iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC	miRNAMap	RAID2
Protein-protein Interaction
IID	HINT
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
UniProt
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	5.60e-27	93.0	149	179
UBD/Beta-Prp	6.30e-66	222.9	12	300

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWD 29
           gHt+ v++++  ++ +l+++Gs D+tik+W 
   Q: 149  GHTAAVWAVKIlPEqGLMLTGSADKTIKLWK 179
           8*********99999***************7 PP

UBD/Beta-Prp

   S: 3    ktlkghhksvitcvkf.spdksllatgsrdgtikvwdvttgkl....lrslsgheaevtavkfspdgk.....ilvtgseDrtikvwdl 81
           ++l gh+ +v   v++  p +  +++ srd+t+++w  ++++     ++++sgh+++v++v+++p+++     +++tg++D++i++++l
   Q: 12   CSLPGHELDVRGLVCClYPPGA-FVSVSRDRTTRLWAPDSPNRgfteMHCMSGHSNFVSCVCIIPSSDiyphgLIATGGNDHNICIFSL 99
           7788899999999999666666.888889*************999***********************999999*************** PP
   S: 82   stgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgk 170
           +++ ++++lkgh+d+v+sls+ +   +l+sGs+d t++vw   +++c+  tl+gh+++v+ v++ p++ l+ +Gs+D+t++lW  k g+
   Q: 100  DSPMPLYILKGHKDTVCSLSSGK-FGTLLSGSWDTTAKVW--LNDKCMM-TLQGHTAAVWAVKILPEQGLMLTGSADKTIKLW--KAGR 182
           **********************9.9***************..9******.*********************************..88** PP
   S: 171  llrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllkt 259
           + rt++g h+d v+ l++ s+ +e++s+++d +++ w++ tgec+  + ght+ ++s+ ++pn   +v++++D+s+riW  ++g++ +t
   Q: 183  CERTFSG-HEDCVRGLAILSE-TEFLSCANDASIRRWQI-TGECLGVYYGHTNYIYSISVFPNCRDFVTTAEDRSLRIW--KHGECAQT 266
           ******9.*********9996.8****************.***************************************..9******* PP
   S: 260  lqlhnssvisvavlsfgdnvlvlgsedskvniwklk 295
           + l+++s+++++v  +++  +v g++d++++++  +
   Q: 267  IRLPAQSIWCCCV--LDNGDIVVGASDGIIRVFTEA 300
           *************..9999*************9865 PP

Organism

Rattus norvegicus

Functional Description
(View)

Involved in the maintenance of ubiquitin levels.

Protein Sequence
(Fasta)

MASGAARYRL SCSLPGHELD VRGLVCCLYP PGAFVSVSRD RTTRLWAPDS PNRGFTEMHC 60
MSGHSNFVSC VCIIPSSDIY PHGLIATGGN DHNICIFSLD SPMPLYILKG HKDTVCSLSS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCGCCCCTC TCTTGCAGGC GGGTCTCGGG CCGCATCCTG GCGCACGCCA GCTCGGGCCT 60
GTGGACGAGT CTCGCGCTGT GCCGGGGAGC CGGGCTCCGG ATCCACGCTG GCCATGGCGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR033510--PLAA/Doa1/Lub1
IPR015155--PLAA_fam_Ub-bd_PFU
IPR013535--PUL_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS51394--PFU
PS51396--PUL
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF09070--PFU
PF08324--PUL
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0016005--F:phospholipase A2 activator activity
GO:0043130--F:ubiquitin binding
GO:0006954--P:inflammatory response
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0010992--P:ubiquitin homeostasis

KEGG

rno:116645

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000146	Aegilops tauschii	31.44	1.00e-92	333.00
IUUC-Aml-002125	Ailuropoda melanoleuca	94.12	0.00e+00	1566.00
IUUC-Atr-002554	Amborella trichopoda	31.67	5.00e-98	352.00
IUUC-Apl-004094	Anas platyrhynchos	80.61	0.00e+00	1256.00
IUUC-Aca-004726	Anolis carolinensis	79.87	0.00e+00	1328.00
IUUC-Aly-005961	Arabidopsis lyrata	32.46	6.00e-107	381.00
IUUC-Ath-006639	Arabidopsis thaliana	32.24	3.00e-102	365.00
IUUC-Ago-007772	Ashbya gossypii	29.48	9.00e-82	298.00
IUUC-Acl-008316	Aspergillus clavatus	32.48	2.00e-88	320.00
IUUC-Afl-008532	Aspergillus flavus	32.50	1.00e-90	328.00
IUUC-Afu-008950	Aspergillus fumigatus	32.66	4.00e-91	329.00
IUUC-Ani-009186	Aspergillus nidulans	34.12	3.00e-96	346.00
IUUC-Ang-009575	Aspergillus niger	31.33	2.00e-88	320.00
IUUC-Aor-010086	Aspergillus oryzae	32.50	1.00e-90	328.00
IUUC-Ate-010541	Aspergillus terreus	30.66	2.00e-85	310.00
IUUC-Ame-011633	Astyanax mexicanus	67.67	0.00e+00	1121.00
IUUC-Bgr-012292	Blumeria graminis	31.24	2.00e-95	343.00
IUUC-Bta-013218	Bos taurus	93.09	0.00e+00	1565.00
IUUC-Bci-013876	Botrytis cinerea	33.80	3.00e-98	353.00
IUUC-Bdi-014810	Brachypodium distachyon	33.68	3.00e-106	379.00
IUUC-Bol-016006	Brassica oleracea	32.94	3.00e-108	385.00
IUUC-Bra-017593	Brassica rapa	33.29	8.00e-109	388.00
IUUC-Cel-018703	Caenorhabditis elegans	28.18	1.00e-74	274.00
IUUC-Cja-019270	Callithrix jacchus	93.58	0.00e+00	1568.00
IUUC-Cfa-021262	Canis familiaris	94.12	0.00e+00	1563.00
IUUC-Cpo-021449	Cavia porcellus	88.47	0.00e+00	1436.00
IUUC-Csa-024140	Chlorocebus sabaeus	94.47	0.00e+00	1579.00
IUUC-Cho-024923	Choloepus hoffmanni	91.69	0.00e+00	753.00
IUUC-Cin-025373	Ciona intestinalis	39.93	2.00e-174	606.00
IUUC-Csv-026324	Ciona savignyi	42.35	0.00e+00	655.00
IUUC-Cgl-026711	Colletotrichum gloeosporioides	31.90	2.00e-88	320.00
IUUC-Cne-026998	Cryptococcus neoformans	32.47	1.00e-87	317.00
IUUC-Cme-027154	Cyanidioschyzon merolae	31.03	3.00e-58	220.00
IUUC-Dre-028674	Danio rerio	65.83	0.00e+00	1102.00
IUUC-Dno-028966	Dasypus novemcinctus	93.08	0.00e+00	1561.00
IUUC-Dor-030343	Dipodomys ordii	86.53	0.00e+00	902.00
IUUC-Dse-031385	Dothistroma septosporum	31.52	4.00e-85	309.00
IUUC-Dme-032044	Drosophila melanogaster	37.12	4.00e-127	449.00
IUUC-Ete-032506	Echinops telfairi	82.41	0.00e+00	814.00
IUUC-Eca-033547	Equus caballus	94.10	0.00e+00	1572.00
IUUC-Eeu-034462	Erinaceus europaeus	79.87	0.00e+00	671.00
IUUC-Fca-035893	Felis catus	94.35	0.00e+00	1571.00
IUUC-Fal-037235	Ficedula albicollis	81.78	0.00e+00	1370.00
IUUC-Fox-037836	Fusarium oxysporum	31.41	4.00e-95	342.00
IUUC-Fso-038251	Fusarium solani	32.17	3.00e-97	349.00
IUUC-Gmo-038648	Gadus morhua	65.48	0.00e+00	951.00
IUUC-Ggr-039867	Gaeumannomyces graminis	35.37	2.00e-72	267.00
IUUC-Gga-040989	Gallus gallus	79.02	0.00e+00	1316.00
IUUC-Gac-041344	Gasterosteus aculeatus	67.04	0.00e+00	1065.00
IUUC-Gma-043067	Glycine max	31.71	3.00e-105	375.00
IUUC-Ggo-045009	Gorilla gorilla	93.43	0.00e+00	1201.00
IUUC-Hsa-046807	Homo sapiens	94.59	0.00e+00	1578.00
IUUC-Itr-048636	Ictidomys tridecemlineatus	94.85	0.00e+00	1580.00
IUUC-Kpa-049134	Komagataella pastoris	43.84	5.00e-89	322.00
IUUC-Lch-049597	Latimeria chalumnae	73.00	0.00e+00	739.00
IUUC-Lpe-050821	Leersia perrieri	32.11	8.00e-102	364.00
IUUC-Loc-051849	Lepisosteus oculatus	72.44	0.00e+00	1202.00
IUUC-Lma-053297	Leptosphaeria maculans	34.07	2.00e-103	370.00
IUUC-Laf-053495	Loxodonta africana	92.74	0.00e+00	1546.00
IUUC-Meu-055983	Macropus eugenii	79.29	0.00e+00	643.00
IUUC-Mor-057006	Magnaporthe oryzae	35.40	1.00e-71	264.00
IUUC-Mpo-057465	Magnaporthe poae	35.16	1.00e-71	264.00
IUUC-Mtr-058374	Medicago truncatula	33.25	5.00e-114	405.00
IUUC-Mla-058895	Melampsora laricipopulina	37.10	2.00e-79	289.00
IUUC-Mvi-060297	Microbotryum violaceum	35.48	2.00e-110	394.00
IUUC-Mmr-060810	Microcebus murinus	88.86	0.00e+00	1457.00
IUUC-Mdo-062671	Monodelphis domestica	87.06	0.00e+00	1436.00
IUUC-Mmu-063536	Mus musculus	97.48	0.00e+00	1592.00
IUUC-Mac-064902	Musa acuminata	31.88	2.00e-100	360.00
IUUC-Mpu-066085	Mustela putorius furo	94.97	0.00e+00	1584.00
IUUC-Mlu-067907	Myotis lucifugus	90.61	0.00e+00	986.00
IUUC-Nfi-068457	Neosartorya fischeri	31.91	1.00e-73	271.00
IUUC-Ncr-068622	Neurospora crassa	31.46	3.00e-97	349.00
IUUC-Nle-069049	Nomascus leucogenys	93.71	0.00e+00	1549.00
IUUC-Opr-071013	Ochotona princeps	73.44	0.00e+00	646.00
IUUC-Ont-071339	Oreochromis niloticus	69.86	0.00e+00	1150.00
IUUC-Oan-073353	Ornithorhynchus anatinus	82.55	7.00e-112	396.00
IUUC-Ocu-074625	Oryctolagus cuniculus	94.59	0.00e+00	1580.00
IUUC-Oba-075226	Oryza barthii	29.32	4.00e-86	312.00
IUUC-Obr-076875	Oryza brachyantha	33.33	2.00e-111	396.00
IUUC-Ogl-077057	Oryza glaberrima	32.58	1.00e-110	394.00
IUUC-Ogu-078156	Oryza glumaepatula	32.42	1.00e-110	394.00
IUUC-Oin-079373	Oryza indica	32.08	6.00e-109	388.00
IUUC-Olo-080849	Oryza longistaminata	29.36	1.00e-74	274.00
IUUC-Ome-081654	Oryza meridionalis	28.80	6.00e-86	311.00
IUUC-Oni-082221	Oryza nivara	29.30	2.00e-88	320.00
IUUC-Opu-084103	Oryza punctata	29.22	6.00e-86	311.00
IUUC-Oru-084751	Oryza rufipogon	28.45	2.00e-84	307.00
IUUC-Osa-085584	Oryza sativa	32.05	3.00e-109	389.00
IUUC-Ola-086974	Oryzias latipes	68.59	0.00e+00	1147.00
IUUC-Oga-088052	Otolemur garnettii	89.32	0.00e+00	1476.00
IUUC-Oar-089509	Ovis aries	92.65	0.00e+00	1551.00
IUUC-Ptr-090911	Pan troglodytes	94.72	0.00e+00	1579.00
IUUC-Pan-092141	Papio anubis	93.98	0.00e+00	1569.00
IUUC-Psi-093543	Pelodiscus sinensis	82.14	0.00e+00	1283.00
IUUC-Pno-094952	Phaeosphaeria nodorum	33.38	4.00e-98	352.00
IUUC-Ppa-095881	Physcomitrella patens	32.88	3.00e-109	389.00
IUUC-Pfo-096739	Poecilia formosa	67.50	0.00e+00	1133.00
IUUC-Pab-098641	Pongo abelii	94.59	0.00e+00	1575.00
IUUC-Pop-099621	Populus trichocarpa	31.64	4.00e-104	372.00
IUUC-Pca-100599	Procavia capensis	83.78	0.00e+00	1291.00
IUUC-Ppe-101874	Prunus persica	32.08	2.00e-109	389.00
IUUC-Pva-103009	Pteropus vampyrus	89.87	0.00e+00	1263.00
IUUC-Pgr-103260	Puccinia graminis	32.78	3.00e-94	339.00
IUUC-Ptt-103711	Puccinia triticina	32.99	7.00e-95	341.00
IUUC-Pte-104337	Pyrenophora teres	33.07	1.00e-93	337.00
IUUC-Pyt-104475	Pyrenophora triticirepentis	33.33	2.00e-95	343.00
IUUC-Sce-106351	Saccharomyces cerevisiae	32.23	1.00e-85	311.00
IUUC-Sha-106758	Sarcophilus harrisii	86.36	0.00e+00	1436.00
IUUC-Sja-107687	Schizosaccharomyces japonicus	40.31	3.00e-95	342.00
IUUC-Spo-108093	Schizosaccharomyces pombe	33.38	2.00e-98	353.00
IUUC-Ssl-108623	Sclerotinia sclerotiorum	33.08	7.00e-97	348.00
IUUC-Smo-109368	Selaginella moellendorffii	30.95	7.00e-98	351.00
IUUC-Sit-109699	Setaria italica	33.98	4.00e-111	395.00
IUUC-Sly-111063	Solanum lycopersicum	33.25	9.00e-106	377.00
IUUC-Sar-113199	Sorex araneus	95.74	0.00e+00	819.00
IUUC-Sbi-114745	Sorghum bicolor	33.24	2.00e-103	370.00
IUUC-Sre-115080	Sporisorium reilianum	33.00	4.00e-106	379.00
IUUC-Ssc-115666	Sus scrofa	92.88	0.00e+00	1554.00
IUUC-Tgu-116877	Taeniopygia guttata	80.65	0.00e+00	1356.00
IUUC-Tru-117580	Takifugu rubripes	66.79	0.00e+00	1122.00
IUUC-Tsy-118946	Tarsius syrichta	94.09	0.00e+00	1446.00
IUUC-Tni-119755	Tetraodon nigroviridis	64.64	0.00e+00	1056.00
IUUC-Tca-120977	Theobroma cacao	31.11	5.00e-99	355.00
IUUC-Tre-122217	Trichoderma reesei	32.38	2.00e-97	350.00
IUUC-Tvi-122671	Trichoderma virens	31.67	2.00e-96	346.00
IUUC-Tae-125581	Triticum aestivum	33.51	9.00e-108	384.00
IUUC-Tme-126971	Tuber melanosporum	35.01	1.00e-114	407.00
IUUC-Tbe-127858	Tupaia belangeri	75.73	0.00e+00	647.00
IUUC-Ttr-128173	Tursiops truncatus	91.58	0.00e+00	1512.00
IUUC-Uma-129322	Ustilago maydis	33.75	7.00e-108	385.00
IUUC-Vda-129682	Verticillium dahliae	31.86	5.00e-90	325.00
IUUC-Vpa-130607	Vicugna pacos	91.02	0.00e+00	1399.00
IUUC-Vvi-131153	Vitis vinifera	33.25	2.00e-112	400.00
IUUC-Xtr-132208	Xenopus tropicalis	74.43	0.00e+00	1236.00
IUUC-Xma-133098	Xiphophorus maculatus	68.58	0.00e+00	1132.00
IUUC-Yli-134646	Yarrowia lipolytica	39.38	3.00e-95	343.00
IUUC-Zma-135920	Zea mays	31.13	2.00e-93	336.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence