iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ata-000456

Ensembl Protein ID

EMT16594

UniProt Accession

R7WD52; R7WD52_AEGTA

Genbank Protein ID

EMT16594.1

Protein Name

Ubiquitin-activating enzyme E1 1

Genbank Nucleotide ID

KD537195

Gene Name

F775_27868

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
F775_27868	EMT16594	EMT16594

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	3.10e-171	570.9	410	898

Active Site

Position(s)	Description	Evidence
591	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv.....gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvnveahees 96
           YD Qi ++G++ q+kl+ ak+++vG g+lGcE+lKnL+l+G+     g++tv+D+d +e+snl+rqFLfr++++g++K+ vaa a+  +np+ +vea +++
   Q: 410  YDAQISVFGSKLQNKLEAAKIFMVGSGALGCEFLKNLALMGIscsqnGNLTVTDDDVIEKSNLSRQFLFRDWNIGQPKSTVAATAAMVINPKLHVEALQNR 510
           ***************************************************************************************************** PP
   S: 97   iteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsddppqktiPfctlketpnaaehtiewa.... 190
            ++++e+++   F +++d Vv+aldn+ ar++++++c++ ++pl+esgtlG + +++ +i++lte y +s+dpp+k++P+ct+ ++p +++h+++wa    
   Q: 511  ASPETENVFndaFWENLDAVVNALDNVTARMYIDSRCVYFQKPLLESGTLGAKCNTQMVIPHLTENYGASRDPPEKQAPMCTVHSFPHNIDHCLTWArsef 611
           *******99*****************************************************************************************999 PP
   S: 191  ........vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakttinsikqllksfecdivtkskspfwv......... 274
                     +n +l++ +   + +     ++ ++ +++v + l   + e+f++ i++a+ +f+ +++n +kql+  f+ d vt+s++pfw+         
   Q: 612  egllektpTEVNAFLSNPTTYISAARTAGDAQARDQLERVIECLDRDKCETFQDSITWARLKFEDYFSNRVKQLTFTFPEDSVTSSGAPFWSapkrfprpv 712
           988888885555555544444444444555666666666666777788899************************************************** PP
   S: 275  ..................................................sfcsnaealqvpekvekdeevvkasap.lylllralerfekk..kgrkpge 322
                                                               +++  ++ ++ek+++   ++ ++a+ ++ l+++le+++k+  +g  ++ 
   Q: 713  dfsssdpsqlsfilaaailraetfgipipewaktpnklaaeavdkvivpdFQPKQGVKIVTDEKATSLSSASVDDAAvIEELIAKLEEVSKTlpSGFHMNP 813
           *******************************99999988888888766643334444444555555555544444448***********99755899**** PP
   S: 323  lsfekddds..avdlvtaaanlraeslgiepkldddlikeiagniipaiattnavvgGlaaqEviKvvsg..kfeplknfflfdae 404
           ++fekddd   ++d+++ +an+ra +++i++ +d+ + k iag+iipaiat +a+  Gl+++E++K++ g  k e ++n+f ++a+
   Q: 814  IQFEKDDDTnfHMDVIAGFANMRARNYSIPE-VDKLKAKFIAGRIIPAIATSTAMATGLVCLELYKALAGghKVEDYRNTFANLAI 898
           *******************************.*************************************9999********99876 PP

Organism

Aegilops tauschii

Protein Sequence
(Fasta)

MAGRGNEIDE DLHSRQLAVY GRETMKRLFG SNVLVSGLQG LGAEIAKNLV LAGVKSVTLH 60
DDGNVELWDL SSNFFLSEND VGQNRAQACV QKLQELNNAV LVSALTGDLT KEHLSKFQAV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCAGGGA GGGGGAACGA GATCGACGAG GACCTGCACA GTCGCCAGCT CGCCGTCTAT 60
GGCCGCGAGA CCATGAAGCG CCTCTTCGGT TCCAACGTCC TCGTCTCTGG ACTCCAGGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-0833--Ubl conjugation pathway

Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR018074--UBQ-activ_enz_E1_CS
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like

PROSITE

PS00536--UBIQUITIN_ACTIVAT_1
PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys

PRINTS

PR01849--UBIQUITINACT

SMART

SM00985--UBA_e1_C

Gene Ontology

GO:0005524--F:ATP binding
GO:0008641--F:small protein activating enzyme activity
GO:0006464--P:cellular protein modification process

KEGG

ats:F775_27868

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Atr-002684	Amborella trichopoda	78.90	0.00e+00	1643.00
IUUC-Apl-004158	Anas platyrhynchos	40.20	0.00e+00	686.00
IUUC-Aly-005418	Arabidopsis lyrata	78.22	0.00e+00	1685.00
IUUC-Ath-006891	Arabidopsis thaliana	77.18	0.00e+00	1665.00
IUUC-Ame-010933	Astyanax mexicanus	46.75	0.00e+00	846.00
IUUC-Bgr-012281	Blumeria graminis	43.76	0.00e+00	810.00
IUUC-Bdi-014335	Brachypodium distachyon	95.86	0.00e+00	1973.00
IUUC-Bol-015665	Brassica oleracea	78.40	0.00e+00	1655.00
IUUC-Bra-017252	Brassica rapa	78.91	0.00e+00	1689.00
IUUC-Cho-024682	Choloepus hoffmanni	36.38	2.00e-101	363.00
IUUC-Csv-026084	Ciona savignyi	43.05	0.00e+00	842.00
IUUC-Cgl-026512	Colletotrichum gloeosporioides	47.32	0.00e+00	881.00
IUUC-Cme-027290	Cyanidioschyzon merolae	39.83	0.00e+00	694.00
IUUC-Dre-028149	Danio rerio	47.49	0.00e+00	874.00
IUUC-Dme-032045	Drosophila melanogaster	44.85	0.00e+00	843.00
IUUC-Ete-033124	Echinops telfairi	39.91	5.00e-133	468.00
IUUC-Fal-036848	Ficedula albicollis	39.61	0.00e+00	690.00
IUUC-Gmo-039338	Gadus morhua	44.18	0.00e+00	834.00
IUUC-Ggr-039823	Gaeumannomyces graminis	44.41	0.00e+00	853.00
IUUC-Gga-040747	Gallus gallus	40.00	0.00e+00	682.00
IUUC-Gac-041773	Gasterosteus aculeatus	44.92	0.00e+00	842.00
IUUC-Gma-043198	Glycine max	80.99	0.00e+00	1700.00
IUUC-Lch-050371	Latimeria chalumnae	46.24	0.00e+00	886.00
IUUC-Lma-053315	Leptosphaeria maculans	46.06	0.00e+00	865.00
IUUC-Mtr-058572	Medicago truncatula	80.63	0.00e+00	1663.00
IUUC-Mga-059721	Meleagris gallopavo	40.24	0.00e+00	662.00
IUUC-Ont-071671	Oreochromis niloticus	46.43	0.00e+00	874.00
IUUC-Oan-073268	Ornithorhynchus anatinus	41.42	0.00e+00	632.00
IUUC-Oba-075120	Oryza barthii	90.34	0.00e+00	1811.00
IUUC-Obr-076557	Oryza brachyantha	90.93	0.00e+00	1831.00
IUUC-Oin-079370	Oryza indica	87.88	0.00e+00	1799.00
IUUC-Ome-081942	Oryza meridionalis	90.83	0.00e+00	1823.00
IUUC-Oni-082365	Oryza nivara	90.73	0.00e+00	1821.00
IUUC-Opu-083301	Oryza punctata	90.63	0.00e+00	1816.00
IUUC-Ola-087002	Oryzias latipes	47.14	0.00e+00	885.00
IUUC-Olu-087687	Ostreococcus lucimarinus	59.00	0.00e+00	1142.00
IUUC-Ptr-090609	Pan troglodytes	41.01	0.00e+00	686.00
IUUC-Psi-093489	Pelodiscus sinensis	39.61	0.00e+00	689.00
IUUC-Pma-094214	Petromyzon marinus	47.02	2.00e-33	134.00
IUUC-Pno-095154	Phaeosphaeria nodorum	44.35	0.00e+00	826.00
IUUC-Ppa-095227	Physcomitrella patens	74.09	0.00e+00	1551.00
IUUC-Pfo-097184	Poecilia formosa	46.33	0.00e+00	871.00
IUUC-Pop-098934	Populus trichocarpa	79.03	0.00e+00	1662.00
IUUC-Ppe-102012	Prunus persica	78.90	0.00e+00	1690.00
IUUC-Pva-102584	Pteropus vampyrus	46.28	0.00e+00	915.00
IUUC-Pte-104200	Pyrenophora teres	45.36	0.00e+00	857.00
IUUC-Pyt-104441	Pyrenophora triticirepentis	44.76	0.00e+00	851.00
IUUC-Sce-106245	Saccharomyces cerevisiae	44.88	0.00e+00	845.00
IUUC-Sja-107841	Schizosaccharomyces japonicus	45.50	0.00e+00	851.00
IUUC-Spo-108034	Schizosaccharomyces pombe	44.25	0.00e+00	824.00
IUUC-Smo-108912	Selaginella moellendorffii	72.57	0.00e+00	1526.00
IUUC-Sit-110281	Setaria italica	91.44	0.00e+00	1867.00
IUUC-Stu-112109	Solanum tuberosum	78.44	0.00e+00	1684.00
IUUC-Sbi-114089	Sorghum bicolor	91.83	0.00e+00	1868.00
IUUC-Tgu-116565	Taeniopygia guttata	39.56	0.00e+00	685.00
IUUC-Tru-118742	Takifugu rubripes	46.95	0.00e+00	833.00
IUUC-Tca-121436	Theobroma cacao	79.88	0.00e+00	1686.00
IUUC-Tur-126330	Triticum urartu	99.51	0.00e+00	2037.00
IUUC-Vvi-130857	Vitis vinifera	81.84	0.00e+00	1712.00
IUUC-Xtr-132026	Xenopus tropicalis	40.08	0.00e+00	670.00
IUUC-Xma-133805	Xiphophorus maculatus	46.13	0.00e+00	849.00
IUUC-Yli-134547	Yarrowia lipolytica	45.28	0.00e+00	852.00
IUUC-Zma-135758	Zea mays	89.94	0.00e+00	1828.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence