iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cfa-020667

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Baculoviral IAP repeat-containing protein 3; RING-type E3 ubiquitin transferase BIRC3

Genbank Nucleotide ID

EF102104

Gene Name

BIRC3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000015105.3	ENSCAFT00000024001.2	ENSCAFP00000022282.2

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	74.50	0.00e+00	871.00	IUUC-Hsa-046144
UBD/Alpha-Helix/UBA	74.50	0.00e+00	871.00	IUUC-Hsa-046144

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Canis familiaris

Functional Description
(View)

Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8.

Protein Sequence
(Fasta)

MNIVQNSIFL SNLLRSSPVF ELKYDHSCEL YRMSTYSTFP AGVPVSERSL ARAGFYYTGA 60
KDRVRCFCCG LMLDNWKAGD SPTGKHRNLY PSCSFIQNLS AVSTVGAASQ PPAPLSEARS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAACATAG TACAAAATAG CATATTCTTG TCAAATCTGC TGAGAAGCAG CCCTGTGTTC 60
GAACTGAAGT ACGACCACTC ATGTGAACTG TACCGCATGT CCACATACTC GACATTCCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001370--BIR_rpt
IPR001315--CARD
IPR011029--DEATH-like_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS01282--BIR_REPEAT_1
PS50143--BIR_REPEAT_2
PS50209--CARD
PS50089--ZF_RING_2

Pfam

PF00653--BIR
PF00619--CARD

SMART

SM00238--BIR
SM00114--CARD
SM00184--RING

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0043027--F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:1990001--P:inhibition of cysteine-type endopeptidase activity involved in apoptotic process
GO:0060546--P:negative regulation of necroptotic process
GO:0031398--P:positive regulation of protein ubiquitination
GO:0034121--P:regulation of toll-like receptor signaling pathway

KEGG

cfa:489433

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Atr-002499	Amborella trichopoda	46.43	3.00e-12	66.20
IUUC-Acl-008330	Aspergillus clavatus	31.52	3.00e-14	73.90
IUUC-Afl-008648	Aspergillus flavus	32.12	2.00e-14	74.70
IUUC-Afu-008813	Aspergillus fumigatus	31.10	5.00e-15	76.60
IUUC-Ang-009667	Aspergillus niger	29.70	5.00e-14	73.20
IUUC-Ate-010501	Aspergillus terreus	32.73	1.00e-15	78.60
IUUC-Bgr-012051	Blumeria graminis	36.08	2.00e-17	84.70
IUUC-Bta-013105	Bos taurus	71.03	0.00e+00	839.00
IUUC-Bci-013905	Botrytis cinerea	35.37	3.00e-17	83.60
IUUC-Cel-018418	Caenorhabditis elegans	40.00	1.00e-08	54.30
IUUC-Cho-024929	Choloepus hoffmanni	72.35	0.00e+00	831.00
IUUC-Cgl-026472	Colletotrichum gloeosporioides	36.59	8.00e-20	92.80
IUUC-Cne-027029	Cryptococcus neoformans	32.95	1.00e-14	74.70
IUUC-Eca-034417	Equus caballus	76.82	0.00e+00	900.00
IUUC-Fox-037889	Fusarium oxysporum	35.40	5.00e-15	76.60
IUUC-Fso-038452	Fusarium solani	35.40	3.00e-13	70.90
IUUC-Ggr-039891	Gaeumannomyces graminis	35.00	9.00e-17	82.40
IUUC-Ggo-044605	Gorilla gorilla	74.55	0.00e+00	854.00
IUUC-Hsa-046144	Homo sapiens	74.50	0.00e+00	861.00
IUUC-Lma-052958	Leptosphaeria maculans	33.56	5.00e-12	66.60
IUUC-Laf-053720	Loxodonta africana	75.87	0.00e+00	870.00
IUUC-Mpo-057489	Magnaporthe poae	33.88	4.00e-17	83.60
IUUC-Mmr-060719	Microcebus murinus	76.49	0.00e+00	893.00
IUUC-Mmu-063340	Mus musculus	68.87	0.00e+00	807.00
IUUC-Mac-065489	Musa acuminata	36.73	3.00e-08	52.40
IUUC-Mpu-066740	Mustela putorius furo	76.16	0.00e+00	871.00
IUUC-Mlu-067988	Myotis lucifugus	73.34	0.00e+00	848.00
IUUC-Nfi-068591	Neosartorya fischeri	31.52	2.00e-14	75.10
IUUC-Ncr-068787	Neurospora crassa	30.48	2.00e-12	68.20
IUUC-Nle-069942	Nomascus leucogenys	74.67	0.00e+00	849.00
IUUC-Opr-070597	Ochotona princeps	73.18	0.00e+00	852.00
IUUC-Ocu-074698	Oryctolagus cuniculus	75.83	0.00e+00	887.00
IUUC-Osa-085816	Oryza sativa	42.55	4.00e-08	51.60
IUUC-Oga-089080	Otolemur garnettii	72.07	0.00e+00	842.00
IUUC-Oar-089496	Ovis aries	76.86	0.00e+00	889.00
IUUC-Ptr-091203	Pan troglodytes	74.83	0.00e+00	863.00
IUUC-Pma-094277	Petromyzon marinus	38.14	5.00e-111	395.00
IUUC-Pno-094971	Phaeosphaeria nodorum	33.99	3.00e-12	67.00
IUUC-Pte-104098	Pyrenophora teres	34.57	3.00e-15	76.30
IUUC-Pyt-104561	Pyrenophora triticirepentis	33.12	2.00e-14	73.60
IUUC-Rno-105292	Rattus norvegicus	69.37	0.00e+00	820.00
IUUC-Sja-107720	Schizosaccharomyces japonicus	34.67	1.00e-16	82.00
IUUC-Spo-108317	Schizosaccharomyces pombe	33.53	3.00e-20	94.40
IUUC-Smo-109461	Selaginella moellendorffii	39.29	2.00e-10	59.70
IUUC-Sly-110837	Solanum lycopersicum	47.92	8.00e-09	54.70
IUUC-Stu-112233	Solanum tuberosum	47.92	3.00e-09	56.20
IUUC-Sar-113239	Sorex araneus	72.56	0.00e+00	808.00
IUUC-Tre-121884	Trichoderma reesei	31.71	9.00e-12	65.90
IUUC-Tvi-122552	Trichoderma virens	31.88	3.00e-12	67.40
IUUC-Ttr-128766	Tursiops truncatus	76.99	0.00e+00	904.00
IUUC-Vpa-130761	Vicugna pacos	77.65	0.00e+00	911.00
IUUC-Yli-134629	Yarrowia lipolytica	35.00	4.00e-16	79.70

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence