iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Zinc metalloprotease that cleaves 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, but is not implicated in protein degradation by the 26S proteasome, deneddylation, or desumoylation. Required for intracellular trafficking (e.g. trafficking from the Golgi to the vacuole and the vacuolar trafficking of endocytosed cargo), endocytosis and vacuole biogenesis.

Protein Sequence
(Fasta)

MKIDLNKVAR EIEVDNRIPL RNYYRIADNL LRQASIYREE KNVVDLYIML LRYSSLISET 60
IPFHRDYQAS LPQERLGSRK RLRAVINELE SLKPEFNQLV DKLNRVEDES RQDGSDLPVV 120

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Nucleotide Sequence
(Fasta)

TTTATTCCAC TTGATATAAT ATTGCAACTC CACACAATTC GATCATCAGC TGGTTGAAAC 60
CACTTAATAG TTCCATAAGA TATCATTCCA CATTGAAAAT TTCAAATATA CCCCTAAAGT 120

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Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0254--Endocytosis
KW-0378--Hydrolase
KW-0472--Membrane
KW-0479--Metal-binding
KW-0482--Metalloprotease
KW-0645--Protease
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0833--Ubl conjugation pathway
KW-0926--Vacuole
KW-0862--Zinc

Interpro

IPR000555--JAMM/MPN+_dom
IPR015063--USP8_dimer

Pfam

PF01398--JAB
PF08969--USP8_dimer

SMART

SM00232--JAB_MPN

Gene Ontology

GO:0016021--C:integral component of membrane
GO:0005774--C:vacuolar membrane
GO:0046872--F:metal ion binding
GO:0008237--F:metallopeptidase activity
GO:0006897--P:endocytosis
GO:0046907--P:intracellular transport
GO:0090316--P:positive regulation of intracellular protein transport
GO:0044090--P:positive regulation of vacuole organization
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0015031--P:protein transport
GO:0007033--P:vacuole organization

KEGG

ath:AT4G16144

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aly-005808	Arabidopsis lyrata	94.80	0.00e+00	781.00
IUUC-Bol-015371	Brassica oleracea	85.15	0.00e+00	667.00
IUUC-Bra-017428	Brassica rapa	84.52	0.00e+00	677.00
IUUC-Cel-018572	Caenorhabditis elegans	33.33	5.00e-03	35.40
IUUC-Cne-026908	Cryptococcus neoformans	48.15	1.00e-01	30.40
IUUC-Gma-044253	Glycine max	57.42	3.00e-127	447.00
IUUC-Mmr-061347	Microcebus murinus	34.41	1.00e-11	62.00
IUUC-Ola-087457	Oryzias latipes	28.21	1.00e-07	48.10
IUUC-Pop-098795	Populus trichocarpa	60.24	1.00e-134	472.00
IUUC-Tae-124652	Triticum aestivum	45.54	6.00e-73	267.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence