iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Eca-033718

Ensembl Protein ID

ENSECAP00000013831.1

UniProt Accession

F6TW45; F6TW45_HORSE

Protein Name

Uncharacterized protein

Gene Name

NWD1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000016197.1	ENSECAT00000017071.1	ENSECAP00000013831.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.50e-24	84.0	867	897
UBD/Beta-Prp	2.70e-47	161.6	867	1039

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 5    svtclaf.sd.tllvsGsdDgtikvWDlrtg 33
           ++t+la+ ++ +llv+G+ Dg + vWD+ ++
   Q: 867  GITALAWsPEeKLLVVGTQDGIVAVWDMEEQ 897
           59******999****************8766 PP

UBD/Beta-Prp

   S: 96   svlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl.....tg 177
            +++l++sp+ + lv+G++d ++ vwd+e++q+++ +l gh+g v+c++v  +g + +s+s+D t+rlW+l +g+   t      + 
   Q: 867  GITALAWSPEEKLLVVGTQDGIVAVWDMEEQQVIH-FLPGHRGEVRCLKVLAKGTCAISASKDHTLRLWNLLSGREKFTIwdrgsKD 952
           58899999999999999999999999999999999.999999999999999999999999999999999998887776666865322 PP
   S: 178  ghtdsvyslsfdsngkelvsgsldgtvklwdlqtgec.vrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlh 263
             ++++ sl  d+  k lv+ +   +v  w+l+t e   r+l + +d+ k+ +++  +  l+ +s+ g +++W + +g l ++  l+
   Q: 953  PPEPQICSLHADE-IKKLVYLASGAKVSAWNLETAELvFRILGDASDPWKCTAALAPQAVLLAVSEAGLVSLWSSATGRLQRKQRLS 1038
           2333444444443.4999999999999999999666515677778899999999999999999999999999988888776655554 PP
   S: 264  n 264
            
   Q: 1039 S 1039
           4 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

MQREKLCRAP PTPRQTFCQK HGLMFEVVDL RWGVRSAEAT EHMTTELCLE ELDRCRKTSI 60
GPAFVALMGN QYGPCPVPAL IEEKEWEALQ AQLAARPGDL ELVAQRFRRD ENAVPPAYVL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCAGAGAG AGAAGCTCTG CAGAGCGCCG CCTACCCCGA GGTGCAGACT TTCTGCCAGA 60
AGCACGGCCT GATGTTCGAG GTGAGCACCT GCCCGCTCCT CGCTGCCTGG GTCCCCTCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR024977--Apc4_WD40_dom
IPR027417--P-loop_NTPase
IPR011047--Quinoprotein_ADH-like_supfam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12894--ANAPC4_WD40
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0071013--C:catalytic step 2 spliceosome
GO:0071011--C:precatalytic spliceosome
GO:0005682--C:U5 snRNP
GO:0008380--P:RNA splicing

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001525	Ailuropoda melanoleuca	82.27	0.00e+00	2532.00
IUUC-Apl-003467	Anas platyrhynchos	60.09	4.00e-82	297.00
IUUC-Ame-011400	Astyanax mexicanus	35.52	0.00e+00	917.00
IUUC-Bta-013223	Bos taurus	82.25	0.00e+00	2221.00
IUUC-Cel-018404	Caenorhabditis elegans	27.75	5.00e-96	346.00
IUUC-Cja-018773	Callithrix jacchus	76.86	0.00e+00	1447.00
IUUC-Cfa-020334	Canis familiaris	82.88	0.00e+00	2558.00
IUUC-Cpo-022316	Cavia porcellus	65.40	0.00e+00	1852.00
IUUC-Csa-023631	Chlorocebus sabaeus	79.39	0.00e+00	2441.00
IUUC-Cin-025646	Ciona intestinalis	32.33	2.00e-124	440.00
IUUC-Csv-026191	Ciona savignyi	23.87	5.00e-20	92.00
IUUC-Dre-028241	Danio rerio	35.26	0.00e+00	887.00
IUUC-Dno-029990	Dasypus novemcinctus	79.95	0.00e+00	694.00
IUUC-Dor-030869	Dipodomys ordii	56.21	3.00e-149	522.00
IUUC-Ete-033059	Echinops telfairi	82.43	0.00e+00	817.00
IUUC-Fca-035748	Felis catus	81.42	0.00e+00	2350.00
IUUC-Gac-041507	Gasterosteus aculeatus	34.55	0.00e+00	707.00
IUUC-Ggo-044551	Gorilla gorilla	76.05	0.00e+00	2318.00
IUUC-Hsa-046787	Homo sapiens	78.39	0.00e+00	2426.00
IUUC-Itr-048104	Ictidomys tridecemlineatus	81.19	0.00e+00	1026.00
IUUC-Lch-049578	Latimeria chalumnae	46.56	0.00e+00	1372.00
IUUC-Loc-052039	Lepisosteus oculatus	40.03	0.00e+00	1158.00
IUUC-Laf-054240	Loxodonta africana	78.89	0.00e+00	2476.00
IUUC-Mcc-054657	Macaca mulatta	73.19	0.00e+00	2102.00
IUUC-Meu-056591	Macropus eugenii	59.76	0.00e+00	1068.00
IUUC-Mmr-061577	Microcebus murinus	76.31	0.00e+00	2310.00
IUUC-Mdo-062895	Monodelphis domestica	59.52	0.00e+00	1704.00
IUUC-Mmu-063866	Mus musculus	73.26	0.00e+00	2205.00
IUUC-Mpu-066510	Mustela putorius furo	81.11	0.00e+00	2545.00
IUUC-Mlu-067855	Myotis lucifugus	81.11	0.00e+00	2438.00
IUUC-Nle-069557	Nomascus leucogenys	74.22	0.00e+00	2214.00
IUUC-Opr-071196	Ochotona princeps	64.10	0.00e+00	634.00
IUUC-Ont-072070	Oreochromis niloticus	34.99	0.00e+00	766.00
IUUC-Oan-073437	Ornithorhynchus anatinus	55.00	0.00e+00	1199.00
IUUC-Ocu-074941	Oryctolagus cuniculus	52.59	7.00e-29	120.00
IUUC-Ola-086624	Oryzias latipes	32.82	0.00e+00	668.00
IUUC-Oga-088313	Otolemur garnettii	79.08	0.00e+00	2225.00
IUUC-Oar-090123	Ovis aries	81.50	0.00e+00	2521.00
IUUC-Ptr-090552	Pan troglodytes	80.89	0.00e+00	1046.00
IUUC-Psi-093963	Pelodiscus sinensis	54.11	0.00e+00	1589.00
IUUC-Pfo-096197	Poecilia formosa	34.34	0.00e+00	781.00
IUUC-Pab-097755	Pongo abelii	79.11	0.00e+00	872.00
IUUC-Pca-100809	Procavia capensis	74.71	0.00e+00	1126.00
IUUC-Pva-102554	Pteropus vampyrus	78.33	0.00e+00	2174.00
IUUC-Rno-105174	Rattus norvegicus	68.18	0.00e+00	2002.00
IUUC-Sha-107304	Sarcophilus harrisii	58.71	0.00e+00	1874.00
IUUC-Sar-113168	Sorex araneus	70.64	0.00e+00	906.00
IUUC-Tru-118251	Takifugu rubripes	33.94	6.00e-171	595.00
IUUC-Tsy-119276	Tarsius syrichta	77.90	2.00e-115	410.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence