iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-012829

UUCD1 version

UUC-BoT-00842

Ensembl Protein ID

ENSBTAP00000020499.3

UniProt Accession

Q0VC24; A5PJI2; WDR12_BOVIN

Genbank Protein ID

ABM06142.1; AAI20387.1; AAI42122.1

Protein Name

Ribosome biogenesis protein WDR12; WD repeat-containing protein 12

Genbank Nucleotide ID

BT029892; BC120386; BC142121

Gene Name

WDR12

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000015424.3	ENSBTAT00000020499.3	ENSBTAP00000020499.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.50e-44	147.4	341	376
UBD/Beta-Prp	2.30e-47	161.7	246	412

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf..sd.tllvsGsdDgtikvWDlrtgv 34
           Ht++vt++++  +    l+sGs D+ +k+WD+r+++
   Q: 341  HTGWVTSVKWspTHeQQLISGSLDNMVKLWDTRSCK 376
           **********9533678**************99876 PP

UBD/Beta-Prp

   S: 83   tgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl..ktg 169
           t+++++tl+gh++ + s+ +s   + + s+s+d ti+vwd+e+g+  + tl+g++ v nc++++p ++ l+sGs+Dr +rlWd   k g
   Q: 246  TRTPIVTLSGHKEAISSVLWSD-AEEICSASWDHTIKVWDVESGSLKS-TLTGNK-VFNCISYSPLCKRLASGSTDRHIRLWDPrtKDG 331
           67899****************9.99**********************9.***987.99**************************54456 PP
   S: 170  kllrtl.tgghtdsvyslsfdsng.kelvsgsldgtvklwdlq.tgecvrtlnghtdnvksvrfspnderlvsgssDgsiriW 249
           +l+    t+ ht+ v+s++++++  ++l+sgsld+ vklwd +  +  ++ l +h+d v+sv+ + ++ +l+sg++D+ ++ +
   Q: 332  SLVSLSlTS-HTGWVTSVKWSPTHeQQLISGSLDNMVKLWDTRsCKAPLYDLAAHEDKVLSVDWT-DSGLLLSGGADNKLYSY 412
           666644366.************9889*****************54566****************9.***********998765 PP

Organism

Bos taurus

Functional Description
(View)

Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.

Protein Sequence
(Fasta)

MAQLQTRFFT DNKKYAVDDV PFSIPAASEI ADLSNLINKL LEAKNEFHKH VEFDFLIKGQ 60
FLRMPLFKHM ELENISSEEV VELEYVEKYT APQPEQCMFH DDWISAIEGT EEWILTGSYD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGATAGCCT GCGAACATTT CAAACGGAGA GAAGTCGGTT TGAAACGGGC CTCTTTCTAT 60
CTCCATAATC GATCGCAAGC TTAAATATAT ATTTTTTTAA AAATACAAAA AAAAAATATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0690--Ribosome biogenesis
KW-0698--rRNA processing
KW-0832--Ubl conjugation
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR012972--NLE
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR028599--WDR12/Ytm1

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08154--NLE
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0070545--C:PeBoW complex
GO:0030687--C:preribosome, large subunit precursor
GO:0008283--P:cell proliferation
GO:0000460--P:maturation of 5.8S rRNA
GO:0000466--P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000470--P:maturation of LSU-rRNA
GO:0000463--P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0007219--P:Notch signaling pathway

KEGG

bta:528209

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000532	Aegilops tauschii	32.54	2.00e-56	213.00
IUUC-Aml-001997	Ailuropoda melanoleuca	96.83	0.00e+00	750.00
IUUC-Atr-002544	Amborella trichopoda	32.86	2.00e-55	209.00
IUUC-Apl-003981	Anas platyrhynchos	86.97	0.00e+00	646.00
IUUC-Aca-004370	Anolis carolinensis	85.18	0.00e+00	704.00
IUUC-Aly-006455	Arabidopsis lyrata	33.99	8.00e-58	217.00
IUUC-Ath-006669	Arabidopsis thaliana	33.42	2.00e-53	203.00
IUUC-Ago-007864	Ashbya gossypii	30.39	1.00e-37	150.00
IUUC-Acl-008177	Aspergillus clavatus	27.74	5.00e-35	142.00
IUUC-Afl-008617	Aspergillus flavus	28.46	1.00e-34	140.00
IUUC-Afu-008752	Aspergillus fumigatus	27.80	3.00e-31	129.00
IUUC-Ani-009136	Aspergillus nidulans	29.49	4.00e-34	139.00
IUUC-Ang-009701	Aspergillus niger	27.44	4.00e-32	132.00
IUUC-Aor-009884	Aspergillus oryzae	28.72	3.00e-34	139.00
IUUC-Ame-011432	Astyanax mexicanus	76.60	0.00e+00	655.00
IUUC-Bgr-012218	Blumeria graminis	27.64	2.00e-30	127.00
IUUC-Bci-013953	Botrytis cinerea	29.46	5.00e-34	138.00
IUUC-Bdi-014351	Brachypodium distachyon	35.31	1.00e-55	210.00
IUUC-Bol-016190	Brassica oleracea	33.77	4.00e-53	202.00
IUUC-Bra-017876	Brassica rapa	33.00	2.00e-55	209.00
IUUC-Cel-018569	Caenorhabditis elegans	31.80	5.00e-48	185.00
IUUC-Cja-019468	Callithrix jacchus	95.27	0.00e+00	751.00
IUUC-Cfa-020471	Canis familiaris	95.74	0.00e+00	747.00
IUUC-Cpo-022260	Cavia porcellus	95.98	0.00e+00	756.00
IUUC-Cre-022614	Chlamydomonas reinhardtii	29.70	4.00e-37	148.00
IUUC-Csa-023989	Chlorocebus sabaeus	95.74	0.00e+00	756.00
IUUC-Cho-024426	Choloepus hoffmanni	92.06	3.00e-158	551.00
IUUC-Cin-025789	Ciona intestinalis	43.41	7.00e-97	347.00
IUUC-Cne-027063	Cryptococcus neoformans	24.34	7.00e-21	95.10
IUUC-Dre-027907	Danio rerio	77.07	0.00e+00	668.00
IUUC-Dno-029225	Dasypus novemcinctus	94.56	0.00e+00	763.00
IUUC-Dor-031082	Dipodomys ordii	79.20	4.00e-170	590.00
IUUC-Dse-031308	Dothistroma septosporum	27.53	5.00e-35	142.00
IUUC-Dme-032189	Drosophila melanogaster	41.50	1.00e-92	333.00
IUUC-Ete-032247	Echinops telfairi	88.42	0.00e+00	707.00
IUUC-Eca-034285	Equus caballus	97.16	0.00e+00	778.00
IUUC-Eeu-035322	Erinaceus europaeus	85.68	0.00e+00	647.00
IUUC-Fca-036114	Felis catus	96.22	0.00e+00	772.00
IUUC-Fal-036891	Ficedula albicollis	86.44	2.00e-174	604.00
IUUC-Fox-037965	Fusarium oxysporum	25.37	2.00e-33	137.00
IUUC-Fso-038244	Fusarium solani	25.58	6.00e-32	132.00
IUUC-Gmo-039040	Gadus morhua	75.65	0.00e+00	668.00
IUUC-Gga-040610	Gallus gallus	84.40	0.00e+00	715.00
IUUC-Gac-042117	Gasterosteus aculeatus	75.41	0.00e+00	654.00
IUUC-Gma-043146	Glycine max	36.93	7.00e-66	244.00
IUUC-Ggo-045179	Gorilla gorilla	95.27	0.00e+00	748.00
IUUC-Hsa-046114	Homo sapiens	95.98	0.00e+00	753.00
IUUC-Hvu-047331	Hordeum vulgare	33.08	4.00e-52	198.00
IUUC-Itr-048275	Ictidomys tridecemlineatus	96.45	0.00e+00	774.00
IUUC-Kpa-049304	Komagataella pastoris	28.89	6.00e-41	161.00
IUUC-Lch-050655	Latimeria chalumnae	77.91	3.00e-144	504.00
IUUC-Lpe-051675	Leersia perrieri	34.37	2.00e-57	216.00
IUUC-Loc-052868	Lepisosteus oculatus	82.03	0.00e+00	675.00
IUUC-Lma-053258	Leptosphaeria maculans	27.59	5.00e-32	133.00
IUUC-Laf-053993	Loxodonta africana	95.27	0.00e+00	772.00
IUUC-Mcc-055128	Macaca mulatta	78.72	7.00e-172	596.00
IUUC-Meu-056501	Macropus eugenii	79.89	1.00e-163	568.00
IUUC-Mor-057114	Magnaporthe oryzae	25.11	2.00e-24	107.00
IUUC-Mtr-058367	Medicago truncatula	36.21	2.00e-59	223.00
IUUC-Mla-059107	Melampsora laricipopulina	27.65	7.00e-30	124.00
IUUC-Mga-059745	Meleagris gallopavo	82.35	0.00e+00	688.00
IUUC-Mvi-060362	Microbotryum violaceum	29.85	8.00e-35	141.00
IUUC-Mdo-062257	Monodelphis domestica	86.87	0.00e+00	727.00
IUUC-Mmu-063546	Mus musculus	93.38	0.00e+00	758.00
IUUC-Mac-065540	Musa acuminata	33.25	2.00e-53	203.00
IUUC-Mpu-066284	Mustela putorius furo	97.64	0.00e+00	783.00
IUUC-Mlu-067241	Myotis lucifugus	95.51	0.00e+00	770.00
IUUC-Nfi-068260	Neosartorya fischeri	27.07	5.00e-33	135.00
IUUC-Ncr-068719	Neurospora crassa	26.53	1.00e-25	110.00
IUUC-Nle-068981	Nomascus leucogenys	95.74	0.00e+00	733.00
IUUC-Opr-071218	Ochotona princeps	86.93	0.00e+00	667.00
IUUC-Ont-071646	Oreochromis niloticus	77.59	0.00e+00	672.00
IUUC-Oan-073453	Ornithorhynchus anatinus	90.07	0.00e+00	761.00
IUUC-Ocu-074008	Oryctolagus cuniculus	96.22	0.00e+00	775.00
IUUC-Oba-075712	Oryza barthii	30.29	3.00e-41	162.00
IUUC-Obr-076721	Oryza brachyantha	34.05	1.00e-57	217.00
IUUC-Ogl-077229	Oryza glaberrima	34.13	6.00e-57	214.00
IUUC-Ogu-078977	Oryza glumaepatula	30.29	1.00e-41	163.00
IUUC-Oin-079683	Oryza indica	34.13	2.00e-57	216.00
IUUC-Olo-080291	Oryza longistaminata	30.30	4.00e-28	118.00
IUUC-Ome-081834	Oryza meridionalis	34.37	5.00e-58	218.00
IUUC-Oni-082507	Oryza nivara	33.01	3.00e-53	202.00
IUUC-Opu-083396	Oryza punctata	34.13	9.00e-58	218.00
IUUC-Oru-085220	Oryza rufipogon	33.57	7.00e-53	201.00
IUUC-Osa-085767	Oryza sativa	34.13	2.00e-57	216.00
IUUC-Ola-087420	Oryzias latipes	77.54	0.00e+00	671.00
IUUC-Olu-087740	Ostreococcus lucimarinus	27.40	3.00e-35	142.00
IUUC-Oga-088264	Otolemur garnettii	95.27	0.00e+00	750.00
IUUC-Oar-089335	Ovis aries	99.05	0.00e+00	790.00
IUUC-Ptr-091320	Pan troglodytes	95.98	0.00e+00	753.00
IUUC-Pan-092833	Papio anubis	95.27	0.00e+00	751.00
IUUC-Psi-093504	Pelodiscus sinensis	87.94	0.00e+00	737.00
IUUC-Pma-094189	Petromyzon marinus	69.34	1.00e-171	595.00
IUUC-Pno-094929	Phaeosphaeria nodorum	26.17	2.00e-31	130.00
IUUC-Ppa-095429	Physcomitrella patens	34.91	6.00e-64	238.00
IUUC-Pfo-096337	Poecilia formosa	75.65	0.00e+00	674.00
IUUC-Pab-097571	Pongo abelii	95.51	0.00e+00	752.00
IUUC-Pop-099977	Populus trichocarpa	34.86	1.00e-62	233.00
IUUC-Pca-100394	Procavia capensis	89.98	0.00e+00	674.00
IUUC-Ppe-101848	Prunus persica	34.86	2.00e-59	223.00
IUUC-Pva-102921	Pteropus vampyrus	95.95	2.00e-115	409.00
IUUC-Pgr-103637	Puccinia graminis	28.82	2.00e-34	139.00
IUUC-Ptt-103781	Puccinia triticina	28.82	3.00e-34	139.00
IUUC-Pte-104135	Pyrenophora teres	26.30	1.00e-32	135.00
IUUC-Pyt-104609	Pyrenophora triticirepentis	26.15	2.00e-31	130.00
IUUC-Rno-105114	Rattus norvegicus	92.91	0.00e+00	754.00
IUUC-Sce-106401	Saccharomyces cerevisiae	29.61	2.00e-38	153.00
IUUC-Sha-107122	Sarcophilus harrisii	87.10	0.00e+00	697.00
IUUC-Sja-107766	Schizosaccharomyces japonicus	32.01	1.00e-47	183.00
IUUC-Spo-108134	Schizosaccharomyces pombe	29.36	7.00e-39	154.00
IUUC-Ssl-108398	Sclerotinia sclerotiorum	29.02	3.00e-35	142.00
IUUC-Smo-108720	Selaginella moellendorffii	32.62	1.00e-55	210.00
IUUC-Sit-110311	Setaria italica	35.29	6.00e-56	211.00
IUUC-Sly-111023	Solanum lycopersicum	31.86	7.00e-53	201.00
IUUC-Stu-112778	Solanum tuberosum	34.84	2.00e-59	223.00
IUUC-Sar-113596	Sorex araneus	78.72	6.00e-175	606.00
IUUC-Sbi-114193	Sorghum bicolor	34.70	4.00e-57	215.00
IUUC-Sre-115002	Sporisorium reilianum	24.57	4.00e-11	63.20
IUUC-Ssc-116066	Sus scrofa	98.11	0.00e+00	783.00
IUUC-Tgu-117048	Taeniopygia guttata	85.11	0.00e+00	639.00
IUUC-Tsy-119573	Tarsius syrichta	62.20	1.00e-130	459.00
IUUC-Tni-119820	Tetraodon nigroviridis	76.01	0.00e+00	670.00
IUUC-Tca-121605	Theobroma cacao	35.34	9.00e-61	227.00
IUUC-Tre-121947	Trichoderma reesei	26.07	5.00e-33	135.00
IUUC-Tvi-122481	Trichoderma virens	26.07	3.00e-34	139.00
IUUC-Tae-125861	Triticum aestivum	32.78	9.00e-57	214.00
IUUC-Tur-126586	Triticum urartu	33.33	4.00e-54	205.00
IUUC-Tme-126900	Tuber melanosporum	31.68	7.00e-48	184.00
IUUC-Tbe-127736	Tupaia belangeri	72.61	9.00e-152	529.00
IUUC-Ttr-129041	Tursiops truncatus	85.58	0.00e+00	671.00
IUUC-Uma-129628	Ustilago maydis	24.49	3.00e-11	63.50
IUUC-Vpa-130260	Vicugna pacos	97.87	0.00e+00	783.00
IUUC-Vvi-131009	Vitis vinifera	34.76	1.00e-59	223.00
IUUC-Xtr-132083	Xenopus tropicalis	81.80	0.00e+00	679.00
IUUC-Xma-133094	Xiphophorus maculatus	74.94	0.00e+00	667.00
IUUC-Yli-134531	Yarrowia lipolytica	23.25	9.00e-20	91.70
IUUC-Zma-135509	Zea mays	33.33	8.00e-58	217.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence