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Basic Information Integrated Annotations

Tag Content
iUUCD ID IUUC-Cel-018145
UUCD1 version UUC-CaE-00017
Ensembl Protein ID D2030.9a.1
UniProt Accession P90794; Q9U3K9; DCA11_CAEEL
Genbank Protein ID CAA98121.1; CAB54209.1
Protein Name DDB1- and CUL4-associated factor 11 homolog; WD repeat-containing protein 23
Genbank Nucleotide ID Z73906; Z73906
Gene Name wdr-23; D2030.9
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
WBGene00008419 D2030.9a.1 D2030.9a.1
WBGene00008419 D2030.9b.1 D2030.9b.1
WBGene00008419 D2030.9c D2030.9c
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNARAID2
Protein-protein Interaction
IIDiRefIndexPINA
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD WD_repeat 19273594
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.00e-26 92.2 310 341
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf....sdtllvsGsdDgtikvWDl 30
    H+d+v++++f s +l+ s++dDg +kvWD
   Q: 310 HEDDVNSVCFadlgS-NLIYSAGDDGLVKVWDK 341
    ***********9643.9***************6 PP
   

Organism Caenorhabditis elegans
Functional Description
(View)

Functional Description



     Involved in regulation of lifespan (PubMed:17411345). Required for dopaminergic CEP neuron degeneration in response to Mn(2+) (PubMed:23721876).
Involved in regulation of lifespan (PubMed:17411345). Required for dopaminergic CEP neuron degeneration in response to Mn(2+) (PubMed:23721876).
Protein Sequence
(Fasta)
MGNWITSTFL RFDLFQRHQP NRFLEYTRVQ HSNQSPAYSV RTAAEIVAHQ RMKPNHSNDS 60
DTDFSSDDEG CPKMTPHEEQ QMFEREQHIA FSGRCHIGDP ESCTQLRNEI NSRCGPRPST 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Cel-018145|E3,WD_repeat|Caenorhabditis elegans
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TGCTTCGCCC TATGCTCGAA TGGGCAACTG GATAACGTCG ACGTTCCTCC GATTTGATCT 60
TTTTCAACGT CATCAGCCCA ACCGATTTCT CGAATATACA AGAGGTAAGC GAGAAGAGGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Cel-018145|E3,WD_repeat|Caenorhabditis elegans
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR017399--DCAF11/LEC14B
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0030424--C:axon
GO:0005737--C:cytoplasm
GO:0005741--C:mitochondrial outer membrane
GO:0005739--C:mitochondrion
GO:0043025--C:neuronal cell body
GO:0005634--C:nucleus
GO:0055120--C:striated muscle dense body
GO:0008021--C:synaptic vesicle
GO:0008134--F:transcription factor binding
GO:0008340--P:determination of adult lifespan
GO:1905803--P:negative regulation of cellular response to manganese ion
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0040018--P:positive regulation of multicellular organism growth
GO:1901216--P:positive regulation of neuron death
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0080135--P:regulation of cellular response to stress

KEGG cel:CELE_D2030.9
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000659 Aegilops tauschii 43.33 6.00e-51 193.00
IUUC-Aml-001732 Ailuropoda melanoleuca 39.90 4.00e-87 314.00
IUUC-Atr-002856 Amborella trichopoda 34.25 8.00e-53 199.00
IUUC-Aca-005081 Anolis carolinensis 42.82 9.00e-88 316.00
IUUC-Aly-006571 Arabidopsis lyrata 39.12 2.00e-64 238.00
IUUC-Ath-007313 Arabidopsis thaliana 38.86 7.00e-65 239.00
IUUC-Acl-008126 Aspergillus clavatus 33.07 1.00e-50 193.00
IUUC-Afl-008513 Aspergillus flavus 34.41 6.00e-56 211.00
IUUC-Afu-008765 Aspergillus fumigatus 33.86 8.00e-52 197.00
IUUC-Ani-009456 Aspergillus nidulans 34.28 1.00e-59 223.00
IUUC-Ang-009781 Aspergillus niger 30.22 1.00e-46 179.00
IUUC-Aor-010093 Aspergillus oryzae 34.41 6.00e-56 211.00
IUUC-Ate-010456 Aspergillus terreus 33.86 8.00e-52 197.00
IUUC-Ame-011825 Astyanax mexicanus 40.10 6.00e-80 290.00
IUUC-Bgr-012310 Blumeria graminis 31.45 1.00e-47 182.00
IUUC-Bta-013043 Bos taurus 40.75 4.00e-87 314.00
IUUC-Bci-013758 Botrytis cinerea 31.70 1.00e-48 186.00
IUUC-Bdi-014379 Brachypodium distachyon 35.25 3.00e-60 224.00
IUUC-Bol-016065 Brassica oleracea 39.12 2.00e-65 241.00
IUUC-Bra-017541 Brassica rapa 39.12 3.00e-65 241.00
IUUC-Cja-018940 Callithrix jacchus 39.14 2.00e-86 311.00
IUUC-Cfa-020064 Canis familiaris 39.90 7.00e-87 313.00
IUUC-Cpo-022220 Cavia porcellus 42.05 6.00e-86 310.00
IUUC-Cre-022728 Chlamydomonas reinhardtii 42.62 3.00e-48 183.00
IUUC-Csa-023158 Chlorocebus sabaeus 42.59 1.00e-86 312.00
IUUC-Cho-024797 Choloepus hoffmanni 57.43 5.00e-30 124.00
IUUC-Cgl-026444 Colletotrichum gloeosporioides 34.22 8.00e-52 197.00
IUUC-Cne-026917 Cryptococcus neoformans 28.81 3.00e-34 139.00
IUUC-Cme-027273 Cyanidioschyzon merolae 30.99 2.00e-43 169.00
IUUC-Dre-028711 Danio rerio 43.16 7.00e-86 310.00
IUUC-Dno-029851 Dasypus novemcinctus 42.32 5.00e-86 310.00
IUUC-Dor-030952 Dipodomys ordii 42.05 2.00e-82 298.00
IUUC-Dse-031288 Dothistroma septosporum 30.79 5.00e-50 191.00
IUUC-Dme-031925 Drosophila melanogaster 37.38 3.00e-70 257.00
IUUC-Ete-032983 Echinops telfairi 38.19 8.00e-83 299.00
IUUC-Eca-033499 Equus caballus 40.50 6.00e-87 313.00
IUUC-Eeu-035179 Erinaceus europaeus 42.14 7.00e-70 256.00
IUUC-Fca-035615 Felis catus 41.86 9.00e-87 312.00
IUUC-Fox-037867 Fusarium oxysporum 31.56 1.00e-44 172.00
IUUC-Fso-038274 Fusarium solani 31.35 1.00e-45 176.00
IUUC-Gmo-038731 Gadus morhua 43.42 1.00e-86 312.00
IUUC-Ggr-039861 Gaeumannomyces graminis 32.14 1.00e-47 182.00
IUUC-Gac-041615 Gasterosteus aculeatus 43.42 3.00e-87 314.00
IUUC-Gma-043167 Glycine max 38.93 5.00e-66 243.00
IUUC-Hsa-046061 Homo sapiens 42.59 6.00e-87 313.00
IUUC-Hvu-047177 Hordeum vulgare 47.76 2.00e-47 180.00
IUUC-Itr-048985 Ictidomys tridecemlineatus 39.41 6.00e-88 317.00
IUUC-Lch-050257 Latimeria chalumnae 32.54 5.00e-49 187.00
IUUC-Lpe-051521 Leersia perrieri 35.64 3.00e-60 224.00
IUUC-Lma-053067 Leptosphaeria maculans 34.69 3.00e-42 165.00
IUUC-Laf-054259 Loxodonta africana 42.59 1.00e-86 312.00
IUUC-Mcc-054958 Macaca mulatta 39.14 7.00e-87 313.00
IUUC-Meu-056889 Macropus eugenii 38.90 2.00e-86 311.00
IUUC-Mor-057196 Magnaporthe oryzae 32.90 2.00e-50 192.00
IUUC-Mpo-057340 Magnaporthe poae 32.49 3.00e-47 182.00
IUUC-Mtr-058464 Medicago truncatula 39.89 8.00e-65 239.00
IUUC-Mla-058873 Melampsora laricipopulina 30.19 1.00e-38 153.00
IUUC-Mvi-060439 Microbotryum violaceum 29.52 5.00e-45 174.00
IUUC-Mmr-061329 Microcebus murinus 41.89 2.00e-83 301.00
IUUC-Mdo-062123 Monodelphis domestica 38.90 3.00e-87 314.00
IUUC-Mmu-063616 Mus musculus 42.59 8.00e-87 313.00
IUUC-Mac-064473 Musa acuminata 37.03 2.00e-61 228.00
IUUC-Mpu-066351 Mustela putorius furo 41.28 7.00e-72 263.00
IUUC-Mlu-067043 Myotis lucifugus 42.59 7.00e-87 313.00
IUUC-Nfi-068552 Neosartorya fischeri 33.60 7.00e-52 197.00
IUUC-Ncr-068715 Neurospora crassa 34.15 9.00e-50 190.00
IUUC-Nle-070052 Nomascus leucogenys 39.95 9.00e-87 312.00
IUUC-Opr-070605 Ochotona princeps 42.86 2.00e-86 311.00
IUUC-Ont-072411 Oreochromis niloticus 43.95 2.00e-82 298.00
IUUC-Ocu-074078 Oryctolagus cuniculus 39.14 3.00e-87 314.00
IUUC-Oba-075609 Oryza barthii 34.67 3.00e-60 224.00
IUUC-Obr-076556 Oryza brachyantha 33.81 2.00e-60 225.00
IUUC-Ogl-077227 Oryza glaberrima 36.17 2.00e-60 224.00
IUUC-Ogu-078264 Oryza glumaepatula 36.27 3.00e-59 221.00
IUUC-Oin-079655 Oryza indica 36.17 1.00e-60 226.00
IUUC-Olo-080362 Oryza longistaminata 34.40 3.00e-51 194.00
IUUC-Ome-081712 Oryza meridionalis 36.63 2.00e-60 225.00
IUUC-Oni-083108 Oryza nivara 36.17 1.00e-60 226.00
IUUC-Opu-084070 Oryza punctata 36.27 1.00e-61 229.00
IUUC-Oru-085194 Oryza rufipogon 36.17 1.00e-60 226.00
IUUC-Osa-086287 Oryza sativa 34.43 4.00e-59 220.00
IUUC-Ola-086329 Oryzias latipes 44.36 7.00e-87 313.00
IUUC-Oga-088779 Otolemur garnettii 42.86 5.00e-87 313.00
IUUC-Oar-089262 Ovis aries 40.75 3.00e-87 314.00
IUUC-Ptr-091346 Pan troglodytes 42.59 6.00e-87 313.00
IUUC-Pan-092716 Papio anubis 39.14 8.00e-87 313.00
IUUC-Pma-094148 Petromyzon marinus 51.76 4.00e-75 273.00
IUUC-Pno-095116 Phaeosphaeria nodorum 31.96 3.00e-40 158.00
IUUC-Ppa-095260 Physcomitrella patens 35.48 4.00e-63 234.00
IUUC-Pfo-096424 Poecilia formosa 42.82 1.00e-86 312.00
IUUC-Pab-098091 Pongo abelii 40.97 4.00e-82 297.00
IUUC-Pop-099597 Populus trichocarpa 37.68 4.00e-65 241.00
IUUC-Pca-100153 Procavia capensis 42.05 3.00e-85 307.00
IUUC-Ppe-102075 Prunus persica 37.66 4.00e-62 230.00
IUUC-Pva-102598 Pteropus vampyrus 39.43 2.00e-86 311.00
IUUC-Pgr-103327 Puccinia graminis 29.95 8.00e-40 157.00
IUUC-Ptt-103861 Puccinia triticina 28.71 2.00e-14 72.00
IUUC-Pte-104286 Pyrenophora teres 32.82 6.00e-50 191.00
IUUC-Pyt-104745 Pyrenophora triticirepentis 34.01 3.00e-44 171.00
IUUC-Rno-104890 Rattus norvegicus 42.59 4.00e-87 314.00
IUUC-Sha-106540 Sarcophilus harrisii 38.95 1.00e-84 306.00
IUUC-Ssl-108528 Sclerotinia sclerotiorum 28.71 2.00e-36 146.00
IUUC-Smo-109115 Selaginella moellendorffii 34.31 3.00e-58 217.00
IUUC-Sit-109840 Setaria italica 32.51 6.00e-62 230.00
IUUC-Sly-110856 Solanum lycopersicum 39.06 7.00e-67 246.00
IUUC-Stu-112589 Solanum tuberosum 37.57 8.00e-58 216.00
IUUC-Sar-113742 Sorex araneus 39.82 6.00e-87 313.00
IUUC-Sbi-114505 Sorghum bicolor 40.32 3.00e-53 200.00
IUUC-Sre-115073 Sporisorium reilianum 28.64 8.00e-37 147.00
IUUC-Ssc-116019 Sus scrofa 39.67 5.00e-87 313.00
IUUC-Tru-118536 Takifugu rubripes 40.33 4.00e-86 310.00
IUUC-Tsy-119518 Tarsius syrichta 40.10 1.00e-86 311.00
IUUC-Tni-120264 Tetraodon nigroviridis 40.33 6.00e-86 310.00
IUUC-Tca-121554 Theobroma cacao 39.06 1.00e-64 239.00
IUUC-Tre-122144 Trichoderma reesei 32.45 3.00e-43 167.00
IUUC-Tvi-122472 Trichoderma virens 30.79 3.00e-46 178.00
IUUC-Tae-123212 Triticum aestivum 34.88 2.00e-60 224.00
IUUC-Tur-126484 Triticum urartu 47.37 3.00e-53 201.00
IUUC-Tme-127050 Tuber melanosporum 34.20 1.00e-50 192.00
IUUC-Tbe-127495 Tupaia belangeri 37.72 5.00e-87 313.00
IUUC-Ttr-128553 Tursiops truncatus 40.50 5.00e-87 313.00
IUUC-Uma-129557 Ustilago maydis 29.72 2.00e-36 146.00
IUUC-Vda-129951 Verticillium dahliae 33.25 2.00e-54 205.00
IUUC-Vpa-130542 Vicugna pacos 51.09 2.00e-39 155.00
IUUC-Vvi-131266 Vitis vinifera 36.19 4.00e-63 234.00
IUUC-Xtr-132525 Xenopus tropicalis 42.56 8.00e-86 309.00
IUUC-Xma-133165 Xiphophorus maculatus 42.63 1.00e-86 312.00
IUUC-Yli-134635 Yarrowia lipolytica 23.96 5.00e-17 82.00
IUUC-Zma-135833 Zea mays 36.49 1.00e-58 219.00
Created Date 25-Jun-2017

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