iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046144

UUCD1 version

UUC-HoS-00112

Ensembl Protein ID

ENSP00000263464.3

UniProt Accession

Q13489; Q16628; Q9HC27; Q9UP46; BIRC3_HUMAN

Genbank Protein ID

AAC41943.1; AAC50371.1; AAC50507.1; AAC83232.1; AAU88144.1; AAH37420.1; AAG09369.1

Protein Name

Baculoviral IAP repeat-containing protein 3; Apoptosis inhibitor 2; Cellular inhibitor of apoptosis 2; IAP homolog C; Inhibitor of apoptosis protein 1; RING finger protein 49; RING-type E3 ubiquitin transferase BIRC3; TNFR2-TRAF-signaling complex protein 1

Genbank Nucleotide ID

L49432; U45878; U37546; AF070674; AY764389; BC037420; AF178945

Gene Name

BIRC3; API2; MIHC; RNF49

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000023445.13	ENST00000263464.7	ENSP00000263464.3
ENSG00000023445.13	ENST00000527309.1	ENSP00000431718.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
OMIM
Drug and target
TTD	GRAC
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
BioGRID	mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	19279678; 19854138; 18997792; 20097753; 18997792; 16235027
UBD/Alpha-Helix/UBA	UBA	18939944

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/UBA	2.80e-05	25.7	376	419

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBA

   S: 1    sededkleqlveMGFdreealqaLra....annnleaAveyLld 40
           ++++++++ +veMGF+r++++q  ++    ++ n+  + +++ld
   Q: 376  MMNTPVINAAVEMGFSRSLVKQTVQRkilaTGENYRLVNDLVLD 419
           789**************************66*******999986 PP

Organism

Homo sapiens

Functional Description
(View)

Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8.

Protein Sequence
(Fasta)

MNIVENSIFL SNLMKSANTF ELKYDLSCEL YRMSTYSTFP AGVPVSERSL ARAGFYYTGV 60
NDKVKCFCCG LMLDNWKRGD SPTEKHKKLY PSCRFVQSLN SVNNLEATSQ PTFPSSVTNS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCATTTAAAA GACAGCGTGA GACTCGCGCC CTCCGGCACG GAAAAGGCCA GGCGACAGGT 60
GTCGCTTGAA AAGACTGGGC TTGTCCTTGC TGGTGCATGC GTCGTCGGCC TCTGGGCAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0053--Apoptosis
KW-0160--Chromosomal rearrangement
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001370--BIR_rpt
IPR001315--CARD
IPR011029--DEATH-like_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS01282--BIR_REPEAT_1
PS50143--BIR_REPEAT_2
PS50209--CARD
PS50089--ZF_RING_2

Pfam

PF00653--BIR
PF00619--CARD

SMART

SM00238--BIR
SM00114--CARD
SM00184--RING

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0045121--C:membrane raft
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0043234--C:protein complex
GO:0043027--F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0016740--F:transferase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007166--P:cell surface receptor signaling pathway
GO:0007249--P:I-kappaB kinase/NF-kappaB signaling
GO:1990001--P:inhibition of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043066--P:negative regulation of apoptotic process
GO:0060546--P:negative regulation of necroptotic process
GO:0038061--P:NIK/NF-kappaB signaling
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0031398--P:positive regulation of protein ubiquitination
GO:0016579--P:protein deubiquitination
GO:0051291--P:protein heterooligomerization
GO:0042981--P:regulation of apoptotic process
GO:2000116--P:regulation of cysteine-type endopeptidase activity
GO:0050727--P:regulation of inflammatory response
GO:0045088--P:regulation of innate immune response
GO:0060544--P:regulation of necroptotic process
GO:0070424--P:regulation of nucleotide-binding oligomerization domain containing signaling pathway
GO:0039535--P:regulation of RIG-I signaling pathway
GO:0034121--P:regulation of toll-like receptor signaling pathway
GO:0010803--P:regulation of tumor necrosis factor-mediated signaling pathway
GO:0007283--P:spermatogenesis
GO:0035666--P:TRIF-dependent toll-like receptor signaling pathway
GO:0033209--P:tumor necrosis factor-mediated signaling pathway

KEGG

hsa:330

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Atr-002499	Amborella trichopoda	48.21	4.00e-13	68.90
IUUC-Apl-003549	Anas platyrhynchos	70.72	0.00e+00	832.00
IUUC-Acl-008330	Aspergillus clavatus	29.89	7.00e-14	72.80
IUUC-Afu-008813	Aspergillus fumigatus	30.82	1.00e-13	72.40
IUUC-Ani-009424	Aspergillus nidulans	27.12	1.00e-14	75.50
IUUC-Ate-010501	Aspergillus terreus	30.86	1.00e-15	79.00
IUUC-Bta-013105	Bos taurus	78.97	0.00e+00	890.00
IUUC-Cel-018418	Caenorhabditis elegans	44.07	2.00e-09	57.00
IUUC-Cfa-020667	Canis familiaris	74.50	0.00e+00	871.00
IUUC-Csa-024159	Chlorocebus sabaeus	86.75	0.00e+00	1013.00
IUUC-Cho-024929	Choloepus hoffmanni	80.63	0.00e+00	914.00
IUUC-Csv-026182	Ciona savignyi	31.40	2.00e-67	250.00
IUUC-Cgl-026472	Colletotrichum gloeosporioides	36.53	7.00e-20	93.20
IUUC-Cne-027029	Cryptococcus neoformans	31.18	1.00e-12	68.60
IUUC-Eca-034417	Equus caballus	86.26	0.00e+00	989.00
IUUC-Fal-037656	Ficedula albicollis	70.54	0.00e+00	834.00
IUUC-Fox-037889	Fusarium oxysporum	32.10	1.00e-14	75.90
IUUC-Fso-038452	Fusarium solani	32.30	4.00e-13	70.50
IUUC-Ggr-039891	Gaeumannomyces graminis	31.98	7.00e-17	82.80
IUUC-Ggo-044605	Gorilla gorilla	99.01	0.00e+00	1114.00
IUUC-Itr-048379	Ictidomys tridecemlineatus	86.92	0.00e+00	1002.00
IUUC-Kpa-049324	Komagataella pastoris	30.00	2.00e-12	69.30
IUUC-Lma-052958	Leptosphaeria maculans	33.33	1.00e-12	68.90
IUUC-Laf-053720	Loxodonta africana	84.00	0.00e+00	942.00
IUUC-Mcc-055282	Macaca mulatta	86.59	0.00e+00	1014.00
IUUC-Mor-057252	Magnaporthe oryzae	32.60	3.00e-17	84.30
IUUC-Mpo-057489	Magnaporthe poae	31.98	1.00e-16	82.00
IUUC-Mtr-057913	Medicago truncatula	29.29	4.00e-09	54.70
IUUC-Mvi-060388	Microbotryum violaceum	26.63	1.00e-06	48.50
IUUC-Mmr-060719	Microcebus murinus	88.41	0.00e+00	1014.00
IUUC-Mmu-063340	Mus musculus	74.01	0.00e+00	875.00
IUUC-Mac-065489	Musa acuminata	27.72	1.00e-09	57.00
IUUC-Mpu-066740	Mustela putorius furo	71.69	0.00e+00	852.00
IUUC-Mlu-067988	Myotis lucifugus	82.28	0.00e+00	922.00
IUUC-Ncr-068787	Neurospora crassa	32.50	5.00e-14	73.20
IUUC-Nle-069942	Nomascus leucogenys	97.35	0.00e+00	1102.00
IUUC-Opr-070597	Ochotona princeps	83.11	0.00e+00	956.00
IUUC-Ocu-074698	Oryctolagus cuniculus	86.92	0.00e+00	1009.00
IUUC-Osa-085816	Oryza sativa	40.43	2.00e-08	52.80
IUUC-Oga-089080	Otolemur garnettii	80.83	0.00e+00	950.00
IUUC-Oar-089496	Ovis aries	85.64	0.00e+00	959.00
IUUC-Ptr-091203	Pan troglodytes	99.01	0.00e+00	1116.00
IUUC-Pno-094971	Phaeosphaeria nodorum	35.14	5.00e-14	73.20
IUUC-Ppa-095167	Physcomitrella patens	42.86	7.00e-12	65.10
IUUC-Pte-104098	Pyrenophora teres	35.00	3.00e-16	79.70
IUUC-Pyt-104561	Pyrenophora triticirepentis	34.59	3.00e-16	79.70
IUUC-Rno-105292	Rattus norvegicus	74.01	0.00e+00	881.00
IUUC-Spo-108317	Schizosaccharomyces pombe	27.17	3.00e-16	81.30
IUUC-Smo-109461	Selaginella moellendorffii	42.59	4.00e-11	61.60
IUUC-Sly-110837	Solanum lycopersicum	50.00	3.00e-09	56.20
IUUC-Stu-112233	Solanum tuberosum	50.00	1.00e-09	57.80
IUUC-Sar-113239	Sorex araneus	76.53	0.00e+00	841.00
IUUC-Tgu-116931	Taeniopygia guttata	70.05	0.00e+00	843.00
IUUC-Tsy-118958	Tarsius syrichta	81.94	8.00e-177	613.00
IUUC-Tre-121884	Trichoderma reesei	32.52	5.00e-13	70.10
IUUC-Tvi-122552	Trichoderma virens	33.12	3.00e-13	70.90
IUUC-Ttr-128766	Tursiops truncatus	85.76	0.00e+00	996.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence