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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046047
UUCD1 version UUC-HoS-00386
Ensembl Protein ID ENSP00000365944.4
UniProt Accession Q9NRD1; B1AK42; B2RC88; Q9UKT3; FBX6_HUMAN
Genbank Protein ID AAF04470.1; AAF67153.1; BAG37485.1; CAI20214.1; CAI20215.1; EAW71696.1; AAH20880.1
Protein Name F-box only protein 6; F-box protein that recognizes sugar chains 2; F-box/G-domain protein 2
Genbank Nucleotide ID AF129536; AF233223; AK314989; AL031731; AL031731; CH471130; BC020880
Gene Name FBXO6; FBG2; FBS2; FBX6
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000116663.10 ENST00000376753.8 ENSP00000365944.4
ENSG00000116663.10 ENST00000449067.1 ENSP00000388781.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbCircNetmiRTarBasemicroRNA
TRANSFACTargetScanRepTarSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtBioGRIDmUbiSiDa
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box F-box 18203720; 19515249
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/SCF/F-box 0.00075 21.2 4 56
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/SCF/F-box
   S: 94   peegpdaglldrlpeeilveilklldkee.llraarvcrrwqelasqkalwkt 145
           p   +  +++++lpe+il+e ++++++++ ll++++vc  w+ l++  +lwk+
   Q: 4    PHSKAALDSINELPENILLELFTHVPARQlLLNCRLVCSLWRDLIDLMTLWKR 56
           6667777899***************999989***********99998999987 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranlocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication.
 Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranlocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication.
Protein Sequence
(Fasta)
MDAPHSKAAL DSINELPENI LLELFTHVPA RQLLLNCRLV CSLWRDLIDL MTLWKRKCLR 60
EGFITKDWDQ PVADWKIFYF LRSLHRNLLR NPCAEEDMFA WQIDFNGGDR WKVESLPGAH 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046047|E3,F-box|Homo sapiens
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Nucleotide Sequence
(Fasta)
GCGCGTTCGG GAGCTTCGGC CCTGCGTAGG AGGCGGGTGC AGGTGTGGGT GCTGAGCCGC 60
CCGCCGCCTG GAGGGGGAGA CAGCTTCAGG ACACGCAGGC CGCAGCGAGG GCCCGGGCCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046047|E3,F-box|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0227--DNA damage
KW-0234--DNA repair
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0834--Unfolded protein response
Interpro

IPR007397--F-box-assoc_dom
IPR001810--F-box_dom
IPR008979--Galactose-bd-like
PROSITE

PS51114--FBA
PS50181--FBOX
Pfam

PF12937--F-box-like
PF04300--FBA
SMART

SM01198--FBA
SM00256--FBOX
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0044322--C:endoplasmic reticulum quality control compartment
GO:0019005--C:SCF ubiquitin ligase complex
GO:0030246--F:carbohydrate binding
GO:0001948--F:glycoprotein binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0000077--P:DNA damage checkpoint
GO:0006281--P:DNA repair
GO:0006516--P:glycoprotein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0006508--P:proteolysis
GO:0006986--P:response to unfolded protein
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0030433--P:ubiquitin-dependent ERAD pathway
KEGG hsa:26270
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002387 Ailuropoda melanoleuca 80.22 8.00e-127 446.00
IUUC-Apl-003256 Anas platyrhynchos 60.63 3.00e-93 334.00
IUUC-Aca-005249 Anolis carolinensis 57.48 9.00e-74 270.00
IUUC-Afl-008397 Aspergillus flavus 33.33 5.40e-02 31.60
IUUC-Aor-010183 Aspergillus oryzae 33.33 5.40e-02 31.60
IUUC-Ame-011181 Astyanax mexicanus 45.00 2.00e-60 226.00
IUUC-Bta-012446 Bos taurus 80.68 2.00e-131 461.00
IUUC-Cel-018409 Caenorhabditis elegans 29.22 1.00e-13 71.20
IUUC-Cja-019690 Callithrix jacchus 83.22 2.00e-133 468.00
IUUC-Cfa-020399 Canis familiaris 80.85 6.00e-137 480.00
IUUC-Cpo-022113 Cavia porcellus 78.95 2.00e-135 474.00
IUUC-Csa-023732 Chlorocebus sabaeus 96.59 8.00e-163 565.00
IUUC-Dno-029725 Dasypus novemcinctus 80.49 2.00e-121 428.00
IUUC-Dor-030820 Dipodomys ordii 84.56 1.00e-124 439.00
IUUC-Ete-032617 Echinops telfairi 81.62 3.00e-89 320.00
IUUC-Eca-033658 Equus caballus 83.00 5.00e-128 450.00
IUUC-Eeu-035144 Erinaceus europaeus 75.00 1.00e-115 409.00
IUUC-Fca-036511 Felis catus 85.29 8.00e-138 482.00
IUUC-Fal-037154 Ficedula albicollis 60.89 1.00e-85 309.00
IUUC-Gga-041011 Gallus gallus 58.66 2.00e-87 315.00
IUUC-Gac-041813 Gasterosteus aculeatus 44.88 3.00e-60 225.00
IUUC-Ggo-044771 Gorilla gorilla 98.98 8.00e-167 579.00
IUUC-Itr-048961 Ictidomys tridecemlineatus 86.94 3.00e-130 457.00
IUUC-Loc-051984 Lepisosteus oculatus 50.43 1.00e-60 226.00
IUUC-Laf-054388 Loxodonta africana 82.33 1.00e-124 439.00
IUUC-Mcc-055219 Macaca mulatta 96.59 5.00e-163 566.00
IUUC-Meu-056508 Macropus eugenii 72.51 9.00e-112 395.00
IUUC-Mga-060039 Meleagris gallopavo 62.50 8.00e-86 310.00
IUUC-Mmr-060599 Microcebus murinus 80.46 1.00e-128 452.00
IUUC-Mmu-064158 Mus musculus 74.60 1.00e-112 399.00
IUUC-Mac-064664 Musa acuminata 31.25 3.70e-02 33.10
IUUC-Mpu-065798 Mustela putorius furo 82.56 8.00e-130 456.00
IUUC-Mlu-067931 Myotis lucifugus 78.71 3.00e-126 444.00
IUUC-Nle-069509 Nomascus leucogenys 87.39 1.00e-123 435.00
IUUC-Opr-070619 Ochotona princeps 82.38 2.00e-126 444.00
IUUC-Ont-072665 Oreochromis niloticus 48.78 2.00e-68 251.00
IUUC-Ocu-074270 Oryctolagus cuniculus 80.46 2.00e-126 445.00
IUUC-Ola-086867 Oryzias latipes 45.31 4.00e-63 234.00
IUUC-Oga-088988 Otolemur garnettii 84.31 2.00e-130 458.00
IUUC-Oar-089871 Ovis aries 78.52 8.00e-130 456.00
IUUC-Ptr-091362 Pan troglodytes 99.32 4.00e-168 583.00
IUUC-Pan-091935 Papio anubis 96.25 2.00e-162 564.00
IUUC-Psi-092980 Pelodiscus sinensis 63.83 3.00e-92 331.00
IUUC-Pfo-097249 Poecilia formosa 43.59 4.00e-59 221.00
IUUC-Pab-098167 Pongo abelii 97.95 7.00e-166 576.00
IUUC-Pca-100483 Procavia capensis 77.13 1.00e-83 302.00
IUUC-Pva-103073 Pteropus vampyrus 77.46 3.00e-129 454.00
IUUC-Pte-104184 Pyrenophora teres 30.23 1.60e-02 33.90
IUUC-Rno-106045 Rattus norvegicus 77.20 5.00e-117 413.00
IUUC-Sha-107560 Sarcophilus harrisii 71.26 2.00e-115 408.00
IUUC-Sar-113378 Sorex araneus 77.29 7.00e-120 422.00
IUUC-Ssc-115889 Sus scrofa 82.58 2.00e-132 464.00
IUUC-Tgu-116573 Taeniopygia guttata 62.50 5.00e-86 310.00
IUUC-Tru-117734 Takifugu rubripes 45.87 3.00e-58 218.00
IUUC-Tni-120432 Tetraodon nigroviridis 44.13 6.00e-63 233.00
IUUC-Tbe-127475 Tupaia belangeri 80.21 5.00e-134 470.00
IUUC-Ttr-129048 Tursiops truncatus 77.24 4.00e-130 457.00
Created Date 25-Jun-2017

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