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Tag Content
iUUCD ID IUUC-Pno-094825
Ensembl Protein ID SNOT_03476
UniProt Accession Q0UXN8; ATG5_PHANO
Genbank Protein ID EAT88681.2
Protein Name Autophagy protein 5
Genbank Nucleotide ID CH445329
Gene Name ATG5; SNOG_03476
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
SNOG_03476 SNOT_03476 SNOT_03476
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 adaptor/Cullin RING/Other 20.58 3.00e-11 63.90 IUUC-Sce-106216
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Phaeosphaeria nodorum
Functional Description
(View)

Functional Description



     Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes (By similarity).
Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes (By similarity).
Protein Sequence
(Fasta)
MSSREVTSRL REKIQFPRLS YLALLIHKLH AFFAPSLIYP DIHPSDLWFS YEGVPLKWHY 60
PLGLLYDLYS GAEPYHPSDS PPPSPTTPSK QDSKQPLPWR LTLHTSAYPT TQLIPLDNNN 120
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Protein Fasta Sequence



>IUUC-Pno-094825|E3,Cullin RING/Other|Phaeosphaeria nodorum
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Nucleotide Sequence
(Fasta)
ATGTCGAGCC GCGAAGTCAC GAGCCGCCTG CGCGAGAAAG TGTGGAATGG GAGCGTGCCG 60
CTGGAAATAA GACTGCACAA GGGGGATTGT AGGACGTACG ATGATTCGGA TGCTTATCTC 120
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Nucleotide Fasta Sequence



>IUUC-Pno-094825|E3,Cullin RING/Other|Phaeosphaeria nodorum
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0832--Ubl conjugation

Interpro

IPR007239--Atg5

Pfam

PF04106--APG5

Gene Ontology

GO:0034274--C:Atg12-Atg5-Atg16 complex
GO:0034045--C:pre-autophagosomal structure membrane
GO:0000045--P:autophagosome assembly
GO:0006501--P:C-terminal protein lipidation
GO:0006995--P:cellular response to nitrogen starvation
GO:0000422--P:mitophagy
GO:0044804--P:nucleophagy
GO:0015031--P:protein transport

KEGG pno:SNOG_03476
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000583 Aegilops tauschii 28.41 8.00e-20 90.90
IUUC-Aml-002403 Ailuropoda melanoleuca 28.98 4.00e-24 103.00
IUUC-Atr-002645 Amborella trichopoda 32.91 8.00e-22 95.90
IUUC-Apl-003611 Anas platyrhynchos 27.76 3.00e-28 117.00
IUUC-Aca-004411 Anolis carolinensis 28.17 5.00e-27 112.00
IUUC-Aly-005636 Arabidopsis lyrata 35.44 2.00e-18 85.10
IUUC-Ath-006959 Arabidopsis thaliana 35.44 2.00e-18 84.30
IUUC-Ago-007978 Ashbya gossypii 25.90 4.00e-17 79.70
IUUC-Acl-008328 Aspergillus clavatus 46.04 1.00e-57 214.00
IUUC-Afl-008638 Aspergillus flavus 44.88 5.00e-62 229.00
IUUC-Afu-009042 Aspergillus fumigatus 46.15 1.00e-63 234.00
IUUC-Ani-009364 Aspergillus nidulans 44.22 2.00e-57 214.00
IUUC-Aor-009889 Aspergillus oryzae 44.79 2.00e-62 230.00
IUUC-Ate-010511 Aspergillus terreus 44.74 4.00e-24 101.00
IUUC-Ame-011644 Astyanax mexicanus 41.07 1.00e-06 42.00
IUUC-Bgr-012153 Blumeria graminis 35.56 1.00e-33 135.00
IUUC-Bta-012360 Bos taurus 32.90 2.00e-16 76.60
IUUC-Bci-013723 Botrytis cinerea 37.24 1.00e-46 177.00
IUUC-Bdi-014520 Brachypodium distachyon 31.33 4.00e-17 80.50
IUUC-Bol-016053 Brassica oleracea 34.81 9.00e-21 92.40
IUUC-Bra-017072 Brassica rapa 35.44 1.00e-21 95.10
IUUC-Cel-018529 Caenorhabditis elegans 24.26 5.00e-16 76.30
IUUC-Cja-019569 Callithrix jacchus 28.47 2.00e-25 107.00
IUUC-Cfa-020473 Canis familiaris 28.83 9.00e-26 108.00
IUUC-Cpo-021421 Cavia porcellus 28.11 6.00e-25 105.00
IUUC-Cre-022862 Chlamydomonas reinhardtii 28.70 2.00e-07 47.80
IUUC-Csa-024197 Chlorocebus sabaeus 28.47 3.00e-25 107.00
IUUC-Cho-024521 Choloepus hoffmanni 27.34 4.00e-22 96.30
IUUC-Cin-025119 Ciona intestinalis 26.22 1.00e-22 98.20
IUUC-Csv-026192 Ciona savignyi 26.32 9.00e-22 95.10
IUUC-Cgl-026686 Colletotrichum gloeosporioides 33.22 2.00e-31 127.00
IUUC-Dre-028466 Danio rerio 27.02 1.00e-26 111.00
IUUC-Dse-031228 Dothistroma septosporum 51.07 3.00e-82 296.00
IUUC-Dme-031703 Drosophila melanogaster 26.32 3.00e-19 87.00
IUUC-Ete-032482 Echinops telfairi 28.09 7.00e-24 102.00
IUUC-Eca-034036 Equus caballus 28.83 2.00e-25 107.00
IUUC-Eeu-035235 Erinaceus europaeus 32.69 9.00e-16 75.50
IUUC-Fca-036263 Felis catus 28.83 2.00e-25 107.00
IUUC-Fal-037064 Ficedula albicollis 27.40 1.00e-27 114.00
IUUC-Fox-037813 Fusarium oxysporum 36.53 4.00e-40 156.00
IUUC-Fso-038139 Fusarium solani 37.27 5.00e-42 162.00
IUUC-Gmo-039509 Gadus morhua 27.35 3.00e-20 90.10
IUUC-Ggr-040111 Gaeumannomyces graminis 38.08 4.00e-38 150.00
IUUC-Gga-040517 Gallus gallus 27.40 5.00e-28 116.00
IUUC-Gac-042270 Gasterosteus aculeatus 28.40 1.00e-21 94.70
IUUC-Gma-044400 Glycine max 34.18 4.00e-20 89.70
IUUC-Ggo-045048 Gorilla gorilla 28.07 8.00e-26 108.00
IUUC-Hsa-046744 Homo sapiens 28.47 2.00e-25 107.00
IUUC-Kpa-049174 Komagataella pastoris 24.48 7.00e-24 102.00
IUUC-Lch-049475 Latimeria chalumnae 29.54 2.00e-28 117.00
IUUC-Lpe-051283 Leersia perrieri 30.77 6.00e-20 91.30
IUUC-Loc-052446 Lepisosteus oculatus 28.47 2.00e-29 120.00
IUUC-Lma-053278 Leptosphaeria maculans 75.27 1.00e-111 394.00
IUUC-Laf-054020 Loxodonta africana 28.62 9.00e-24 102.00
IUUC-Mcc-055176 Macaca mulatta 28.47 2.00e-25 107.00
IUUC-Mor-057164 Magnaporthe oryzae 37.78 2.00e-41 160.00
IUUC-Mpo-057428 Magnaporthe poae 37.24 7.00e-38 148.00
IUUC-Mtr-058424 Medicago truncatula 34.18 4.00e-20 89.70
IUUC-Mla-058872 Melampsora laricipopulina 27.30 4.00e-24 103.00
IUUC-Mga-059859 Meleagris gallopavo 27.40 5.00e-28 116.00
IUUC-Mmr-061482 Microcebus murinus 28.47 1.00e-25 108.00
IUUC-Mdo-062371 Monodelphis domestica 28.01 9.00e-28 115.00
IUUC-Mmu-063139 Mus musculus 27.76 4.00e-26 109.00
IUUC-Mac-065332 Musa acuminata 31.25 2.00e-19 88.20
IUUC-Mpu-066783 Mustela putorius furo 28.47 4.00e-25 106.00
IUUC-Mlu-068165 Myotis lucifugus 27.92 3.00e-23 100.00
IUUC-Nfi-068578 Neosartorya fischeri 45.80 1.00e-62 231.00
IUUC-Ncr-068636 Neurospora crassa 34.40 8.00e-36 142.00
IUUC-Nle-069740 Nomascus leucogenys 28.47 2.00e-25 107.00
IUUC-Opr-070802 Ochotona princeps 31.45 1.00e-15 74.70
IUUC-Ont-072222 Oreochromis niloticus 27.37 7.00e-26 108.00
IUUC-Oan-072760 Ornithorhynchus anatinus 31.41 1.00e-21 94.40
IUUC-Ocu-074844 Oryctolagus cuniculus 24.20 7.00e-10 55.10
IUUC-Oba-075834 Oryza barthii 34.81 1.00e-20 92.00
IUUC-Obr-076230 Oryza brachyantha 31.36 7.00e-12 62.80
IUUC-Ogl-077554 Oryza glaberrima 34.81 1.00e-20 92.00
IUUC-Ogu-078687 Oryza glumaepatula 34.18 5.00e-20 90.10
IUUC-Oin-079677 Oryza indica 31.58 6.00e-22 96.30
IUUC-Olo-081078 Oryza longistaminata 35.22 1.00e-20 92.40
IUUC-Ome-081548 Oryza meridionalis 35.22 1.00e-20 93.20
IUUC-Oni-082050 Oryza nivara 34.81 2.00e-20 91.70
IUUC-Opu-083609 Oryza punctata 34.81 9.00e-21 92.40
IUUC-Oru-085057 Oryza rufipogon 34.81 2.00e-20 91.30
IUUC-Osa-085917 Oryza sativa 34.18 5.00e-19 86.70
IUUC-Ola-087032 Oryzias latipes 26.32 1.00e-24 104.00
IUUC-Oga-088468 Otolemur garnettii 28.62 1.00e-26 111.00
IUUC-Oar-089751 Ovis aries 28.83 1.00e-25 107.00
IUUC-Ptr-091064 Pan troglodytes 28.47 2.00e-25 107.00
IUUC-Pan-092505 Papio anubis 28.62 8.00e-24 102.00
IUUC-Psi-093086 Pelodiscus sinensis 28.37 7.00e-28 115.00
IUUC-Ppa-095419 Physcomitrella patens 32.70 2.00e-19 88.20
IUUC-Pfo-096224 Poecilia formosa 26.32 4.00e-25 106.00
IUUC-Pab-098501 Pongo abelii 28.07 2.00e-25 107.00
IUUC-Pop-099243 Populus trichocarpa 32.47 1.00e-18 85.10
IUUC-Ppe-101255 Prunus persica 29.84 1.00e-19 89.00
IUUC-Pva-102828 Pteropus vampyrus 29.18 3.00e-25 107.00
IUUC-Pgr-103672 Puccinia graminis 27.67 2.00e-19 88.20
IUUC-Ptt-104013 Puccinia triticina 26.35 4.00e-19 87.00
IUUC-Pyt-104615 Pyrenophora triticirepentis 69.18 1.00e-105 374.00
IUUC-Rno-106089 Rattus norvegicus 27.72 3.00e-25 106.00
IUUC-Sce-106216 Saccharomyces cerevisiae 20.94 7.00e-13 65.90
IUUC-Sha-106484 Sarcophilus harrisii 28.01 2.00e-27 114.00
IUUC-Sja-107699 Schizosaccharomyces japonicus 31.05 1.00e-38 150.00
IUUC-Spo-108177 Schizosaccharomyces pombe 30.45 2.00e-35 140.00
IUUC-Ssl-108475 Sclerotinia sclerotiorum 37.24 1.00e-47 181.00
IUUC-Smo-109473 Selaginella moellendorffii 30.67 2.00e-16 78.20
IUUC-Sit-110736 Setaria italica 33.33 1.00e-19 89.00
IUUC-Sly-111657 Solanum lycopersicum 36.48 9.00e-22 95.90
IUUC-Sar-113050 Sorex araneus 33.33 2.00e-19 87.40
IUUC-Sbi-114258 Sorghum bicolor 29.11 3.00e-19 87.40
IUUC-Sre-114902 Sporisorium reilianum 31.22 1.00e-16 79.30
IUUC-Ssc-116166 Sus scrofa 27.40 2.00e-23 100.00
IUUC-Tgu-116814 Taeniopygia guttata 27.76 9.00e-29 118.00
IUUC-Tru-118172 Takifugu rubripes 26.67 2.00e-25 107.00
IUUC-Tsy-119010 Tarsius syrichta 32.46 9.00e-21 92.00
IUUC-Tni-120397 Tetraodon nigroviridis 28.72 7.00e-20 88.60
IUUC-Tca-121283 Theobroma cacao 33.54 7.00e-19 86.30
IUUC-Tvi-122545 Trichoderma virens 35.27 6.00e-37 145.00
IUUC-Tae-122685 Triticum aestivum 29.39 2.00e-21 94.00
IUUC-Tur-126407 Triticum urartu 28.83 3.00e-21 94.00
IUUC-Tme-126913 Tuber melanosporum 40.81 1.00e-56 211.00
IUUC-Tbe-127738 Tupaia belangeri 23.56 8.00e-13 65.10
IUUC-Ttr-128528 Tursiops truncatus 28.83 8.00e-26 108.00
IUUC-Uma-129625 Ustilago maydis 30.59 3.00e-18 84.70
IUUC-Vda-129906 Verticillium dahliae 36.06 3.00e-35 139.00
IUUC-Vpa-130223 Vicugna pacos 28.57 6.00e-24 102.00
IUUC-Vvi-131617 Vitis vinifera 32.70 1.00e-17 82.00
IUUC-Xtr-132288 Xenopus tropicalis 29.18 2.00e-31 127.00
IUUC-Xma-134214 Xiphophorus maculatus 31.77 4.00e-21 92.40
IUUC-Yli-134377 Yarrowia lipolytica 33.48 1.00e-22 98.20
IUUC-Zma-135108 Zea mays 32.70 2.00e-19 87.80
Created Date 25-Jun-2017

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