridis	81.43	0.00e+00	784.00
IUUC-Tca-121246	Theobroma cacao	41.29	3.00e-109	389.00
IUUC-Tre-121969	Trichoderma reesei	38.88	6.00e-69	254.00
IUUC-Tvi-122543	Trichoderma virens	35.05	2.00e-78	286.00
IUUC-Tae-125484	Triticum aestivum	42.68	5.00e-110	391.00
IUUC-Tur-126128	Triticum urartu	32.75	3.00e-68	252.00
IUUC-Tbe-128030	Tupaia belangeri	90.16	0.00e+00	855.00
IUUC-Ttr-128701	Tursiops truncatus	96.93	0.00e+00	779.00
IUUC-Uma-129657	Ustilago maydis	37.36	1.00e-65	244.00
IUUC-Vda-129723	Verticillium dahliae	32.71	2.00e-71	263.00
IUUC-Vpa-130284	Vicugna pacos	70.08	0.00e+00	640.00
IUUC-Vvi-131037	Vitis vinifera	42.77	5.00e-109	387.00
IUUC-Xtr-132235	Xenopus tropicalis	85.25	0.00e+00	874.00
IUUC-Xma-133840	Xiphophorus maculatus	82.62	0.00e+00	810.00
IUUC-Yli-134453	Yarrowia lipolytica	36.78	9.00e-84	303.00
IUUC-Zma-135669	Zea mays	36.79	2.00e-96	345.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence