iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Ath-006751

UUCD1 version

UUC-ArT-00665

Ensembl Protein ID

AT5G57360.1

UniProt Accession

Q94BT6; Q9LDF6; ADO1_ARATH

Genbank Protein ID

AAF70288.1; AAF32300.1; BAB18914.1; AAK27433.1; BAB08473.1; AED96891.1; AAK64006.1; AAP68211.1

Protein Name

Adagio protein 1; Clock-associated PAS protein ZTL; F-box only protein 2b; Flavin-binding kelch repeat F-box protein 1-like protein 2; LOV kelch protein 1; Protein ZEITLUPE

Genbank Nucleotide ID

AF254413; AF216525; AB038796; AF252294; AB016891; CP002688; AY039902; BT008772

Gene Name

ADO1; FKL2; LKP1; ZTL; At5g57360; MSF19.2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AT5G57360	AT5G57360.2	AT5G57360.2
AT5G57360	AT5G57360.1	AT5G57360.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
Protein-protein Interaction
iRefIndex	PINA	HINT	Mentha
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box	F-box	18433436; 18562312

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/SCF/F-box	0.025	15.5	200	242

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/SCF/F-box

   S: 106  lpeeil.veilklldkeellraarvcrrwqelasqkalwktvt 147
           l++e++ ++il++l+++++ ++++vcrr++ l++++ lw++v+
   Q: 200  LSDEVVsMKILSRLTPRDVASVSSVCRRLYVLTKNEDLWRRVC 242
           55555439**********************99999****9875 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Component of an E3 ubiquitin ligase complex that plays a central role in blue light-dependent circadian cycles. Acts as a blue light photoreceptor, due to the presence of FMN, that mediates light-regulated protein degradation of critical clock components by targeting them to the proteasome complex. The SCF(ADO1) E3 ubiquitin ligase complex is involved in the regulation of circadian clock-dependent processes including the transition to flowering time, hypocotyl elongation, cotyledons and leaf movement rhythms. APRR1/TOC1 and APRR5, but not 'GIGANTEA', are proteolytic substrates of this ubiquitin ligase complex. Blue light enhances cooperative stabilization of 'GIGANTEA' and ADO1/ZTL, leading to amplification and sharpening of the expression profile of APRR1/TOC1. ADO1/ZTL interacts with ADO3, preventing the interaction of ADO3 with CDF1.

Protein Sequence
(Fasta)

MEWDSGSDLS ADDASSLADD EEGGLFPGGG PIPYPVGNLL HTAPCGFVVT DAVEPDQPII 60
YVNTVFEMVT GYRAEEVLGG NCRFLQCRGP FAKRRHPLVD SMVVSEIRKC IDEGIEFQGE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGAGTTTTA TGGTTTTATC TACTTGACCC GACAGAGAAA TCCGGACCCG GATAAAATCC 60
GACCCGTTCG AATGAACTCA TACGGCCGAG ATTTTTCCAC CAAACTCGAC GGTTACCACT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0090--Biological rhythms
KW-0157--Chromophore
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0285--Flavoprotein
KW-0287--Flowering
KW-0288--FMN
KW-0880--Kelch repeat
KW-0539--Nucleus
KW-0600--Photoreceptor protein
KW-0675--Receptor
KW-1185--Reference proteome
KW-0677--Repeat
KW-0716--Sensory transduction
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR001810--F-box_dom
IPR011043--Gal_Oxase/kelch_b-propeller
IPR015915--Kelch-typ_b-propeller
IPR000014--PAS

PROSITE

PS50181--FBOX
PS50112--PAS

Pfam

PF12937--F-box-like
PF13426--PAS_9

SMART

SM00256--FBOX

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0009881--F:photoreceptor activity
GO:0009908--P:flower development
GO:0016567--P:protein ubiquitination
GO:0018298--P:protein-chromophore linkage
GO:0048511--P:rhythmic process

KEGG

ath:AT5G57360

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000275	Aegilops tauschii	75.80	0.00e+00	882.00
IUUC-Atr-002804	Amborella trichopoda	80.20	0.00e+00	926.00
IUUC-Aly-006384	Arabidopsis lyrata	98.95	0.00e+00	1051.00
IUUC-Aor-010180	Aspergillus oryzae	28.69	6.00e-08	50.80
IUUC-Bgr-012290	Blumeria graminis	27.61	1.00e-09	57.00
IUUC-Bdi-014409	Brachypodium distachyon	78.20	0.00e+00	903.00
IUUC-Cel-018449	Caenorhabditis elegans	26.72	2.00e-05	43.90
IUUC-Cho-024551	Choloepus hoffmanni	26.37	4.00e-10	59.30
IUUC-Csv-026017	Ciona savignyi	35.71	7.00e-03	34.30
IUUC-Gma-043308	Glycine max	85.55	0.00e+00	962.00
IUUC-Hvu-047503	Hordeum vulgare	79.24	0.00e+00	910.00
IUUC-Lpe-051257	Leersia perrieri	78.55	0.00e+00	921.00
IUUC-Lma-053201	Leptosphaeria maculans	23.43	1.00e-05	43.50
IUUC-Mtr-058566	Medicago truncatula	83.52	0.00e+00	1022.00
IUUC-Mdo-062483	Monodelphis domestica	30.53	7.00e-08	51.20
IUUC-Mmu-064113	Mus musculus	25.64	3.00e-11	63.20
IUUC-Mac-065225	Musa acuminata	73.57	0.00e+00	800.00
IUUC-Nfi-068521	Neosartorya fischeri	29.81	3.00e-12	66.60
IUUC-Ont-072365	Oreochromis niloticus	27.32	2.00e-10	60.80
IUUC-Ocu-074656	Oryctolagus cuniculus	24.41	4.00e-10	59.30
IUUC-Oba-075246	Oryza barthii	76.27	0.00e+00	909.00
IUUC-Obr-076719	Oryza brachyantha	80.45	0.00e+00	935.00
IUUC-Ogl-077713	Oryza glaberrima	80.38	0.00e+00	932.00
IUUC-Ogu-078834	Oryza glumaepatula	76.27	0.00e+00	909.00
IUUC-Oin-079547	Oryza indica	80.38	0.00e+00	932.00
IUUC-Olo-080732	Oryza longistaminata	80.90	0.00e+00	833.00
IUUC-Ome-081964	Oryza meridionalis	80.38	0.00e+00	932.00
IUUC-Oni-083029	Oryza nivara	80.38	0.00e+00	932.00
IUUC-Opu-083260	Oryza punctata	77.85	0.00e+00	894.00
IUUC-Oru-084672	Oryza rufipogon	76.27	0.00e+00	909.00
IUUC-Osa-085774	Oryza sativa	80.38	0.00e+00	932.00
IUUC-Pop-099147	Populus trichocarpa	87.29	0.00e+00	849.00
IUUC-Ppe-101531	Prunus persica	86.80	0.00e+00	828.00
IUUC-Rno-105811	Rattus norvegicus	25.13	1.00e-10	61.20
IUUC-Smo-108794	Selaginella moellendorffii	71.30	0.00e+00	823.00
IUUC-Sit-109764	Setaria italica	78.55	0.00e+00	889.00
IUUC-Sly-111708	Solanum lycopersicum	81.61	0.00e+00	826.00
IUUC-Sar-113343	Sorex araneus	24.41	2.00e-10	60.80
IUUC-Sbi-114442	Sorghum bicolor	79.24	0.00e+00	895.00
IUUC-Tca-121031	Theobroma cacao	86.64	0.00e+00	1013.00
IUUC-Tre-122100	Trichoderma reesei	38.64	8.00e-03	35.00
IUUC-Tvi-122410	Trichoderma virens	38.64	7.00e-03	35.00
IUUC-Tae-124476	Triticum aestivum	62.56	0.00e+00	723.00
IUUC-Tur-126191	Triticum urartu	77.34	0.00e+00	853.00
IUUC-Vda-129892	Verticillium dahliae	41.44	2.00e-21	94.40
IUUC-Vvi-131721	Vitis vinifera	84.18	0.00e+00	985.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence