iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089429

Ensembl Protein ID

ENSOARP00000015769.1

UniProt Accession

W5PZ83; W5PZ83_SHEEP

Genbank Protein ID

ENSOARP00000015769

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

AMGL01079065

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000014701.1	ENSOART00000016001.1	ENSOARP00000015769.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	6.10e-134	446.8	543	875

Active Site

Position(s)	Description	Evidence
844	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl+v f+gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+ l++F f+Gr++++al++g+++d+
   Q: 543  PYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTI-NPDLLSYFCFIGRFIAMALFHGKFIDT 630
           6799*******************************************************98.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+kkl+++dle++d e+y+sl +i++n   +iee+gl++ fsv+ eilg++++++Lk gG+ni Vt+eNk+eY+ l++e
   Q: 631  GFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDN---NIEECGLEMYFSVDMEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTE 716
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +g++eq++af +Gfnev+pl++l++F+e+ele+++cG++e+d+ d++++t y++ yt++s++i+wFw++++e ++e r ++LqFv
   Q: 717  WRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRH-YTRNSKQIIWFWQFVKETDNEVRMRLLQFV 804
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlPlgGfael+    p++f+i+k ++d++lP+s+TCfn+L+LP+Y+s+e+lkekLl+Aieet+gF++
   Q: 805  TGTCRLPLGGFAELMgsngPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQ 875
           *********************************************************************96 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

IQGRVSASAA SGVLSNPKWD EQLTVNVTPQ TTLEFRVWSH HTIKADALLG RATVDLKQAL 60
LIHNRKLEKV KEQLKLSLET KNGVVQTGEL TVVLDGLVIE QENITNGSSS PAIEVQQNGD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATCCAGGGGC GGGTGTCGGC GAGCGCGGCG AGCGGGGTCC TAGTGGCTNN NNNNNNNNNN 60
NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Cel-018299	Caenorhabditis elegans	67.18	0.00e+00	835.00
IUUC-Csa-023805	Chlorocebus sabaeus	95.03	0.00e+00	1305.00
IUUC-Cho-024943	Choloepus hoffmanni	83.42	0.00e+00	1170.00
IUUC-Csv-026256	Ciona savignyi	72.66	0.00e+00	899.00
IUUC-Dre-028245	Danio rerio	72.45	0.00e+00	1225.00
IUUC-Dme-032041	Drosophila melanogaster	69.97	0.00e+00	898.00
IUUC-Ggo-045001	Gorilla gorilla	93.09	0.00e+00	1525.00
IUUC-Lch-050398	Latimeria chalumnae	77.77	0.00e+00	1317.00
IUUC-Loc-052116	Lepisosteus oculatus	74.42	0.00e+00	1290.00
IUUC-Ola-087438	Oryzias latipes	91.36	0.00e+00	1160.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence