iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	30.15	7.00e-50	195.00	IUUC-Dme-031819
E3 activity/RING/RING	81.57	0.00e+00	969.00	IUUC-Hsa-045769

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MENSTVLSNW TKENKEKMKY DFSCELYRMS TYSAFPRGVP VSERSLARAG FYYTGVNDKV 60
KCFCCGLMLD NWKQGDSPTE KHRQFYPSCS FVQTLLSGGL QSAAKNTSPA KSRFAHSLPL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCAGTTCAGT CAGAAGACCG TGAATGTGTC CAGTTAGCTG TCTGCTGTCT CATTCCCGTC 60
TATGGTAGAG ATCTTGTGTG AAGTAGTGAG GAGCTTCATA TGGAAGTTTA AGCTGCCAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001370--BIR_rpt
IPR028795--C-IAP1
IPR001315--CARD
IPR011029--DEATH-like_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS01282--BIR_REPEAT_1
PS50143--BIR_REPEAT_2
PS50209--CARD
PS50089--ZF_RING_2

Pfam

PF00653--BIR
PF00619--CARD

SMART

SM00238--BIR
SM00114--CARD
SM00184--RING

Gene Ontology

GO:0035631--C:CD40 receptor complex
GO:0005737--C:cytoplasm
GO:0009898--C:cytoplasmic side of plasma membrane
GO:0045121--C:membrane raft
GO:0005634--C:nucleus
GO:0043234--C:protein complex
GO:0001741--C:XY body
GO:0043027--F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0003713--F:transcription coactivator activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0071356--P:cellular response to tumor necrosis factor
GO:1990001--P:inhibition of cysteine-type endopeptidase activity involved in apoptotic process
GO:0070266--P:necroptotic process
GO:0043066--P:negative regulation of apoptotic process
GO:0060546--P:negative regulation of necroptotic process
GO:1902443--P:negative regulation of ripoptosome assembly involved in necroptotic process
GO:0001890--P:placenta development
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:1902524--P:positive regulation of protein K48-linked ubiquitination
GO:1902523--P:positive regulation of protein K63-linked ubiquitination
GO:1902527--P:positive regulation of protein monoubiquitination
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051291--P:protein heterooligomerization
GO:0000209--P:protein polyubiquitination
GO:0051726--P:regulation of cell cycle
GO:0045595--P:regulation of cell differentiation
GO:0050727--P:regulation of inflammatory response
GO:1901222--P:regulation of NIK/NF-kappaB signaling
GO:2000377--P:regulation of reactive oxygen species metabolic process
GO:0034121--P:regulation of toll-like receptor signaling pathway
GO:0051591--P:response to cAMP
GO:0045471--P:response to ethanol
GO:0001666--P:response to hypoxia
GO:0014070--P:response to organic cyclic compound
GO:0010243--P:response to organonitrogen compound

KEGG

rno:60371

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000162	Aegilops tauschii	40.74	2.00e-08	53.90
IUUC-Aml-002369	Ailuropoda melanoleuca	80.17	0.00e+00	942.00
IUUC-Apl-003549	Anas platyrhynchos	68.59	0.00e+00	800.00
IUUC-Aca-004515	Anolis carolinensis	64.74	0.00e+00	724.00
IUUC-Ath-007365	Arabidopsis thaliana	43.48	2.00e-08	57.00
IUUC-Acl-008330	Aspergillus clavatus	31.75	7.00e-18	86.30
IUUC-Afl-008648	Aspergillus flavus	32.43	2.00e-18	87.80
IUUC-Afu-008813	Aspergillus fumigatus	33.15	4.00e-17	83.60
IUUC-Ani-009424	Aspergillus nidulans	32.98	6.00e-18	86.30
IUUC-Ang-009667	Aspergillus niger	33.54	4.00e-16	80.10
IUUC-Ame-011877	Astyanax mexicanus	53.61	3.00e-177	615.00
IUUC-Bta-012450	Bos taurus	77.76	0.00e+00	856.00
IUUC-Bci-013905	Botrytis cinerea	37.50	2.00e-19	90.50
IUUC-Bol-015478	Brassica oleracea	32.76	2.00e-10	63.90
IUUC-Bra-017001	Brassica rapa	33.62	1.00e-10	65.10
IUUC-Cel-018418	Caenorhabditis elegans	41.67	6.00e-09	55.10
IUUC-Cja-018895	Callithrix jacchus	80.40	0.00e+00	941.00
IUUC-Cfa-020419	Canis familiaris	79.73	0.00e+00	944.00
IUUC-Cpo-022048	Cavia porcellus	80.74	0.00e+00	939.00
IUUC-Csa-024159	Chlorocebus sabaeus	75.87	0.00e+00	872.00
IUUC-Cho-024277	Choloepus hoffmanni	75.59	0.00e+00	868.00
IUUC-Cin-025521	Ciona intestinalis	28.76	2.00e-73	270.00
IUUC-Dre-028647	Danio rerio	52.64	2.00e-173	602.00
IUUC-Dno-029509	Dasypus novemcinctus	74.71	0.00e+00	878.00
IUUC-Dor-030796	Dipodomys ordii	70.63	5.00e-91	328.00
IUUC-Dme-031819	Drosophila melanogaster	29.83	3.00e-68	252.00
IUUC-Eca-033393	Equus caballus	81.30	0.00e+00	952.00
IUUC-Eeu-035114	Erinaceus europaeus	78.06	0.00e+00	913.00
IUUC-Fca-036034	Felis catus	78.26	0.00e+00	911.00
IUUC-Fal-037656	Ficedula albicollis	67.00	0.00e+00	784.00
IUUC-Fox-037889	Fusarium oxysporum	33.91	7.00e-18	86.30
IUUC-Fso-038452	Fusarium solani	32.79	1.00e-15	78.60
IUUC-Ggr-039891	Gaeumannomyces graminis	36.08	1.00e-17	85.10
IUUC-Gga-040601	Gallus gallus	68.75	0.00e+00	801.00
IUUC-Gac-041467	Gasterosteus aculeatus	55.14	6.00e-172	597.00
IUUC-Ggo-044857	Gorilla gorilla	80.40	0.00e+00	949.00
IUUC-Hsa-045769	Homo sapiens	80.74	0.00e+00	952.00
IUUC-Itr-048441	Ictidomys tridecemlineatus	83.31	0.00e+00	980.00
IUUC-Lch-050259	Latimeria chalumnae	59.77	0.00e+00	684.00
IUUC-Loc-052169	Lepisosteus oculatus	53.02	2.00e-163	568.00
IUUC-Lma-052958	Leptosphaeria maculans	33.77	8.00e-12	65.90
IUUC-Laf-053449	Loxodonta africana	79.80	0.00e+00	922.00
IUUC-Mcc-055282	Macaca mulatta	74.38	0.00e+00	875.00
IUUC-Meu-056241	Macropus eugenii	62.27	0.00e+00	639.00
IUUC-Mpo-057489	Magnaporthe poae	36.08	8.00e-17	82.80
IUUC-Mtr-058211	Medicago truncatula	46.81	5.00e-09	59.30
IUUC-Mga-059947	Meleagris gallopavo	68.26	0.00e+00	798.00
IUUC-Mdo-062352	Monodelphis domestica	71.74	0.00e+00	842.00
IUUC-Mmu-064340	Mus musculus	90.36	0.00e+00	1063.00
IUUC-Mac-065489	Musa acuminata	40.82	3.00e-09	55.50
IUUC-Mpu-065890	Mustela putorius furo	78.60	0.00e+00	866.00
IUUC-Mlu-068077	Myotis lucifugus	80.17	0.00e+00	959.00
IUUC-Nfi-068591	Neosartorya fischeri	32.97	1.00e-17	85.50
IUUC-Ncr-068787	Neurospora crassa	34.59	1.00e-15	78.60
IUUC-Nle-070081	Nomascus leucogenys	79.73	0.00e+00	951.00
IUUC-Opr-070561	Ochotona princeps	77.72	0.00e+00	892.00
IUUC-Ont-071776	Oreochromis niloticus	54.04	1.00e-175	609.00
IUUC-Oan-073604	Ornithorhynchus anatinus	70.42	0.00e+00	832.00
IUUC-Ocu-073963	Oryctolagus cuniculus	80.90	0.00e+00	949.00
IUUC-Ogu-078452	Oryza glumaepatula	45.45	8.00e-07	48.10
IUUC-Oni-082044	Oryza nivara	43.64	2.00e-09	57.00
IUUC-Opu-084085	Oryza punctata	39.58	3.00e-06	46.20
IUUC-Oru-085060	Oryza rufipogon	44.19	2.00e-06	47.00
IUUC-Ola-086446	Oryzias latipes	52.59	3.00e-167	582.00
IUUC-Oga-087976	Otolemur garnettii	82.24	0.00e+00	953.00
IUUC-Oar-090097	Ovis aries	78.77	0.00e+00	936.00
IUUC-Ptr-091137	Pan troglodytes	80.57	0.00e+00	952.00
IUUC-Pan-092673	Papio anubis	81.24	0.00e+00	957.00
IUUC-Psi-092992	Pelodiscus sinensis	66.72	0.00e+00	779.00
IUUC-Pno-094971	Phaeosphaeria nodorum	33.33	8.00e-12	65.50
IUUC-Pfo-096790	Poecilia formosa	53.87	4.00e-167	581.00
IUUC-Pab-098734	Pongo abelii	81.07	0.00e+00	954.00
IUUC-Pop-099439	Populus trichocarpa	27.19	3.00e-08	57.00
IUUC-Pca-100708	Procavia capensis	68.48	2.00e-158	551.00
IUUC-Ppe-101533	Prunus persica	45.65	4.00e-08	56.60
IUUC-Pva-102788	Pteropus vampyrus	80.60	0.00e+00	944.00
IUUC-Pyt-104561	Pyrenophora triticirepentis	33.53	3.00e-16	79.30
IUUC-Sha-107229	Sarcophilus harrisii	66.83	0.00e+00	783.00
IUUC-Sja-107720	Schizosaccharomyces japonicus	35.57	2.00e-18	88.20
IUUC-Spo-108317	Schizosaccharomyces pombe	32.50	4.00e-19	90.50
IUUC-Ssc-115804	Sus scrofa	79.70	0.00e+00	925.00
IUUC-Tgu-116931	Taeniopygia guttata	67.00	0.00e+00	797.00
IUUC-Tru-117620	Takifugu rubripes	52.88	4.00e-174	604.00
IUUC-Tni-119683	Tetraodon nigroviridis	53.07	2.00e-173	602.00
IUUC-Tre-121884	Trichoderma reesei	32.30	4.00e-13	70.50
IUUC-Tvi-122552	Trichoderma virens	31.88	2.00e-13	71.20
IUUC-Tbe-127523	Tupaia belangeri	81.24	0.00e+00	957.00
IUUC-Ttr-128954	Tursiops truncatus	77.63	0.00e+00	902.00
IUUC-Vpa-130441	Vicugna pacos	79.93	0.00e+00	946.00
IUUC-Xma-132984	Xiphophorus maculatus	53.47	2.00e-169	589.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence